Digital Commons Network^™

Sensitivity And Concordance Study Of An Open Source Epid-Based Linear Accelerator Test Suite, Lana C Critchfield, Cory S Knill, Ellie Durussel, Justin K Mikell, Michael Barnes, Michael Pillainayagam, William P Donahue, Seng Boh Lim, John J Demarco, Mario Perez, Nilendu Gupta, Hania Al-Hallaq, Richard A Popple, Jim Irrer, Jean M Moran

2020-Current year OA Pubs

BACKGROUND: Electronic portal imaging devices (EPIDs) enhance linear accelerator (linac) quality assurance (QA) efficiency but are not universally used beyond patient-specific IMRT QA. A multi-institutional Consortium seeks to standardize linac QA utilizing an EPID-based test suite.

PURPOSE: This study evaluates the sensitivity of a test suite to intentional linac and plan errors and the concordance with linac fluctuations over time.

METHODS: Baseline and error-introduced tests were performed on a Varian TrueBeam and Clinac. Evaluated parameters included enhanced dynamic wedge factors (EDW) (6MV), central axis dose (6MV, 6MV FFF, 16MV), focal spot alignment and beam symmetry (6MV, 16MV), dose rate-gantry speed …

Apoe-Stratified Proteomic And Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation And Lipid Dysregulation In Alzheimer's Disease, Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M Holtzman, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). However, it is known that other pathways independent of APOE also play a role in AD. Disentangling APOE-dependent and independent effects is instrumental for understanding the biology of AD. We conducted an APOE-stratified multi-omic analysis in multiple large datasets to identify AD-associated plasma proteins and metabolites. More than 64% of the identified proteins were not found in non-APOE stratified studies, and 17% of the proteins showed APOE-specific trends. Mitochondrial dysfunction was associated in AD independently of APOE and was accompanied by disruptions in glucose and lipid …

The Femoral Head Edema Zone: A Novel Classification Scheme To Better Predict Osteonecrosis Progression, Deniz C Ince, Vivek P Shah, Kenichi Kikuchi, Kyle P O'Connor, Elizabeth L Yanik, John C Clohisy, Cecilia Pascual-Garrido

2020-Current year OA Pubs

BACKGROUND: This study proposed a new classification, the Edema Zone classification, that uses magnetic resonance imaging images to grade the extent of edema in osteonecrosis of the femoral head. The purpose of the study was (1) to examine how the Edema Zone classification compared to the Japanese Investigation Committee (JIC) classification's prognostic ability for early conversion to total hip arthroplasty (THA), and (2) to determine how accurately and reliably the Edema Zone classification performed as a classification system.

METHODS: This was a retrospective study of hips that converted to THA from a core decompression within 26 months compared to hips …

Predictors Of Opioid Misuse And Abuse Among Pregnant Women In The Us, Henry Ofori Duah, Diane Von Ah, Ethan Morgan

College of Nursing Faculty Research and Publications

Introduction

Opioid misuse and abuse during pregnancy can adversely affect maternal and infant outcomes. Factors that drive the burden of opioid misuse and abuse are multifaceted and understudied. This study sought to explore predictors of opioid misuse and abuse among pregnant women in the United States.

Methods

Secondary data analysis of the National Survey on Drug Use and Health (NSDUH) data from 2015-2019 was performed. The primary outcomes were past-year opioid misuse, past-month misuse, and past-year opioid abuse. Data analysis included weight-adjusted univariate, bivariate, and multivariable logistic regression.

Results

The pooled weighted sample comprised 2,258,599 pregnant women. The prevalence of …

Reimagining Incarceration: Scandinavian-Inspired Policy Innovation In Pennsylvania And California, Isabel M. Mallory

College Honors Program

The United States’ decentralized system of incarceration leaves individual states largely responsible for criminal justice policy, yet the country continues to maintain the highest incarceration rate in the world, prompting growing interest in reforms that both reduce incarceration and improve outcomes. One such approach emphasizes rehabilitation over traditional goals such as deterrence and incapacitation, drawing on the example of Scandinavian prison systems as an evidence-based practice. This thesis examines how states, as laboratories of democracy, are experimenting with rehabilitation-centered models of incarceration through different mechanisms of policy change. Focusing on two case studies – Pennsylvania’s Scandinavian Prison Project as a …

Learning Techniques In Prediction Of Functional Epigenomic Events, Mohammad Shiri

