Digital Commons Network^™

Drug Specificity And Affinity Are Encoded In The Probability Of Cryptic Pocket Opening In Myosin Motor Domains, Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman

2020-Current year OA Pubs

The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least six of its members cause numerous diseases. Allosteric modulators, like the myosin-II inhibitor blebbistatin, are a promising means to achieve specificity. However, it remains unclear why blebbistatin inhibits myosin-II motors with different potencies given that it binds at a highly conserved pocket that is always closed in blebbistatin-free experimental structures. We hypothesized that the probability of pocket opening is an important determinant of the …

Development Of De Novo Nonalcoholic Fatty Liver Disease Following Pancreatectomy, Vanisha Patel, Parth Shah, Daniel R. Ludwig, Chet W. Hammill, Motaz Ashkar

2020-Current year OA Pubs

De novo non-alcoholic fatty liver disease (NAFLD) after pancreatectomy is a recognized phenomenon; however, its pathophysiology is poorly understood. This study aimed to determine the incidence and identify peri-operative risk factors for the development of de novo NAFLD within various pancreatectomy groups. This single-center retrospective cohort study included patients who underwent pancreatectomy between 2000 and 2020. The incidence rate of de novo NAFLD and time to diagnosis were recorded across patients with malignant versus benign indications for pancreatectomy. The overall incidence of de novo NAFLD after pancreatectomy was 17.5% (24/136). Twenty-one percent (20/94) of patients with malignant indications for surgery …

Session 4 - Ethnic Studies In The Library: Supporting New Curriculum, Nicole Hunter

High School Libraries Workshop

Starting in 2025, California public high schools will be required to offer Ethnic Studies courses. While this mandate may not affect your school, the waves of this movement are likely to impact course content at all grade levels and in all schools in coming years. How can we as library workers support the needs that will come with these exciting changes? In this session, I will talk about my role in piloting an Ethnic Studies course at San Francisco University High School, walk you through a short lesson, and then we will have time to talk about ways that libraries …

The Acute Effects Of Ischemic Preconditioning On Short-Duration Cycling: A Randomized Crossover Study, Cassidy R. Nelson, Colten R. Brand, Matthew R. Chitty, Chad B. Birger, Shane D. Scholten

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 148-158, 2023. There is recent interest from coaches and athletes regarding IPC as an effective way to generate better competitive outcomes. Regarding cycling specifically, the impact of IPC remains unclear. This study aimed to assess the effectiveness of IPC treatment for improving athletic performance during short-duration cycling. After the exclusion and inclusion criteria, there were 11 volunteers for the 3-minute cycling TT and 13 volunteers for the 6-minute cycling TT. All volunteers were competitive athletes of aerobic sports. The IPC treatment consisted of three alternating cycles of 5 minutes of 100% occlusion followed by …

Do Female University Varsity Athletes Have A Greater Risk Of Injury Within A Competitive Varsity Season?, Aidan K. Comeau, Eric C. Parent, Michael D. Kennedy

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 129-147, 2023. Previous varsity sport injury research has analyzed how acute and chronic injury severity, type, and location differs between sport and sexes, with limited research in time to injury. Canadian university varsity sport injury research is especially sparse and mostly retrospective. Thus, we aimed to understand injury differences in male and female competitive university athletes competing in the same sport. Athletes who competed on the basketball, volleyball, soccer, ice hockey, football (male), rugby (female), and wrestling teams were eligible for the study. There were 182 male and 113 female athletes who provided informed …

Acute Blood Flow Responses To Varying Blood Flow Restriction Pressures In The Lower Limbs, Bjoern Hornikel, Keith S. Saffold, Jacob A. Mota, Michael R. Esco, Michael V. Fedewa, Stefanie A. Wind, Lee J. Winchester

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 118-128, 2023. The purpose of this study was to investigate lower limb blood flow responses under varying blood flow restriction (BFR) pressures based on individualized limb occlusion pressures (LOP) using a commonly used occlusion device. Twenty-nine participants (65.5% female, 23.8 ± 4.7 years) volunteered for this study. An 11.5cm tourniquet was placed around participants’ right proximal thigh, followed by an automated LOP measurement (207.1 ± 29.4mmHg). Doppler ultrasound was used to assess posterior tibial artery blood flow at rest, followed by 10% increments of LOP (10-90% LOP) in a randomized order. All data were …

A Pilot Study On Cannabidiol (Cbd) And Eccentric Exercise: Impact On Inflammation, Performance, And Pain, Whitley J. Stone, Danilo Tolusso, Guillermo Pacheco, Shea M. Brgoch, Van T. Nguyen

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 109-117, 2023. Cannabidiol (CBD) is a non-psychoactive cannabinoid purported to reduce symptoms of discomfort. Individuals are now using CBD to treat symptoms of multiple sclerosis, seizures, and chronic pain. Animal models indicate that CBD may be effective at reducing inflammation post fatiguing exercise. However, little evidence is available to evaluate these findings in humans. Therefore, the purpose of this investigation was to evaluate the impact of two doses of CBD oil on inflammation (IL-6), performance, and pain after an eccentric loading protocol. Participants (n = 4) participated in three conditions (placebo, low dose, …

A Unique Path To Nationwide Paid Family And Medical Leave: Through The U.S. States, Yan Goodwin

DePaul Law Review

No abstract provided.

Against Personal Jurisdiction Law, John Leubsdorf

DePaul Law Review

No abstract provided.

Segregation On-Demand: Limiting Discriminatory Municipal Incorporations, Shai Stern

DePaul Law Review

No abstract provided.

Reflections On Establishing The Depaul Law Review, Allen Moye

DePaul Law Review

No abstract provided.

