Digital Commons Network^™

Dyadic Associations Between Stress And Sleep Quality And Moderating Effects Of Emotional Intimacy And In Survivors Of Young Adult Cancer And Their Spouses: An Observational Study, Haejeong An, Seokhun Kim, Michael Roth, Kathrin Milbury, Dalnim Cho

Faculty, Staff and Student Publications

Background: Survivors of young adult (YA) cancer often experience substantial stress during the transition to survivorship, which may impair sleep. Although the stress-sleep link is well established, its role within survivor-spouse dyads remains unclear. Emotional intimacy may influence how couples regulate stress and affect sleep. This study examined dyadic associations between stress and sleep among survivors of YA cancer and their spouses and significant others (hereafter spouses) and tested emotional intimacy as a moderator.

Methods: A total of 103 survivor of YA cancer-spouse dyads completed self-reported measures of stress, emotional intimacy, and sleep quality. An actor-partner interdependence moderation model was …

Associations Between Sociodemographic Predictors And Age Of Referral For Autism Spectrum Disorder (Asd) Diagnosis Since The Beginning Of The Covid-19 Pandemic, Mallika Mathur, Ruosha Li, Sandra Mckay, Christine Markham, Deepali K Ernest, Shreela Sharma

Faculty, Staff and Student Publications

Purpose: Sociodemographic characteristics, such as race and ethnicity, are associated with delays in ASD diagnosis. However, limited literature has examined the characteristics associated with delayed diagnosis since the start of the COVID-19 pandemic. This study aimed to identify the individual and aggregate sociodemographic characteristics associated with the age at which a child receives a referral for a diagnosis (from March 2020 to May 2023) and evaluate the impacts of the pandemic on this association.

Methods: Using cross-sectional data obtained from patients' electronic health records and the U.S. Census Bureau, we examined associations using linear regressions (N = 507). A subgroup …

Physical Activity For Public Health In The 21st Century, Deborah Salvo, Inacio Crochemore-Silva, Andrea Wendt, Jakob Tarp, Eric J Shiroma, Richard J Simpson, I-Min Lee, Ulf Ekelund, Ester Cerin, Youssouf Keita, Adrian Bauman, Pedro C Hallal, Andrea Ramirez Varela, Michael Pratt, Rodrigo Reis, Erica Hinckson, Ding Ding, Harold W Kohl, James Sallis

Faculty, Staff and Student Publications

With over 5 million attributed deaths per year, physical inactivity is a major global public health issue. Although the importance of physical activity is well recognized within the scope of obesity and cardiometabolic disease prevention and control, its broader benefits for the health of individuals and societies are yet to be fully harnessed. Furthermore, the role of active leisure, active transport and active labor-primary domains of physical activity-in supporting or hindering social and health equity has been largely overlooked. Here we (1) used a health equity lens to describe global domain-specific physical activity inequalities through an analysis of World Health …

Outcomes After Pulmonary Artery Flow Reducer Implantation In High-Risk Neonates With Congenital Heart Disease And Pulmonary Overcirculation, Cihangir Buyukgoz, Shyam Sathanandam, Neil Tailor, Ashley Molloy, Thomas Spentzas, Karthik Ramakrishnan, Christopher Knott-Craig, Umar Boston

Faculty, Staff and Student Publications

Background: Surgical outcomes in neonates with complex congenital heart disease (CHD) and pulmonary overcirculation (POC) initially palliated with pulmonary flow reducers (PFRs) were evaluated.

Methods: This was a retrospective study conducted between January 1, 2020 and December 31, 2023. Eleven neonates underwent PFR palliation. Fenestrated Medtronic microvascular plugs (PFRs) were delivered into the branch pulmonary artery (PA). The target surgical procedure involved the removal of PFRs and biventricular repair (n = 9) or single-ventricle palliation (n = 2).

