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Factors Associated With Lapses In Care Among People Living With Hiv In South Carolina, Xueying Yang Ph.D., Fanghui Shi, Shujie Chen, Gavi Samuel, Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D. Apr 2026

Factors Associated With Lapses In Care Among People Living With Hiv In South Carolina, Xueying Yang Ph.D., Fanghui Shi, Shujie Chen, Gavi Samuel, Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Utilizing statewide electronic health records (EHR) data, this study aims to assess the factors determining the occurrence of lapses in HIV care among people with HIV (PWH) in South Carolina (SC). All adult (≥ 18 years old) PWH who were diagnosed with HIV between 2006 and 2018 with at least two HIV care encounters and at least 1-year follow-up record were included in the analysis. The outcome, a lapse in care, was defined as a repeated measure of HIV care encounter that occurs over a year following the previous visit. Generalized Estimation Equation models were employed. The study cohort had …


Bcaas Newsletter Spring 2026, Bcaas Apr 2026

Bcaas Newsletter Spring 2026, Bcaas

BCAAS Newsletter

No abstract provided.


Lessons Learned From The Implementation Of A Pragmatic Trial Evaluating Non-Pharmacological Approaches To Dementia Care In Us Nursing Homes, Carin Wong, Catherine V. Piersol, Felicia Chew, Cara Lekovitch, Victoria Shier, Mike Morris, Jenny Martínez, Julie Britton, Natalie E. Leland Apr 2026

Lessons Learned From The Implementation Of A Pragmatic Trial Evaluating Non-Pharmacological Approaches To Dementia Care In Us Nursing Homes, Carin Wong, Catherine V. Piersol, Felicia Chew, Cara Lekovitch, Victoria Shier, Mike Morris, Jenny Martínez, Julie Britton, Natalie E. Leland

Department of Occupational Therapy Faculty Papers

RATIONALE: The consistent delivery of effective evidence into nursing home practice has been shown to enhance quality of care and residents' outcomes. Pragmatic trials enable the evaluation of efficacious interventions in a real-world context, including care of residents living with Alzheimer's Disease and Related Dementias (ADRD). Yet, there are limited pragmatic trials conducted in nursing homes and even less evidence on the strategies to successfully conduct such research in this setting.

OBJECTIVE: To identify the lessons learned from a pragmatic trial and provide recommendations for future successful studies in United States (US) nursing homes.

METHODS: Drawing on a case example …


From Ideas To Impact: Cultivating Innovation Among Newly Licensed Nurses, Kate Campbell, Hannah Taylor Apr 2026

From Ideas To Impact: Cultivating Innovation Among Newly Licensed Nurses, Kate Campbell, Hannah Taylor

MaineHealth Maine Medical Center

New nurses often face challenges in adapting to the dynamic healthcare environment and contributing ideas due to a lack of exposure to innovative thinking in their education programs. To address this gap, an innovation workshop was developed and integrated into the Nurse Residency Program (NRP).


2026 (Spring) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department Apr 2026

2026 (Spring) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department

ENSI Informer Magazine Archive

The ENSI Informer Magazine published in the spring of 2026.


Shaping The Medical Educators Of Tomorrow: Developing Residents' Teaching And Educational Scholarship Skills, Devang Pastakia, Jen King, Alyssa Schlotman, Ryan Hanson, Kyle Langford, Lauren Starnes, Ryan Wolf, Tara Minor Apr 2026

Shaping The Medical Educators Of Tomorrow: Developing Residents' Teaching And Educational Scholarship Skills, Devang Pastakia, Jen King, Alyssa Schlotman, Ryan Hanson, Kyle Langford, Lauren Starnes, Ryan Wolf, Tara Minor

Presentations

It is widely accepted that residents play an integral role in educating medical students.1 It is estimated that medical students receive approximately one-third of their clinical education from residents.2 It has been demonstrated that good education from residents positively impacts medical student clerkship satisfaction and influences career choices.2 Despite the fact that residents participate in educational responsibilities and many residents want to incorporate medical education into their future careers, residencies often do not have programs that provide a foundation for developing future medical educators.3 Dedicated programs may also serve as an avenue through which residents can explore medical education careers …


