Digital Commons Network^™

If A Machine Could Talk, We Would Not Understand It: Canadian Innovation And The Copyright Act’S Tpm Interoperability Framework, Anthony D. Rosborough

Canadian Journal of Law and Technology

This analysis examines the legal implications of technological protection measures (‘‘TPMs”) under Canada’s Copyright Act. Through embedded computing systems and proprietary interfaces, TPMs are being used by original equipment manufacturers (‘‘OEMs”) of agricultural equipment to preclude reverse engineering and follow-on innovation. This has anti-competitive effects on Canada’s ‘‘shortline” agricultural equipment industry, which produces add-on or peripheral equipment used with OEM machinery. This requires interoperability between the interfaces, data formats, and physical connectors, which are often the subject of TPM control. Exceptions under the Act have provided little assistance to the shortline industry. The research question posed by this analysis is: …

Recalibrating Governance - Part Ii, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

The frequent takeovers by military regimes and the consequential screening of hundreds of civil servants led to the subservience of the civil service to military rulers, erosion of the authority of the traditional institutions of governance and loss of initiative by the higher bureaucracy. Given the insecurity of service, the priority shifted from public service to maximizing personal interests by those in power. A glaring example of elites using public policy to promote their self-interest and undue accumulation of wealth at the expense of the poor of the population is the major preoccupation of all civil servants, military officials, media …

4d Lung Mri With High-Isotropic-Resolution Using Half-Spoke (Ute) And Full-Spoke 3d Radial Acquisition And Temporal Compressed Sensing Reconstruction, Can Wu, Guruprasad Krishnamoorthy, Victoria Yu, Ergys Subashi, Andreas Rimner, Ricardo Otazo

Faculty, Staff and Student Publications

Objective:

To develop a respiratory motion-resolved 4D MRI technique with high-isotropic-resolution (1.1 mm) using 3D radial sampling, camera-based respiratory motion sensing, and temporal compressed sensing reconstruction for lung cancer imaging.

Approach:

Free-breathing half- and full-spoke 3D golden-angle radial acquisitions were performed on eight healthy volunteers and eight patients with lung tumors of varying size. A back-and-forth k-space ordering between consecutive interleaves of the 3D radial acquisition was performed to minimize eddy current-related artifacts. Data were sorted into respiratory motion states using camera-based motion navigation and 4D images were reconstructed using temporal compressed sensing to reduce scan time. Normalized sharpness indices …

Monitoring And Modulating Diet And Gut Microbes To Enhance Response And Reduce Toxicity To Cancer Treatment, Anne Knisely, Yongwoo David Seo, Jennifer A Wargo, Manoj Chelvanambi

Faculty, Staff and Student Publications

The gut microbiome comprises a diverse array of microbial species that have been shown to dynamically modulate host immunity both locally and systemically, as well as contribute to tumorigenesis. In this review, we discuss the scientific evidence on the role that gut microbes and diet play in response and toxicity to cancer treatment. We highlight studies across multiple cancer cohorts that have shown an association between particular gut microbiome signatures and an improved response to immune checkpoint blockade, chemotherapy, and adoptive cell therapies, as well as the role of particular microbes in driving treatment-related toxicity and how the microbiome can …

Integration Of Transcriptome-Wide Association Study With Neuronal Dysfunction Assays Provides Functional Genomics Evidence For Parkinson’S Disease Genes, Jiayang Li, Bismark Kojo Amoh, Emma Mccormick, Akash Tarkunde, Katy Fan Zhu, Alma Perez, Megan Mair, Justin Moore, Joshua M Shulman, Ismael Al-Ramahi, Juan Botas

Faculty, Staff and Students Publications

Genome-wide association studies (GWAS) have markedly advanced our understanding of the genetics of Parkinson's disease (PD), but they currently do not account for the full heritability of PD. In many cases it is difficult to unambiguously identify a specific gene within each locus because GWAS does not provide functional information on the identified candidate loci. Here we present an integrative approach that combines transcriptome-wide association study (TWAS) with high-throughput neuronal dysfunction analyses in Drosophila to discover and validate candidate PD genes. We identified 160 candidate genes whose misexpression is associated with PD risk via TWAS. Candidates were validated using orthogonal …

Seeing In The Dark: A Review Of The Use Of Side-Scan Sonar To Detect And Study Manatees, With An Emphasis On Latin America, Daniel Gonzalez-Socoloske, León David Olivera-Gómez

