Digital Commons Network^™

Mechanistic Prediction Of Apixaban And Rivaroxaban Secretion Into Human Milk And Infant Systemic Exposure Through An Integrated Physiologically Based Pharmacokinetic Framework, Bofang Yi, Sung Hun Bae, Yongzong Yang, Linda Jiang, Shirley Chen, Allesandra Stratigakis, Zhongyuan Zhao, Mohammad Asikur Rahman, Yanyan Li, Xinrui (Sarea) Wang, Peng Zou, Tao Zhang

Pharmacy Faculty Scholarship

Accurately characterizing the transfer of apixaban and rivaroxaban into human milk is essential for evaluating their safety during lactation and for guiding anticoagulant therapy in breastfeeding patients. This study aimed to establish a mechanistic physiologically based pharmacokinetic (PBPK) modeling approach linking maternal exposure, mammary drug transport, and infant systemic levels for both anticoagulants. Passive permeability and efflux transport across the mammary epithelium were measured using an in vitro human mammary epithelial cell model, providing information on diffusion and transporter-mediated clearance, whereas milk protein binding was determined using rapid equilibrium dialysis to account for unbound drug available for transfer. These experimentally …

Cv: Rebecca Pruitt (Early Childhood Special Education), Rebecca Pruitt

Education Department Faculty Curricula Vitae

No abstract provided.

Measurable Residual Disease Testing In Acute Myeloid Leukemia: Current State, Foundational Models, And Tools For Future Development, Joseph Van Galen, Stephen D. Willis, Ashish Bains, Sara H. Small

Department of Medical Oncology Faculty Papers

Acute myeloid leukemia (AML) is a lethal and rapidly progressive hematologic malignancy with high rates of relapse and treatment refractoriness. Management of AML is complicated by biological heterogeneity in a disease that is broadly defined by the clonal expansion of myeloblasts that otherwise play an important role in healthy marrow tissues. While subtypes of AML are increasingly defined by druggable driver mutations including FLT3-ITD, IDH1, IDH2, and NPM1, conventional chemotherapy and reduced intensity induction regimens (e.g., azacitidine-venetoclax) remain therapeutic backbones. One area of active development for personalization of AML treatment is the assessment of measurable residual disease (MRD). MRD testing …

Eeoc Rules That Transgender Federal Employees May Be Denied Insurance Coverage For Gender-Affirming Care, Arthur S. Leonard

Other Publications

No abstract provided.

Artificial Accelerated Aging And Red Wine Staining On Color Stability In Dental Composites, Zeynep Hale Keleş, Marilia Mattos Sly, Rosa Llisel Ocampo Escobedo, Nuray Kösem, Yonca Korkmaz-Ceyhan

Faculty, Staff and Student Publications

Background

The resistance of composite resins to discoloration, staining, and aging is essential for preserving both the aesthetic quality and long-term durability of dental restorations.

Objective

The study aims to evaluate the effects of artificial accelerated aging (AAA) and red wine staining on the color stability of resin composites.

Methods

A2 color disc-shaped specimens (10-mm in diameter, 2-mm thick, n = 5) of 3 resin composites: G-aenial Universal Injectable (GC Corp, Japan), G-aenial A’CHORD (GC Corp, Japan), G-aenial Anterior (GC Corp, Japan), were polymerized using a curing light through a Mylar strip and a 1-mm glass slide for 40 s. …

Qualitative Analysis Of Emotion Schemes Theory Of Compassion Satisfaction In Emotion - Focused Therapy, Bronislava Šoková, Lenka Janík Blašková, Katarína Greškovičová, Júlia Halamová

The Qualitative Report

There is little to no research focused on the qualitative understanding of compassion satisfaction among helping professionals, despite the demanding nature of the profession. Our aim was to examine how helping professionals experience compassion satisfaction through the lens of emotion scheme theory applied in emotion-focused therapy. Eight helping professionals were randomly selected from the pool of 29 participants representing a convenience sample, with the age range from 20 to 44 years. Data were collected via online in-depth interviews with open-ended questions concerning emotion scheme of their intense experience of compassion satisfaction. To analyze the data, phenomenology and consensual qualitative analysis …