Exploring How Parental Involvement Impacts Police Encounters And Delinquent Behaviors Among Black Adolescent Girls, Danielle Porter, Elizabeth A. Otto, Dyamon Brown, Jasmine Alli, Robyn Douglas, Noni Gaylord-Harden Apr 2026

Exploring How Parental Involvement Impacts Police Encounters And Delinquent Behaviors Among Black Adolescent Girls, Danielle Porter, Elizabeth A. Otto, Dyamon Brown, Jasmine Alli, Robyn Douglas, Noni Gaylord-Harden

Presentations

Adolescents’ contact with police is a complex outcome that is influenced by both individual behavior and the broader social context. Specifically, while delinquent behavior can lead to more police contact (Crutchfield et al., 2012), hyper-surveillance often occurs in marginalized communities, increasing unjustified police contact for youth of color (Campos-Manzo et al., 2020; Geller, 2021). Indeed, racial disparities in police contact during adolescence persist even after accounting for delinquent behavior (Campos-Manzo et al., 2020; Crutchfield et al., 2012). Thus, it is important to identify factors that may protect Black youth from contact with police. Parental involvement refers to parents’ active and …


Antibiotic-Pathogen Concordance In Pediatric Complicated Community-Acquired Pneumonia, Makenna Steger Md, Marina Dantas Md, Mscr, Berina Karisik Do, Smit Shah, Alaina Burns Pharmd, Jessica Markham Apr 2026

Antibiotic-Pathogen Concordance In Pediatric Complicated Community-Acquired Pneumonia, Makenna Steger Md, Marina Dantas Md, Mscr, Berina Karisik Do, Smit Shah, Alaina Burns Pharmd, Jessica Markham

Presentations

Background Complicated community-acquired pneumonia (cCAP)—defined by effusion, empyema, abscess, cavitation, or necrosis—is associated with worse outcomes than uncomplicated pneumonia. Methicillin resistant Staphylococcus aureus (MRSA) data in cCAP are limited and often merged with uncomplicated cases. Although guidelines recommend MRSA coverage only in select cases, it is empirically used in >70% of encounters. Lack of pathogen identification likely drives overuse due to diagnostic uncertainty. Clarifying Member of AAP, APA, APS, SPR, ASPN, or PIDS? PIDS JM Jessica Markham, MD, MSc Position: Associate Professor of Pediatrics Organization: Children's Mercy Hospitals and Clinics Email: [email protected] Role: Co-Author Disclosure Status: Complete Disclosure: Nothing to …


Discovery And Genome Annotation Of Tuti And Charminar: Two Newly Discovered Gordonia Rubripertincta Bacteriophages Apr 2026

Discovery And Genome Annotation Of Tuti And Charminar: Two Newly Discovered Gordonia Rubripertincta Bacteriophages

Undergraduate Student Symposium

As the most abundant organisms, bacteria are both beneficial and harmful, highlighting the significance of regulating their growth. Bacteriophages (phages) are ubiquitous viruses that require a host bacterial organism for replication, making them an essential component of the microbial ecosystem and used as tools for killing bacteria. Since their discovery in 1915, phages have been used in real-world applications including alternatives to antibiotics, diagnostic agents, pest control in agriculture, wastewater treatment, and bioremediation. Since bacteriophages remain mostly undiscovered, continued isolation and genetic characterization of novel phages are essential for advancing scientific knowledge and potential applications. Through Nova Southeastern University's SEA-PHAGES …


Exercise As An Intervention Against Neuroinflammation During Binge Drinking Withdrawal, Shaina Binu, Ellie Wind, Ariana Hernandez, Iliana Uribe, Victoria Pulido-Correa Apr 2026

Exercise As An Intervention Against Neuroinflammation During Binge Drinking Withdrawal, Shaina Binu, Ellie Wind, Ariana Hernandez, Iliana Uribe, Victoria Pulido-Correa

