Digital Commons Network^™

Reasons For Ineligibility For Clinical Trials Of Patients With Medication-Resistant Epilepsy, Wesley T. Kerr, Hai Chen, Mariana Figuera Losada, Christopher Cheng, Tiffany Liu, Jaqueline French

School of Medicine Faculty Publications

Selection criteria for clinical trials for medication-resistant epilepsy are used to limit variability and to ensure safety. However, it has become more challenging to recruit subjects for trials. This study investigated the impact of each inclusion and exclusion criterion on medication-resistant epilepsy clinical trial recruitment at a large academic epilepsy center. We retrospectively identified all patients with medication-resistant focal or generalized onset epilepsy who attended an outpatient clinic over a consecutive 3-month period. We assessed each patient's eligibility for trials with commonly required inclusion and exclusion criteria to evaluate the proportion of eligible patients and the most common reasons for …

An 8-Week Peer Health Coaching Intervention Among College Students: A Pilot Randomized Study, Zi Yan, Jessica Cellucci, Juliana Cohen, Laura Kurdziel, Sarah Benes, Seungbin Oh, April Bowling

Health Sciences Faculty Publications

This study explored the effects of an 8-week peer coaching program on physical activity (PA), diet, sleep, social isolation, and mental health among college students in the United States. A total of 52 college students were recruited and randomized to the coaching (n = 28) or the control group (n = 24). The coaching group met with a trained peer health coach once a week for 8 weeks focusing on self-selected wellness domains. Coaching techniques included reflective listening, motivational interviews, and goal setting. The control group received a wellness handbook. PA, self-efficacy for eating healthy foods, quality of sleep, social …

Population Pharmacokinetics And Exposure–Response Analysis For The Phase 3 Cosmic-311 Trial Of Cabozantinib For Radioiodine-Refractory Differentiated Thyroid Cancer, Neang S. Ly, Jing Li, Raffaella Faggioni, Lorin K. Roskos, Marcia S Brose

Kimmel Cancer Center Faculty Papers

Background and Objective

In the USA, cabozantinib was approved for the treatment of patients aged ≥ 12 years with radioiodine-refractory differentiated thyroid cancer (DTC) who progressed on prior vascular endothelial growth factor (VEGFR)-targeted therapy based on the Phase 3 COSMIC-311 trial, which evaluated cabozantinib 60 mg/day versus placebo. Approved dosing is 60 mg/day for adults and for pediatric patients aged ≥ 12 years with body surface area (BSA) ≥ 1.2 m2, and 40 mg/day for pediatric patients aged ≥ 12 years with BSA < 1.2 m2. This report describes a population pharmacokinetic (PopPK) and exposure–response analysis of COSMIC-311.

Methods

A PopPK model was developed using concentration-time data from COSMIC-311 and 6 other cabozantinib studies. The …

Squamous Cell Carcinoma With Suspected Metastases To The Myocardial Wall As Evidenced By Contrast Transthoracic Echocardiogram., Trent Davidge, Shashitha Gavini, Thomas H. Fox, Mehnaz Rahman

School of Medicine Faculty Publications

American College of Cardiology Conference ACC.23, March 4 - 6, 2023, New Orleans, LA

A Case Of Bartonella Vinsonii Endocarditis Of Non-Native Pulmonic Valve In A Patient With Tetralogy Of Fallot., Emily Riley, Jesus C. Jaile Iv, Sergio Bartakian

School of Medicine Faculty Publications

American College of Cardiology Conference ACC.23, March 4 - 6, 2023, New Orleans, LA

Ablation Of Rare Accessory Pathway From Right Atrial Appendage Diverticulum To Anatomic Left Ventricle In Cc-Tga., Shree Lata Radhakrishnan, Robert Drutel, Cody Williams, Raman Danrad, Kelly Gajewski, Paul A. Lelorier

School of Medicine Faculty Publications

American College of Cardiology Conference ACC.23, March 4 - 6, 2023, New Orleans, LA

The New Solar Farms: Growing A Fertile Policy Environment For Agrivoltaics, Sarah Brunswick, Danika Marzillier

Minnesota Journal of Law, Science & Technology

No abstract provided.

