Digital Commons Network^™

Going Back In Time: Increasing Penicillin Susceptibility Among Methicillin-Susceptible Staphylococcus Aureus Osteoarticular Infections In Children, J Chase Mcneil, Lauren M Sommer, Jesus G Vallejo, Mary Boyle, Kristina G Hulten, Sheldon L Kaplan, Stephanie A Fritz

Faculty, Staff and Students Publications

In the late 1940s to 1950s, Staphylococcus aureus isolates first-gained resistance to penicillin. Recently, some centers have described an increase in the proportion of methicillin susceptible S. aureus (MSSA) which are also susceptible to penicillin (PSSA). There are little data on the frequency of PSSA infections in children. We investigated the prevalence of penicillin susceptibility among pediatric MSSA acute hematogenous osteoarticular infection (OAI) isolates. MSSA OAI isolates were obtained through surveillance studies at Texas Children’s and St. Louis Children’s Hospitals from January 2011 to December 2019. All isolates underwent PCR for blaZ β-lactamase, PVL genes and agr group. All blaZ …

Effect Of Intensive Blood Pressure Control On Troponin And Natriuretic Peptide Levels: Findings From Sprint, Jarett D Berry, Haiying Chen, Vijay Nambi, Walter T Ambrosius, Simon B Ascher, Michael G Shlipak, Joachim H Ix, Rajesh Gupta, Anthony Killeen, Robert D Toto, Dalane W Kitzman, Christie M Ballantyne, James A De Lemos

Faculty, Staff and Students Publications

Background: Given the important role of cardiac injury and neurohormonal activation in the pathways leading from hypertension to heart failure and strong associations observed between hypertension and its sequelae on hs-cTnT (high-sensitivity cardiac troponin T) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, we hypothesized that intensive systolic blood pressure (SBP) lowering would decrease levels of hs-cTnT and NT-proBNP.

Methods: hs-cTnT and NT-proBNP were measured at baseline and 1 year from stored specimens in SPRINT (Systolic Blood Pressure Intervention Trial). Changes in biomarkers were evaluated continuously on the log scale and according to categories (≥50% increase, ≥50% decrease, or < 50% change). The effect of intensive SBP lowering on continuous and categorical changes in biomarker levels were assessed using linear and multinomial logistic regression models, respectively. The association between changes in biomarkers on heart failure and death was assessed using multivariable-adjusted Cox proportional hazards models.

Results: Randomization …

Legal Financial Obligations In The United States: A Review Of Recent Research, Angela Lascala-Gruenewald, Leslie Paik

Publications and Research

In the United States, legal financial obligations (LFOs) include many types of monetary sanctions. For example, fines are tied to specific offenses and imposed at conviction and fees charge people for the “use” of courts, prisons, and other public services. With the rise of mass incarceration, millions of people across the U.S. owe billions of dollars in LFOs. Yet despite the widespread use of monetary sanctions, it was not until the last decade that research began to uncover the vast system of LFOs embedded throughout U.S. laws and understand their far-reaching socioeconomic consequences. This paper reviews recent research on LFOs …

Enhancer-Promoter Entanglement Explains Their Transcriptional Interdependence, Anil K Panigrahi, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Enhancers not only activate target promoters to stimulate messenger RNA (mRNA) synthesis, but they themselves also undergo transcription to produce enhancer RNAs (eRNAs), the significance of which is not well understood. Transcription at the participating enhancer-promoter pair appears coordinated, but it is unclear why and how. Here, we employ cell-free transcription assays using constructs derived from the human GREB1 locus to demonstrate that transcription at an enhancer and its target promoter is interdependent. This interdependence is observable under conditions where direct enhancer-promoter contact (EPC) takes place. We demonstrate that transcription activation at a participating enhancer-promoter pair is dependent on i) …

Genetics And Pathogenesis Of Parkinson's Syndrome, Hui Ye, Laurie A Robak, Meigen Yu, Matthew Cykowski, Joshua M Shulman

