Digital Commons Network^™

Implicit Bias Mask: The Unity In Diversity Mask, Petar Martinovski, Anthony Bally, Nadeen Sukhon, Yousif Jafar, Sarah Chamdin, Manahil Shaikh

Patient Education Projects

No abstract provided.

Implicit Bias Mask: Evil Eye, Sesilia Kammo, Hamza Ali, Alexander Eskandarian, Michael Wang, Sonja Klumpp, Swetha Reddy

Patient Education Projects

No abstract provided.

Implicit Bias Mask: Our Journey Inside Out, Juwan Taylor, Salvatore Serra, Alexa Kalaj, Hannah Lee, Saleh Al-Juburi, Amrutha Kotlure

Patient Education Projects

No abstract provided.

Implicit Bias Mask: (Gettin' The) Best Of Me, Julia Malewicz, Nasser Junedi, Kirsten Brinkmeier, Alisha Williams, Hovhannes Hayrapetyan, John Gallagher

Patient Education Projects

No abstract provided.

Implicit Bias Mask: Internalizing The Medical Student Identity, Samantha Odeesho, Brennan Burrows, Nickolas Vinokurov, Gabriella Cascio, Sumeet Saini, Tiffany Chu

Patient Education Projects

No abstract provided.

Implicit Bias Mask: The Value Of Time In Medical School, Markiesha Baines, Arifbillah Sarowar, Saachi Mittal, Meaghan Osborne, Karthik Babu Kolisetty, Connor Sakis

Patient Education Projects

No abstract provided.

Resetting The Rules On Trade And Gender? A Comparative Assessment Of Gender Approaches In Regional Trade Agreements In The Context Of A Possible Gender Protocol Under The African Continental Free Trade Area, Katrin Kuhlmann

Georgetown Law Faculty Publications and Other Works

At long last, gender and trade are together on the international agenda, with significant implications for women entrepreneurs and traders around the world. Alongside the landmark 2017 Joint Declaration on Trade and Women’s Empowerment, regional trade agreements (RTAs) have taken the lead on more tangible gender commitments. One such RTA is the African Continental Free Trade Area (AfCFTA), in which gender appears as an express priority alongside sustainable and inclusive socio-economic development. Yet, this is only a starting point. A gender-focused protocol has been proposed under the AfCFTA framework, representing a significant opportunity to reassess RTA provisions on gender and …

Drug Specificity And Affinity Are Encoded In The Probability Of Cryptic Pocket Opening In Myosin Motor Domains, Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman

2020-Current year OA Pubs

The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least six of its members cause numerous diseases. Allosteric modulators, like the myosin-II inhibitor blebbistatin, are a promising means to achieve specificity. However, it remains unclear why blebbistatin inhibits myosin-II motors with different potencies given that it binds at a highly conserved pocket that is always closed in blebbistatin-free experimental structures. We hypothesized that the probability of pocket opening is an important determinant of the …

Gold Nanoparticle-Enhanced X-Ray Microtomography Of The Rodent Reveals Region-Specific Cerebrospinal Fluid Circulation In The Brain, Shelei Pan, Peter H Yang, Dakota Defreitas, Sruthi Ramagiri, Peter O Bayguinov, Carl D Hacker, Abraham Z Snyder, Jackson Wilborn, Hengbo Huang, Gretchen M Koller, Dhvanii K Raval, Grace L Halupnik, Sanja Sviben, Rui Tang, Gabriel Haller, James D Quirk, James A J Fitzpatrick, Prabagaran Esakky, Jennifer M Strahle, Et Al.

2020-Current year OA Pubs

Cerebrospinal fluid (CSF) is essential for the development and function of the central nervous system (CNS). However, the brain and its interstitium have largely been thought of as a single entity through which CSF circulates, and it is not known whether specific cell populations within the CNS preferentially interact with the CSF. Here, we develop a technique for CSF tracking, gold nanoparticle-enhanced X-ray microtomography, to achieve micrometer-scale resolution visualization of CSF circulation patterns during development. Using this method and subsequent histological analysis in rodents, we identify previously uncharacterized CSF pathways from the subarachnoid space (particularly the basal cisterns) that mediate …

Implementation Of Mrsa Nasal Swabs As An Antimicrobial Stewardship Intervention To Decrease Anti-Mrsa Therapy In Covid-19 Infection, Alaina Dekerlegand, Emily Johnston, Britney Mellor, Melanie Rae Schrack, Catherine O’Neal