Child Weight Status: The Role Of Feeding Styles And Highly Motivated Eating In Children, Maria A Papaioannou, Thomas G Power, Teresia M O'Connor, Jennifer O Fisher, Nilda E Micheli, Sheryl O Hughes

Children’s Nutrition Research Center Staff Publications

Although parental feeding plays an important role in child eating and weight status, high food motivation among children may also be a factor shaping how feeding impacts child weight. This study explored whether individual differences in preschool children’s food motivation interacted with mothers’ feeding styles in predicting subsequent child weight status. Participants included 129 Hispanic Head Start mother/child dyads. Data were collected at ages 4–5 years (Time 1) and 7–9 (Time 3). Staff measured heights/weights and observed children in an eating in the absence of hunger task. Mothers reported on feeding styles/practices and children’s eating behaviors. A principal components analysis …

An Exploration In Social And Emotional Health Of Vietnamese High School Students, Thien-Vu Giang, Van Son Huynh Prof., My-Hanh Mai

The Qualitative Report

Social and emotional health (SEH) aims to promote academic success and create school well-being. SEH has not been studied in Vietnam. This article focused on exploring the SEH of Vietnamese high school students because of the high-risk level in mental health that appeared in this group. The study was carried out using a qualitative case study approach to interviewing 74 students, 12 teachers, 7 school administrators, and 4 school counselors. We interpreted four features of SEH's expression of Vietnamese students: (1) Confident but lack of individual perspectives, (2) Respectful but lack of listening and empathy in school relationships, (3) Balanced …

Altruism In Medical Education: Assessing Attitudes Of Hospital In-Patients Towards Face-To-Face Contact With Medical Students During The Covid-19 Pandemic, Alison Gritzner, Thomas Scurr, Catharine Pearce, Lexy Sorrell, Georgina Dalton, Joseph Solola, David Derry

Peninsula Medical School

Abstract Background Limited research indicated patients were largely amenable to seeing medical students pre-pandemic. However, the COVID-19 pandemic has highlighted the potential risk of nosocomial transmission and harm to patients from students. Patient opinions regarding these risks remain unexplored, which impacts elicitation of informed consent. We aim to identify these, and explore whether reflection on the risks and benefits of direct student interaction influenced patients’ attitudes. For guidance, we further explored measures to reduce perceived infection risk. Method We designed an original questionnaire for a cross-sectional study, completed by 200 inpatients from 25 wards between 18/02 and 16/03/2022 at Derriford …

Resilience As A Moderator Of Role Overload And Sleep Disturbance Among Caregivers Of Persons With Dementia, Elliane Irani, Fei Wang, Stephanie Griggs, Ronald L. Hickman

Faculty Scholarship

The purpose of this study was to examine if resilience moderates the association between role overload and sleep disturbance among caregivers of persons with dementia. This was a secondary analysis of data on 437 informal caregivers (mean age=61.77 years, SD=13.69) of persons with dementia in the United States. Data from the 2017 wave of the National Study of Caregiving were analyzed using multiple regression with interaction terms to evaluate the moderation effect of resilience, while controlling for caregivers’ age, race, gender, education, self-rated health, caregiving hours, and primary caregiving status. Higher role overload was associated with greater sleep disturbance and …

Determinants Of Child Stunting, Wasting, And Underweight: Evidence From 2017 To 2018 Pakistan Demographic And Health Survey, Maryam Siddiqa, Gulzar H. Shah, Tilicia Mayo-Gamble, Amber Zubair