Christopher Radziewicz V. Usa

2026 Decisions

USDC for the District of Delaware

Using Diffusion Mri To Relate Hippocampal Subfield Microstructure To Delayed Verbal Memory In Cognitively Intact Individuals At Genetic Risk For Developing Alzheimer's Disease, Jennapher Lingo Vangilder, Andrew Hooyman, Sasha Hakhu, Kurt G. Schilling, Leland S. Hu, Yuxiang Zhou, Richard J. Caselli, Leslie C. Baxter, Scott C. Beeman

Physical Therapy Faculty Articles and Research

Intervention to delay the onset of Alzheimer's disease (AD) is an important treatment strategy but detecting at-risk individuals before significant disease progression remains challenging. This study evaluates the relationship between hippocampal microstructure and verbal cognition in cognitively intact older adults, focusing on the differences between APOΕ ε4 allele carriers and noncarriers. Participants (n = 41 noncarriers, 33 carriers) over 60 years old (mean ± SD: carriers 71 ± 6.6; noncarriers 71 ± 6.4 years) underwent diffusion-weighted magnetic resonance imaging (dMRI) and volumetric assessments. We assessed hippocampal structure, including microstructure, using Neurite Orientation Dispersion and Density Imaging (NODDI), diffusion tensor …

March 27, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Prescription Tradeoff Decision Support For Pancreas Stereotactic Body Radiation Therapy: From Templates To Artificial Intelligence Models, Yibo Xie, Manisha Palta, Ruilin Li, Wentao Wang, Qiuwen Wu, Yaorong Ge, Q. Jackie Wu, Yang Sheng

Department of Radiation Oncology Faculty Papers

Objective: To develop an artificial intelligence (AI) driven plan tradeoff decision making assistant for radiation oncologists. Methods: A user interface (UI) was developed to integrate the assistant with the treatment planning system to facilitate prescription decision process. The assistant is powered by a machine learning core which was trained to learn the balance between planning target volume (PTV) coverage and organs-at-risk (OAR) sparing. A group of 98 pancreatic stereotactic body radiation therapy (SBRT) cases were retrospectively included for this study. The clinical plan's PTV coverage was compared against the model predicted value. A 10-fold cross validation was performed for all …

Residential Life As An Equity Strategy For First-Year Persistence Among First-Generation, Low-Income, And Racially Minoritized Students, Joshua Kwaku Addai

Poster Presentations

Despite decades of research on student retention, first-year attrition continues to disproportionately affect first-generation, low-income, and racially minoritized students. Institutional responses have largely emphasized financial aid, advising reform, and classroom-based interventions. However, students spend much of their first year within residential environments; spaces that profoundly shape belonging, identity development, and daily engagement. This study argues that residential life is not merely a housing function but a critical, and often underexamined, site of equity-driven student persistence. Drawing on Tinto’s theory of academic and social integration and Museus’s Culturally Engaging Campus Environments (CECE) model, this literature review synthesizes interdisciplinary research to examine …

Wic Staffs’ Perspectives On Underutilization Of Wic In Rhode Island, Ophelia Xorlali Mensah, Fred B. Addo, Kathryn Roy, Ann Barone

Poster Presentations

Background and Objectives: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) improve food security, nutrition, and overall health for low income pregnant and postpartum women, infants, and young children in the U.S. However, continuous participation and retention drop as children age in the WIC program. Very few studies have assessed these challenges faced by caregivers from the perspectives of the WIC staff. We therefore explored perspectives of WIC staff on caregivers’ participation and early dropout from WIC. Methods: We conducted in-depth interviews among 3-4 staff from each of the major WIC agencies in Rhode Island (n=20). By …

Depression And Hypertension Among U.S. Adults: A Cross-Sectional Analysis Of Nhanes Data, Abimbola Sola-Aremu

Poster Presentations

Objectives

Depression and hypertension are prevalent chronic conditions in the United States and may co-occur due to shared behavioral and physiological risk factors. This study examined the association between depression and hypertension among U.S. adults using nationally representative survey data.