Results: Patients were deemed high risk on the basis of prematurity (n = 5), early gestational age (n = 5), heterotaxy (n …

Using Confirmatory Factor Analysis To Identify Symptom Clusters In Individuals With Acquired Disabilities, David S Tulsky, Aaron J Boulton, Pamela A Kisala, Callie E Tyner, Ryan Pohlig, Nancy D Chiaravalloti, Jerry Slotkin, Heather B Taylor, Mark Sherer

Faculty, Staff and Student Publications

Purpose: Acquired disabilities, such as spinal cord injury, traumatic brain injury, limb loss (or other major limb injury/illness), or stroke, are typically accompanied by an array of physical and emotional symptoms and social challenges that interfere with recovery and affect quality of life (QOL). Despite advances in personalized medicine, interrelationships between symptoms remain unclear, and clinicians often treat individual symptoms in isolation. The objective of this study was to identify clusters of symptoms that occur across sudden-onset disability populations, with a long-term goal of identifying targets for clinical intervention.

Methods: Participants were 755 adults who sustained a spinal cord injury, …

Probability Of Fentanyl Adulteration In Cocaine Selectively Decreases Cocaine Demand, Cecilia Nunez, Jin H Yoon, James Mackillop, Margaret C Wardle

Faculty, Staff and Student Publications

Fentanyl-related, cocaine-overdose deaths have drastically increased, yet research on how people who use cocaine perceive fentanyl adulteration is limited. This study developed the novel Adulterated Cocaine Purchasing Task (ACocPT), a modification of the original Cocaine Purchasing Task, to quantify how people respond to fentanyl adulteration in cocaine. In the ACocPT, participants indicated how much cocaine they would purchase when cocaine had no (0%) vs. some (10%) probability of fentanyl adulteration. Study aims were: 1) determine how possible fentanyl adulteration affects cocaine demand, and 2) determine which individual characteristics predict continued demand for cocaine despite fentanyl adulteration. This Amazon Mechanical Turk …

A Treat-To-Target Approach For Obesity Management: A Post Hoc Analysis Of The Surmount-5 Trial., Carel W Le Roux, Luca Busetto, Louis Aronne, Deborah Bade Horn, Georgios K Dimitriadis, Beverly Falcon, Luis-Emilio Garcia-Perez, Elisa Gomez Valderas, Theresa Hunter Gibble, Cagri Senyucel, Julia P Dunn

Faculty, Staff and Student Publications

Introduction: With new advancements in obesity medicine, clarity on goals and expectations for successful disease management is limited. This post hoc analysis assessed application of proposed treat-to-target (TtT) thresholds for obesity to the outcome measures of SURMOUNT-5, which randomised participants with obesity to tirzepatide or semaglutide.

Methods: The proportion of participants in each treatment group reaching proposed TtT thresholds for waist to height ratio (WHtR) < 0.53, body mass index (BMI) < 27 kg/m2, or a combination was evaluated. The associations between the thresholds and achieving low disease activity to remission (meeting goals for at least four of five defined cardiometabolic risk parameters) and normalisation or improvement in SF-36v2 physical component score (PCS) from baseline to week 72 were explored.

Results: About 23.1%-33.9% of participants treated with tirzepatide and 14.2%-20.7% treated with semaglutide reached the TtT thresholds, with greater weight reduction than the overall population. About 77% of participants who reached WHtR < 0.53 achieved low disease activity to remission, with an odds ratio of 2.31 (p < 0.001) compared to those who did not reach this target. The BMI threshold was not statistically associated with the assessed outcomes for SF-36v2 PCS.

Conclusion: In this …

Tumor Flare Reaction With Brentuximab-Vedotin In Mycosis Fungoides, Rishabh Lohray, Seda Purnak, Samruddhi Arkatkar, Madeleine Duvic, Victor Prieto, Carlos Torres-Cabala, Auris Huen

Faculty, Staff and Student Publications

No abstract provided.

