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Articles 259021 - 259050 of 1791766
Full-Text Articles in Entire DC Network
The Ra-Be-Real Multinational, Prospective, Observational Study In Patients With Rheumatoid Arthritis Receiving Baricitinib, Targeted Synthetic, Or Biologic Disease-Modifying Therapies: A 6-Month Interim Analysis, Rieke Alten, Gerd R Burmester, Marco Matucci-Cerinic, Jean-Hugues Salmon, Pedro Lopez-Romero, Walid Fakhouri, Inmaculada De La Torre, Liliana Zaremba-Pechmann, Thorsten Holzkämper, Bruno Fautrel
The Ra-Be-Real Multinational, Prospective, Observational Study In Patients With Rheumatoid Arthritis Receiving Baricitinib, Targeted Synthetic, Or Biologic Disease-Modifying Therapies: A 6-Month Interim Analysis, Rieke Alten, Gerd R Burmester, Marco Matucci-Cerinic, Jean-Hugues Salmon, Pedro Lopez-Romero, Walid Fakhouri, Inmaculada De La Torre, Liliana Zaremba-Pechmann, Thorsten Holzkämper, Bruno Fautrel
Faculty, Staff and Student Publications
INTRODUCTION: RA-BE-REAL has the overall aim of defining a profile of patients with rheumatoid arthritis (RA) starting baricitinib or any other targeted synthetic (ts) or any biologic (b) disease-modifying antirheumatic drug (DMARD) for the first time, and the primary objective of estimating time until discontinuation from any cause (excluding sustained response) of the initial treatment.
METHODS: RA-BE-REAL is an ongoing, prospective, observational, 36-month study in patients with RA initiating treatment with baricitinib (cohort A) or any other tsDMARD or any bDMARD (cohort B) for the first time. The primary objective is to assess the time until treatment discontinuation from any …
Hetrombopag Plus Porcine Atg And Cyclosporine For The Treatment Of Aplastic Anaemia: Early Outcomes Of A Prospective Pilot Study, Wenrui Yang, Xin Zhao, Xu Liu, Youzhen Xiong, Huihui Fan, Li Zhang, Jianping Li, Lei Ye, Kang Zhou, Yuan Li, Yang Yang, Guangxin Peng, Liping Jing, Fengkui Zhang
Hetrombopag Plus Porcine Atg And Cyclosporine For The Treatment Of Aplastic Anaemia: Early Outcomes Of A Prospective Pilot Study, Wenrui Yang, Xin Zhao, Xu Liu, Youzhen Xiong, Huihui Fan, Li Zhang, Jianping Li, Lei Ye, Kang Zhou, Yuan Li, Yang Yang, Guangxin Peng, Liping Jing, Fengkui Zhang
Faculty, Staff and Student Publications
Hetrombopag, a small molecular thrombopoietin-receptor agonist, has shown encouraging efficiency in immunosuppressive therapy refractory or relapsed severe aplastic anaemia. To investigate the response rate of hetrombopag combined with IST as first-line treatment, we designed a prospective pilot study including 32 patients with SAA treated with anti-human T lymphocyte porcine immunoglobulin (p-ATG), cyclosporine, and hetrombopag. In addition, 96 patients with SAA treated with p-ATG and cyclosporine alone were matched as controls. In total, 21.9% of patients treated with hetrombopag achieved complete response (CR) at 3 months, while 5.2% of patients achieved CR in the control group (P = 0.005). At …
Adverse Pregnancy Outcomes And Long Term Risk Of Ischemic Heart Disease In Mothers: National Cohort And Co-Sibling Study, Casey Crump, Jan Sundquist, Mary Ann Mclaughlin, Siobhan M Dolan, Usha Govindarajulu, Weiva Sieh, Kristina Sundquist
Adverse Pregnancy Outcomes And Long Term Risk Of Ischemic Heart Disease In Mothers: National Cohort And Co-Sibling Study, Casey Crump, Jan Sundquist, Mary Ann Mclaughlin, Siobhan M Dolan, Usha Govindarajulu, Weiva Sieh, Kristina Sundquist
Faculty, Staff and Student Publications
OBJECTIVE: To examine the associations between five major adverse pregnancy outcomes and long term risks of ischemic heart disease in mothers.
DESIGN: National cohort study.
SETTING: Sweden.
PARTICIPANTS: All 2 195 266 women with a first singleton delivery in Sweden during 1973-2015.