Faculty, Staff and Students Publications

Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous, resisting distillation to a single, cohesive disorder. Instead, each affected individual develops a virtually unique form of Parkinson's syndrome. Clinical manifestations consist of variable motor and nonmotor features, and myriad overlaps are recognized with other neurodegenerative conditions. Although most commonly characterized by alpha-synuclein protein pathology throughout the central and peripheral nervous systems, the distribution varies and other pathologies commonly modify PD or trigger similar manifestations. Nearly all PD is genetically influenced. More than 100 genes or genetic loci have been identified, and most cases likely arise from interactions among many common …

Investigating The Potential Role Of Termites As Pathogen Vectors In The Decline Of Ironwood Trees (Casuarina Equisetifolia) In Guam, Garima Setia

LSU Master's Theses

Termites have been found associated with the decline of Casuarina equisetifolia (ironwood), an important agro-forestry species in Guam. While the ironwood tree decline (IWTD) was first reported in 2002, its association with termites as well as with bacteria Ralstonia solanacearum and Klebsiella species (K. oxytoca and K. variicola) was determined in 2010 and 2012 respectively. In 2019, the termite species attacking the ironwood trees were identified as Nasutitermes takasagoensis, Coptotermes gestroi, and Microcerotermes crassus. However, the role of termites in IWTD is not known. Since termites are repositories of bacteria and consume wood, termite foragers might …

Evaluation Of Raavrh74 Gene Therapy Vector Seroprevalence By Measurement Of Total Binding Antibodies In Patients With Duchenne Muscular Dystrophy, Natalie L Goedeker, Sachi D Dharia, Danielle A Griffin, Jesantha Coy, Todd Truesdale, Rajan Parikh, Kasen Whitehouse, Sourav Santra, Damon R Asher, Craig M Zaidman

2020-Current year OA Pubs

BACKGROUND: Adeno-associated virus (AAV) vectors are a promising platform for

OBJECTIVE: To evaluate prevalence of total binding antibodies (neutralizing and non-neutralizing) against rAAVrh74 in patients with DMD.

METHODS: Eligible individuals (

RESULTS: A large preponderance (86.1%) of patients with DMD in this data set was seronegative for anti-rAAVrh74 total binding antibodies. These patients would potentially meet the antibody status eligibility criterion for entry into rAAVrh74-based gene therapy clinical trials.

CONCLUSION: Measuring total binding antibodies is a more comprehensive approach to assess pre-existing immune response

Homeless In A Mountain Town: How Idaho Resort Communities Are Combatting The Affordable Housing Crisis, Alexandra Brockmann

Idaho Law Review

No abstract provided.

Will Housing Become The Inflection Point For Realignment Of State Land Use Structures, Edward J. Sullivan

Idaho Law Review

No abstract provided.

Tackling The Affordability Crisis In The West: The Colorado Housing Affordability Project And The Challenge Of Zoning Reform, Brian J. Connolly, Andrew L.W. Peters, Heidi Aggeler, Avilia Bueno, Julia Jones, Susan Daggett

Idaho Law Review

No abstract provided.

Accessibility, Acceptance, And Equity: Examining Disability-Linked Health Disparities As Nursing And Communication Scholars, Sarah Parsloe, Stacey M. Carroll

Nursing Communication

People with disabilities (PWD) experience health disparities, often related to contextual factors beyond the physical differences in body structure and function. The purpose of this article was to develop a research agenda for nursing and communication scholars that explores how developing accessible and empowering communication environments in healthcare contexts might mitigate disability-linked health disparities. We focused on two broad research objectives: developing both accessible communication environments and empowering communication environments in healthcare settings. Elements proposed as comprising accessible communication environments were: making health literacy accessible, addressing complex communication needs, and communicating the embodied experience of disability. Empowering communication environments were …

Elsa, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a film review of Elsa (2023), directed by Cameron S. Mitchell.

Our Males And Females, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a film review of Our Males and Females (2023), directed by Ahmad Alyaseer.