When Rescue Becomes Reprogramming: Long-Term Cardiovascular Outcomes In Offspring Following Prenatal Steroid Exposure., Selina M. Tucker, Jessica L. Bradshaw

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Impacts Of Listening Practice On Work Performance While Wearing Hearing Protection., Patricia Mcclain, Matthew G. Wisniewski

Manuscripts, Articles, Book Chapters and Other Papers

Individuals who work in loud environments often choose not to wear hearing protection devices (HPDs) while on the job. A prevailing justification for this decision involves potential performance impairments that come with HPD use. While previous research has been successful in characterizing the overwhelming prevalence of this issue, the question of how to go about improving HPD use still remains. In this study, we investigated the possibility that performance while wearing an HPD could improve if people are given listening training with a simulated HPD. Participants listened to podcasts in which the audio was filtered to simulate wearing an HPD …

Using Gloves Wisely: Rethinking Glove Use For Health, Safety, And Environmental Sustainability., M Lauren Lalakea, Radhika Sheth, Elizabeth Cerceo, Yvonne Huckleberry, Preeti Jaggi, Vidya Mony, Elizabeth Monsees

Manuscripts, Articles, Book Chapters and Other Papers

Non-sterile gloves (NSG) are essential for reducing transmission of pathogens and for protecting patients and staff. Their overconsumption can lead not only to an increased risk of cross-contamination but also increased plastic waste and downstream environmental effects. Glove reduction campaigns worldwide have safely and successfully reduced their inappropriate use and associated waste. In this multidisciplinary commentary, we discuss the sweeping public health and environmental consequences of NSG overuse and strategies to implement a successful glove stewardship campaign.

Identifying Sorafenib Benefit Among Patients With Hepatocellular Carcinoma: A Transcriptomic And Genomic Approach, Sun Young Yim, Hayeon Kim, Tae Hyung Kim, Sang-Hee Kang, Youngwoo Lee, Eunho Choi, Yang Jae Yoo, Seong Hee Kang, Young-Sun Lee, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kyung Suk Yang, Yitao Tang, Bowha Sohn, Yun Seong Jeong, Hyewon Park, Han Liang, Ju-Seog Lee, Ji Hoon Kim

Faculty, Staff and Student Publications

Background & aims: Sorafenib has been a cornerstone of hepatocellular carcinoma (HCC) therapy; however, its efficacy is limited, and identifying patients who will benefit from sorafenib is challenging. We aimed to identify predictive biomarkers of sorafenib benefit in patients with HCC.

Methods: Gene expression data from 33 HCC tumors treated with sorafenib were analyzed to construct a prediction model aimed at identifying patients with greater benefit from sorafenib treatment. The robustness of the predictor was validated using gene expression data from two phase III clinical trials, IMbrave150 and STORM.

Results: The analysis of transcriptome data revealed a 50-gene signature, the …

Platelets Cause Microvascular Occlusion And Delayed Neurological Deficits After Subarachnoid Hemorrhage In Mice., Ari Dienel, Sung-Ha Hong, Kiara Torres, Kanako Matsumura, Jose Guzman, Peeyush Thankamani Pandit, Bibek Samal, Harveen Kaur, Samitha Nemirajaiah, Angelica Bernal, H Alex Choi, Louise D Mccullough, Spiros L Blackburn, Jaroslaw Aronowski, Devin W Mcbride

Faculty, Staff and Student Publications

After subarachnoid hemorrhage (SAH), some patients develop delayed neurological deficits (DND). Microthrombi are considered a contributing factor to DND, but clinical trials of antiplatelets had mixed results. Existing research suggests that platelets play a role in the etiology of DND, but no comprehensive study has tested causality between platelets and DND after SAH. Here we hypothesize that after SAH, platelet activation promotes microthrombi formation, occlusion of the brain microvasculature and contributes to DND, and that inhibiting platelet aggregation is a therapeutic strategy. Mice experiencing SAH were administered various interventions. The animals were subjected to stimulation of platelets, platelet depletion, or …

Eating For Healthy Eyes: The Role Of Nutrition In Ocular Health, Brianna Stroh

Honors Program: Senior Projects (Public)

The central research question of this thesis asks: How does nutrition influence ocular health overall and the impact of nutrition on the development or progression of common eye diseases? Building upon existing research in optometry/ophthalmology, nutrition science, and public health, this project examines the physiological mechanisms linking diet to eye health and evaluates how specific nutrients and dietary patterns contribute to disease prevention and visual function. This thesis employs a comprehensive review of peer-reviewed literature to evaluate the relationship between nutrition and ocular disease. Key areas of focus include the role of oxidative stress in eye disease development, the protective …

