Digital Commons Network^™

The Murder Of George Floyd: A Case Study Examining How The Policing Of Black Men And Grassroots Activism Influence The Will Of Black Women To Lead, Ella Gates-Mahmoud

Doctorate in Education

This study's objective investigates the viewpoints held by Black women in two urban areas of Minnesota about the social upheaval that followed the murder of George Floyd in 2020 for using a counterfeit $20 bill. In the last decade, police killings of innocent Black people in the United States have received more attention, and Floyd's death is only one example of this phenomenon. In the U.S., the likelihood of a police officer taking the life of a Black man is higher than that of a White man. Between 2013-2019 there have been 1,641 fatal shootings of defenseless Black men by …

A Prospective Evaluation Of The Effects Of The Covid-19 Pandemic On Youth With Primary Headache Disorders., Mark Connelly, Jennifer J. Dilts, Madeline Boorigie, Trevor Gerson

Manuscripts, Articles, Book Chapters and Other Papers

Alterations in certain academic and social/family routines during the COVID-19 pandemic have been speculated to be either a risk factor or buffer for poor health outcomes for youth with stress-sensitive health conditions such as primary headache disorders. The current study evaluated patterns and moderators of pandemic impacts on youth with primary headache disorders, with an aim of extending our understanding of the relationship between stress, resilience, and outcomes in this population. Children recruited from a headache clinic in the midwestern United States reported on their headaches, schooling, routines, psychological stress, and coping at four timepoints ranging from within a few …

Circadian Rhythms As Modulators Of Brain Health During Development And Throughout Aging, Rachel Van Drunen, Kristin Eckel-Mahan

Faculty, Staff and Student Publications

The circadian clock plays a prominent role in neurons during development and throughout aging. This review covers topics pertinent to the role of 24-h rhythms in neuronal development and function, and their tendency to decline with aging. Pharmacological or behavioral modification that augment the function of our internal clock may be central to decline of cognitive disease and to future chronotherapy for aging-related diseases of the central nervous system.

Long-Term Bidirectional Association Between Asthma And Attention Deficit Hyperactivity Disorder: A Big Data Cohort Study, Hye Jin Park, Young Hyeon Kim, Da Ye Na, Seong Won Jeong, Min Gyu Lee, Jong-Hwan Lee, Yun Na Yang, Min Gu Kang, Sang Woo Yeom, Jong Seung Kim

Faculty, Staff and Student Publications

BACKGROUND: Previous studies have argued that attention deficit hyperactivity disorder (ADHD) is associated with asthma. However, reliable evidence to verify this association has not yet been reported.

OBJECTIVES: To investigate the bidirectional association between asthma and ADHD through a 12-year big data cohort study.

METHODS: The independent variable group was extracted from 3.5 million individuals randomly sampled by the National Health Insurance Service (NHIS). In Study 1, the incidence of ADHD according to asthma was evaluated, while in Study 2, the incidence of asthma according to ADHD was analyzed. Propensity score (PS) matching with several variables was used to obtain …

A Comprehensive Assessment Of Cell Type-Specific Differential Expression Methods In Bulk Data, Guanqun Meng, Wen Tang, Emina Huang, Ziyi Li, Hao Feng

Faculty, Staff and Student Publications

Accounting for cell type compositions has been very successful at analyzing high-throughput data from heterogeneous tissues. Differential gene expression analysis at cell type level is becoming increasingly popular, yielding biomarker discovery in a finer granularity within a particular cell type. Although several computational methods have been developed to identify cell type-specific differentially expressed genes (csDEG) from RNA-seq data, a systematic evaluation is yet to be performed. Here, we thoroughly benchmark six recently published methods: CellDMC, CARseq, TOAST, LRCDE, CeDAR and TCA, together with two classical methods, csSAM and DESeq2, for a comprehensive comparison. We aim to systematically evaluate the performance …

Ccsynergy: An Integrative Deep-Learning Framework Enabling Context-Aware Prediction Of Anti-Cancer Drug Synergy, Sayed-Rzgar Hosseini, Xiaobo Zhou