The Effects Of Acute Rauwolscine (Α-Yohimbine) Ingestion On Repeated Wingate Sprint Performance In Healthy Males, Megan E. Barnes, Tyler Williams, Camryn R. Cowan, Brenden A. Torres, W. Tanner Clark, Rebecca R. Rogers, Luke R. Harms, Christopher G. Ballmann

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 1, 2023. Background: Rauwolscine (RW), also known as α-Yohimbine, is an α-2-adrenergic receptor antagonist which possesses sympathomimetic properties. RW is commercially sold in pre-workout and energy supplements. However, the ergogenic potential of RW has not been determined. The purpose of this study was to investigate the effects of acute RW supplementation on repeated sprint performance. Methods: Healthy male participants (n=12) completed 3 × 15-second Wingate anaerobic tests (WAnT) separated by 2 minutes of active recovery. Blood lactate (La) was collected before exercise (Pre) and immediately following exercise …

Effects Of Acute Exercise On Affect In Females With Substance Use Disorder, Victoria A. Torok, Christi B. Brewer, Hayley N. Lake

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 95-108, 2023. Negative mood states experienced during the withdrawal stage of substance dependence have been associated with relapse in persons suffering from substance use disorder (SUD). Exercise is gaining attention as an adjunct therapy for SUD due to its ability to alleviate negative mood states experienced during withdrawal. The purpose of this study was to investigate the effects of acute, controlled bouts of aerobic and resistance exercise versus sedentary control (quiet reading) on positive affect (PA) and negative affect (NA) in females undergoing SUD treatment at inpatient facilities. Females (n=11; 34 + 8 yrs) …

Improvements In Flexibility Depending On Stretching Duration, Konstantin Warneke, Klaus Wirth, Michael Keiner, Stephan Schiemann

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 83-94, 2023. To improve flexibility, stretching is most commonly used and in training interventions duration-dependent effects are hypothesized. However, there are strong limitations in used stretching protocols in most studies, particularly regarding documentation of intensity and performed procedure. Thus, aim of this study was to compare different stretching durations on flexibility in the plantar flexors and to exclude potential biases. Eighty subjects were divided into four groups performing daily stretching training of 10min (IG10), 30min (IG30) and 1h (IG60) and one control group (CG). Flexibility was measured in bended and extended knee joint. Stretching …

The Relationship Between Health And Movement Screens And Field-Based Physical Fitness Tests In Reserve Officer Training Corps Students, Lukas Krumpl, Nickolai J. P. Martonick, Youngmin Chun, Ann F. Brown, Joshua P. Bailey

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 42-52, 2023. The purpose of the present study was to evaluate the relationship between scores achieved in physical fitness tests and outcomes of health and movement screens (HMS) in ROTC students. Twenty-eight students (20 males: 21.8 yrs [± 3.4] & 8 females: 20.7 yrs [± 1.8]) enrolled in an ROTC branch (Army, Air Force, Navy, or Marines) completed a series of screens, including body composition analysis via Dual-Energy X-Ray Absorptiometry (DXA), balance and functional movement tasks via a lower-quarter Y-Balance test, and knee and hip joint concentric strength testing on an isokinetic dynamometer. Official …

The Effects Of Anabolic-Androgenic Steroids On Gene Expression In Skeletal Muscle: A Systematic Review, Luke M. Pelton, Stephen A. Maris, Joshua Loseke

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 53-82, 2023. Anabolic-androgenic steroids (AAS) act via androgen receptor (AR) interaction to induce muscle protein synthesis. This process is achieved via altered gene expression via the Notch, Wnt, and Numb pathways and their interactions at the AR, manifesting in key skeletal muscle (SM) phenotypes such as morphology, ion conductance, and functionality. This review aims to report on the effects of AAS administration on gene expression in SM. Peer-reviewed empirical studies evaluating AAS administration on SM phenotypes and gene expression were considered for inclusion. The following databases were searched using a data range of Jan …

Serving The Underserved Amid Covid-19: The Case Of A Virtual, Culturally Responsive Summer Engineering Camp, Tonisha B. Lane, Eugenia Vomvoridi-Ivanovic, Leia K. Cain, Selene Willis, Salam Ahmad, Jonathan Gaines

Journal of Pre-College Engineering Education Research (J-PEER)

The societal disruptions due to the novel coronavirus (COVID-19) pandemic are well noted, especially in the context of science, technology, engineering, and mathematics (STEM) education. Absent a concerted effort to sustain hands-on learning opportunities in STEM amid the crisis, the consequences of COVID-19 may exacerbate existing inequities and racial disparities among youth of color further stratifying the STEM fields. In the current study, we applied a mixed-method descriptive case study design, using online learning theory and culturally responsive pedagogy as our conceptual framework, to describe how participants experienced this camp, held online due to disruptions of COVID-19, in the southeastern …