Health Policy & Community Health: Faculty Publications

Child malnutrition persists in low-resource countries such as Pakistan, indicating an urgent need for interventions and policies aimed to address this critical population health issue. The World Health Organization Global Target 2025 includes the reduction of malnourishment in the form of stunting, wasting, and low weight. This study aims to examine the prevalence of factors associated with three measures of child malnutrition, i.e., stunting, wasting, and low weight in Pakistan. This study uses a secondary data analysis design based on data from Pakistan Demographic and Health Survey (2017-18) that used a two-stage cluster sampling approach. National level data covering urban …

Clinically Adjudicated Reference Standards For Evaluation Of Infectious Diseases Diagnostics, Robin Patel, Ephraim L Tsalik, Scott Evans, Vance G Fowler, Sarah B Doernberg, Antibacterial Resistance Leadership Group

Faculty, Staff and Student Publications

Lack of a gold standard can present a challenge for evaluation of diagnostic test accuracy of some infectious diseases tests, particularly when the test's accuracy potentially exceeds that of its predecessors. This approach may measure agreement with an imperfect reference, rather than correctness, because the right answer is unknown. Solutions consist of multitest comparators, including those that involve a test under evaluation if multiple new tests are being evaluated together, using latent class modeling, and clinically adjudicated reference standards. Clinically adjudicated reference standards may be considered as comparator methods when no predefined test or composite of tests is sufficiently accurate; …

Torn Between The Real Me And The Social Me: Educated Women’S Perspectives Of Surviving Marital Abuse, Mayada A. Daibes, Reema R. Safadi

The Qualitative Report

The perspectives of educated women on surviving abusive marital relationships have not been adequately explored, thus implying a gap in the literature regarding the role of education in enhancing or mitigating the prevalence of intimate partner violence (IPV). In this context, the question is how do educated women perceive surviving abusive relationships? Interpretative Phenomenological Analysis (IPA), using flexible semi-structured face-to-face interviews, was conducted to understand the experiences of eight highly educated women (master’s, Ph.D.) in abusive marriage. Four superordinate interrelated themes were developed: (a) developing an awareness of self-respect generating role confusion, (b) being torn between traditions and ambitions, (c) …

Dorothy Jean Welch-Griggs

African American Funeral Programs

No abstract provided.

Politics Through Fashion: Jokowi, Semiotics, And The Age Of Social Media, Mawar Sharon Terang, I Ketut Putra Erawan, Anak Agung Sagung Mirah Mahaswari Jayant

Jurnal Wacana Politik

This study explores the complexity of Jokowi’s political fashion as a visual marker of status, identity, and political power, along with the digital technology advancement. The purpose of this article is to analysed details about Jokowi’s political power through fashion, which is related to five specific moments during the 2019 political campaign until his current leadership. The authors classified two typologies of clothing, including white and black shades of casual clothes and Indonesia’s traditional clothes. Roland Barthes’s semiotics theory and methods helps us to interpret series of symbols on Jokowi’s clothing. This is a qualitative research with document analysis procedure, …

The Role Of Ethical Principles In Ai Startups, James Bessen, Stephen Michael Impink, Robert Seamans

Faculty Scholarship

Do high-tech startups benefit from developing more ethical AI? AI startups implement policies and take actions to manage ethical issues associated with data collection, storage, and usage and adapt to the norms of their industry. This paper describes these startups' ethics-related actions, including ethical AI policy adoption, and examines how these actions relate to startup performance. We find that merely adopting an ethical AI policy (i.e., a less costly signal) does not relate to increased performance. However, there is evidence that investors reward startups that take more costly preventative pro-ethics actions, like seeking expert guidance, training employees about unconscious bias, …

Child Weight Status: The Role Of Feeding Styles And Highly Motivated Eating In Children, Maria A Papaioannou, Thomas G Power, Teresia M O'Connor, Jennifer O Fisher, Nilda E Micheli, Sheryl O Hughes