Methods

A cross-sectional analysis was conducted using data from the 2021–2023 National Health and Nutrition Examination Survey (NHANES). Depression was defined as a Patient Health Questionnaire-9 (PHQ-9) score ≥10. Hypertension was defined by measured systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, self-reported physician diagnosis, or antihypertensive medication use. Participant characteristics were compared by depression status using …

Using Multi-Group Path Analysis To Examine Variability In Risk For Alcohol Problems Across Race/Ethnicity And Gender, Riza Tolga Ulman, Liam Rozum, Milagros Grados, Chrystal Vergara-Lopez, Hector Lopez-Vergara

Poster Presentations

Student Author and Department: Riza Tolga Ulman, Department of Human Development and Family Science, College of Health Sciences, URI Faculty Sponsor/Advisor and Department: Hector Lopez-Vergara, Department of Psychology, College of Health Sciences, URI Full citation: Ulman, R. T., Rozum, W., Grados, M., Vergara-Lopez, C., & Lopez-Vergara, H. I. (2026, March 27–28). Using multi-group path analysis to examine variability in risk for alcohol problems across race/ethnicity and gender [Poster presentation]. Graduate Student Conference, University of Rhode Island, Kingston, RI. (Submitted) Background: Previous research has shown that alcohol use problems are a substantial public health concern. The addiction literature has previously identified …

The Importance Of Sports Physical Leading To The Diagnosis Of Loeys–Dietz Syndrome, Fnu Varnika, Anastasia Dihel, Michael Bereisha, Nergess Taheri

Cooper Rowan Medical Journal

Abstract

The pre-participation school or sports physical, introduced in the mid-20th century, remains a cornerstone of adolescent health screening, primarily aimed at ensuring athletic safety. While most evaluations reveal benign conditions, these encounters occasionally uncover critical yet asymptomatic disorders. This report highlights the incidental discovery of Loeys–Dietz syndrome (LDS) type 4 in a 17-year-old male during a routine sports physical, underscoring the clinical value of thorough cardiovascular assessment and recognition of subtle phenotypic cues in preventive settings.

Significance: Loeys–Dietz syndrome is a rare, autosomal dominant connective tissue disorder affecting fewer than 1 in 100,000 individuals, often misdiagnosed as Marfan syndrome …

Deprescribing Following Access To Lifestyle Treatment: A Retrospective Chart Review Of Primary Care Outcomes In Patients With Type 2 Diabetes, Yoav Jacob, Kara L Staffier, Samveda Menon, Puja B Gandhi, Joeita F Macfield, Gia Merlo, Stefanie M Meyer, Shivani S Patel, Caroline Rhéaume, Madeline Watson, David Donohue, Wayne S Dysinger, Micaela C Karlsen

Faculty, Staff and Student Publications

Background: Among individuals with type 2 diabetes (T2D), lifestyle improvements can restore glycemic control, yet few studies have examined deprescribing in settings where it was necessitated by improvements in health. This study aimed to (1) identify instances of medication deprescribing among adults with T2D in a primary care setting where patients had access to lifestyle medicine (LM), (2) document lifestyle changes among deprescribed patients, (3) assess changes in body mass index (BMI), glucose, and hemoglobin A1c (HbA1c) following deprescribing, and (4) assess the safety of deprescribing in the context of LM-informed care by identifying adverse events.

Methods: A …

Functional And Structural Basis Of A Hypermorphic Trpc3 Variant, Briar Bell, Angela M Jaramillo-Granada, Luis O Romero, Irene A Gutierrez, Venkata K P S Mallampalli, Guizhen Fan, Sameer Varma, Matthew L Baker, Irina I Serysheva, Valeria Vásquez, Julio F Cordero-Morales

Faculty, Staff and Student Publications

Cerebellar ataxias are characterized by impaired motor coordination resulting from neuronal dysfunction within the cerebellum. The mechanisms underlying this pathology and its cerebellar-specific neurodegeneration remain unknown. We uncover how a gain-of-function canonical transient receptor potential member 3 (TRPC3) mutation, coupled with a cerebellum-specific isoform, stabilizes the channel’s open state, resists the leading inhibitor Pyr3, and drives calcium-dependent cell death. Restoring calcium homeostasis by expressing a Purkinje cell calcium pump improves cell viability. Transgenic expression of the TRPC3 hypermorphic variant in Caenorhabditis elegans induces neurodegeneration, confirming its pathogenicity across species. Cryo–electron microscopy and molecular simulations reveal the structural basis for the …

Social Isolation And Firearm Secure Storage In The Usa: Results From The 2022 Brfss, Alexander Testa, Daniel Semenza, Dylan B Jackson, Karyn Fu, Sandra Mckay, Kyle T Ganson, Jason M Nagata, Jack Tsai

Faculty, Staff and Student Publications

Background: Firearm secure storage (ie, storing firearms unloaded and locked) is recommended to reduce unintentional injuries and suicides. However, the relationship between psychological states, such as social isolation, and firearm secure storage practices is under-researched.