Computer Science Theses & Dissertations

Accurately predicting functional epigenomic events from DNA sequences is critical to understanding gene regulation and the functional impact of non-coding variants. Despite considerable progress, critical challenges hamper the effectiveness and efficiency of existing deep learning approaches. These challenges include negative transfer in multi-task learning (MTL), suboptimal network architectures, and pervasive label noise, particularly the positive-unlabeled problem arising from data sparsity in single-cell assays. This dissertation presents a cohesive framework of novel learning techniques to effectively address these challenges. First, a highly scalable task grouping framework is presented to mitigate negative transfer in deep MTL. This method clusters tasks based on …

A Critical Discourse Analysis Of Community College Presidential Job Announcements And The American Association Of Community Colleges Competencies For Community College Leaders, Leslie M. Boon

Educational Leadership & Workforce Development Theses & Dissertations

Women are overrepresented as students and employees of community college, yet they are underrepresented in presidential leadership roles. Prior research has examined the career trajectories and experiences of women aspiring to community college presidencies; however, less research has examined how discourse shapes expectations of leadership. Because community colleges have been described as gendered, the language used to describe leadership competencies may reinforce gendered assumptions about effective leadership. The purpose of this study was to examine the discourse of community college presidential job announcements and the American Association of Community Colleges’ (AACC) Competencies for Community College Leaders (4th edition) to examine …

Bug-In-Ear ECoaching To Enhance Parents' Use Of Embedded Learning Opportunities With Preschool-Age Children With Autism Spectrum Disorder, Aeshah Alturki

Human Movement Studies & Special Education Theses & Dissertations

The increasing prevalence of autism spectrum disorder (ASD) has heightened the need for effective communication interventions. Parents are key partners in intervention and, with appropriate support, can serve as effective intervention agents. However, parents often require ongoing support to implement evidence-based practices. The purpose of this study was to experimentally evaluate the effects of online Bug-in-Ear (BIE) eCoaching on parents’ fidelity of embedded choice-making during family routines with their preschool-aged children with ASD. This study also examined the generalization and maintenance, children’s communicative responses, and parents’ perceptions of the intervention. A single-subject nonconcurrent multiple baseline design across two parent–child dyads …

An Integrated Bayesian Network-Based Zero Trust Model To Quantify Cyber Risk In Small-Medium Businesses, Ahmed Abdelmagid

Engineering Management & Systems Engineering Theses & Dissertations

Small-medium businesses (SMBs) play a pivotal role in the worldwide economy as they constitute the most considerable portion of businesses in developed countries like the UK and the US. As such, SMBs are likely targets of cybercrimes by malicious agents because of their vulnerable IT systems. The digital infrastructure of SMBs is more likely to be hit by cyberattacks than large businesses due to many factors that facilitate hackers’ missions. These factors include a limited financial budget devoted to cybersecurity, a lack of knowledge, an underrating of how dangerous cyber threats are, and a shortage of IT expertise. The enormous …

Identifying Professional Development Needs Of Deans At California Community Colleges, Matilda D. Chavez

Educational Leadership & Workforce Development Theses & Dissertations

This quantitative, descriptive study examined the professional development needs of deans, associate deans, and directors in the California Community Colleges System. Using the American Association of Community Colleges leadership competencies, the study analyzed how mid-level leaders rated the importance of leadership tasks and their ability to perform them. It also compared results by gender, race or ethnicity, years in the role, district type, and preferred professional development methods.

Data were collected with a 47-item, fixed-format survey using Qualtrics. The sample was a nonprobability quota drawn from 17 California community colleges (N = 71). Descriptive and inferential statistical analyses, including t-tests …

Education And Training In Water Operator Certification And Its Role In Water Utility System Performance, Heath A. Edelman

Educational Leadership & Workforce Development Theses & Dissertations

Access to safe and reliable drinking water is a foundational component of public health and environmental protection. The United States drinking water sector is highly regulated and increasingly challenged by workforce shortages, aging infrastructure, and variability in operator training requirements across states. Despite the federal mandate for operator certification under the Safe Drinking Water Act Amendments of 1996, empirical evidence on the effectiveness of certification policies in improving regulatory compliance outcomes remains limited.