MAIN OUTCOME MEASURES: The main outcome measure was incidence of ischemic heart disease from delivery to 2018, identified from nationwide inpatient and outpatient diagnoses. Cox regression was used to calculate hazard ratios for ischemic heart disease associated with preterm delivery, small for gestational age, pre-eclampsia, other hypertensive disorders of pregnancy, and gestational diabetes, adjusting for other adverse pregnancy …
Spatiotemporal View Of Malignant Histogenesis And Macroevolution Via Formation Of Polyploid Giant Cancer Cells, Xiaoran Li, Yanping Zhong, Xudong Zhang, Anil K Sood, Jinsong Liu
Spatiotemporal View Of Malignant Histogenesis And Macroevolution Via Formation Of Polyploid Giant Cancer Cells, Xiaoran Li, Yanping Zhong, Xudong Zhang, Anil K Sood, Jinsong Liu
Faculty, Staff and Student Publications
To understand how malignant tumors develop, we tracked cell membrane, nuclear membrane, spindle, and cell cycle dynamics in polyploid giant cancer cells (PGCCs) during the formation of high-grade serous carcinoma organoids using long-term time-lapse imaging. Single cells underwent traditional mitosis to generate tissue with uniform nuclear size, while others formed PGCCs via asymmetric mitosis, endoreplication, multipolar endomitosis, nuclear fusion, and karyokinesis without cytokinesis. PGCCs underwent restitution multipolar endomitosis, nuclear fragmentation, and micronuclei formation to increase nuclear contents and heterogeneity. At the cellular level, the development of PGCCs was associated with forming transient intracellular cells, termed fecundity cells. The fecundity cells …
Cognitive Evaluation In Parkinson’S Disease: Applying The Movement Disorder Society Recommendations In A Population With A Low Level Of Formal Education, Natalia Pessoa Rocha, Eduarda Xavier Carreira, Ana Carolina De Almeida Prado, Fabíola Tavares, Mayra Tavares, Francisco Cardoso, Antônio Jaeger, Leonardo Cruz De Souza, Antônio Lucio Teixeira
Cognitive Evaluation In Parkinson’S Disease: Applying The Movement Disorder Society Recommendations In A Population With A Low Level Of Formal Education, Natalia Pessoa Rocha, Eduarda Xavier Carreira, Ana Carolina De Almeida Prado, Fabíola Tavares, Mayra Tavares, Francisco Cardoso, Antônio Jaeger, Leonardo Cruz De Souza, Antônio Lucio Teixeira
Faculty, Staff and Student Publications
Background The diagnosis of cognitive disorders in Parkinson disease (PD) can be very challenging. Aiming at establishing uniform and reliable diagnostic procedures, the International Parkinson's Disease and Movement Disorder Society (MDS) commissioned task forces to delineate diagnostic criteria for mild cognitive impairment (MCI) and dementia in PD.
Objectives To investigate the applicability of the MDS recommendations for cognitive evaluation in a Brazilian sample of patients with PD with low levels of formal education.
Methods A total of 41 patients with PD were subjected to a comprehensive neuropsychological evaluation based on tests proposed by the MDS, which included the Mini-Mental State …
Profiling Human Pathogenic Repeat Expansion Regions By Synergistic And Multi-Level Impacts On Molecular Connections, Cong Fan, Ken Chen, Yukai Wang, Edward V Ball, Peter D Stenson, Matthew Mort, Albino Bacolla, Hildegard Kehrer-Sawatzki, John A Tainer, David N Cooper, Huiying Zhao
Profiling Human Pathogenic Repeat Expansion Regions By Synergistic And Multi-Level Impacts On Molecular Connections, Cong Fan, Ken Chen, Yukai Wang, Edward V Ball, Peter D Stenson, Matthew Mort, Albino Bacolla, Hildegard Kehrer-Sawatzki, John A Tainer, David N Cooper, Huiying Zhao