Faculty, Staff and Students Publications

Although parental feeding plays an important role in child eating and weight status, high food motivation among children may also be a factor shaping how feeding impacts child weight. This study explored whether individual differences in preschool children’s food motivation interacted with mothers’ feeding styles in predicting subsequent child weight status. Participants included 129 Hispanic Head Start mother/child dyads. Data were collected at ages 4–5 years (Time 1) and 7–9 (Time 3). Staff measured heights/weights and observed children in an eating in the absence of hunger task. Mothers reported on feeding styles/practices and children’s eating behaviors. A principal components analysis …

The Ipdgc/Gp2 Hackathon - An Open Science Event For Training In Data Science, Genomics, And Collaboration Using Parkinson's Disease Data, Hampton L Leonard, Ruqaya Murtadha, Alejandro Martinez-Carrasco, Alina Jama, Amica Corda Müller-Nedebock, Ana-Luisa Gil-Martinez, Anastasia Illarionova, Anni Moore, Bernabe I Bustos, Bharati Jadhav, Brook Huxford, Catherine Storm, Clodagh Towns, Dan Vitale, Devina Chetty, Eric Yu, Francis P Grenn, Gabriela Salazar, Geoffrey Rateau, Hirotaka Iwaki, Inas Elsayed, Isabelle Francesca Foote, Zuné Jansen Van Rensburg, Jonggeol Jeff Kim, Jie Yuan, Julie Lake, Kajsa Brolin, Konstantin Senkevich, Lesley Wu, Manuela M X Tan, María Teresa Periñán, Mary B Makarious, Michael Ta, Nikita Simone Pillay, Oswaldo Lorenzo Betancor, Paula R Reyes-Pérez, Pilar Alvarez Jerez, Prabhjyot Saini, Rami Al-Ouran, Ramiya Sivakumar, Raquel Real, Regina H Reynolds, Ruifneg Hu, Shameemah Abrahams, Shilpa C Rao, Tarek Antar, Thiago Peixoto Leal, Vassilena Iankova, William J Scotton, Yeajin Song, Andrew Singleton, Mike A Nalls, Sumit Dey, Sara Bandres-Ciga, Cornelis Blauwendraat, Alastair J Noyce, The International Parkinson Disease Genomics Consortium (Ipdgc) And The Global Parkinson’S Genetics Program (Gp2)

Faculty, Staff and Students Publications

Open science and collaboration are necessary to facilitate the advancement of Parkinson's disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of …

Consensus Recommendations For The Use Of Automated Insulin Delivery Technologies In Clinical Practice, Moshe Phillip, Revital Nimri, Richard M Bergenstal, Katharine Barnard-Kelly, Thomas Danne, Roman Hovorka, Boris P Kovatchev, Laurel H Messer, Christopher G Parkin, Louise Ambler-Osborn, Stephanie A Amiel, Lia Bally, Roy W Beck, Sarah Biester, Torben Biester, Julia E Blanchette, Emanuele Bosi, Charlotte K Boughton, Marc D Breton, Sue A Brown, Bruce A Buckingham, Albert Cai, Anders L Carlson, Jessica R Castle, Pratik Choudhary, Kelly L Close, Claudio Cobelli, Amy B Criego, Elizabeth Davis, Carine De Beaufort, Martin I De Bock, Daniel J Desalvo, J Hans Devries, Klemen Dovc, Francis J Doyle, Laya Ekhlaspour, Naama Fisch Shvalb, Gregory P Forlenza, Geraldine Gallen, Satish K Garg, Dana C Gershenoff, Linda A Gonder-Frederick, Ahmad Haidar, Sara Hartnell, Lutz Heinemann, Simon Heller, Irl B Hirsch, Korey K Hood, Diana Isaacs, David C Klonoff, Olga Kordonouri, Aaron Kowalski, Lori Laffel, Julia Lawton, Rayhan A Lal, Lalantha Leelarathna, David M Maahs, Helen R Murphy, Kirsten Nørgaard, David O'Neal, Sean Oser, Tamara Oser, Eric Renard, Michael C Riddell, David Rodbard, Steven J Russell, Desmond A Schatz, Viral N Shah, Jennifer L Sherr, Gregg D Simonson, R Paul Wadwa, Candice Ward, Stuart A Weinzimer, Emma G Wilmot, Tadej Battelino