Faculty, Staff and Student Publications

Combination therapy is a promising strategy for confronting the complexity of cancer. However, experimental exploration of the vast space of potential drug combinations is costly and unfeasible. Therefore, computational methods for predicting drug synergy are much needed for narrowing down this space, especially when examining new cellular contexts. Here, we thus introduce CCSynergy, a flexible, context aware and integrative deep-learning framework that we have established to unleash the potential of the Chemical Checker extended drug bioactivity profiles for the purpose of drug synergy prediction. We have shown that CCSynergy enables predictions of superior accuracy, remarkable robustness and improved context generalizability …

Editorial: A Surgeon’S Framework For The Unplanned Intraoperative Consultation, Sunjay Kumar, Talar Tatarian, Francesco Palazzo

Department of Surgery Faculty Papers

Surgeons during their career will likely be called in to assist or offer advice with an unanticipated intraoperative event or finding. Yet, there is no practical framework of how to respond to these consults nor is there any formal training in this area.

Review of the limited literature and expert senior opinion can help explain the ethical components involved but do not address some of the practical aspects that the consulting surgeon may need to confront when responding to an unplanned intraoperative consultation.

In this manuscript we present a selected review of the available literature on the topic, establish some …

Montana Kaimin, January 19, 2023, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Ultrasound Assessment Of Spastic Muscles In Ambulatory Chronic Stroke Survivors Reveals Function-Dependent Changes, Javier González-Buonomo, Alexander H Pham, Jaskiran Ghuman, Aila Malik, Nuray Yozbatiran, Gerard E Francisco, Walter R Frontera, Sheng Li

Faculty, Staff and Student Publications

OBJECTIVE: To correlate ultrasound characteristics of spastic muscles with clinical and functional measurements in chronic stroke survivors.

METHODS: Ultrasound assessment and clinical and functional assessments were performed in 28 ambulatory stroke survivors (12 females, mean age 57.8 ± 11.8 years, 76 ± 45 months after stroke).

RESULTS: Muscle thickness in the affected side was decreased compared with the contralateral side (p < 0.001). The decrease was more evident in the upper limb muscles. On the affected side, the modified Heckmatt scale score was lowest (closer to normal) in the rectus femoris (RF) muscle compared with other muscles (biceps brachii (BB), flexor carpi ulnaris (FCU) and medial gastrocnemius (MG)). Muscle thickness and echogenicity of spastic muscles did not correlate with spasticity, as measured with the modified Ashworth scale (MAS), Fugl-Meyer motor assessment scores, age, or time since stroke. There was a significant negative correlation between grip strength and percentage decrease in muscle thickness for the spastic FCU muscle (r = -0.49, p = 0.008). RF muscle thickness correlated with ambulatory function (Timed Up and Go test (r = 0.44, p = 0.021) and 6-metre walk test (r = 0.41, p = 0.032)). There was no significant correlation between echogenicity and functional assessments Conclusion: Ambulatory chronic stroke survivors had function-dependent changes in muscle thickness on the affected side. Muscle thickness and echogenicity of spastic muscles did not correlate with spasticity, Fugl-Meyer motor assessment scores, age, or time since stroke.

Cortical Connectomic Mediations On Gamma Band Synchronization In Schizophrenia, Xiaoming Du, Stephanie Hare, Ann Summerfelt, Bhim M Adhikari, Laura Garcia, Wyatt Marshall, Peng Zan, Mark Kvarta, Eric Goldwaser, Heather Bruce, Si Gao, Hemalatha Sampath, Peter Kochunov, Jonathan Z Simon, L Elliot Hong

Faculty, Staff and Student Publications

Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophrenia remain poorly understood. Sixty-six patients with schizophrenia spectrum disorders and 85 age- and gender-matched healthy controls completed one electroencephalography session measuring 40 Hz ASSR and one imaging session for resting-state functional connectivity (rsFC) assessments. The associations between the normalized power of 40 Hz ASSR and rsFC were assessed via linear regression and mediation models. We found that rsFC among auditory, precentral, postcentral, and prefrontal cortices were positively associated with 40 Hz ASSR in …

Politics And Policy Of The Falling Birth Rate In Italy: Predictions And Concerns, Erin Lindsay

Cardozo International & Comparative Law Review (CICLR) Blog

The birth rate in Italy had been a topic of concern for the past couple decades, making it a source of conversation and debate among political parties and candidates in Italy. With the election of a new Italian government and the prediction of Giorgia Meloni being Italy’s new prime minister, how Meloni and her party have spoken of and plan to tackle the falling birth rate is a discussion occurring around the world. The falling birth rate was concerning to country leaders prior to the start of the COVID-19 pandemic, but statistics show that the Italian birth rate has fallen …