Purr-Spectives: Connections Between Feline Coat Color And Human Preferences And Perceptions In Northeast Arkansas, Tiffany L. Batchelor

Honors Theses

Felines have played an important role in the lives and culture of humans for thousands of years. The purpose of this study is to investigate perceptions of felines and feline demographics to gain a better understanding of the relationship between cats and humans in the Northeast Arkansas (NEA) area in particular. For Study 1, data on phenotype and health conditions (n = 2,277 feline patients) were collected from patient files from three Northeast Arkansas veterinary clinics. For Study 2, an anonymous survey generated using Qualtrics titled “Purr-spectives: Feline Behavioral Perceptions Survey” was published through the College of Agriculture social media …

Msh 115 - World Music Writing Intensive, Margaret Farrell

Open Educational Resources

This syllabus guided our exploration of music around the globe. In this writing intensive section, music served as a means to internalize information through writing as well as inspiration for developing a clear and persuasive writing style. Our investigations included consideration the forms of the music as well as their cultural and historical contexts.

Exploring The U.S. Public Service Employees’ Experiences With Gamified Cybersecurity Awareness Training, Bisola Adepoju

Human Resource Development Theses and Dissertations

The purpose of this qualitative study was to explore the U.S. public service employees' experiences with gamified cybersecurity awareness training. The primary research question guiding this inquiry was: How do U.S. public service employees make sense of their lived experiences with gamified cybersecurity awareness training? Two secondary questions examined what aspects of the training employees perceive as meaningful or disengaging, and how they interpret their motivation, engagement, and cybersecurity awareness during training. I chose an interpretive qualitative research design grounded in a constructivist paradigm and purposefully selected 11 U.S. public service employees who had participated in gamified cybersecurity awareness training. …

Single-Center Experience Using Endologix Anatomically Fixated Endograft Device For Treatment Of Aortoiliac Occlusive Disease, Isabella Muti, Gaurang Joshi, Dawn M. Salvatore, Michael J. Nooromid, Paul J. Dimuzio, Babak Abai

Department of Surgery Faculty Papers

OBJECTIVE: The covered endovascular reconstruction of the aortic bifurcation (CERAB) technique was developed in recent years as a novel surgical intervention for aortoiliac occlusive disease (AIOD). One tool frequently used in such procedures is the anatomically fixated endograft (AFX), manufactured by Endologix. The present study aimed to review the outcomes of patients with AIOD after CERAB procedure using the Endologix AFX device.

METHODS: This is an institutional review board-approved retrospective study investigating the experience of a single center in using Endologix's AFX device as CERAB for AIOD from September 2018 to June 2024. Data were obtained from the medical records …

Initial Site Of Metastasis Influences Prognosis In Pancreatic Ductal Adenocarcinoma, Eleanor Mancheski, David Baek, Wilbur Bowne, Harish Lavu, Charles Yeo, Avinoam Nevler

Department of Surgery Faculty Papers

INTRODUCTION: Metastatic pancreatic ductal adenocarcinoma (mPDAC) is a highly aggressive malignancy. Prior studies suggest that the initial site of metastasis may impact prognosis. This study investigates whether overall survival in mPDAC patients differs between patients first presenting with lung metastases versus those presenting with liver metastases.

METHODS: This retrospective analysis utilized the multi-institutional TriNetX database, identifying patients with histologically diagnosed PDAC who initially presented with either liver or lung metastases. Demographic, histologic, and outcome data were collected and analyzed. Patients were matched 1:1 using a nearest neighbor propensity score (PS) algorithm, and Kaplan-Meier survival analyses were performed. Cox regression was …

Enhancing Undergraduate Learning In Physics: The Effects Of Ai-Assisted And Ai-Guided Instruction On Knowledge, Self-Efficacy, And Satisfaction, Stephen Woods

Doctoral Dissertations and Master's Theses

Generative artificial intelligence (AI) tools such as large language models are increasingly used for self-directed learning, yet there is limited experimental evidence on whether they improve learning outcomes and whether theory-informed guidance adds value beyond AI use alone. Prior literature suggests that effective learning depends not only on access to information, but also on how instruction supports attention, working memory, long-term memory, and cognitive load, while also fostering motivational processes such as self-efficacy. Individual differences such as Need for Cognition may also shape how learners engage with cognitively demanding instructional tools such as AI.