Faculty Publications

Manatees are aquatic mammals that live in a variety of environments. Many of those shallow water environments have murky water, making detection using traditional visual surveys very challenging. Side-scan sonar was first proposed as a tool to detect and study manatees in these complicated habitats in 2005. Here, we summarize the use of this tool from 2005 to 2022 by searching the available literature. Our literature search revealed that this tool is being widely used in more than 20 locations and over 15 countries. All three manatee species are being studied with side-scan sonar. It is most useful in murky …

Accomplishments And Challenges Of The Research On Antillean Manatee: A Bibliometric Analysis, Delma Nataly Castelblanco-Martínez, Daniel Gonzalez-Socoloske, Leslie Cabrias, Natalia Garcés-Cuartas, Gloria Katerin Arévalo-González, João Carlos Gomes Borges, Miriam Marmontel

Faculty Publications

The Antillean manatee (Trichechus manatus manatus) is an endangered subspecies of the West Indian manatee inhabiting countries of South America, Meso America and the Caribbean. Basic and applied research is necessary to inform management plans for the effective recovery of this subspecies. The purpose of this study was to systematically review literature regarding Antillean manatees, without restriction of the research topic. Article selection and screening process are described. Our final database consisted of 456 publications, of which peer-reviewed literature (articles, reviews, and notes in research journals) represent the most important type (63.4%), followed by BSc, MSc, and PhD theses (28.1%). …

Drug Specificity And Affinity Are Encoded In The Probability Of Cryptic Pocket Opening In Myosin Motor Domains, Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman

2020-Current year OA Pubs

The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least six of its members cause numerous diseases. Allosteric modulators, like the myosin-II inhibitor blebbistatin, are a promising means to achieve specificity. However, it remains unclear why blebbistatin inhibits myosin-II motors with different potencies given that it binds at a highly conserved pocket that is always closed in blebbistatin-free experimental structures. We hypothesized that the probability of pocket opening is an important determinant of the …

Gold Nanoparticle-Enhanced X-Ray Microtomography Of The Rodent Reveals Region-Specific Cerebrospinal Fluid Circulation In The Brain, Shelei Pan, Peter H Yang, Dakota Defreitas, Sruthi Ramagiri, Peter O Bayguinov, Carl D Hacker, Abraham Z Snyder, Jackson Wilborn, Hengbo Huang, Gretchen M Koller, Dhvanii K Raval, Grace L Halupnik, Sanja Sviben, Rui Tang, Gabriel Haller, James D Quirk, James A J Fitzpatrick, Prabagaran Esakky, Jennifer M Strahle, Et Al.

2020-Current year OA Pubs

Cerebrospinal fluid (CSF) is essential for the development and function of the central nervous system (CNS). However, the brain and its interstitium have largely been thought of as a single entity through which CSF circulates, and it is not known whether specific cell populations within the CNS preferentially interact with the CSF. Here, we develop a technique for CSF tracking, gold nanoparticle-enhanced X-ray microtomography, to achieve micrometer-scale resolution visualization of CSF circulation patterns during development. Using this method and subsequent histological analysis in rodents, we identify previously uncharacterized CSF pathways from the subarachnoid space (particularly the basal cisterns) that mediate …

Monitoring Fluid Migration Using In-Situ Nuclear Magnetic Resonance Core Flooding System Integrated With Fiber Optic Sensors: A Proof Of Concept, Bruno Da Silva Falcão, Lionel Esteban, Ausama Giwelli, Yevhen Kovalyshen, Stephen Banks, Ahmed Al-Yaseri, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

In-situ nuclear magnetic resonance (NMR) core flooding system has enabled researchers to monitor several rock properties such as porosity, pore size distribution, and fluid saturation along the tested samples with high resolutions and under reservoir conditions. However, spatially resolved rock strength/mechanical property alteration coupled to fluid migration/substitution remains poorly characterized. To this end, Fiber Bragg Grating (FBG) multiplex sensors were integrated with NMR core flooding system to monitor rock strength changes, or generally speaking, to observe hydro-mechanical-chemical coupling mechanisms during core flooding tests. In this study, we present a novel approach on how to conduct core flooding experiments, while simultaneously …

The Double-Edged Sword Of Social Media Usage During The Covid-19 Pandemic: Demographical And Cultural Analyses, Khaled A. Alshare, Murad Moqbel, Mohammad I. Merhi

Information Systems Faculty Publications

Purpose

This exploratory research aims to (1) investigate the bright and dark sides of social media use during the COVID-19 pandemic; (2) explore the impact of demographic factors on social media usage; and (3) assess the effects of cultural dimensions on social media usage.