January 19, 2023, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Student Movement Volume 107 Issue 12: Revisiting "The Dream": Students Celebrate Mlk Day, Grace No, Nora Martin, Gloria Oh, Ysabelle Fernando, Solana Campbell, Amelia Stefanescu, Brendan Oh, Julia Randall, Gabriela Francisco, Peter Lyons, Anthony Bosman, Martin Hanna, Ryan T. Hayes, Karin Thompson, Melissa Moore, Wambui Karanja, Desmond H. Murray, Scott Moncrieff

The Student Movement v. 107 (2022-2023)

HUMANS

Andrews Gaming Club, Interviewed by: Grace No

Meet Gio Lee, Interviewed by: Nora Martin

New Year, Happier Me, Gloria Oh

ARTS & ENTERTAINMENT

Art @ AU: Harrigan's Gallery, Ysabelle Fernando

Currently: The Way of Water, Solana Campbell

Ode to 2022, Amelia Stefanescu

Where Do I Find God - Part I, Anonymous

NEWS

Honoring Martin Luther King Jr.'s Legacy, Brendan Oh

Is America Safe?: First Grader Shoots Teacher, Julia Randall

A House Divided: Current Issues Within the School of Architecture and Interior Design, Student Movement Editorial Staff

IDEAS

Harry & Meghan: Unpacking Royal Pains, Gabriela Francisco

A New Space for …

Comments On The Draft Butte Priority Soils Operable Unit (Bpsou) Clark Tailings Consolidated Waste Management Area Site Investigation Quality Assurance Project Plan (Qapp) (Dated June 17, 2022), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Kenyon Collegian - January 19, 2023

The Kenyon Collegian

No abstract provided.

Control Of Craniofacial Development By The Collagen Receptor, Discoidin Domain Receptor 2, Fatma F Mohamed, Chunxi Ge, Shawn A Hallett, Alec C Bancroft, Randy T Cowling, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Benjamin Levi, Vesa M Kaartinen, Renny T Franceschi

Faculty, Staff and Student Publications

Development of the craniofacial skeleton requires interactions between progenitor cells and the collagen-rich extracellular matrix (ECM). The mediators of these interactions are not well-defined. Mutations in the discoidin domain receptor 2 gene (DDR2), which encodes a non-integrin collagen receptor, are associated with human craniofacial abnormalities, such as midface hypoplasia and open fontanels. However, the exact role of this gene in craniofacial morphogenesis is not known. As will be shown, Ddr2-deficient mice exhibit defects in craniofacial bones including impaired calvarial growth and frontal suture formation, cranial base hypoplasia due to aberrant chondrogenesis and delayed ossification at growth plate …

Exploring The Link Between Food Insecurity And Eating Disorders, Ayden Hayes

Electronic Theses and Dissertations Archive

In the last five years, research regarding the link between food insecurity and eating disorders has been on the rise. This review was conducted to explore this link and identify potential gaps and limitations that exist among the current research and how future research can address these. Evidence gathered throughout this review supports a need for changes to screening tools for eating disorders as well as food assistance programs, which indicates some ways that this research can direct future practice for nutrition professionals. The Academy of Nutrition and Dietetics defines disordered eating as irregular eating patterns that are not indicative …

Psychosocial Measures And Outcomes Among Caregivers Of Children With Tracheostomies: A Systematic Review, Darlene E Acorda, Jennifer N Brown, Elton M Lambert, Karen Divalerio Gibbs

Library Staff Publications

OBJECTIVE: Children with tracheostomies have complex medical issues that require long-term technology dependence and continuous medical care at home. Parents of tracheostomy-dependent children often assume the majority of their child's home care leading to a shift in family dynamics and a decrease in caregiver quality of life. This systematic review sought to identify instruments to measure caregiver psychosocial outcomes after their child's tracheostomy and report on the findings.

DATA SOURCES: A systematic review was performed using Medline, CINAHL, and EMBASE.

REVIEW METHODS: Studies that evaluated psychosocial outcomes in caregivers of tracheostomy-dependent children were included.

RESULTS: We screened a total of …

2023-01-19 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate newsletter from January 19, 2022.

2023-01-19 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from January 19, 2023.