Faculty, Staff and Student Publications
Whilst DNA repeat expansions cause numerous heritable human disorders, their origins and underlying pathological mechanisms are often unclear. We collated a dataset comprising 224 human repeat expansions encompassing 203 different genes, and performed a systematic analysis with respect to key topological features at the DNA, RNA and protein levels. Comparison with controls without known pathogenicity and genomic regions lacking repeats, allowed the construction of the first tool to discriminate repeat regions harboring pathogenic repeat expansions (DPREx). At the DNA level, pathogenic repeat expansions exhibited stronger signals for DNA regulatory factors (e.g. H3K4me3, transcription factor-binding sites) in exons, promoters, 5'UTRs and …
Incidence Of Postoperative Complications Following Pancreatectomy For Pancreatic Cystic Lesions Or Pancreatic Cancer, Eileen C Donovan, Laura R Prakash, Yi-Ju Chiang, Morgan L Bruno, Jessica E Maxwell, Naruhiko Ikoma, Ching-Wei D Tzeng, Matthew H G Katz, Jeffrey E Lee, Michael P Kim
Incidence Of Postoperative Complications Following Pancreatectomy For Pancreatic Cystic Lesions Or Pancreatic Cancer, Eileen C Donovan, Laura R Prakash, Yi-Ju Chiang, Morgan L Bruno, Jessica E Maxwell, Naruhiko Ikoma, Ching-Wei D Tzeng, Matthew H G Katz, Jeffrey E Lee, Michael P Kim
Faculty, Staff and Student Publications
Background: In contrast to pancreatic ductal adenocarcinoma (PDAC), the risks of pancreatectomy for mucinous pancreatic cysts (MCs) are balanced against the putative goal of removing potentially malignant tumors. Despite undergoing similar operations, different rates of perioperative complications and morbidity between MC and PDAC patient populations may affect recommendations for resection. We therefore sought to compare the rates of postoperative complications between patients undergoing pancreatectomies for MCs or PDAC.
Methods: A prospectively maintained institutional database was used to identify patients who underwent surgical resection for MCs or PDAC from July 2011 to August 2019. Patient demographics, complications, and perioperative data were …
A 24-Month Updated Analysis Of The Comparative Effectiveness Of Zuma-5 (Axi-Cel) Vs Scholar-5 External Control In Relapsed/Refractory Follicular Lymphoma, M Lia Palomba, Paola Ghione, Anik R Patel, Myrna Nahas, Sara Beygi, Anthony J Hatswell, Steve Kanters, Eve H Limbrick-Oldfield, Sally W Wade, Markqayne D Ray, Jessica Owen, Sattva S Neelapu, John Gribben, John Radford, Sabela Bobillo
A 24-Month Updated Analysis Of The Comparative Effectiveness Of Zuma-5 (Axi-Cel) Vs Scholar-5 External Control In Relapsed/Refractory Follicular Lymphoma, M Lia Palomba, Paola Ghione, Anik R Patel, Myrna Nahas, Sara Beygi, Anthony J Hatswell, Steve Kanters, Eve H Limbrick-Oldfield, Sally W Wade, Markqayne D Ray, Jessica Owen, Sattva S Neelapu, John Gribben, John Radford, Sabela Bobillo
Faculty, Staff and Student Publications
Background: In the ZUMA-5 trial (Clinical trials identification: NCT03105336), axicabtagene ciloleucel (axi-cel; a chimeric antigen receptor T-cell therapy) demonstrated high rates of durable response in relapsed/refractory (r/r) follicular lymphoma (FL) patients and clear superiority relative to the SCHOLAR-5 external control cohort. We update this comparison using the ZUMA-5 24-month data.