Covid-19 Policies & Their Impact On Housing And Health Outcomes In The City Of Chicago, Khushbu Patel

DePaul Journal of Health Care Law

The COVID-19 mandates and policies that were implemented by both the state of Illinois and the City of Chicago, such as the eviction moratorium, dramatically improved health outcomes by alleviating the financial stress of many households. Discussing social determinants of health and evaluating the impact that each social determinant had on housing and health outcomes allows for an in-depth look at the overall concept of housing in Chicago and the health outcomes of low-income individuals. Comparing the housing laws in place before COVID-19 at the federal, state, and local levels allows for analyzing the impact of the COVID-19 policies and …

A Case For Brandeisian Federalism: The Erisa Preemption Clause And State Health Care Reform, Jordan May

DePaul Journal of Health Care Law

The United States spends more for health care per capita than any other country in the world. Despite spending more, the United States has weaker health care outcomes than other similarly developed countries. This fact alone makes health care an important subject for policy reform. Given the current partisan gridlock in Congress, it is difficult to foresee any significant legislation in the area of health care reform at the federal level in the near future. As a result, Congress has allocated major health care reform efforts to the states. However, ERISA stands as a huge obstacle to state health care …

Environmentalism: Flint Michigan Water Crisis, Zamzam Mohammed

Religion: Student Scholarship & Creative Works

This essay examines the public health hazard of Flint Michigan that affected tens of thousands of individuals predominately Black and African Americans. This event was not only systematic, but it portrayed a sense of racial bias and environmental injustice. Not only were Flint residents getting sick due to the unhealthy supply of water source but they were silenced. Unfortunately Black and African Americans felt undermined and oppressed. The underdevelopment and unethical abandonment of the city portrays how much power and authority the city officials possess. Their disregard for the health hazard proves that they care more about monetary gain than …

Medical School Watercooler Newsletter - January 26, 2023, Lindsey Lyle

Watercooler Newsletter

This is the January 26, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Nominations due Jan. 31 for 50 people of influence award
• Student groups to host period product drive
• Meet a Med Student: Alexander Lund

Arl-Wavelet-Bpf Optimization Using Pso Algorithm For Bearing Fault Diagnosis, Muhammad Ahsan, Dariusz Bismor, Muhammad Arslan Manzoor

Computer Vision Faculty Publications

Rotating element bearings are the backbone of every rotating machine. Vibration signals measured from these bearings are used to diagnose the health of the machine, but when the signal-to-noise ratio is low, it is challenging to diagnose the fault frequency. In this paper, a new method is proposed to enhance the signal-to-noise ratio by applying the Asymmetric Real Laplace wavelet Bandpass Filter (ARL-wavelet-BPF). The Gaussian function of the ARL-wavelet represents an excellent BPF with smooth edges which helps to minimize the ripple effects. The bandwidth and center frequency of the ARL-wavelet-BPF are optimized using the Particle Swarm Optimization (PSO) algorithm. …

January 2023 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.

Falls And Associated Risk Factors In A Sample Of Old Age Population In Egyptian Community, Abd El Hamied Ibrahim El Sayed, Mohamed T. Said, Omnia Mohsen, Aziza M. Abozied

Faculty Journal Articles

No abstract provided.

Vol.50 N.27 January 26th 2023, Voice Media Ventures

Black Voice News

No abstract provided.

The Chanticleer, 2023-01-26, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

February 2, 2023: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the February 2, 2023, meeting of the University Senate. 26 pages

2023.01.26 - Academic/Student Affairs, Enrollment, And Technology Committee Meeting Minutes, Northeastern Illinois University Board Of Trustees

Board of Trustees - 2023

Meeting materials for the NEIU Academic/Student Affairs, Enrollment, and Technology Committee

St. Louis Community College And Lindenwood University Sign Transfer Partnership, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

Lvhn Weekly, Lehigh Valley Health Network

LVHN Weekly

No abstract provided.

In Re: Te Holdcorp, Llc

2023 Decisions

USDC for the District of Delaware

The Bison, January 26, 2023

The Bison Newspapers

No abstract provided.

2023 January 26 - Academic Council Agenda And Minutes, Academic Council, East Tennessee State University

Academic Council Agenda and Minutes

No abstract provided.

3d Printed Coronary Arteries: A Useful Tool In Anatomical Education, Zachary Pang, Shreyas Chandragiri, Alexander Hajduczok, Md, Zachary Mace, Jesse Ottaway, Cannon Greco Hiranaka, Michael Wong, Tammy Yoshioka, Noah Haroian, Md, Pharmd, Guiyun Zhang, Md, Phd

Department of Medical Education Posters

Introduction

Learning 3D anatomy from 2D figures can be challenging. The use of 3D printing in medical education has shown to improve knowledge and skill in surgical training⁽¹⁾. We investigated the efficacy of 3D printed coronary artery models in teaching coronary anatomy to medical students.

Complete Healthcare Medical Center Dba Lafollette Family Clinic, Lafollette, Tennessee, Tenncare Visits And Payments, January 1, 2017, Through December 31, 2021, Tennessee. Comptroller Of The Treasury.

TennCare Examinations

No abstract provided.

Epa And Army’S New Wotus Definition And Another Finalized Rule This Spring, Joe Retzer

SLU Law Journal Online

On December 30, 2022, the EPA finalized its rule interpreting "waters of the United States," which redefined the boundaries of the Clean Water Act's jurisdiction. In this article, Joe Retzer discusses the new rule that attempts to implement public input by providing a definition that is clear and consistent for stakeholders and discusses future rules that may be on the horizon.