Design/methodology/approach

The data are collected through an online survey. Factors derived from grounded theories and models such as affordance theory and Hofstede's cultural framework were considered. Spearman correlation and nonparametric analysis were used to test the hypotheses.

Findings

The results revealed that social media usage was positively associated with healing and affiliation, and negatively associated with …

Regenerative Agriculture - A Literature Review On The Practices And Mechanisms Used To Improve Soil Health, Ravjit Khangura, David Ferris, Cameron Wagg, Jamie Bowyer

Natural Resources Research Articles

Conventional farming practices can lead to soil degradation and a decline in productivity. Regenerative agriculture (RA) is purported by advocates as a solution to these issues that focuses on soil health and carbon sequestration. The fundamental principles of RA are to keep the soil covered, minimise soil disturbance, preserve living roots in the soil year round, increase species diversity, integrate livestock, and limit or eliminate the use of synthetic compounds (such as herbicides and fertilisers). The overall objectives are to rejuvenate the soil and land and provide environmental, economic, and social benefits to the wider community. Despite the purported benefits …

Displaying And Delivering Viral Membrane Antigens Via Ww Domain–Activated Extracellular Vesicles, Sengjin Choi, Zhiping Yang, Qiyu Wang, Zhi Qiao, Maoyun Sun, Joshua Wiggins, Shi-Hua Xiang, Quan Lu

Nebraska Center for Virology: Faculty Publications

Membrane proteins expressed on the surface of enveloped viruses are conformational antigens readily recognized by B cells of the immune system. An effective vaccine would require the synthesis and delivery of these native conformational antigens in lipid membranes that preserve specific epitope structures. We have created an extracellular vesicle–based technology that allows viral membrane antigens to be selectively recruited onto the surface of WW domain–activated extracellular vesicles (WAEVs). Budding of WAEVs requires secretory carrier-associated membrane protein 3, which through its proline-proline-alanine-tyrosine motif interacts with WW domains to recruit fused viral membrane antigens onto WAEVs. Immunization with influenza and HIV viral …

Displaying And Delivering Viral Membrane Antigens Via Ww Domain–Activated Extracellular Vesicles, Sengjin Choi, Zhiping Yang, Qiyu Wang, Zhi Qiao, Maoyun Sun, Joshua Wiggins, Shi-Hua Xiang, Quan Lu

Nebraska Center for Virology: Faculty Publications

Membrane proteins expressed on the surface of enveloped viruses are conformational antigens readily recognized by B cells of the immune system. An effective vaccine would require the synthesis and delivery of these native conformational antigens in lipid membranes that preserve specific epitope structures. We have created an extracellular vesicle–based technology that allows viral membrane antigens to be selectively recruited onto the surface of WW domain–activated extracellular vesicles (WAEVs). Budding of WAEVs requires secretory carrier-associated membrane protein 3, which through its proline-proline-alanine-tyrosine motif interacts with WW domains to recruit fused viral membrane antigens onto WAEVs. Immunization with influenza and HIV viral …

Displaying And Delivering Viral Membrane Antigens Via Ww Domain–Activated Extracellular Vesicles, Sengjin Choi, Zhiping Yang, Qiyu Wang, Zhi Qiao, Maoyun Sun, Joshua Wiggins, Shi-Hua Xiang, Quan Lu

School of Veterinary and Biomedical Sciences: Faculty Publications

Membrane proteins expressed on the surface of enveloped viruses are conformational antigens readily recognized by B cells of the immune system. An effective vaccine would require the synthesis and delivery of these native conformational antigens in lipid membranes that preserve specific epitope structures. We have created an extracellular vesicle–based technology that allows viral membrane antigens to be selectively recruited onto the surface of WW domain–activated extracellular vesicles (WAEVs). Budding of WAEVs requires secretory carrier-associated membrane protein 3, which through its proline-proline-alanine-tyrosine motif interacts with WW domains to recruit fused viral membrane antigens onto WAEVs. Immunization with influenza and HIV viral …