Research design and methods: The SCHOLAR-5 cohort is comprised of r/r FL patients who initiated ≥3rd line of therapy after July 2014 and meeting ZUMA-5 eligibility criteria. Groups were balanced for patient characteristics through propensity scoring on prespecified prognostic factors using standardized mortality ratio (SMR) weighting. The overall response …
Vip152 Is A Selective Cdk9 Inhibitor With Pre-Clinical In Vitro And In Vivo Efficacy In Chronic Lymphocytic Leukemia, Steven Sher, Ethan Whipp, Janek Walker, Pu Zhang, Larry Beaver, Katie Williams, Shelley Orwick, Janani Ravikrishnan, Brandi Walker, Elizabeth Perry, Charles Gregory, Matthew Purcell, Alexander Pan, Pearlly Yan, Lapo Alinari, Amy J Johnson, Melanie M Frigault, Joy M Greer, Ahmed Hamdy, Raquel Izumi, Xiaokui Mo, Deepa Sampath, Jennifer Woyach, James Blachly, John C Byrd, Rosa Lapalombella
Vip152 Is A Selective Cdk9 Inhibitor With Pre-Clinical In Vitro And In Vivo Efficacy In Chronic Lymphocytic Leukemia, Steven Sher, Ethan Whipp, Janek Walker, Pu Zhang, Larry Beaver, Katie Williams, Shelley Orwick, Janani Ravikrishnan, Brandi Walker, Elizabeth Perry, Charles Gregory, Matthew Purcell, Alexander Pan, Pearlly Yan, Lapo Alinari, Amy J Johnson, Melanie M Frigault, Joy M Greer, Ahmed Hamdy, Raquel Izumi, Xiaokui Mo, Deepa Sampath, Jennifer Woyach, James Blachly, John C Byrd, Rosa Lapalombella
Faculty, Staff and Student Publications
Chronic lymphocytic leukemia (CLL) is effectively treated with targeted therapies including Bruton tyrosine kinase inhibitors and BCL2 antagonists. When these become ineffective, treatment options are limited. Positive transcription elongation factor complex (P-TEFb), a heterodimeric protein complex composed of cyclin dependent kinase 9 (CDK9) and cyclin T1, functions to regulate short half-life transcripts by phosphorylation of RNA Polymerase II (POLII). These transcripts are frequently dysregulated in hematologic malignancies; however, therapies targeting inhibition of P-TEFb have not yet achieved approval for cancer treatment. VIP152 kinome profiling revealed CDK9 as the main enzyme inhibited at 100 nM, with over a 10-fold increase in …
Sox17: A Highly Sensitive And Specific Immunomarker For Ovarian And Endometrial Carcinomas, Xudong Zhang, Jun Yao, Na Niu, Xiaoran Li, Yan Liu, Lei Huo, Elizabeth D Euscher, Huamin Wang, Diana Bell, Anil K Sood, Guoliang Wang, Barrett C Lawson, Preetha Ramalingam, Anais Malpica, Aysegul A Sahin, Qingqing Ding, Jinsong Liu
Sox17: A Highly Sensitive And Specific Immunomarker For Ovarian And Endometrial Carcinomas, Xudong Zhang, Jun Yao, Na Niu, Xiaoran Li, Yan Liu, Lei Huo, Elizabeth D Euscher, Huamin Wang, Diana Bell, Anil K Sood, Guoliang Wang, Barrett C Lawson, Preetha Ramalingam, Anais Malpica, Aysegul A Sahin, Qingqing Ding, Jinsong Liu
Faculty, Staff and Student Publications
PAX8 is the most commonly used immunomarker to link a carcinoma to the gynecologic tract; however, it lacks specificity. Through mining The Cancer Genome Atlas mRNA expression profile data, we identified SOX17 as a potential specific marker at the mRNA level for gynecologic tumors. To evaluate the utility of this marker in the identification of the gynecologic origin of a given carcinoma, we performed immunochemical staining in a large cohort of ovarian and endometrial cancer cases (n = 416), together with a large cohort of solid tumors from other organs (n = 1544) in tissue microarrays. Similar to PAX8, SOX17 …
Nih Data Management And Sharing, Alice Sherwood
Nih Data Management And Sharing, Alice Sherwood
TMC Library Newsletter (2015-)
NIH has issued the Data Management and Sharing (DMS) policy (effective January 25, 2023) to promote the sharing of scientific data. Sharing scientific data accelerates biomedical research discovery, in part, by enabling the validation of research results.
Do you need to find more information on data management and sharing policies?
Visit the library's NIH Data Management and Sharing LibGuide.
Psychotherapy Library: New Ebook Collection, Joanne Romano
Psychotherapy Library: New Ebook Collection, Joanne Romano
TMC Library Newsletter (2015-)
The Psychotherapy Library is a robust list of curated psychotherapy titles. This collection covers a multitude of topics including cognitive behavior therapy, psychoanalysis, mentalizing, and more—all within a single search and navigation interface that integrates journals and books.
Browse over 20 ebooks from the Psychotherapy Library at Psychiatry Online. Many titles include vignette videos that illustrate key clinical problems, techniques, and more!
Are Open Access Journals Cited More Often?, Joanne Romano
Are Open Access Journals Cited More Often?, Joanne Romano
TMC Library Newsletter (2015-)
Open Access content is freely accessible to all, with no access fees charged to the user. This means that scholars and researchers whose institutions lack a subscription, or researchers who lack institutional affiliation, can access the book or article online without paying a fee.