Faculty, Staff and Students Publications

The significant and growing global prevalence of diabetes continues to challenge people with diabetes (PwD), healthcare providers, and payers. While maintaining near-normal glucose levels has been shown to prevent or delay the progression of the long-term complications of diabetes, a significant proportion of PwD are not attaining their glycemic goals. During the past 6 years, we have seen tremendous advances in automated insulin delivery (AID) technologies. Numerous randomized controlled trials and real-world studies have shown that the use of AID systems is safe and effective in helping PwD achieve their long-term glycemic goals while reducing hypoglycemia risk. Thus, AID systems …

E2: Equity And Excellence Framework, Adrienne Coleman

Professional Learning Day

Considering there is a national and global equity focused call to action, IMSA engaged in a process to institutionalize and operationalize Equity and Excellence to address educational inequities. This included policy development, capacity building to engage in equity work, an inclusive and comprehensive data collection methodology, data meaning making, as well as an equity and excellence plan and scorecard development. This presentation will provide participants with an understanding of educational equity, share tools to assist in drafting datainformed policy/plans, and provide a framework to score and measure progress in advancing equity. It will share how to approach equity and excellence …

Identifying And Strengthening Existing Support For Students On A Research To Publication Pathway, Connie James-Jenkin, Sowmya Anjur, Jean Bigger, Amberly Carter, Raven Mckelvin '24

Professional Learning Day

Participants will 1) learn how IMSA is generating and disseminating scholarship and incorporating students on a Research to Publication pathway, 2) discover classroom activities that support and promote an understanding of scientific inquiry and the nature of research, 3) discuss student work in IMSA’s repository and student portfolios, 4) hear how we are engaging and supporting our CLED students, like Raven McKelvin ’24, who will share her experience as an Intern and student liaison.

The Mathematics Of City Planning And Crisis Management, Patrick Young

Professional Learning Day

What if you managed a small city that was beset by severe weather and an influx of climate refugees? What types of math would your team need to employ to adapt your city to deal with these crises? Try some sample activities and gain access to an entire curriculum developed to integrate career awareness with middle school math standards.

Adolescent Pregnancy Prevention: How Cultural Components Play A Role In Programs Tailored For Minority Youth, Sarah B. Maness, Shristi Bhochhibhoya, Marshall Cheney

Journal of Health Disparities Research and Practice

Introduction: Cultural tailoring of adolescent pregnancy prevention programs has been utilized as a way to reduce persisting racial and ethnic disparities. This study explored how cultural components are included in evidence-based adolescent pregnancy prevention programs.

Methods: This study qualitatively assessed curricula of six federally supported evidence-based adolescent pregnancy prevention programs specifically tailored for African American and/or Hispanic youth. Patterns were analyzed within and between programs by two independent coders.

Results: Cultural components fell into five major themes: cultural art forms, traditions, history, community, and language. The most commonly included area was traditions (i.e. values, pride).

Conclusions: Variations exist in …

Diabetes Self-Management Support Program In Predominantly Hispanic Faith Community Settings: A Pilot Study, Leah Carrillo, Summer R. Wilmoth, Raymundo Mendoza, Ashton Balarin, Meixia Pan, Elena Martinez,, Erica T. Sosa, Zenong Yin, Sarah Ullevig, Meizi He

Journal of Health Disparities Research and Practice

Objectives: This study aimed to assess the feasibility, facilitators, barriers, and impact of adopting the Self-Management Resource Center Diabetes Self-Management Program (SMRC DSMP) on diabetes-related outcomes.