School of Medicine Faculty Publications

In the early stages of treating patients with SARS-CoV-2, limited information was available to guide antimicrobial stewardship interventions. The COVID-19 Task Force and Antimicrobial Stewardship Committee, at a 988-bed academic medical center, implemented the use of methicillin-resistant Staphylococcus aureus (MRSA) nasal swab polymerase chain reaction (PCR) testing to assist with the de-escalation of anti-MRSA therapy in patients with suspected superimposed bacterial pneumonia in COVID-19. A retrospective study was conducted to evaluate the impact of MRSA nasal swab PCR testing on the rate of anti-MRSA therapy between 13 April 2020 and 26 July 2020. A total of 122 patients were included …

Development Of De Novo Nonalcoholic Fatty Liver Disease Following Pancreatectomy, Vanisha Patel, Parth Shah, Daniel R. Ludwig, Chet W. Hammill, Motaz Ashkar

2020-Current year OA Pubs

De novo non-alcoholic fatty liver disease (NAFLD) after pancreatectomy is a recognized phenomenon; however, its pathophysiology is poorly understood. This study aimed to determine the incidence and identify peri-operative risk factors for the development of de novo NAFLD within various pancreatectomy groups. This single-center retrospective cohort study included patients who underwent pancreatectomy between 2000 and 2020. The incidence rate of de novo NAFLD and time to diagnosis were recorded across patients with malignant versus benign indications for pancreatectomy. The overall incidence of de novo NAFLD after pancreatectomy was 17.5% (24/136). Twenty-one percent (20/94) of patients with malignant indications for surgery …

The Diamond, January 27, 2023, Dordt University

Dordt Diamond

• Front Page: Remembering Emma Nibbelink; Progress Through Collaboration; East Campus Apartments to Get New Appliances
• News: Increased Vandalism Prompts Mandatory Meeting; Goodbye Twosdays; Howard Wilson Retires
• Feature: Swimming into the Future; Winter Storms Impact
• Opinion: America's Health Literacy Crisis; Conservatives on Campus Need Coordination
• Art & Entertainment: The 13-Year Sequel - Avatar: The Way of Water Film Review; Puss in Boots: The Last Wish; Beloved Video Game "The Last of Us" Turned into Live-Action TV; The Art of War; First High School Art Exhibit to Begin March 1st; New Sports Broadcasting Class …

Dosimetric Impact Of Lesion Number, Size, And Volume On Mean Brain Dose With Stereotactic Radiosurgery For Multiple Brain Metastases, Alonso La Rosa De Los Rios, D Jay Wieczorek, Ranjini Tolakanahalli, Cecilia Lee, Tugce Kutuk, Matthew Hall, Michael Mcdermott, Minesh Mehta, Alonso Gutierrez, Rupesh Kotecha

All Publications

We evaluated the effect of lesion number and volume for brain metastasis treated with SRS using GammaKnife® ICON™ (GK) and CyberKnife® M6™ (CK). Four sets of lesion sizes (<5 mm, 5-10 mm, >10-15 mm, and >15 mm) were contoured and prescribed a dose of 20 Gy/1 fraction. The number of lesions was increased until a threshold mean brain dose of 8 Gy was reached; then individually optimized to achieve maximum conformity. Across GK plans, mean brain dose was linearly proportional to the number of lesions and total GTV for all sizes. The numbers of lesions needed to reach this threshold for GK were …

A Framework To Predict Variability Characteristics In Building Load Profiles, Sam Moayedi, Andrew Parker, Kevin James, Xiaoyue Cheng, Michael Hempel, Hamid Sharif, Mahmoud A. Alahmad

Durham School of Architectural Engineering and Construction: Faculty Publications

The expansion of Advanced Metering Infrastructure (AMI) has provided building operators and researchers detailed information on building energy consumption. The majority of AMI systems, however, record data at relatively low resolutions of 15, 30, or 60 minutes, due to cost, storage and bandwidth limitations. Emerging applications in power flow analysis, Quasi-Static Time-Series Simulation (QSTS), smart grid integration and load matching, however, require data at higher resolutions. Short-term energy demand can deviate significantly from long-term averages, with an unknown magnitude and frequency when only low-resolution load profile data is available. This paper presents a novel data-driven approach to predict characteristics of …

Recognizing Operators’ Duties To Properly Select And Supervise Ai Agents – A (Better?) Tool For Algorithmic Accountability, Richard Zuroff

Canadian Journal of Law and Technology

In November of 2020, the Privacy Commissioner of Canada proposed creating GDPR-inspired rights for decision subjects and allowing financial penalties for violations of those rights. Shortly afterward, the proposal to create a right to an explanation for algorithmic decisions was incorporated into Bill C-11, the Digital Charter Implementation Act. This commentary proposes that creating duties for operators to properly select and supervise artificial agents would be a complementary, and potentially more effective, accountability mechanism than creating a right to an explanation. These duties would be a natural extension of employers’ duties to properly select and retain human employees. Allowing victims …