A Case Report Of Subacute Combined Degeneration Due To Nitrous Oxide-Induced Vitamin B12 Deficiency, Jorge Nadal Bosch, Javier Malcolm, Mario Moya, Michael Menowsky, Roberto A. Cruz
A Case Report Of Subacute Combined Degeneration Due To Nitrous Oxide-Induced Vitamin B12 Deficiency, Jorge Nadal Bosch, Javier Malcolm, Mario Moya, Michael Menowsky, Roberto A. Cruz
School of Medicine Publications
Nitrous oxide, also known as “laughing gas,” is a naturally occurring gas that is colorless, odorless, nonflammable, and nontoxic. It has been used as an inhalant anesthetic in the medical field for more than 150 years for dental and surgical procedures. Due to its wide availability and ability to cause euphoria, its recreational use is on the rise. We present a case of subacute combined degeneration (SCD) due to nitrous oxide-induced vitamin B12 deficiency. The patient presented with bilateral lower extremity paresthesia, weakness, and ataxic gait. The patient was found to have vitamin B12 deficiency. An MRI of the cervical …
Updated Virophage Taxonomy And Distinction From Polinton-Like Viruses, Simon Roux, Matthias G. Fischer, Thomas Hackl, Laura A. Katz, Frederik Schulz, Natalya Yutin
Updated Virophage Taxonomy And Distinction From Polinton-Like Viruses, Simon Roux, Matthias G. Fischer, Thomas Hackl, Laura A. Katz, Frederik Schulz, Natalya Yutin
Biological Sciences: Faculty Publications
Virophages are small dsDNA viruses that hijack the machinery of giant viruses during the co-infection of a protist (i.e., microeukaryotic) host and represent an exceptional case of “hyperparasitism” in the viral world. While only a handful of virophages have been isolated, a vast diversity of virophage-like sequences have been uncovered from diverse metagenomes. Their wide ecological distribution, idiosyncratic infection and replication strategy, ability to integrate into protist and giant virus genomes and potential role in antiviral defense have made virophages a topic of broad interest. However, one limitation for further studies is the lack of clarity regarding the nomenclature and …
Shakespeare On Zoom, Fandom, And The Uncanny Humor Of Imperfections And Plurality: A Comparative Study Of The Show Must Go Online And Zoom Shakespeare Productions, Hyemin Kim
Dissertations, Theses, and Capstone Projects
This thesis surveys the phenomena of Shakespeare performance on Zoom (‘Shakespeare on Zoom’) that have emerged during the current Covid pandemic in order to illuminate a complex intersection of lockdown culture, fandom, and new media’s techno-social archive, including its affective resonances. As case studies, this study pays attention to The Show Must Go Online (TSMGO) and Zoom Shakespeare Productions (ZSP) to examine countercultural fandom, vernacular creativity, and technologically imperfect aesthetics (or anti-aesthetics) in ‘Shakespeare on Zoom’ performed by underfunded artists or amateur fans. In analyzing TSMGO’s and ZSP’s endeavors of production and dramaturgy, I bring in Sigmund Freud’s …
A Female Pharaoh And The Emperor’S Wife: Hatshepsut, Julia Domna, And Female Authority In Antiquity, Gabriella E. Ramalho
A Female Pharaoh And The Emperor’S Wife: Hatshepsut, Julia Domna, And Female Authority In Antiquity, Gabriella E. Ramalho
Dissertations, Theses, and Capstone Projects
This thesis analyzes how historical notions of masculinity and femininity shaped perceptions of power between the Egyptian female pharaoh Hatshepsut and Roman empress Julia Domna. Both rulers carefully created visual narratives of masculinity and femininity to leverage respect from their citizens, in accordance with what was contextually appropriate for their respective societies.