Undergraduate Student Symposium

Binge drinking, a public health concern in the United States, is associated with negative emotional and cognitive effects during alcohol withdrawal. These effects are believed to result from changes in brain regions involved in stress regulation, emotion, and decision-making, including the prefrontal cortex, amygdala, and hippocampus. Alcohol exposure has been shown to increase neuroinflammation in these regions, which may contribute to anxiety-like behaviors and difficulty regulating emotions during withdrawal. In contrast, aerobic exercise is a promising non-pharmacological intervention that has been shown to reduce anxiety and support brain health. This project investigates how exercise can reduce withdrawal-related anxiety-like behaviors, following …


Transcranial Magnetic Stimulation For Substance Use Disorder, Sarah Defrant Apr 2026

Transcranial Magnetic Stimulation For Substance Use Disorder, Sarah Defrant

Undergraduate Student Symposium

This review evaluates transcranial magnetic stimulation (TMS) as a supplemental intervention for decreasing substance use disorder (SUD) relapse rates by synthesizing understandings of neurobiological mechanisms and clinical outcomes. TMS stimulates the activity of neural cells in the dorsolateral prefrontal cortex (DLPFC), a small portion of the prefrontal cortex that houses impulse control and decision-making skills. This leads to improved neuroplasticity and dopamine regulation, both of which are disrupted by unregulated substance use. Although TMS is not FDA-approved for substance use disorder, the neurobiological similarities between SUD and its comorbidities like major depressive disorder or anxiety highlight TMS's theoretical potential to …


Proximal Power Gains In Football: Position-Specific Adaptations Revealed Through Compositional Data Analysis, Isabella Estrada Hernandez, Alyana Andal Apr 2026

Proximal Power Gains In Football: Position-Specific Adaptations Revealed Through Compositional Data Analysis, Isabella Estrada Hernandez, Alyana Andal

Undergraduate Student Symposium

Training-induced adaptations in joint power distribution during speed running may enhance performance, but how these changes manifest across different American football position groups remains poorly understood. We investigated the influence of training and player position on joint power composition among players training for the National Football League draft. Forty-eight draft-eligible players performed pre- and post-training camp running trials at 23.4 km/h. We used motion capture software and MATLAB to calculate bilateral peak hip, knee, and ankle joint power. Compositional data analysis (CoDA) was used, in which positive/generated and negative/absorbed power compositions were expressed as isometric log-rations: hip versus knee + …


Baseline Emotional Valence Predicts Subsequent Executive Function Task Performance, Andrea Fajardo Aguilar, Alyssa Harris, Isidora Varas-Sanchez, Julia Ribeiro, Dylan Kuni Apr 2026

Baseline Emotional Valence Predicts Subsequent Executive Function Task Performance, Andrea Fajardo Aguilar, Alyssa Harris, Isidora Varas-Sanchez, Julia Ribeiro, Dylan Kuni

Undergraduate Student Symposium

Executive functioning (EF) supports goal-directed behavior and is influenced by affective state. While prior research has largely focused on the effects of emotional valence during task performance, less is known about the influence of pre-task self-reported valence on subsequent EF performance. Our ongoing study will examine whether self-reported ratings of emotional valence assessed prior to the start of a task will predict performance. Participants will report valence ratings during a resting baseline period before performing two EF tasks: the Vertical Stroop and the Go/No-Go. Performance will be assessed using reaction time and accuracy. Regression analyses will be conducted to …


Comparison Of Bacteria From Varied Soils With Potential Antimicrobial Activity, Nicole Nesterovitch, Nyobi Fleming, Andrew Sourial Apr 2026

Comparison Of Bacteria From Varied Soils With Potential Antimicrobial Activity, Nicole Nesterovitch, Nyobi Fleming, Andrew Sourial

Undergraduate Student Symposium

Antibiotic resistance is increasing at a rate that surpasses the discovery and development of new antimicrobial compounds, creating a widening resistance-innovation gap that poses a global public health concern. To address this need for new antibiotic-producing organisms, we partnered with Tiny Earth, a global initiative that engages students in antibiotic discovery through soil sample collection, bacterial isolation, and antimicrobial screening. We isolated bacteria from local soil in Davie, Florida as well as soil from the White River Badlands, South Dakota with the hypothesis that distinct soil conditions may yield different antimicrobial producers with varied activity and chemical profiles. 42 unique …