This study examined the relationship between operator certification policies and drinking water compliance outcomes under the Safe Drinking Water Act, with particular attention to differences across violation …

Sensemaking By Rural Community College Mid-Level Academic Leaders During Localized Disruptions: A Critical Incident Technique Study, Donata Worrell

Educational Leadership & Workforce Development Theses & Dissertations

Mid-level academic leaders in community colleges play a critical role in the success of community colleges. Beyond performing administrative tasks, they advocate for faculty, staff, and students as well as implement directives. Their work is affected by localized disruptions. However, limited research has examined how these leaders experience such disruptions. The purpose of this qualitative study was to explore how mid-level community college leaders experience and make sense of those unexpected operational disruptions and their emotional responses to those events. Guided by Weick’s theory of sensemaking, this study used the critical incident technique (CIT) to collect detailed accounts of the …

"On The Same Rope": An Exploratory Study Of Staff Experiences At The Mountain Seed Foundation's Healing Base Camp Program, Jill C. Kivikoski

Counseling & Human Services Theses & Dissertations

Since the escalation of Russia’s invasion of Ukraine in 2022, Ukrainians have faced significant social and public health challenges, particularly among Service Members, Veterans, and their Families (SMVF), including disability, traumatic stress, and barriers to mental health care (Kostenko et al., 2024; Krasnodemska et al., 2023; O’Grady & Galouchka, 2023). Retreat based programs grounded in shared military identity may offer an accessible form of support (Barrett & Currin, 2024). Mountain Seed Foundation’s (MSF) Healing Base Camp (HBC) was developed to promote healing and resilience among Ukrainian SMVF (Mountain Seed Foundation, n.d.).

This qualitative dissertation used a single-case study design (Yin, …

The Physiology Of The Work: Chronic Stress, Allostatic Load, And Faculty Wellness In Counselor Education, Ajayla S. Evins

Counseling & Human Services Theses & Dissertations

Counselor educators embody multifaceted professional roles across teaching, supervision, research, leadership, and service, exerting a profound influence on the formation of counselors and the ongoing development of the profession (CACREP, 2024; Calley & Hawley, 2008). While wellness is recognized as a core professional value in counseling (ACA, 2014), research has focused almost exclusively on emotional and psychological dimensions, leaving the physiological consequences of chronic stress largely underexplored (Bovee, 2024; Faheem et al., 2025; Lewis et al., 2022). In neighboring fields, such as public health and medicine, chronic stress has been linked to dysregulation in cardiovascular, neuroendocrine, immune inflammatory, and metabolic …

The Lived Experiences Of Master's Level Counselors In Professional Counseling Association Leadership, Catalina R. Kraft

Counseling & Human Services Theses & Dissertations

Leadership and advocacy are essential for all counselors (Lewis, 2022; McKibben, 2016; Paradise et al., 2010; Sweeney, 2022). However, within research and professional counseling associations, there appears to be a bias in which counselor educators are the expected, default leaders within the counseling profession (Burns, 2015; Kleist, 2018; Speciale & Goodrich, 2020). While counselor educators may have experience as counselors, they primarily work in academia, so their experiences do not authentically represent the needs of professional counselors. Counseling leaders need to represent and understand the people they serve: counselors. Therefore, this study sought to understand the lived experiences of master’s …

Considering Special Education Program Performance Analysis And Teacher And Student Involvement In Transition Planning: A Delphi Study To Prioritize Student Interests, Strengths, And Transition Assessment, Charles S. Thull

STEMPS Theses & Dissertations

Individualized education program (IEP) transition plans are required to be based on student interests and strengths, and use age-appropriate transition assessments, yet limited guidance exists on how to prioritize these elements. Despite decades of transition planning research and policy development, students with disabilities continue to experience poor postsecondary transition outcomes, special education teachers report limited readiness to support transition planning, university special education programs lack transition focused coursework, and transition plans are created for compliance and lack transition assessment information. Considering these concerns, this study used a modified Delphi method, informed by Human Performance Technology (HPT) and Ecological Systems Theory …

Exploring The Physical Education Experiences Of Blind And Visually Impaired Hispanic Multilingual Learners In Integrated Settings, Sheyla G. Martinez-Rivera

Human Movement Studies & Special Education Theses & Dissertations

Although students with visual impairments (VI) are increasingly placed in integrated physical education (PE) classes (U.S. Department of Education, 2023), the embodied experiences of those who also identify as multilingual learners (MLs) and as Hispanics remain largely unexplored. This retrospective qualitative study examined how these students experience integrated PE during their K-12 education, focusing on how language and disability identities shaped their participation. Participants included seven Hispanic students, all MLs, and identified under the Individuals with Disabilities Education Act (IDEA) as blind or visually impaired. At the time of the study, participants were between 18 and 33 years old and …