Methods: The SMRC DSMP was implemented in five churches in San Antonio, Texas. A single group pre-post-test design was used to evaluate program effect on improving T2D outcomes. The primary outcome was glycohemoglobin (HbA1c) and secondary outcomes included Self-Efficacy for Diabetes, health-related quality of life (HRQOL), and patterns of eating and physical activity. Program feasibility, facilitators, and barriers were assessed through documentation and in-person interviews with participants.

Results: A total of 96 participants were …

Associated Factors With Colorectal Cancer (Crc) Screening Awareness In The Black Belt Region Of Alabama: A Comparison Among Three Types Of Crc Screening, Hee Yun Lee, Yan Luo, Chiahung Chou, Mi Hwa Lee, Marion Bennett

Journal of Health Disparities Research and Practice

Objective: The present study aims to assess the levels of awareness of three types of CRC screening tests (FIT or FBOT, sigmoidoscopy, and colonoscopy) among African Americans living in the Black Belt area, and examine the factors associated with awareness of CRC screening tests among this population.

Methods: The current study utilized a survey research design. Univariate analysis was used to assess the awareness of three types of colorectal cancer screening: FIT or FOBT, sigmoidoscopy, and colonoscopy. Three sets of logistic regression analyses were conducted to examine the factors associated with the awareness level of each of the three colorectal …

Advancing Health Equity In The Us Military, James D. Mancuso, John Young, Jennifer Rusiecki, Shauna Stahlman, Natasha Schvey, Toya Randolph, Candy Wilson, Catherine Witkop, Patrick Hyde, Althea Green, Patcho Santiago, Donald Shell, Tracy Sbrocco

Journal of Health Disparities Research and Practice

Eliminating health disparities and achieving health equity are central to US national health objectives and the Military Health System’s “quadruple aim,” which has readiness as its core aim. Because military service members enjoy universal eligibility for health care, it is sometimes assumed that health disparities do not exist in the Department of Defense (DoD). However, while some studies have shown that disparities have been attenuated or eliminated in the DoD, others suggest that significant disparities remain. Reasons these disparities may remain include that universal eligibility for care does not necessarily result in equal to access to care, and that equal …

Recruitment Of Young Black Men Into Trauma And Mental Health Services Research: Recommendations And Lessons Learned, Alexandria G. Bauer, Jannette Y. Berkley-Patton

Journal of Health Disparities Research and Practice

Young Black/African American men are more likely to experience repeated trauma that escalates throughout young adulthood, compared to young White men. Exposure to trauma has impacts on mental health outcomes, but young Black men face substantial barriers to mental health care. In order to begin to address these disparities, it is imperative to increase understanding of the needs, preferences, and priorities of young Black men for mental health care services following trauma. Yet, young Black men are often underrepresented in mental health services research. The purpose of the current study was to describe strategies for recruitment of young Black men …

Beliefs About Race Differences In Pain Vs. Actual Race Differences In Pain: An Experimental Investigation., Lauren E. Mehok, Samantha M. Meints, Megan M. Miller, Leslie Ashburn-Nardo, Adam Hirsh

Journal of Health Disparities Research and Practice

Objective: Race differences in pain are consistently reported, but the underlying mechanisms are not well understood. This study examined how beliefs about race differences in pain are related to actual differences in experimentally induced pain between Black and White individuals.

Methods: Black and White participants completed questionnaires (demographics, pain-related beliefs, pain coping, and mood) and a cold pressor task (CPT) in the laboratory. Beliefs about race differences in pain were tested as potential moderators of the relationship between race and pain tolerance on a CPT.

Results: Participants reported beliefs that White people are more pain sensitive (i.e., less pain tolerant) …

Mastery Based Grading For Secondary Mathematics, Anderson Trimm

Professional Learning Day

Dr. Trimm will discuss in detail his design and implementation of a mastery grading system in calculus at IMSA and how it offers many benefits over traditional grading. Dr. Trimm will also explain how it makes creating assessments and grading easier and less work for the teacher, while being more accurate.