Assessing Recovery In Collegiate Swimmers Through Wearable Technology, Sara Quintero Apr 2026

Assessing Recovery In Collegiate Swimmers Through Wearable Technology, Sara Quintero

Undergraduate Student Symposium

Collegiate swimmers face extreme physiological demands during high-intensity training phases like "Hell Week," a winter training intensive loading microcycle, that makes recovery monitoring critical for maintaining performance. This study investigated the relationship between sleep quality and recovery markers. Specifically, Heart Rate Variability (HRV) and Resting Heart Rate (RHR), in nine female collegiate swimmers (ages 19-23) across all collegiate years. Participants included sprinters, mid-distance, and distance swimmers, leading to varied total yardage across training groups. Over an eight-day period (seven training days and one rest day), data was collected via screenshots from Garmin (n=4) and WHOOP (n=5) wearable devices. Metrics included …


Developing New Digital Methods To Study And Improve Eyewitness Testimony, Isabella Ryan, Brianna Munoz, Adam Durnin, Tanya Schrader, Joana Vinagre Apr 2026

Developing New Digital Methods To Study And Improve Eyewitness Testimony, Isabella Ryan, Brianna Munoz, Adam Durnin, Tanya Schrader, Joana Vinagre

Undergraduate Student Symposium

Witnesses play a crucial role in criminal investigations. However, their ability to recall important details is influenced by cognitive processes such as memory. To improve eyewitness testimony, psychologists developed science-based interviewing techniques, such as the Cognitive Interview, which are used by police to elicit accurate accounts. We also created new retrieval strategies, namely the Category Clustering Recall (CCR), which has been implemented by agencies such as the Los Angeles Police Department. However, research supporting the use of these techniques predominantly used the mock-witness paradigm, where participants observed a mock-crime on a two-dimensional (2D) screen and recalled it in a controlled …


Group Differences In Conflict Processing Between Bilinguals And Monolinguals, Isidora Varas-Sanchez, Dylan Kuni, Julia Ribeiro, Andrea Fajardo Aguilar, Alyssa Harris Apr 2026

Group Differences In Conflict Processing Between Bilinguals And Monolinguals, Isidora Varas-Sanchez, Dylan Kuni, Julia Ribeiro, Andrea Fajardo Aguilar, Alyssa Harris

Undergraduate Student Symposium

There is an ongoing debate in the literature on the existence of a bilingual advantage on tests of attention. Hypothetically, bilinguals have an advantage over monolinguals on tests of attention because both attention and language control share the same inhibitory mechanism. Because bilinguals engage this mechanism more often than monolinguals, inhibitory control is believed to be stronger and confer an advantage. However, research findings on the bilingual advantage are inconsistent and attempts to reproduce prior results have sometimes failed. The argument is that studies may have failed to capture the important aspects of language linked to attention. Prior research from …


Interventions For Reducing Barriers To Future Employment Success In First-Generation College Students., Kellie M. Burke Apr 2026

Interventions For Reducing Barriers To Future Employment Success In First-Generation College Students., Kellie M. Burke

Doctor of Social Work Capstone Projects

First-generation college students (FGCS) comprise a significant and diverse segment of the U.S. undergraduate population, yet they remain disproportionately vulnerable to barriers that impede both academic achievement and career advancement. These challenges, rooted in intersecting factors (e.g., race & gender), are amplified by institutional structures that inadequately address the realities faced by FGCS. Despite the proliferation of career development programs, internship participation, and subsequent employment, among FGCS remains notably low, revealing persistent gaps in support, access, and program efficacy.

This qualitative study evaluates the Rising Leaders Program, an agency-driven intervention designed to promote career readiness for FGCS at Kentucky universities …


Exploring The Professional Quality Of Life Of Female Collegiate Head Coaches., Jennifer Marie Boa Apr 2026

Exploring The Professional Quality Of Life Of Female Collegiate Head Coaches., Jennifer Marie Boa

Doctor of Social Work Capstone Projects

Before Title IX passed in 1972, most female college sports teams were coached by women. Today, only 42% of head coaches are women, even though participation in women’s collegiate sports has increased by 637% since 1971. This study explored the factors influencing the professional quality of life of female college coaches. Variables considered in this study included parenting and work, organizational culture, women’s role in the workforce, unique issues faced by female collegiate coaches, and professional quality of life. The study used a mixed-methods cross-sectional design and purposive sampling, resulting in 107 valid responses. The results indicate that respondents felt …


Vol 71 #2, Rebecca Chavez Apr 2026

Vol 71 #2, Rebecca Chavez

MPLA Newsletter

No abstract provided.