If A Machine Could Talk, We Would Not Understand It: Canadian Innovation And The Copyright Act’S Tpm Interoperability Framework, Anthony D. Rosborough

Canadian Journal of Law and Technology

This analysis examines the legal implications of technological protection measures (‘‘TPMs”) under Canada’s Copyright Act. Through embedded computing systems and proprietary interfaces, TPMs are being used by original equipment manufacturers (‘‘OEMs”) of agricultural equipment to preclude reverse engineering and follow-on innovation. This has anti-competitive effects on Canada’s ‘‘shortline” agricultural equipment industry, which produces add-on or peripheral equipment used with OEM machinery. This requires interoperability between the interfaces, data formats, and physical connectors, which are often the subject of TPM control. Exceptions under the Act have provided little assistance to the shortline industry. The research question posed by this analysis is: …

Recalibrating Governance - Part Ii, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

The frequent takeovers by military regimes and the consequential screening of hundreds of civil servants led to the subservience of the civil service to military rulers, erosion of the authority of the traditional institutions of governance and loss of initiative by the higher bureaucracy. Given the insecurity of service, the priority shifted from public service to maximizing personal interests by those in power. A glaring example of elites using public policy to promote their self-interest and undue accumulation of wealth at the expense of the poor of the population is the major preoccupation of all civil servants, military officials, media …

4d Lung Mri With High-Isotropic-Resolution Using Half-Spoke (Ute) And Full-Spoke 3d Radial Acquisition And Temporal Compressed Sensing Reconstruction, Can Wu, Guruprasad Krishnamoorthy, Victoria Yu, Ergys Subashi, Andreas Rimner, Ricardo Otazo

Faculty, Staff and Student Publications

Objective:

To develop a respiratory motion-resolved 4D MRI technique with high-isotropic-resolution (1.1 mm) using 3D radial sampling, camera-based respiratory motion sensing, and temporal compressed sensing reconstruction for lung cancer imaging.

Approach:

Free-breathing half- and full-spoke 3D golden-angle radial acquisitions were performed on eight healthy volunteers and eight patients with lung tumors of varying size. A back-and-forth k-space ordering between consecutive interleaves of the 3D radial acquisition was performed to minimize eddy current-related artifacts. Data were sorted into respiratory motion states using camera-based motion navigation and 4D images were reconstructed using temporal compressed sensing to reduce scan time. Normalized sharpness indices …

Monitoring And Modulating Diet And Gut Microbes To Enhance Response And Reduce Toxicity To Cancer Treatment, Anne Knisely, Yongwoo David Seo, Jennifer A Wargo, Manoj Chelvanambi

Faculty, Staff and Student Publications

The gut microbiome comprises a diverse array of microbial species that have been shown to dynamically modulate host immunity both locally and systemically, as well as contribute to tumorigenesis. In this review, we discuss the scientific evidence on the role that gut microbes and diet play in response and toxicity to cancer treatment. We highlight studies across multiple cancer cohorts that have shown an association between particular gut microbiome signatures and an improved response to immune checkpoint blockade, chemotherapy, and adoptive cell therapies, as well as the role of particular microbes in driving treatment-related toxicity and how the microbiome can …

Regenerative Agriculture - A Literature Review On The Practices And Mechanisms Used To Improve Soil Health, Ravjit Khangura, David Ferris, Cameron Wagg, Jamie Bowyer

Natural Resources Research Articles

Conventional farming practices can lead to soil degradation and a decline in productivity. Regenerative agriculture (RA) is purported by advocates as a solution to these issues that focuses on soil health and carbon sequestration. The fundamental principles of RA are to keep the soil covered, minimise soil disturbance, preserve living roots in the soil year round, increase species diversity, integrate livestock, and limit or eliminate the use of synthetic compounds (such as herbicides and fertilisers). The overall objectives are to rejuvenate the soil and land and provide environmental, economic, and social benefits to the wider community. Despite the purported benefits …

Displaying And Delivering Viral Membrane Antigens Via Ww Domain–Activated Extracellular Vesicles, Sengjin Choi, Zhiping Yang, Qiyu Wang, Zhi Qiao, Maoyun Sun, Joshua Wiggins, Shi-Hua Xiang, Quan Lu

Nebraska Center for Virology: Faculty Publications

Membrane proteins expressed on the surface of enveloped viruses are conformational antigens readily recognized by B cells of the immune system. An effective vaccine would require the synthesis and delivery of these native conformational antigens in lipid membranes that preserve specific epitope structures. We have created an extracellular vesicle–based technology that allows viral membrane antigens to be selectively recruited onto the surface of WW domain–activated extracellular vesicles (WAEVs). Budding of WAEVs requires secretory carrier-associated membrane protein 3, which through its proline-proline-alanine-tyrosine motif interacts with WW domains to recruit fused viral membrane antigens onto WAEVs. Immunization with influenza and HIV viral …

