Digital Commons Network^™

Strategic Economic Evaluation Of Microsoft's Post-Acquisition Gaming Portfolio, Brett Hancock, Daniela Orta Castaneda, Travis Stevens, M. Affan Badar

Symposium Projects

Microsoft Gaming is a gaming and entertainment division of Microsoft. In 2023 Microsoft bought Activision Blizzard, another industry leader. Rapidly changing industry and increased operation costs have created challenges. Sound financial analysis required to maintain company profitability and health. The purpose of this study is to analyze the economic data to recommend potential areas of investment and consolidation.

Ai, Antitrust, And The Marketplace Of Ideas, Maurice E. Stucke

Fordham Law Review

No abstract provided.

Is Tax “Law”?, Luís C. Calderón Gómez

Fordham Law Review

Although taxation remains a hotly contested issue in debates by both politicians and political theorists—over the optimal size of government, distributive (and sometimes corrective) justice, or even the legitimacy of current private property arrangements—taxation has been largely ignored by legal theorists, to the detriment of both tax law and legal theory. This Article argues that tax law, driven by its battle against tax evasion, is in deep conflict with widely accepted conceptions of “legality”—that is, the qualities that make a rule distinctively and normatively “law.” This matters because legality is a key buttress in jurisprudential and political theory accounts that …

Minimal Success: The Consequences Of Mandatory Minimums In Youth Sentencing, Maya Chrobot

Fordham Law Review

In New York State, children as young as thirteen can be processed as adults and sentenced to mandatory minimum sentences. Mandatory minimum sentences require judges to sentence the defendant to a statutorily set minimum term of imprisonment. Practitioners, judges, and researchers question the efficacy of mandatory minimum sentences, finding that they are ineffective at deterring crime, decreasing bias in sentencing, and increasing community safety. Additionally, there is clear evidence about the damaging effects of incarceration on young adults. Instead of functioning as rehabilitative punishment, incarceration leads young adults to experience poor mental and physical health outcomes upon release, and they …

State Intervention In Local Zoning: Lessons From Housing Applied To Data Centers, Matthew De Boer

Fordham Law Review

There is growing regulatory tension at the intersection of data center development and local land use law. As states aggressively court data centers with tax incentives and economic policies, they have largely declined to regulate where and how these facilities are sited. Local governments, left to absorb the consequences, have responded unevenly, attempting to fit extraordinary land, water, power, and noise-intensive data centers into zoning frameworks designed for far less demanding industrial uses. The result has been a cycle of uncertainty and conflict: developers face unpredictable approvals, moratoria, and litigation, while residents bear escalating infrastructure strain, environmental impacts, and diminished …

Parental Use Of Digital Location Tracking Technology & The Impacts On Adolescent Development: A Scoping Review, Madison G. Cox

Senior Theses

In the 21st century, many parents rely on digital location tracking applications (e.g., Life360, Find My Friends) to track the whereabouts of their teens and young adults, exerting a new form of parental control in the digital age. Though a popular parenting strategy, it is unclear how utilizing these tools might be affecting adolescent and emerging adulthood development. To better understand these outcomes, the present thesis conducted a scoping review of articles via the PsycINFO database. After screening studies according to the inclusion and exclusion criteria, a total of five studies were included in the scoping review. The included studies …

From Story Time To Self-Esteem: Using Books To Foster Positive Body Image In Pediatric Athletes, Emma Lieser

Senior Theses

This creative project explores the relationship between sport-specific musculature development and body image among pediatric girls, addressing how differing athletic movements shape both physical form and self-perception. Research indicates that girls often disengage from sports at a young age due in part to negative body image and comparison with peers, despite the physical and psychological benefits of participation. This project examines how common athletic movements—such as running, jumping, throwing, and skating—develop distinct muscle groups, contributing to diverse yet functional body types. In addition, the project investigates the influential role of children’s literature in shaping perceptions of body image and physical …