Pharmacological Management Of Disease By Overcoming Structural Adversity, Richard N Sifers

Center on Aging Staff Publications

In this issue of Cell Chemical Biology, Sun et al. utilize computational and protein expression analyses, plus pharmacological proteostasis network activation, to simultaneously correct two genetic diseases linked to a single protein rather than modify the responsible DNA.

Understanding The Experiences Of Latino Medical Students In A Learning Medical Environment, Leslie García

Dissertations and Theses

Very little is known about the experiences and perceptions of underrepresented minority (URiM) medical students in the U.S. allopathic medical schools. The limited literature posits URiMs experience more adverse experiences in the learning environment and have different learning outcomes in comparison to their White peer counterparts. Latino medical students represent 7.1% of all entering medical students across all U.S. medical schools. While they represent the largest ethnic minority in the United States within parity lack representation among the physician workforce [sic]. There is a dearth of knowledge of what factors contribute to the success of Latino medical students progressing in …

Semantic Wikis As Flexible Database Interfaces For Biomedical Applications, Marco Falda, Manfredo Atzori, Maurizio Corbetta

2020-Current year OA Pubs

Several challenges prevent extracting knowledge from biomedical resources, including data heterogeneity and the difficulty to obtain and collaborate on data and annotations by medical doctors. Therefore, flexibility in their representation and interconnection is required; it is also essential to be able to interact easily with such data. In recent years, semantic tools have been developed: semantic wikis are collections of wiki pages that can be annotated with properties and so combine flexibility and expressiveness, two desirable aspects when modeling databases, especially in the dynamic biomedical domain. However, semantics and collaborative analysis of biomedical data is still an unsolved challenge. The …

Urine Cell-Free Dna Multi-Omics To Detect Mrd And Predict Survival In Bladder Cancer Patients, Pradeep S Chauhan, Alexander Shiang, Irfan Alahi, Wenjia Feng, Cayce Nawaf, Kevin Chen, Peter K Harris, Faridi Qaium, Casey Hatscher, Anna Antiporda, Lindsey Brunt, Lindsey R Mayer, Brian C Baumann, Eric H Kim, Melissa A Reimers, Zachary L Smith, Aadel A Chaudhuri, Et Al.

2020-Current year OA Pubs

Circulating tumor DNA (ctDNA) sensitivity remains subpar for molecular residual disease (MRD) detection in bladder cancer patients. To remedy this problem, we focused on the biofluid most proximal to the disease, urine, and analyzed urine tumor DNA in 74 localized bladder cancer patients. We integrated ultra-low-pass whole genome sequencing (ULP-WGS) with urine cancer personalized profiling by deep sequencing (uCAPP-Seq) to achieve sensitive MRD detection and predict overall survival. Variant allele frequency, inferred tumor mutational burden, and copy number-derived tumor fraction levels in urine cell-free DNA (cfDNA) significantly predicted pathologic complete response status, far better than plasma ctDNA was able to. …

Virome Analysis And Association Of Positive Coxsackievirus B Serology During Pregnancy With Congenital Heart Disease, Mathieu Garand, Susie S Y Huang, Lisa S Goessling, Fei Wan, Donna A Santillan, Mark K Santillan, Anoop Brar, Todd N Wylie, Kristine M Wylie, Pirooz Eghtesady

2020-Current year OA Pubs

BACKGROUND: We have previously shown coxsackievirus B (CVB) to be a potent inducer of congenital heart disease (CHD) in mice. The clinical relevance of these findings in humans and the roles of other viruses in the pathogenesis of CHD remain unknown.

METHODS: We obtained plasma samples, collected at all trimesters, from 89 subjects (104 pregnancies), 73 healthy controls (88 pregnancies), and 16 with CHD-affected birth (16 pregnancies), from the Perinatal Family Tissue Bank (PFTB). We performed CVB IgG/IgM serological assays on plasma. We also used ViroCap sequencing and PCR to test for viral nucleic acid in plasma, circulating leukocytes from …

Critical Assessment Of Core Self‐Evaluations Theory, Shefa Salem Al-Sagga/ Besaiso, Laila Hossam Al-Din Shokr, Dina Farouk Al-Agry

Al-Balqa Journal for Research and Studies البلقاء للبحوث والدراسات

This study aims at providing an overview of three decades of core self-evaluation theory and research. It focuses on each of its concepts and criteria and briefly explains its history with a particular emphasis on a critical evaluation of the theory, classification of the mechanisms of its impact on direct outcomes, mediation, moderation, its measurement approaches and models. The study conducted a comprehensive inventory of all qualitative and quantitative research and studies conducted on self-evaluations, which are available on the Web of Science & Scopus of 25 published studies. The findings revealed that core self-evaluation can have a significant impact …