Displaying And Delivering Viral Membrane Antigens Via Ww Domain–Activated Extracellular Vesicles, Sengjin Choi, Zhiping Yang, Qiyu Wang, Zhi Qiao, Maoyun Sun, Joshua Wiggins, Shi-Hua Xiang, Quan Lu

Nebraska Center for Virology: Faculty Publications

Membrane proteins expressed on the surface of enveloped viruses are conformational antigens readily recognized by B cells of the immune system. An effective vaccine would require the synthesis and delivery of these native conformational antigens in lipid membranes that preserve specific epitope structures. We have created an extracellular vesicle–based technology that allows viral membrane antigens to be selectively recruited onto the surface of WW domain–activated extracellular vesicles (WAEVs). Budding of WAEVs requires secretory carrier-associated membrane protein 3, which through its proline-proline-alanine-tyrosine motif interacts with WW domains to recruit fused viral membrane antigens onto WAEVs. Immunization with influenza and HIV viral …

Displaying And Delivering Viral Membrane Antigens Via Ww Domain–Activated Extracellular Vesicles, Sengjin Choi, Zhiping Yang, Qiyu Wang, Zhi Qiao, Maoyun Sun, Joshua Wiggins, Shi-Hua Xiang, Quan Lu

School of Veterinary and Biomedical Sciences: Faculty Publications

Membrane proteins expressed on the surface of enveloped viruses are conformational antigens readily recognized by B cells of the immune system. An effective vaccine would require the synthesis and delivery of these native conformational antigens in lipid membranes that preserve specific epitope structures. We have created an extracellular vesicle–based technology that allows viral membrane antigens to be selectively recruited onto the surface of WW domain–activated extracellular vesicles (WAEVs). Budding of WAEVs requires secretory carrier-associated membrane protein 3, which through its proline-proline-alanine-tyrosine motif interacts with WW domains to recruit fused viral membrane antigens onto WAEVs. Immunization with influenza and HIV viral …

Vaccines Against Group B Coxsackieviruses And Their Importance, Kiruthiga Mone, Ninaad Lasrado, Meghna Sur, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

The group B coxsackieviruses (CVBs) exist in six serotypes (CVB1 to CVB6). Disease associations have been reported for most serotypes, and multiple serotypes can cause similar diseases. For example, CVB1, CVB3, and CVB5 are generally implicated in the causation of myocarditis, whereas CVB1 and CVB4 could accelerate the development of type 1 diabetes (T1D). Yet, no vaccines against these viruses are currently available. In this review, we have analyzed the attributes of experimentally tested vaccines and discussed their merits and demerits or limitations, as well as their impact in preventing infections, most importantly myocarditis and T1D.

Monitoring Fluid Migration Using In-Situ Nuclear Magnetic Resonance Core Flooding System Integrated With Fiber Optic Sensors: A Proof Of Concept, Bruno Da Silva Falcão, Lionel Esteban, Ausama Giwelli, Yevhen Kovalyshen, Stephen Banks, Ahmed Al-Yaseri, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

In-situ nuclear magnetic resonance (NMR) core flooding system has enabled researchers to monitor several rock properties such as porosity, pore size distribution, and fluid saturation along the tested samples with high resolutions and under reservoir conditions. However, spatially resolved rock strength/mechanical property alteration coupled to fluid migration/substitution remains poorly characterized. To this end, Fiber Bragg Grating (FBG) multiplex sensors were integrated with NMR core flooding system to monitor rock strength changes, or generally speaking, to observe hydro-mechanical-chemical coupling mechanisms during core flooding tests. In this study, we present a novel approach on how to conduct core flooding experiments, while simultaneously …

Clarifying The Four Kinds Of " Exacting Scrutiny Used In Current Supreme Court Doctrine, R. Kelso

Penn State Law Review (2003 - Present)

No abstract provided.

An American Freedom: The Intelligentsia And Freedom Of The Press After Blackstone, Matthew Schafer

Penn State Law Review (2003 - Present)

No abstract provided.

Prayer Versus Prejudice: The Achievable Coexistence Of Religion And Just Remedies For Discrimination Involving Workplace Harassment, Salena Moran

Penn State Law Review (2003 - Present)

No abstract provided.

Flip Flops Should Be Limited To Footwear: An Analysis Of The Nlrb's Ever-Changing Interpretations Of Concerted Activity Under The Nlra, Samantha Walter

Penn State Law Review (2003 - Present)

No abstract provided.

Residential Metals Abatement Program Investigation Summary Report (Non-Residential Parcels – Indoor Dust) Highland View Christian School, Environmental Resource Management (Erm)

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.