The Remittance, Foreign Direct Investment, Export, And Economic Growth In Bangladesh: A Time Series Analysis, Al Mamun, M H M Imrul Kabir

Arab Economic and Business Journal

This research empirically examined the effect of internal and external factors on the economic growth of Bangladesh using the annual data from 1976 to 2019. ARDL bounds tests were used to detect cointegration and understand the dynamic effect. This study mainly identified the positive and negative casualties because remittance and export have a significant positive role, and FDI has an adverse role in the economic growth process. Furthermore, this study recommends that the government take appropriate steps to increase export, the inflow of remittance and FDI to achieve long-run economic growth, considering the impact of COVID-19 and present Russia- Ukraine …

Determining The Proportionality Of Ischemic Stroke Risk Factors To Age, Elizabeth Hunter, John D. Kelleher

Articles

While age is an important risk factor, there are some disadvantages to including it in a stroke risk model: age can dominate the risk score and lead to over-or under-predictions in some age groups. There is evidence to suggest that some of these disadvantages are due to the non-proportionality of other risk factors with age, eg, risk factors contribute differently to stroke risk based on an individual’s age. In this paper, we present a framework to test if risk factors are proportional with age. We then apply the framework to a set of risk factors using Framingham heart study data …

2023-01-23_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Jose Beltran-Leon V. Attorney General United States

2023 Decisions

Agency

Social And Financial Incentives For Overcoming A Collective Action Problem, M. Mehrab Bakhtiar, Raymond Guiteras, James Levinsohn, Ahmed Mushfiq Mobarak

Discussion Papers

Addressing public health externalities often requires community-level collective action. Each person’s sanitation behavior can affect the health of neighbors. We report on a cluster randomized controlled trial conducted with 19,000 households in rural Bangladesh where we randomized (1) either group financial incentives or a non-financial “social recognition” reward, and (2) asking each household to make either a private pledge or a public pledge to maintain hygienic latrines. The group financial reward has the strongest impact in the short term (3 months), inducing a 7.5-12.5 percentage point increase in hygienic latrine ownership. Getting people to publicly commit to maintaining and using …

Defining Variability In Evaluation And Management Of Children With Chronic Osteomyelitis, Ganga S. Moorthy, Angelique E. Boutzoukas, Daniel K. Benjamin, Philip M. Polgreen, Susan E. Beekmann, John S. Bradley, Walter Dehority

Pediatrics Research and Scholarship

Pediatric chronic osteomyelitis is a rare, debilitating condition lacking management guidelines. In a national survey of 162 pediatric infectious disease physicians through the Emerging Infections Network, tremendous variability in diagnostic approaches and management were noted, highlighting a need for prospective study to better define the spectrum of pathogens and disease.

Ms 248 Guide To The Robert J. Emery, Drph Papers (1995-2011), Robert J. Emory

Manuscript Finding Aids

This collection contains materials related to Dr. Robert Emery's career on the faculty of the UT School of Public Health. There is a mix of materials specific to UT, along with external training materials, resources, and publications relevant to this work. The UT materials include reports related to areas of the School of Public Health, such as Industrial Hygiene & Air Environment and the Southwest Center for Occupational & Environmental Health. See more at MS 248.

2023 January 23 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

The Utah Statesman, January 23, 2023, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Rider (2023-01-23), Verilu Infante

The Rider Archives

Vol.8 No.16

Meaning In Parenting And Why It Matters, Dr Colm O'Doherty

Irish Journal of Applied Social Studies

The central premise of this article is that parental choices are influenced by economic factors and associated cultural values. Intensive parenting repertoires such as helicopter parenting have come to the fore as social mobility has stalled and economic pressures resulting from neo liberal policies have increased. As a result child rearing has become more of a technical craft than a fulfilling act. Seeking a meritocratic bulwark against increasing inequality parenting has been recast as a technocratic approach to the rearing of successful offspring. Investing in children has become more technical and politicised in order to meet the demands of globalisation. …