Feeding The Mind: Dietary Consumption And Neural Aging, Bhavani Tuppale

Senior Theses

Neural aging is the process of physiological decline in the brain and increased vulnerability to neurodegenerative diseases. Neurodegenerative diseases such as Alzheimer’s disease are associated with aging and the interaction of genetics and lifestyle choices. Previous research studies have connected Alzheimer’s disease with dysfunction in the metabolic system. To combat age-associated dysfunctions in the metabolic system, research studies propose using the ketogenic diet, which utilizes ketone bodies as an energy source instead of glucose. The thesis analyzes literature on the effect of neural aging on various model organisms, how a ketogenic diet affects aging model organisms, and how aging and …

Loss Of Sarm1 Affects Myelin Uptake And Clearance In Macrophages, Grace J. Bergeron

Senior Theses

Clearance of myelin debris is an essential step in nerve regeneration after injury in both the central nervous system (CNS) and peripheral nervous system (PNS), a process that is primarily carried out by macrophages. Failure to phagocytose and clear myelin can prolong inflammation and impair recovery. Sterile alpha and TIR motif-containing protein 1 (SARM1) is well researched as a regulator of axonal degeneration, yet its role in macrophages is still unclear. This study investigates how sarm1 deletion and cytokine signaling influence macrophage uptake and clearance of CNS and PNS myelin in vitro. Splenic macrophages isolated from wild-type (WT) and sarm1 …

The Role Of Community Health Workers In Rural South Carolina, Sarah W. Haselden

Senior Theses

This paper aims to explore the role of Community Health Workers (CHWs) in rural South Carolina through a literature review as well as the data supplied from the Community Health Alignment Initiative (CHAI) and Community Health Workers Changing Outcomes in SC (CCOSC). Through reviewing the collection of materials and data, the effectiveness of CHWs can be studied. Community Health Workers (CHWs) provide a unique aspect to primary care within communities through their aid in prevention of health conditions. CCOSC and CHAI collected data throughout South Carolina to determine the needs of communities and how CHWs can work to address those …

The Effects Of Climate Change On Competition And Recovery From Disturbance In An Iconic Marine Community, Lauren Tibbits

Senior Theses

This paper explores how the recovery of populations of Semibalanus balanoides is affected by climate variation. In intertidal marine ecosystems, larval recruitment is important in shaping all ecological processes. S. balanoides is a cold-water barnacle species that is competitively dominant over Chthamalus montagui and C. stellatus, two warm-water species. This competitive interaction is well studied, though it is not understood how that competition influences the recovery of S. balanoides after a disturbance nor how this process varies over a temperature gradient. 19 sites were studied across the United Kingdom, spanning from northern Scotland to southwestern England. At each site, a …

Discovering Drug-Like Compounds By Targeting Protein-Protein Interactions Using A Yeast-3-Hybrid System, Chesley C. Blake

Senior Theses

Protein-protein interactions are important targets in cancer biology as they can make historically “undruggable” proteins viable drug targets. However, the current approach to targeting protein-protein interactions relies on the use of small molecule drugs, which have low efficiencies as they must cover a large surface area of the interaction. Further, traditional drug therapies often lead to off-target toxicity, limiting therapeutic specificity. The objective of this project is to develop a selection system in yeast to identify short peptide sequences that can disrupt protein-protein interactions specific to cancer cells. Following proof of principle and development of the AH109 yeast strain having …

Evaluating The Impact Of Social Determinants Of Health On Outcomes Of Type Ii Diabetes In South Carolina, Alexander G. Downs

Senior Theses

Type II diabetes mellitus (T2DM) represents a significant public health burden in South Carolina, where 13.5% of adults are affected, surpassing the national rate of 12%. This integrative literature review examines the social determinants of health most strongly associated with T2DM morbidity and mortality in South Carolina, including race and ethnicity, socioeconomic status, rural or urban residence, educational attainment, healthcare access, and food insecurity. Evidence drawn from peer-reviewed studies, epidemiological reports, and state health data reveals that African American, rural, and low-income populations bear a disproportionate share of the diabetes burden in the state. These disparities arise through multilevel mechanisms …

A Guide To Environmentally Sustainable Filmmaking In South Carolina, Christina Vera Dobrowolski