Methods: Data are from 7136 individuals with firearms in their households from the 2022 Behavioral Risk Factor Surveillance System. Multinomial logistic regression was used to explore the relationship between social isolation and firearm storage.

Results: Among respondents, 71.6% reported storing firearms unloaded, 14.2% stored firearms loaded and locked and 14.2% stored firearms loaded and unlocked. Most respondents reported feeling 'never' (40.7%) or 'rarely' (33.3%) socially …

Dhansingh V. Hager

All Decisions

Court granted motion to join DOB as a respondent in HP proceeding seeking correction of a DOB elevator violation, holding that Housing Court has broad jurisdiction under CCA § 110(d) to enforce not only HPD-administered Housing Maintenance Code violations but also violations of the MDL and local laws pertaining to housing standards that are under DOB's responsibility.

Impact Of Who Aware Antibiotic Handbook Training On Antibiotics Prescribing Knowledge Among Private Primary Care Providers: A Vignette-Based, Prep-Post Pilot Study In Patna, India, Poshan Thapa, Prachi Shukla, Chandrashekhar Joshi, Sena Sayood, Pradeep Kumar Sinha, Diwash Timilsina, Mili Dutta, Madhukar Pai, Samira Abbasgholizadeh Rahimi, Sumanth Gandra

2020-Current year OA Pubs

INTRODUCTION: Inappropriate antibiotic prescribing is a major concern in low- and middle-income countries (LMICs), particularly at the primary care level. The WHO AWaRe Antibiotic Handbook was introduced to promote rational antibiotic use, yet its real-world feasibility and potential impact remain underexplored. Our study evaluated the impact and usefulness of the WHO AWaRe Handbook training among private primary care providers (PCPs) in Patna, India.

METHODS: We conducted a pre-post pilot study among 145 private PCPs (40 formal PCPs (FPs) and 105 informal PCPs (IPs) in Patna, India. Participants received training from an infectious disease physician on the WHO AWaRe Antibiotic Handbook. …

Measuring Multimodal Equity In Resource-Challenged Mpos, Christopher Ferrell, David Reinke, John M. Eells

Mineta Transportation Institute

Ensuring transportation investments are equitable across different populations and travel modes is a priority for many agencies, yet existing tools often make these assessments difficult, especially for smaller and resource-constrained organizations. To address this gap, this report provides the findings of Phase II of our study on reviewing and developing transportation equity metrics. The Phase I project investigated transit equity metrics and provided recommendations on advancements in quantitative methods. Building on Phase I recommendations, this study investigates low-cost methods for comparing the equity between auto (roadway) and transit performance or investments for low resource transportation agencies. A literature review revealed …

Mouse White Matter Matters: Cortical Origins And Spatial Organization Of Mouse White Matter Tracts, Sofia D Gordeev, Melissa Franch, Sarah R Heilbronner

Faculty, Staff and Students Publications

White matter—the fundamental structure underlying network connectivity—lies at the heart of the brain’s computational power. White matter is organized into fiber tracts, or bundles, in both human and nonhuman primate brains. These bundles consist of long-range axonal projections with a set of shared origin and termination points and exhibit a predictable organization. However, the organization of white matter in the mouse brain remains relatively unknown. This knowledge gap is surprising given the central role of mice in neuroscience, with mouse brains serving as the dominant model for transgenics, in vivo calcium imaging, and circuit manipulation. To address this gap, we …

3'Utr Mapping Reveals Alternative Polyadenylation In Right Ventricular Failure, Rahul Neupane, Kartiga Natarajan, Erik E Suarez, Henry J Pownall, Kai-Lieh Huang, Eric J Wagner, Ajay Kumar Verma, Rambabu Majji, Hari Krishna Yalamanchili, Ashrith Guha, Rajarajan A Thandavarayan

Children’s Nutrition Research Center Staff Publications

No abstract provided.