Vaccines Against Group B Coxsackieviruses And Their Importance, Kiruthiga Mone, Ninaad Lasrado, Meghna Sur, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

The group B coxsackieviruses (CVBs) exist in six serotypes (CVB1 to CVB6). Disease associations have been reported for most serotypes, and multiple serotypes can cause similar diseases. For example, CVB1, CVB3, and CVB5 are generally implicated in the causation of myocarditis, whereas CVB1 and CVB4 could accelerate the development of type 1 diabetes (T1D). Yet, no vaccines against these viruses are currently available. In this review, we have analyzed the attributes of experimentally tested vaccines and discussed their merits and demerits or limitations, as well as their impact in preventing infections, most importantly myocarditis and T1D.

Clarifying The Four Kinds Of " Exacting Scrutiny Used In Current Supreme Court Doctrine, R. Kelso

Penn State Law Review (2003 - Present)

No abstract provided.

An American Freedom: The Intelligentsia And Freedom Of The Press After Blackstone, Matthew Schafer

Penn State Law Review (2003 - Present)

No abstract provided.

Prayer Versus Prejudice: The Achievable Coexistence Of Religion And Just Remedies For Discrimination Involving Workplace Harassment, Salena Moran

Penn State Law Review (2003 - Present)

No abstract provided.

Flip Flops Should Be Limited To Footwear: An Analysis Of The Nlrb's Ever-Changing Interpretations Of Concerted Activity Under The Nlra, Samantha Walter

Penn State Law Review (2003 - Present)

No abstract provided.

Using Cognitive Interviews To Improve A Measure Of Organizational Readiness For Implementation, Maria Mcclam, Lauren Workman, Emanuelle M Dias, Timothy J Walker, Heather M Brandt, Derek W Craig, Robert Gibson, Andrea Lamont, Bryan J Weiner, Abraham Wandersman, Maria E Fernandez

Faculty, Staff and Student Publications

BACKGROUND: Organizational readiness is a key factor for successful implementation of evidence-based interventions (EBIs), but a valid and reliable measure to assess readiness across contexts and settings is needed. The R = MC

METHODS: We conducted 20 cognitive interviews with FQHC staff (clinical and non-clinical) in South Carolina and Texas. Participants were provided a subset of items from the readiness survey to review. A semi-structured interview guide was developed to elicit feedback from participants using "think aloud" and probing techniques. Participants were recruited using a purposive sampling approach and interviews were conducted virtually using Zoom and WebEx. Participants were asked …

Self-Management By Adolescents And Young Adults Following A Stem Cell Transplant, Caroline F. Morrison

Dissertations

A grounded theory study was conducted to better understand the process AYA use to manage their care following a SCT. Specific aims included: 1) to explore self-management facilitators, barriers, processes and behaviors within individual, family, community and healthcare system domains using the pediatric self-management framework to develop initial interview guides; 2) to describe how AYA manage their care regimen post HSCT; and 3) to describe rates of oral medication adherence for AYA post HSCT and how they relate to patterns of self-management.

Living As A Dying Child: A Gadamerian Analysis Of The Poetry Of Mattie J. T. Stepanek, Corinne A. Settecase-Wu

Dissertations

Yearly, approximately 500,000 children live with life-limiting conditions in the United States; 50,000 die. Yet, details regarding children's days of living as dying are unknown. The aim of this qualitative hermeneutic study is to gain understanding of the phenomenon of living as a dying child. A Gadamerian-inspired approach was implemented to underpin the study, and to analyze poetic text to address the research question: What is it to be living as a dying child? The text sample included 499 poems written by Mattie J. T. Stepanek, a dying child. The Settecase-Wu Conceptual Guide was developed and implemented to ensure …

Quasi-Experimental Study With The Undergraduate Nursing Program Using Simulation Learning To Reduce Medication Errors, Georgette R. Lohrman

Dissertations

Medication errors in the nursing practice are not only costly but may harm or kill a patient. The problem addressed in this study is the relationship that exists between the lack of medication administration skills taught to students in an undergraduate nursing program. The purpose of this quantitative quasi-experimental study with a two-group pretest-posttest design was to examine if the addition of medication-simulated learning was associated with improved medication administration knowledge compared to a traditional Pharmacology classroom setting.