Assessing The Relationship Between Professional Discipline And Perceptions Of Team Functioning Within Hospital-Based Multidisciplinary Child Abuse Teams., Nikki Roth Apr 2026

Assessing The Relationship Between Professional Discipline And Perceptions Of Team Functioning Within Hospital-Based Multidisciplinary Child Abuse Teams., Nikki Roth

Doctor of Social Work Capstone Projects

Abstract

Assessing the Relationship Between Professional Discipline and Perceptions of Team Functioning Within Hospital-based Multidisciplinary Child Abuse Teams

Nicolle Roth

04/03/2026

The multidisciplinary team (MDT) approach, professionals from various disciplines collaborating to solve a problem, has been used for decades in both child welfare and medicine. Benefits of the multidisciplinary approach have been documented through studies in both in the field of child abuse and the medical field and include improved outcomes, shortened intervention timelines, and economic advantages. Although multidisciplinary teamwork has been shown to be effective, not all professionals have the same level of skill in working within a …


Alternative Anticoagulation Strategies For Heparin-Intolerant Patients Undergoing Cardiopulmonary Bypass: A Scoping Review Of Patient Outcomes, Zachary Nelson Apr 2026

Alternative Anticoagulation Strategies For Heparin-Intolerant Patients Undergoing Cardiopulmonary Bypass: A Scoping Review Of Patient Outcomes, Zachary Nelson

Student Works

Background/Introduction: Heparin intolerance, most notably heparin-induced thrombocytopenia (HIT), presents a major clinical challenge during cardiopulmonary bypass (CPB), where systemic anticoagulation is essential for safe circulation through the extracorporeal circuit. While several alternative anticoagulants have been described, there is limited consensus regarding their safety, dosing, and outcomes. The objective of this study was to map existing evidence describing alternative anticoagulation strategies for heparin-intolerant adult patients undergoing CPB and to summarize reported patient outcomes, dosing strategies, and intraoperative management considerations.

Methodology: This scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) …


Peaks Island Star : April 2026, Vol. 46, Issue 4, Service Agencies Of The Island Apr 2026

Peaks Island Star : April 2026, Vol. 46, Issue 4, Service Agencies Of The Island

Peaks Island Star, 2026

The Peaks Island Star is the newsletter of the island's service agencies and other community news.


Oral History Of Dr. Edward Yost, Conducted On February 14, 2026 By Mallory Lough, Edward Yost, Mallory Lough Apr 2026

Oral History Of Dr. Edward Yost, Conducted On February 14, 2026 By Mallory Lough, Edward Yost, Mallory Lough

HIST 4798/5798: Recording Memory: Methods and Uses of Oral History

This interview, conducted by Mallory Lough in February 2026, documents the life and career of Dr. Edward Yost, a retired professor from Ohio University’s College of Business. Dr. Yost grew up in rural Litchfield, Ohio, where he was part of a fourth-generation dairy farming family. After his family’s farm declined, he pursued higher education using the GI Bill, eventually earning a PhD in Business Administration. Mentorship played a key role in guiding him into academia. At Ohio University, where he spent over 30 years, Yost held numerous leadership roles, particularly in graduate and international business programs. He helped develop and …


Oral History Of Ronald Lykins Conducted By Mallory Lough On March 12, 2026, Ronald Lykins, Mallory Lough Apr 2026

Oral History Of Ronald Lykins Conducted By Mallory Lough On March 12, 2026, Ronald Lykins, Mallory Lough