Senior Theses

The entertainment industry has a massive environmental impact. This information is not new in the filmmaking world, as multiple mainstream efforts exist to curb the material-intensive production of live action films and TV. One of these efforts is the use of voluntary sustainable guidelines, which serve as tools that outline sustainable best practices and resources that can help achieve them. However, current guidelines often lack practicality— focusing more on altruism rather than core economic factors that ultimately drive filmmaking. This project aims to address that gap for filmmakers in South Carolina by offering a website featuring attainable, state-specific resources for …

Exploring Synthesized Cbd Derivatives: Implications Of Therapeutic Strategies For Neuroinflammation, Josephine Mosser

Senior Theses

Cannabidiol (CBD) is a non-psychoactive phytocannabinoid derived from Cannabis Sativa with well-documented antioxidant and anti-inflammatory properties, yet its clinical utility is limited by moderate receptor selectivity, rapid hepatic metabolism, and broad pharmacological activity on the central nervous system (CNS). This thesis describes the design and partial execution of a multi-step synthetic route aimed at generating CBD/CBD-derived chalcone intermediates for potential therapeutic applications for neuroinflammation. The steps encompass an O-methylation, O-acetylation, and a Fries rearrangement. The first three steps were completed successfully and reproducibly shown through 1H-NMR and 12C-NMR; however, purification of the fourth step was not successful within the available …

Antibiotics And You: A Comprehensive Guide, Brady Haas

Senior Theses

Antibiotic resistance is a rapidly emerging issue within public health. As resistance grows, the effectiveness of traditional antibiotic therapies diminishes while risk of treatment grows. Alongside novel therapies, public knowledge is a strong combatant of the resistance-related risks of antibiotic usage. Through a comprehensive review of current literature, this work serves as an accessible guide to the mechanisms of antibiotics, bacterial resistance, and the challenges related to current antibiotic usage. Additionally, the ability of current policy and emerging novel treatments, such as nanoparticles and bacteriophage therapy, to fight antibiotic resistance is evaluated. This analysis highlights the importance of improving public …

Cell-Free Mitochondrial Dna (Mtdna) Triggers Vascular Dysfunction Via Toll-Like Receptor 9 (Tlr9)-Dependent Activation Of Inflammasomes, Mohin Amin

Senior Theses

Hypertension is the leading global risk factor for mortality and is closely associated with vascular inflammation and dysfunction. Damaged mitochondria release cell-free mitochondrial DNA (cf-mtDNA), which activates toll-like receptor 9 (TLR9). The binding of TLR9 to mtDNA activates the NLRP3 inflammasome pathway, promoting the release of pro-inflammatory cytokines via gasdermin D (GSDMD), therefore worsening inflammation. However, the mechanisms linking mitochondrial injury to inflammation-induced vascular dysfunction remain unclear. We hypothesize that cf-mtDNA triggers TLR9-dependent NLRP3 inflammasome activation contributing to vascular and endothelial dysfunction. To assess that, adult male C57BL/6 were exposed to 28 consecutive days of chronic unpredictable stress (CUS) or …

Fingerprinting Voice Commands Of Vpn-Protected Smart Speakers, Xiaoguang Guo, Keyang Yu, Qi Li, Dong Chen

Computer Science Faculty Research and Publications

Extensive recent research has shown that it is surprisingly easy to infer Amazon Alexa voice commands over their network traffic data. To prevent these traffic analytics (TA)-based inference attacks, smart home owners are considering deploying virtual private networks (VPNs) to safeguard their smart speakers. In this work, we design a new machine learning-powered attack framework—VoiceAttack that could still accurately fingerprint voice commands on VPN-encrypted voice speaker network traffic. We evaluate VoiceAttack under 5 different real-world settings using Amazon Alexa and Google Home. Our results show that VoiceAttack could correctly infer voice command sentences with a Matthews Correlation Coefficient (MCC) of …

Genetic Factors In Migraine With Aura In Argentina: An Exploratory Case-Control Study, Rebeca González, Magalí Nowik, Silvina M. Miranda, Jorge A. Giglio, Diana M. Hohl, Juan A. Gili, Cecilia I. Catanesi

Human Biology Open Access Pre-Prints

Objective: Genetic characterization of migraine with aura in the population of Buenos Aires Province, Argentina.