The Impact Of Covid-19 Pandemic Upon Non-Elective Admissions And Surgery At A Safety-Net Hospital, Aurelien Amiot, Jean-Francois Rahier, Filip Baert, Stephane Nahon, Ailsa Hart, Nikos Viazis, Livia Biancone, Eugeni Domenech, Catherine Reenears, Laurent Peyrin-Biroulet, Laurent Beaugerie, Johan Burisch, I-Care Collaborator Group

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: There are concerns regarding the potential impact of the COVID-19 outbreak on patients with inflammatory bowel disease [IBD]. We report on the impact of the COVID-19 outbreak in a European prospective cohort study of patients with IBD.

PATIENTS AND METHODS: We prospectively collected data from 5457 patients with IBD nested in the ongoing I-CARE project and still followed up in April 2020, with monthly online monitoring of clinical activity, treatment, imaging and endoscopy. Investigators were also contacted to report incidental cases.

RESULTS: In total, 233 [4.3%] reported COVID-19 and 12 [0.2%] severe COVID-19, with no COVID-19 deaths. …

A Survey With Interventional Components Delivered On Tablet Devices Versus Usual Care To Increase Pre-Exposure Prophylaxis Uptake Among Cisgender Black Women: A Pilot Randomized Controlled Trial, Mandy J Hill, Angela M Heads, Robert Suchting, Angela L Stotts

Faculty, Staff and Student Publications

BACKGROUND: Cisgender (cis) Black women in the USA are more likely to become HIV positive during their lifetime than other women. We developed and implemented a behavioral intervention, Increasing PrEP (iPrEP), the first pilot randomized controlled trial (RCT) aimed at motivating cis Black women to be willing to use PrEP for HIV prevention and attend an initial PrEP clinic visit following an emergency department visit.

METHODS: Eligible participants were Black cisgender women ages 18-55 years who acknowledged recent condomless sex and substance use. Participants were randomized to iPrEP or usual care (UC). iPrEP is a survey-based intervention designed to raise …

Inhibition Of Colorectal Cancer Tumorigenesis By Ursolic Acid And Doxorubicin Is Mediated By Targeting The Akt Signaling Pathway And Activating The Hippo Signaling Pathway, Dan Hu, Ruo Yu Meng, Thi Van Nguyen, Ok Hee Chai, Byung Hyun Park, Ju-Seog Lee, Soo Mi Kim

Faculty, Staff and Student Publications

Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its prevalence is increasing in South Korea. The efficacy of combined treatment with natural product‑derived and chemotherapy agents including curcumin combined with 5‑fluorouracil, resveratrol combined with cisplatin and epigallocatechin‑3‑gallate (EGCG) combined with cisplatin in preventing cancer progression and killing cancer cells has emerged. The Akt and Hippo signaling pathways serve a key role in colorectal tumor growth; however, the exact role of the crosstalk between Akt and Hippo signaling pathways in CRC remains poorly elucidated. The combined effect of UA and DOX on the cell proliferation, apoptosis, migration …

Postbiotics Derived From L Paracasei Et-22 Inhibit The Formation Of S Mutans Biofilms And Bioactive Substances: An Analysis, Zhi Zhao, Jianmin Wu, Zhe Sun, Jinbo Fan, Fudong Liu, Wen Zhao, Wei-Hsien Liu, Ming Zhang, Wei-Lian Hung

Faculty, Staff and Student Publications

Globally, dental caries is one of the most common non-communicable diseases for patients of all ages; Streptococcus mutans (S. mutans) is its principal pathogen. Lactobacillus paracasei (L. paracasei) shows excellent anti-pathogens and immune-regulation functions in the host. The aim of this study is to evaluate the effects of L. paracasei ET-22 on the formation of S. mutans biofilms. The living bacteria, heat-killed bacteria, and secretions of L. paracasei ET-22 were prepared using the same number of bacteria. In vitro, they were added into artificial-saliva medium, and used to coculture with the S. mutans. Results showed …

Implicit Bias Mask: Inner Beauty And Heroic Strength, Madilyn Mason, Jesse Kato, Samaah Saifullah, Brandon Brown, Hasti Nema

Patient Education Projects

No abstract provided.

Implicit Bias Mask: Visualizing Success, Shrila Rajendran, Timothy Li, Daniel Saxon, Andrew Lemmen, Jourdyn Lao, Devun Birk

Patient Education Projects

No abstract provided.