Clinically Aligned Long-Context Transformers For Cross-Platform Mental Health Risk Detection, Aditya Tekale, Mohammad Masum

Faculty Research, Scholarly, and Creative Activity

Social media platforms contain rich but noisy narratives of psychological distress, creating opportunities for early mental health risk detection. However, existing datasets capture heterogeneous constructs such as suicide risk severity, depression diagnosis, and DSM-5 symptom presence, and most prior models are trained and evaluated on a single corpus, limiting their clinical alignment and cross-dataset generalizability. In this study, we fine-tune a domain-specific long-document transformer, AIMH/Mental-Longformer-base-4096, for binary mental health risk detection (risk vs. no risk) using two clinically aligned Reddit datasets: the C-SSRS Reddit corpus and the eRisk 2025 depression dataset. To handle long user histories, we introduce an LLM-based …

Effective Spectrum-Based Antibiotic Resistance Index For Monitoring Resistance In Gram-Negative Bacilli, M Cristina Vazquez Guillamet, Alice Bewley, Nicole J Tarlton, Reid Goodman, Michael J Durkin, Michael Bernauer, Meghan Brett, Kevin Hsueh, Cristian Bologa, George Turabelidze, Andrew Atkinson, Victoria J Fraser

2020-Current year OA Pubs

BACKGROUND: Antimicrobial resistance (AMR) is a growing public health threat, and we currently lack accurate measures to track and trend this resistance. We developed the antibiotic resistance index (ARI) that aggregates resistance of Gram-negative bacilli (GNB) into a single metric which can be tracked across healthcare settings and over time.

METHODS: Culture data were collected from adult patients who met the CDC adult sepsis event criteria across 10 Barnes-Jewish HealthCare (BJC) hospitals between January 2018 and December 2023. An antibiotic's effective spectrum (AES) was calculated as the ratio of susceptible GNB to all identified GNB. The ARI was calculated as …

Collaborative Care For Depression In Chronic Illness: A Narrative Review, Chun Wong, German E. Corso

School of Medicine Publications

Background: Depression commonly coexists with chronic medical illness and is associated with impaired self-management, poor adherence, increased healthcare utilization, and higher mortality.

Objective: To synthesize evidence published between 2000 and late 2025 on the effectiveness of the Collaborative Care Model (CoCM) for depression in adults with chronic medical illness, with particular attention to contemporary U.S. implementation, policy, and equity considerations.

Methods: A narrative review of randomized controlled trials, pragmatic and implementation studies, systematic reviews, and policy analyses was conducted using PubMed, PsycINFO, and Scopus. Evidence addressing collaborative care for depression in adults with chronic medical illness was identified and synthesized …

Bioinformatics Analysis Of Trpv1 Expression And Its Role In Hepatocellular Carcinoma Prognosis, Vivek K. Kashyap, Bhuvnesh P. Sharma, Himanshu N. Singh, Sanjay Kumar, Deepak Verma, Deepak Parashar, Murali M. Yallapu, Everardo Cobos, Subhash Chauhan

School of Medicine Publications

Background: Hepatocellular carcinoma (HCC) is among the most lethal malignancies globally, with a persistently poor prognosis due to late diagnosis and limited therapeutic options available. The transient receptor potential vanilloid 1 (TRPV1), a calcium-permeable cation channel, plays critical roles in cancer pathogenesis across several cancer types, but its role in HCC remains poorly defined.

Methods: We performed an integrative bioinformatics analysis of TRPV1 utilizing multiple public databases, including TCGA, GEO, TIMER, UALCAN, cBioPortal, LinkedOmics, and COSMIC in HCC. We examined the TRPV1 expression profile, prognostic significance, genetic alterations, DNA methylation status, co-expression networks, and correlations with immune infiltration. Single-cell RNA …

Oh, The Places Women In Law Will Go, Judge Jane Gray '79, Secretary Elaine Marshall '81, Dean Raven Byrne '06, Amy Clay '16, Margaret Currin '79 (Moderator)

Conferences

Panel discussion focusing on the women's history of Campbell Law School and what each of the distinguished panelists have accomplished with their law degree.

Lost And Found, Katherine M. Houlden

Nebraska Journal on Advancing Justice

No abstract provided.

Pearl's Perfect Last Will - Crushed By Infantilism Bias, Edward F. Fogarty Mr

Nebraska Journal on Advancing Justice

No abstract provided.