The present study examined how different …

Effect Of Curing Duration On Bridge Deck Concrete Performance, Zhaniya Omarova

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

This study evaluates the influence of curing duration on the performance of bridge deck concrete and investigates the feasibility of reducing curing periods without compromising structural and durability properties. Two concrete mixtures, a standard Nebraska Department of Transportation (NDOT) bridge deck mix (47BD) and an optimized reduced-cement-content mix (O47BD-R100), were evaluated under multiple curing durations Fresh, early-age, mechanical, durability, and shrinkage properties were assessed to characterize the effect of curing on concrete behavior. Internal relative humidity and temperature were monitored using embedded sensors to investigate moisture diffusion and its role in shrinkage development for lab specimens and full-scale slabs.

Results …

Variable Hybridization Rates Between F2 Fundulus Notatus Females, Jordan Tanaka

Honors Theses

Hybridization between two related species has been widely observed and offers a lens into complex evolutionary processes. Endogenous and exogenous factors affect hybrid fitness and diversification, and pre-zygotic and post-zygotic barriers affect species’ ability to hybridize. Female mate choice is a pre-zygotic isolation mechanism which is known to be more significant than male mate choice in many species, a trend which is linked to females often investing more energy into offspring. Detailing the ways in which these mechanisms operate is integral to understanding hybridization on a larger scale. The species examined here, Fundulus notatus and Fundulus olivaceous, are closely …

Brain Candy: Wayne State University School Of Medicine Journal Of Arts And Culture, 13th Edition, Wayne State University School Of Medicine Gold Humanism Honor Society

Gold Humanism Honor Society

Brain Candy incorporates paintings, written pieces, and poetry from all the medical classes at Wayne State University School of Medicine to shed light on the creative process in medicine, the city of Detroit, and the experiences of health care providers. This year, the journal is organized into four sections, each of which denotes a particular time period within medical school. The first edition of Brain Candy was published online and in print in 2009, produced by a generous grant by the Gold Humanism Honor Society (GHHS). The edition featured poetry, nonfiction, short fiction, and different types of artwork. With generous …

Social Support And Mental Wellbeing Among Veterinary Clinic Employees, Madison Koons

Undergraduate Honors Thesis Projects

Mental wellbeing is a significant concern for veterinary professionals and the subject of much discussion in the veterinary and academic fields. To determine whether social support is an effective protective factor for the mental wellbeing of veterinary professionals, I administered a survey to 879 veterinary clinics in Ohio, with ninety-two responses received for final analysis. The scales assessed mental wellbeing, organizational support, and nonorganizational support. I found organizational support, friends support, and family support to be positively correlated with mental wellbeing. Significant other support was not correlated with mental wellbeing. A linear regression evaluating social support as predictors of mental …

Just Unmasking Knowledge? A Critical Interpretation Of Fluctuating Jellyfish Populations For A Mass Media Audience, Wrenne R. Grone

Undergraduate Honors Thesis Projects

While podcasts may not be the most popular form of mass media, they are growing in their accessibility and prevalence in educational discourse. My creative work, in the form of a podcast, unmasks scientific knowledge in an untraditional, mass-media form and will use podcast techniques, such as music transitions and storytelling techniques, to maintain engagement. Additionally, my podcast aims to transpose academic knowledge into a comprehensible, interesting form for a non-academic audience. Jellyfish have no brains, no heart, no blood, and no bones and yet, they have survived for millions of years. The goal of my podcast is to educate …