It will be shown that there are blatant disconnects between how others perceived them and how they wished to be portrayed. Hatshepsut, a rare female pharaoh, depicted herself in the regalia of a male king with a false ceremonial beard, scepters and crowns. Domna was described as the …
Our Pride, Our Joy: An Intersectional Constructivist Grounded Theory Analysis Of Resources That Promote Resilience In Sgm Communities, O. Winslow Edwards, Eliot Lev, Juno Obedin-Maliver, Mitchell R. Lunn, Micah E. Lubensky, Matthew R. Capriotti, J. J. Garrett-Walker, Annesa Flentje
Our Pride, Our Joy: An Intersectional Constructivist Grounded Theory Analysis Of Resources That Promote Resilience In Sgm Communities, O. Winslow Edwards, Eliot Lev, Juno Obedin-Maliver, Mitchell R. Lunn, Micah E. Lubensky, Matthew R. Capriotti, J. J. Garrett-Walker, Annesa Flentje
Faculty Research, Scholarly, and Creative Activity
Introduction Sexual and gender minority (SGM) communities, including lesbian, gay, bisexual, transgender, queer, intersex, asexual, and Two-Spirit people, have historically been researched from a deficits-based approach that fails to highlight the ways communities survive and thrive in the face of adversity. This study endeavored to create a model of resources that promote SGM resilience using a sample that amplified traditionally underrepresented perspectives, including individuals from racial and/or ethnic minority groups, trans and/or gender diverse individuals, individuals on the asexual spectrum, and older adults. Methods Participant responses to three open-ended questions from The PRIDE Study’s (an online national longitudinal cohort study …
The Ntpase Activity Of The Double Fyve Domain-Containing Protein 1 Regulates Lipid Droplet Metabolism., Victoria A. Ismail, Teri Naismith, David J. Kast
The Ntpase Activity Of The Double Fyve Domain-Containing Protein 1 Regulates Lipid Droplet Metabolism., Victoria A. Ismail, Teri Naismith, David J. Kast
2020-Current year OA Pubs
Lipid droplets (LDs) are transient lipid storage organelles that can be readily tapped to resupply cells with energy or lipid building blocks and therefore play a central role in cellular metabolism. However, the molecular factors and underlying mechanisms that regulate the growth and degradation of LDs are poorly understood. It has emerged that proteins that establish contacts between LDs and the endoplasmic reticulum play a critical role in regulating LD metabolism. Recently, the autophagy-related protein, double FYVE domain-containing protein 1 (DFCP1/ZFYVE1) was shown to reside at the interface of the endoplasmic reticulum and LDs, however, little is known about the …
A Word From The Writing Team (February 2023), Pam Walter, Mfa, Liz Declan, Ma, Mfa
A Word From The Writing Team (February 2023), Pam Walter, Mfa, Liz Declan, Ma, Mfa
A Word From the Writing Team (Newsletter)
This issue includes:
- Writing Retreats on First Fridays
- Faculty Days 2023 Deadline
- On-Demand Workshops
Sediment Assessment Of Al-Hindyia And Al-Abbasyia River / Iraq By Aquatic Oligocheata Community As Bioindicators, Nadia Imad Al-Ameen, Dlovan Kammal Al-Jaff
Sediment Assessment Of Al-Hindyia And Al-Abbasyia River / Iraq By Aquatic Oligocheata Community As Bioindicators, Nadia Imad Al-Ameen, Dlovan Kammal Al-Jaff
Baghdad Science Journal
Bioindicators have an important role in assessing the quality of water bodies. Aquatic oligocheates, was used as a bioindicator to assess the sediment quality of Al-Hindyia and AL-Abbasyia river (branches of Euphrates River in Iraq). Two sites in each river have been chosen for this purpose, site S1 was located at Al-Hindyia River and S2 at Al-Abbasyia River. Some kinds of biological indices were used in this study, comprising the percentage of oligochaetes in benthic invertebrates, ranged from 20.3-60.16%. While the percentage of Tubificidae within benthic invertebrates was close 43.3-43.9%.Index of pollution D ranged from 0.13-0.21. The maximum percentage of …
Accumulation Of Heavy Metals In Agricultural Crops And Ecological Series Of Crops Placement, Zafar Zairovich Uzakov, Khusniddin Nagimovich Karimov, Zair Uzakovich Uzakov, Ravshan Abdurazakovich Eshonkulov
Accumulation Of Heavy Metals In Agricultural Crops And Ecological Series Of Crops Placement, Zafar Zairovich Uzakov, Khusniddin Nagimovich Karimov, Zair Uzakovich Uzakov, Ravshan Abdurazakovich Eshonkulov