Background: Migraine is a primary headache disorder with neurovascular involvement. Migraine with aura is a subtype that accounts for approximately 15–40% of all migraine cases. Several studies have shown that the global prevalence of migraine varies depending on the population studied. The population of Buenos Aires Province has an admixed genetic background. Several genetic association studies on migraine have been reported; however, most of them were conducted in cohorts of European ancestry, introducing a bias that overlooks global population diversity.

Methods: DNA …

Exploring The Impact Of Mental Health On Academic Performance And Engagement: An Interpretative Phenomenological Study Of Title I High School Upperclassmen In Northeast Alabama, Nataysia A. Holloway

Dissertations

This dissertation explores the intersection of student mental health and academic success within a Title I school context, particularly the lived experiences of students navigating mental health challenges while facing psychological, social, and educational barriers. Drawing on qualitative data, the study explores how mental health challenges influence student academic performance, engagement, and overall educational outcomes. Chapter one introduces mental health as a prevalent concern for adolescence, and chapter two examines existing research and details the methodological approach and supporting frameworks for this study. Subsequent chapters are devoted to the lived experiences of students and their perception of support and resources …

The Parthenon, April 01, 2026, Baylee Parsons, Kaitlyn Fleming, Abby Ayes, Ella Hatfield, Davina Snyder, Scott Price, Trista Honaker

The Parthenon

No abstract provided.

The Role Of Outer Setting Health System Factors In The Use Of Hydroxyurea For Ugandan Children With Sickle Cell Anemia, Rollins Angela, Joseph Rujumba, Ruth Namazzi, Deogratius Munube, John Chandy, Russell Ware, Doreen Apolot, Andew Ssali, Henry Nancy, Robert Opoka

Paediatrics and Child Health, East Africa

Sickle cell anemia (SCA) causes childhood morbidity and mortality in Uganda and other countries in sub-Saharan Africa. Hydroxyurea is safe and effective, but not currently widely used in Uganda. We piloted a toolkit to support hydroxyurea use in two public health clinics: a regional referral hospital in a peri-urban area and a district hospital in a rural area. Implementation supports included a manual, expert training, and coaching over 2 years. We conducted key informant interviews and focus groups with national stakeholders, hospital leaders, healthcare workers, patient caregivers, and patients early in Year 1 and later in Year 2. Embedded research …

A Mixed-Methods Research Study: Nc Health Department Directors’ Perspective On Local Impact Of Early Medicaid Expansion, Asma Warrich

MUSC Theses and Dissertations

North Carolina became the 41^st state to expand Medicaid under the Affordable Care Act. The bipartisan expansion addressed longstanding challenges; however, little is known about how Local Health Departments (LHDs) adapted to this policy change, especially in the 24 months following expansion. This study sought to fill that gap by documenting the perspectives of LHD Directors in North Carolina utilizing a ten-question REDCap survey with closed- and open-ended questions. Purposeful sampling targeted all 86 LHD Directors. Data was collected anonymously between November 2025 and January 2026. Descriptive and thematic analyses were conducted. Thirty LHD Directors completed the survey, which …

Bias Analysis And The Movement Toward A Bias-Free Curriculum, Haley J. Mcmahon, Denyelle Kenyon

Scholarship Pathways Program

Implicit biases within medical education can influence learners’ perceptions, clinical reasoning, and future patient interactions. This study analyzed implicit bias within the University of South Dakota Sanford School of Medicine’s (USD SSOM) Pillar I pre‑clerkship curriculum using a two‑phase mixed‑methods approach. Phase I consisted of a subjective content analysis of randomly selected lectures across ten system blocks, examining both textual and visual materials for evidence of bias in eleven domains identified by the Association of American Medical Colleges. Phase II employed quantitative survey data from the MD Class of 2027, who rated perceived bias in lecture content, lecture images, exam …