Perceptions Of Virginia Dentists And Dental Hygienists Towards Emerging Alternative Dental Hygiene Workforce Provider Models, Lauren B. Mangum

Dental Hygiene Theses & Dissertations

Background: A perceived shortage of dental hygienists in the United States has been linked to delays in preventive care and concerns about declining oral health outcomes. In response, some states have proposed alternative pathways permitting internationally trained dentists, dental students, and oral preventive assistants (OPAs) with limited or inconsistent education requirements to provide dental hygiene services. Limited evidence exists regarding whether these strategies would effectively address access to care and workforce challenges. Concerns have also been raised about the potential effects of expanding scope of practice for providers with limited education or training on patient safety and quality of care. …

The Effects Of Covid 19 Job Demands On Public Sector Employees’ Organizational Commitment: The Mediating Roles Of Work Engagement And Job Burnout, And The Moderating Role Of Supervisor Support, Benjamin R. Kaufman

Psychology Theses & Dissertations

United States citizens rely on state government employees to provide essential public services. During the COVID-19 pandemic, these employees responded by administering both routine and novel procedures to protect public health, often placing them on the frontlines and at increased risk of contagion. Concurrently, the pandemic-driven economic downturn created budget shortfalls that threatened the job and financial security of the state workforce. Together, these conditions substantially increased job demands for state government employees.

Guided by the Job Demands–Resources (JDR) Model, this study examined how COVID‑19-related job demands influenced state employees’ work engagement, job burnout, and organizational commitment, and whether supervisor …

A Transcendental Phenomenological Study Of The "Intervention Implementation Experience" With Department Chairs And Program Coordinators During A Performance Improvement, Courtney W. Schoolmaster

STEMPS Theses & Dissertations

Minimal research has been conducted on the experiences of department chairs and program coordinators with the implementation of performance improvement in learning outcome assessment. Focusing on a multidisciplinary college that offered associate degrees, technical diplomas, and certificates, located within the SACSCOC region, this transcendental phenomenology aims to understand the lived experiences of department chairs and program coordinators in a community college during the implementation/maintenance phases of a performance improvement initiative for the college’s program and general learning outcome assessment process.

This phenomenological study was conducted with eighteen department chairs and program coordinators, and two semi-structured interviews were conducted via Webex. …

Fabrication Of Flexible Laser-Induced Graphene-Based Non-Enzymatic Glucose Sensor For Diabetes Management, Reagan Aviha

Electrical & Computer Engineering Theses & Dissertations

This research focuses on developing a flexible non-enzymatic glucose sensor to address the issues of cost, stability, and limited sensitivity associated with enzymatic glucose sensors. Regular monitoring of glucose levels is required to manage the global health challenge of diabetes. The sensor is built on a cost-effective, durable, flexible, conductive, and high-surface-area substrate acting as a scaffold for modification with easily tunable and electroactive species to enhance glucose detection. The electroactive materials used are zinc oxide (ZnO), palladium (Pd) and platinum (Pt). Laser-induced graphene (LIG) is created by laser engraving. ZnO, Pd and Pt are electrochemically deposited and optimized based …

Effects Of Cross-Language Instructional Design On Foreign Language Learners' Cognitive Load: Approaching The Redundancy Principle Of Multimedia Learning, Leonor Mendiola Adams

STEMPS Theses & Dissertations

Because conceptualizations of cognitive resources play a critical role in determining the effectiveness of instructional design (Greeno, 2011; Greeno et al., 1996; Mayer, 2011, 2019), this study explores the effects of cross-language instructional design on learners’ perceived intrinsic, extraneous, and germane cognitive load content corresponding to content complexity, instructional presentation demands, and depth of understanding and schema construction, respectively.

Grounded in the redundancy principle of the Cognitive Theory of Multimedia Learning, this research further investigates whether the principle operates differently when learners’ native language is strategically incorporated into foreign language learning contexts. According to the cognitive theory of multimedia learning, …

Personality Predictors Of Cybersecurity Vulnerability: Insights From Self-Reports And Stimulated Threat Scenarios, Saroja Roy Grandhi

Psychology Theses & Dissertations

In this cyber dependent and enabled era, understanding the role of human factors in digital security is essential. This study investigates the relationship between Big-Five personality traits and cybersecurity behaviors by examining both self-reported and stimulated behaviors in security threat scenarios. Participants completed validated questionnaires to report their personality traits, cybersecurity practices and engage in task-based stimulations to capture behaviors such as phishing detection, password creation, and response to security alerts. The study tested whether higher conscientiousness, openness, and agreeableness would be associated with stronger cybersecurity practices and smaller discrepancies between self-reported and observed behaviors. And, whether greater extraversion and …