Baghdad Science Journal
The accumulation of toxic elements in vegetables and melons grown in agriculture, Brassica rapa - turnip, Solanum lycopersicum - tomato, Citrullus lanatus - watermelon, Capsicum annuum - bell pepper, Daucus carota - carrots, Cucurbita pepo - pumpkin, Cucumis melo - melon, and also Prunus armeniaca - apricot from fruit trees were analyzed. The excess of maximum allowable concentrations in agricultural crops of the element As by 1.65-1.75, Cd - 1.6-2.3, Cr -1.2-2.35, Cu -1.6-3.3, Ni - 1.16-3.53, Pb - 1.54-3.08, Al - 1.36-3.5, Sb - 2.0-33, Se - 1.1-3.3 times was established. The maximum allowable concentration of mercury in vegetables …
Phytochemical Profile, Antioxidant, Enzyme Inhibitory And Acute Toxicity Activity Of Astragalus Bruguieri, Ahmed Aj Jabbar, Kamaran Kaiani Abdulrahman, Parween Abdulsamad, Sharoukh Mojarrad, Güldal Mehmetçik, Abdullah Sh Sardar
Phytochemical Profile, Antioxidant, Enzyme Inhibitory And Acute Toxicity Activity Of Astragalus Bruguieri, Ahmed Aj Jabbar, Kamaran Kaiani Abdulrahman, Parween Abdulsamad, Sharoukh Mojarrad, Güldal Mehmetçik, Abdullah Sh Sardar
Baghdad Science Journal
The medicinal plants (Astragalus species) have been used traditionally as anti-inflammatory, antioxidant, and Anti-diabetics. The current research investigates the phytochemistry and some biological activity of methanol extract of different parts of Astragalus bruguieri Bioss., a wild medicinal plant grows on Safeen mountain, Erbil, Iraq. The methanol extracts of A. bruguieri were analyzed for total phenolic, flavonoid, and saponin contents. In-vitro antioxidant activity was analyzed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Furthermore, the plant extracts were examined for in-vitro enzyme inhibitory activity and in-vivo sub-acute toxicity. The results have shown the highest total phenolic (28.83, 20.62 mg GAEs/g …
Reducing The Risk Of Mortality In Chronic Obstructive Pulmonary Disease With Pharmacotherapy: A Narrative Review, Matthew Mintz, Igor Barjaktarevic, Donald A. Mahler, Barry Make, Neil Skolnik, Barbara Yawn, Bree Zeyzus-Johns, Nicola A. Hanania
Reducing The Risk Of Mortality In Chronic Obstructive Pulmonary Disease With Pharmacotherapy: A Narrative Review, Matthew Mintz, Igor Barjaktarevic, Donald A. Mahler, Barry Make, Neil Skolnik, Barbara Yawn, Bree Zeyzus-Johns, Nicola A. Hanania
Abington Jefferson Health Papers
In 2020, chronic obstructive pulmonary disease (COPD) was the fifth leading cause of death in the United States excluding COVID-19, and its mortality burden has been rising since the 1980s. Smoking cessation, long-term oxygen therapy, noninvasive ventilation, and lung volume reduction surgery have had a beneficial effect on mortality; however, until recently, the effects of pharmacologic therapies on all-cause mortality have been unclear. Inhaled pharmacologic treatments for patients with COPD include combinations of long-acting muscarinic receptor antagonists (LAMAs), long-acting-β2-agonists (LABAs), and inhaled corticosteroids (ICS). The recent IMPACT and ETHOS clinical trials reported mortality benefits with ICS/LAMA/LABA triple therapy compared with …
Cryptocurrencies And Climate Change: A Net-Zero Paradox, Jason Maclean
Cryptocurrencies And Climate Change: A Net-Zero Paradox, Jason Maclean
Canadian Journal of Law and Technology
Cryptocurrencies pose a number of complex law and policy problems, the most pressing of which are the industry’s climate and environmental impacts. This article examines the climate and environmental impacts of crypto-assets in the broader law and policy context of the UN Paris Agreement and the global goal of reaching net-zero emissions by 2050 or earlier. This approach not only illuminates the limitations and paradoxical nature of the crypto-industry’s climate commitments, but also the limitations and paradoxical nature of ‘‘net zero” itself as the predominant framing of national, subnational, and nonstate actors’ climate pledges. The article concludes by examining the …
Biotechnology Patent Law Top Ten Of 2021. Experimentation, Blaze Marks, And Unspecified Ranges, Noonan, Kevin E., Torrance, Andrew W.
Biotechnology Patent Law Top Ten Of 2021. Experimentation, Blaze Marks, And Unspecified Ranges, Noonan, Kevin E., Torrance, Andrew W.