Bread, Work, Freedom! The Urgent Call For Action And Accountability In Afghanistan, Nancy J. Newman, Zubaida Akbar, Mahwish Moazzam, Sussan Tahmasebi

UC Law SF International Law Review

This Article examines the systematic degradation of women and girls in Afghanistan since the Taliban reclaimed power in 2021, and the resulting violations of international human rights law. To provide context for the legal analysis, the Article includes a historical perspective of women’s rights before the takeover, as well as first-hand accounts of life under the current regime. Centering its legal analysis on Afghan women’s demands for “Bread, Work, and Freedom,” the Article explains how the Taliban’s edicts have criminalized women’s education, employment, and mobility, erasing women from public life in blatant violation of multiple international treaties and obligations. It …

The Middle-Class Rip-Off'? Subsiding Culture In Contemporary Ireland, Connell Vaughan Dr

Irish Communication Review

In the last few years (roughly since the start of the Covid-19 pandemic) there has been a noted increase in state-led cultural funding in Ireland. Key examples include the raise in the financial allocation to the Arts Council, the introduction of the Basic Income for the Arts scheme, and increased sports capital funding. With reference to the official communication documents of these cases (so-called ‘grey literature’) and deploying the classic 1982 episode of the British sitcom Yes, Minister, ‘The Middle-Class Rip-Off,’ which pitches sports funding against support for the arts, as a satirical lens, this paper reflects on the contemporary …

Buckeye Property Consulting, Stephen Manning

Distinguished Student Scholarship Collection

This business plan outlines the creation and strategic development of Buckeye Property Consulting, a startup firm specializing in compliance consulting for affordable housing property management companies. The plan addresses the growing demand for expert support in navigating complex regulatory requirements associated with U.S. Department of Housing and Urban Development (HUD) and Low‑Income Housing Tax Credit (LIHTC) programs. Through industry and market analysis, the document identifies a service gap faced by small to mid‑sized property management firms that lack sufficient in‑house compliance resources but cannot afford large national consulting firms. The plan details the company’s mission, value proposition, service offerings, competitive …

A Multidimensional Framework For Burnout Resilience In Adults, Anthony Martinez

Distinguished Student Scholarship Collection

This paper explores burnout as a growing public health concern and argues for a multidimensional framework to build resilience in adults. Drawing on contemporary research, the paper defines burnout as a response to chronic stress that undermines emotional, mental, and physical well‑being. It examines how the integration of physical, mental, and spiritual practices can mitigate burnout and enhance long‑term resilience. The analysis highlights the role of physical activity in regulating stress responses and improving mental health, the importance of mental health practices such as self‑regulation, cognitive reframing, and meditation, and the impact of spiritual practices, including prayer and positive religious …

Gun Control In The United States Of America, Blessing Crowder

Distinguished Student Scholarship Collection

This paper examines the issue of gun control in the United States by analyzing the relationship between firearm accessibility and gun‑related crime, including homicide, suicide, and accidental deaths. Drawing on historical examples, scholarly research, legal cases, and public opinion data, the paper argues that restricting access to firearms can significantly reduce gun‑related violence. It explores how firearms often fall into unauthorized hands, the role of mental health and impulsivity in violent outcomes, and the disproportionate risks firearms pose in racially charged environments. The paper also addresses opposing arguments centered on self‑defense and deterrence, evaluating legal precedents and ethical justifications for …

Phase 5 - Post Implementation, Anna Pugerud

Distinguished Student Scholarship Collection

This paper presents a post‑implementation analysis and system design plan for digitizing animal health records within the Animal Health Services (AHS) department. The project addresses inefficiencies, data inaccuracies, and physical storage limitations associated with paper‑based documentation by proposing the adoption of a Software as a Service (SaaS) digital records solution. Through stakeholder interviews, observations, and document analysis, the project identifies functional, non‑functional, and system requirements necessary to support streamlined reporting, treatment tracking, and regulatory compliance. The analysis outlines feasibility across technical, economic, and organizational dimensions, demonstrating that the proposed system can reduce documentation time, improve response times, and lower operational …