HIST 4798/5798: Recording Memory: Methods and Uses of Oral History

Ronald Lykins is a former professor within the College of Business at Ohio University. Raised in rural Adams County, Ohio, in a family facing significant economic hardships, Lykins grew up in a household with no running water or electricity. These early experiences shaped his work ethic, along with giving him a deep appreciation for helping others and granting opportunities. Ron enrolled at Ohio University as a first generation student, graduating with his MBA in 1967 and his PhD in 1971. Following his graduation, Ron developed a career in accounting and financial services, eventually founding his own accounting firm in 1969. …


Kason Jamison V. Chrislyn Morgan Apr 2026

Kason Jamison V. Chrislyn Morgan

2026 Decisions

USDC for the District of New Jersey


Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong Apr 2026

Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong

Markey Cancer Center Faculty Publications

Background/Objectives: Neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Amyotrophic lateral sclerosis (ALS) share common molecular pathways, including neuroinflammation and oxidative stress, which complicate the effectiveness of single-target treatments. Garcinia mangostana L. (mangosteen) has shown neuroprotective properties, but previous studies focused on lipophilic xanthones, which have poor bioavailability and uncertain blood–brain barrier permeability. Methods: In the current study, polar metabolites from G. mangostana peel aqueous extract (GMPE) were assessed for potential multi-target interactions via UHPLC-QTOF-MS-based metabolomics, systems pharmacology, and molecular docking analysis. Further, in silico ADMET screening and network-based analyses assessed for overlap between GMPE compounds and genes associated with neurodegeneration (AD, …


Role Of Succinate Dehydrogenase In Age-Related Th17 Inflammation, Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica-Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath Apr 2026

Role Of Succinate Dehydrogenase In Age-Related Th17 Inflammation, Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica-Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath

Markey Cancer Center Faculty Publications

Age-related cellular changes negatively impact CD4+ T cell function. Our prior work showed that mitochondrial complex II (succinate dehydrogenase [SDH]) expression was upregulated in T cells from older (O) adults (60–80 years old). T cells from older adults also produced higher amounts of cytokines generally considered proinflammatory, such as Th17 cytokines IL-17A/F and IL-21, and the Th-17-supportive cytokine IL-6, compared to T cells from younger (Y) adults (25–40 years old). The objective of our study is to evaluate whether hyperactivation of SDH is required for the induction of proinflammatory cytokines and the mechanistic link between SDH and Th17 cytokine …


Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann Apr 2026

Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann

Markey Cancer Center Faculty Publications

Chronic ethanol (EtOH) consumption is a major contributor to multi-organ dysfunction, yet its systemic effects remain incompletely understood. To address this, we utilized a physiologically relevant long-term mouse model, administering 20% EtOH in drinking water for 60 weeks, to investigate the integrated consequences of chronic exposure. EtOH-consuming mice (0.4–0.5 mL/day) exhibited > 30% reductions in chow and fluid intake, resulting in a 12% decrease in total caloric intake compared to controls (p < 0.001). Body mass remained similar until Week 52, after which EtOH-treated mice had lower body mass due to reductions in both lean and fat mass (p ≤ 0.004). Functional assessments revealed impaired treadmill endurance (−17%) and grip strength (−11%) (p ≤ 0.037), while motor coordination remained unaffected (p = 0.203). Chronic EtOH exposure significantly altered gut microbiota composition, reducing Lactobacillus and enriching Faecalibaculum, Clostridium, and Bifidobacterium at the genus level. These changes were accompanied by marked depletion of short-chain fatty acids (p ≤ 0.05). Indirect markers of gut permeability (serum LPS & zonulin) and liver injury (serum ALT & AST, hepatic amyloid content) were elevated, alongside increased total cholesterol and > 62% upregulation of hepatic TNFα, IL-6 & serum amyloid A (p ≤ 0.046). EtOH also induced dyslipidemia and glucose intolerance (p ≤ 0.041), although transcriptomic changes in white adipose …


Freedom Readers And Sustainable Development Goal 4: Advancing Literacy In Low-Income Communities Of South Carolina, Madison Hayes Apr 2026

Freedom Readers And Sustainable Development Goal 4: Advancing Literacy In Low-Income Communities Of South Carolina, Madison Hayes

Goal 4: Quality Education

No abstract provided.