Concerns Regarding The Efficacy Of Utilizing The Vibrational Response Of Aminocyanine Molecules To Near Infrared Light For Cancer Cell Destruction, Parsa Faghani-Eskandarkolaei, James Welsh, Seyed Ali Reza Mortazavi, Parmis Taghizadeh, Mobina Baramaki, Fatemeh Shams, Mohammed Nasir Abubakari, Seyed Mohammad Javad Mortazavi, Lembit Sihver

Informatics and Engineering Systems Faculty Publications

Recent advancements in cancer treatment have introduced the use of aminocyanine molecules, activated by near-infrared (NIR) light, to induce vibrational responses that can selectively destroy cancer cells. This commentary critically examines a study that reports a 99% efficacy of this method against human melanoma cells in vitro, and significant tumor reduction in murine models. While the findings are promising, our analysis highlights crucial oversights in the study’s implications for clinical applications. Specifically, the persistence of even a small fraction of cancer cells post-treatment poses significant risks for tumor regrowth and acquired resistance. Additionally, the study’s approach neglects the heterogeneity of …

Advancing The Understanding Of Palliative Care In Singapore: Knowledge, Attitudes, Receptiveness, And The Moderating Role Of Media Information-Seeking Preferences, Su Lin Yeo, Angel Lee, Raymond Han Lip Ng, May O. Lwin, Yumin Lin

Research Collection Lee Kong Chian School Of Business

Introduction: Despite the growing demand for palliative care, this specialized medical care remains severely underutilized, with almost 50% of countries worldwide lacking access. Given that misperceptions and stigma continue to hinder progress in healthcare policy, this study aims to examine the relationships between palliative care knowledge, attitudes, and receptiveness to better understand how public health communication can enhance awareness and understanding of the topic in Singapore. Applying the adapted knowledge-attitude-practice (KAP) model, it further extends theory by examining the moderating role of media information-seeking between knowledge and receptiveness.Methods: Mixed-mode surveys involving 1,226 participants (926 online and 300 in-person respondents), representing …

High-Resolution Monitoring Of Intra-Seasonal Agricultural Drought Using Sentinel-2 And Machine Learning Across Bimodal Growing Seasons In Kenya, S. Mohammad Mirmazloumi, Harison Kipkulei, Rose Waswa, Tobias Landmann, Tom Dienya, Maximilian Schwarz, Fabrizio Ramoino, Clément Albergel, Gohar Ghazaryan

All Peer-Reviewed Publications

Drought presents significant challenges to agriculture, threatening food security and livelihoods, across many regions. In Kenya, recurrent droughts across diverse agro-ecological zones emphasize the urgent need for reliable and scalable drought assessment methods. Although drought assessment with various datasets has been carried out for this region, many of them often use course or moderate resolution data. This study uses high-resolution Sentinel-2 observations and machine learning to monitor intra-seasonal crop conditions and assess drought impacts across bimodal growing seasons. Using pixel-based supervised random forest models trained with multiple vegetation indices as input, we classify croplands into drought-affected and unaffected areas. The …

Land-Use Changes Shape Mosquito Assemblages, Host-Feeding And Arbovirus Infection In Baringo County, Kenya, Caroline Getugi, Elizabeth Kokwaro, Anthony Nyamache, Inga Slothouwer, Gilbert Rotich, Rosemary Sang, Sandra Junglen, David P. Tchouassi

All Peer-Reviewed Publications

Environmental transformation driven by human activity has profound implications for the ecology of mosquito vectors and the pathogens they transmit. This study investigated the influence of land-use change on mosquito assemblages, host-feeding patterns, and arbovirus infection across sylvatic-rural-peri-urban land-use types in Marigat subcounty, Rift Valley, Kenya. Adult mosquitoes were collected using CO₂-baited CDC light traps and BG-Sentinel traps across three sites: Kiborgoch conservancy (sylvatic), Ntepes village (rural) and Marigat town (peri-urban). Sampling was conducted during three sessions including September 2022, August 2023, and December 2023. The mosquitoes were morphologically identified to species, and indices of abundance, richness and diversity compared …

Leveraging Section 208 Water Quality Planning To Mitigate Pfas Contamination In Watersheds Across The Waccamaw Region, Anna Dimatteo

Goal 6: Clean Water and Sanitation

No abstract provided.