Mechanisms Of Synergy Between Nanosecond Pulsed Electric Field (Nspef) And Cold Atmospheric Pressure Plasma Discharge (Cap) In Pancreatic Cancer: The Role Of Ros-Mediated Oxidative Stress And Apoptosis, Zobia Minhas

Theses and Dissertations in Biomedical Sciences

Pancreatic ductal adenocarcinoma is a highly lethal malignancy characterized by poor prognosis and resistance to conventional therapies. Novel treatment strategies are needed to overcome this resistance. Non-thermal physical modalities, including nanosecond pulsed electric field (nsPEF) and cold atmospheric pressure plasma discharge (CAP), have emerged as potential anticancer approaches; however, the mechanisms underlying their combined effects remain unclear.

This study evaluated whether nsPEF enhances CAP-induced cytotoxicity and investigated the associated molecular mechanisms using the murine Pan02 pancreatic cancer cell line. Cell viability was assessed by WST-1 metabolic activity assays and electric cell–substrate impedance sensing (ECIS). Intracellular reactive oxygen species (ROS) were …

Social Capital As An Intervening Explanatory Mechanism Linking Socioeconomic Status And Deliberative Decision-Making In Citizen Advisory Boards In California Municipalities, Christopher Gerry

School of Public Service Theses & Dissertations

Citizen advisory boards (CABs) are widely used in local government as institutional mechanisms for participatory governance and public input. While these bodies are intended to promote inclusive and deliberative decision-making, persistent socioeconomic inequalities raise concerns about whether CABs mitigate or reproduce disparities in participation and influence. This dissertation examines how socioeconomic status (SES) shapes deliberative decision-making within CABs and whether this relationship operates indirectly through board-level social capital.

Integrating perspectives from participatory governance, deliberative democracy, and social capital theory, the study conceptualizes deliberative decision-making as a collective, board-level process shaped by relational and institutional dynamics rather than individual attributes alone. …

“Recollecting The Told Story”: Storytelling, Activism, And The Black Maternal Health Emergency, Lamaya C. Williams

English Theses & Dissertations

Storytelling is a foundational component of Black knowledge creation and transmission. This dissertation centers Black women’s stories of birth and mothering—drawing on both primary source birth stories and fictional narratives—to examine the United States’ Black Maternal Health Emergency (BMHE). The BMHE is a complex and urgent issue wherein structural racism, medical bias, and intersecting social determinants disproportionately endanger the health of Black mothers. As such, Black mothers in the United States are three times more likely to die from a pregnancy-related condition compared to their white counterparts.

This study examines the birth stories of women who survived the BMHE and …

Electronic Resource Updates - 2026 Q1, Brigitte Galauner, Gregg Harris

Electronic Resources Quarterly Updates

No abstract provided.

Durham Town Hall Meeting Discusses Guns On Campus, Delaney Nickerson

Digital Edition

No abstract provided.

Zinc Oxide Nanoparticles And Chitosan Exhibited Synergistic Protection Against Diabetic Nephropathy In Mice Model, Abdulkader M Shaikh Omar, Zainab M Al Aamri, Salim M El Hamidy, Muhamed A. El Nobey

Journal of King Abdulaziz University: Meteorology, Environment and Arid Land Agriculture

Diabetic nephropathy (DN) is a progressive complication of diabetes mellitus characterized by oxidative stress, impaired glucose metabolism, and renal dysfunction. This study explored the protective effects of zinc oxide nanoparticles (ZnO NPs), chitosan, and their synergism on renal function disorders, oxidative stress, and histopathological alterations in a streptozotocin (STZ)-induced diabetic mice model. Mice treated with STZ exhibited marked hyperglycemia (284.08 ± 0.76 mg/dL), elevated HbA1c (17.35 ± 0.13%), and reduced insulin levels (3.09 ± 1.00 μI/mL), along with increased levels of renal biomarkers: urea (46.01 ± 0.28 mg/dL), uric acid (8.09 ± 0.19 mg/dL), and creatinine (1.79 ± 0.06 mg/dL). …

Multistage Community Intervention In Lung Cancer Screening Awareness And Uptake In Washington D.C., Shelly Dimri, Santoshi Puvvadi, Shweta Raman, Sam Schwartz, Rhea Sharma, Olivia Turcio

GW Research Showcase 2021-2026

No abstract provided.