Santa Clara High Technology Law Journal
Biotechnology has never demonstrated its benefits to society more than in 2021. The SARS-CoV-2 virus that caused the CoVID-19 pandemic met a formidable opponent in mRNA vaccines developed and supplied by Moderna and Pfizer/BioNTech. These vaccines are claimed in myriad – not Myriad – patents and patent applications, many of which are destined to be litigated over the coming years, not least inspired by the many billions of dollars that have been, and will continue to be, earned by their owners. While the world waits for this storm of patent litigation, federal courts continue to be busy with ownership, licensing, …
City Of Tampa Tree Canopy And Urban Forest Analysis 2021, Shawn M. Landry, Andrew K. Koeser, Rebecca Zarger, Kira Rib, Allyson Salisbury, Robert J. Northrop, Michael G. Andreu, Allison Bednar, Zach Freeman
City Of Tampa Tree Canopy And Urban Forest Analysis 2021, Shawn M. Landry, Andrew K. Koeser, Rebecca Zarger, Kira Rib, Allyson Salisbury, Robert J. Northrop, Michael G. Andreu, Allison Bednar, Zach Freeman
School of Geosciences Faculty and Staff Publications
This report summarizes the fourth tree canopy and urban forest analysis conducted for the City of Tampa and represents the year 2021. The City of Tampa tree ordinance (Ord. No. 2006-74, § 9, 3-23-06) requires an assessment of the tree canopy and urban forest every five years (beginning in 20061). In an effort to reduce concerns over bias, this work has been conducted by a collaborative team from the University of South Florida and the University of Florida following established USDA Forest Service protocols.
This report provides detailed information about the current size, composition, health, and distribution of Tampa’s urban …
Antibacterial Activity Of Three Algal Genera Against Some Pathogenic Bacteria, Janan Jabbar Toma, Farhad Hassan Aziz
Antibacterial Activity Of Three Algal Genera Against Some Pathogenic Bacteria, Janan Jabbar Toma, Farhad Hassan Aziz
Baghdad Science Journal
In the current study, three types of algae namely Tetradesmus nygaardi (MZ801740), Scenedesmus quadricauda (MZ801741) and Coelastrella sp (MZ801742) were extracted by 95% ethanol and hexane against two types of gram positive and two types of gram negative bacteria by wells diffusion methods. Eleven concentrations from the extract of algae (2, 5, 10, 15, 20, 25, 30, 35, 40, 45 and 50 mg/ml) were utilized. It was noticed that ethanolic extraction was more effective than hexane in Scenedesmus quadricauda than the two other mentioned algal species against all pathogenic bacteria, Acintobacter baumanii (ATCC: 19606), Klebsiella pneumonia (ATCC: 13883) Enterococcus faecalis …
Spectrophotometric Method Combined With Hplc For Bisphenol F Determination In Plastic Bottled Water And Thermal Paper, Narjes Mohanad Habib, Maha Al-Tameemi, Mohanad Lateef Tofah, Nahlah Kadhim Salman, Hawraa Mahmood Abdulkareem
Spectrophotometric Method Combined With Hplc For Bisphenol F Determination In Plastic Bottled Water And Thermal Paper, Narjes Mohanad Habib, Maha Al-Tameemi, Mohanad Lateef Tofah, Nahlah Kadhim Salman, Hawraa Mahmood Abdulkareem
Baghdad Science Journal
Based on the diazotization-coupling reaction, a new, simple, and sensitive spectrophotometric method for determining of a trace amount of (BPF) is presented in this paper. Diazotized metoclopramide reagent react with bisphenol F produces an orange azo-compound with a maximum absorbance at 461 nm in alkaline solution. The experimental parameters were optimized such as type of alkaline medium, concentration of NaOH, diazotized metoclopramide amount, order additions, reaction time, temperature, and effect of organic solvents to achieve the optimal performance for the proposed method. The absorbance increased linearly with increasing bisphenol F concentration in the range of 0.5-10 μg mL-1 under ideal …
Retrieving Encrypted Images Using Convolution Neural Network And Fully Homomorphic Encryption, Emad M. Alsaedi, Alaa Kadhim Farhan
Retrieving Encrypted Images Using Convolution Neural Network And Fully Homomorphic Encryption, Emad M. Alsaedi, Alaa Kadhim Farhan
Baghdad Science Journal
A content-based image retrieval (CBIR) is a technique used to retrieve images from an image database. However, the CBIR process suffers from less accuracy to retrieve images from an extensive image database and ensure the privacy of images. This paper aims to address the issues of accuracy utilizing deep learning techniques as the CNN method. Also, it provides the necessary privacy for images using fully homomorphic encryption methods by Cheon, Kim, Kim, and Song (CKKS). To achieve these aims, a system has been proposed, namely RCNN_CKKS, that includes two parts. The first part (offline processing) extracts automated high-level features based …