Evaluating The Role Of Universities As Knowledge Hubs: Jordan University Of Science And Technology As A Case Study, Nasser Abu Anzeh, Tahar Ledraa, Atef Nusair, Maram Foad Obaidat

Al-Balqa Journal for Research and Studies البلقاء للبحوث والدراسات

Considering the substantial contribution of universities to the economic, urban, and social development, the role of universities as knowledge hubs (KHs) has been recently attracting attention of researchers worldwide. The study aims at evaluating the role of Jordan University of Science and Technology (JUST) as a locus of knowledge enhancing its performance and impact on economic, urban, and social development. The study approach consists of a descriptive analysis using knowledge-based urban growth assessment systems. A survey investigating opinions of a sample of faculty members, students, experts and stakeholders was undertaken to collect the required data on performance indicators. The performance …

Pengaruh Budaya Organisasi Dan Komitmen Organisasi Terhadap Kepuasan Kerja Dan Turnover Intention Pada Perawat Rsia Eria Bunda Pekanbaru, Umi Kalsum, Harlen Harlen, Machasin Machasin

Jurnal Sosial Humaniora Terapan

Dalam usaha pencapaian tujuan oleh lembaga yang bergerak di bidang kesehatan, manajemen rumah sakit tidak hanya menghadapi permasalahan pada bahan mentah atau peralatan saja, namun juga perawat yang dimilikinya. Rumah Sakit Ibu dan Anak Eria Bunda adalah sebuah perusahaan penyedia layanan kesehatan yang berada di kota Pekanbaru. Peneliti melakukan penelitian berdasarkan fenomena yang terjadi tentang budaya organisasi dan komitmen organisasi terhadap kepuasan kerja dan turnover intention di RSIA Eria Bunda Pekanbaru. Populasi dalam penelitian ini yaitu seluruh perawat di RSIA Eria Bunda Pekanbaru yang berjumlah 83 orang, karena populasi yang terbatas maka populasi dijadikan sampel. Teknik analisis data yang digunakan …

Pengaruh Personal Resources Dan Workplace Well Being Terhadap Keterikatan Karyawan Dan Turnover Intention Pada Pt. Indah Kiat Pulp And Paper Perawang Divisi Logistic Container, Subari Wiratno Hamif, Isyandi Isyandi, Samsir Samsir

Jurnal Sosial Humaniora Terapan

Penelitian ini dilakukan berdasarkan fenomena yang terjadi saat ini terhadap keterikatan karyawan dan Turnover intention serta didukung jurnal yang ada sehingga peneliti tertarik melakukan penelitian tentang pengaruh Personal resources dan Workplace Well Being terhadap keterikatan karyawan dan Turnover intention pada Pt. Indah Kiat Pulp And Paper Perawang Divisi Logistic Container. Sampel pada penelitian ini yaitu 84 karyawan. Teknik analisis yang digunakan yaitu Smart-PLS. Hasil penelitian menujukkan bahwa Personal resources berpengaruh positif dan signifikan terhadap keterikatan karyawan, Workplace Well Being berpengaruh positif dan signifikan terhadap keterikatan karyawan. keterikatan karyawan tidak berpengaruh terhadap Turnover intention, Personal resources berpengaruh positif dan signifikan terhadap …

A Qualitative Analysis Of Emergency Medical Services Personnel Experiences And Perception Responding To Drug Overdoses In The Us During The Covid-19 Pandemic, Nae Y. Won, Joseph J. Palamar, Stephen A. Mike, Nicole D. Fitzgerald, Linda B. Cottler

Journal of Health Research

Background: The purpose of this work was to describe the experiences of EMS personnel in responding to drug overdose-related calls and the impact the pandemic has had to help better inform current response and treatment efforts.

Methods: Semi-structured interviews were conducted with 99 EMS personnel across 18 areas throughout the United States that were designated as Early Warning Network sentinel sites by the National Institute on Drug Abuse-funded National Drug Early Warning System. Participants were asked about topics including the potential burdens from the pandemic and the opioid crisis. We coded the interview responses and identified themes through qualitative analysis. …