Digital Commons Network^™

Hawks' Herald -- Mar. 6, 2023, Roger Williams University

Hawk's Herald

No abstract provided.

"Sometimes You Have To Take The Person And Show Them How": Adapting Behavioral Activation For Peer Recovery Specialist-Delivery To Improve Methadone Treatment Retention, Mary B. Kleinman, Morgan S. Anvari, Valerie D. Bradley, Julia W. Felton, Annabelle M. Belcher, C. J. Seitz-Brown, Aaron D. Greenblatt, Dwayne Dean, Melanie Bennett, Jessica F. Magidson

Center for Health Policy and Health Services Research Articles

BACKGROUND: Despite efficacy of medication for opioid use disorder, low-income, ethno-racial minoritized populations often experience poor opioid use disorder treatment outcomes. Peer recovery specialists, individuals with lived experience of substance use and recovery, are well-positioned to engage hard-to-reach patients in treatment for opioid use disorder. Traditionally, peer recovery specialists have focused on bridging to care rather than delivering interventions. This study builds on research in other low-resource contexts that has explored peer delivery of evidence-based interventions, such as behavioral activation, to expand access to care.

METHODS: We sought feedback on the feasibility and acceptability of a peer recovery specialist-delivered behavioral …

Evaluation Of Risk Of Bias In Neuroimaging-Based Artificial Intelligence Models For Psychiatric Diagnosis: A Systematic Review, Zhiyi Chen, Xuerong Liu, Qingwu Yang, Yan-Jiang Wang, Kuan Miao, Zheng Gong, Yang Yu, Artemiy Leonov, Chunlei Liu, Zhengzhi Feng, Hu Chuan-Peng

Student Publications [Scholarly]

IMPORTANCE Neuroimaging-based artificial intelligence (AI) diagnostic models have proliferated in psychiatry. However, their clinical applicability and reporting quality (ie, feasibility) for clinical practice have not been systematically evaluated.

OBJECTIVE To systematically assess the risk of bias (ROB) and reporting quality of neuroimagingbased AI models for psychiatric diagnosis.

EVIDENCE REVIEW PubMed was searched for peer-reviewed, full-length articles published between January 1, 1990, and March 16, 2022. Studies aimed at developing or validating neuroimaging-based AI models for clinical diagnosis of psychiatric disorders were included. Reference lists were further searched for suitable original studies. Data extraction followed the CHARMS (Checklist for Critical Appraisal …

Mind The Message: Effects Of Persuasive Message Types And Image Valence On Cognition, Alyssa Harmon, Ashley Lopez Vargas, Emily Sorrells, Amanda Cloud

Research Horizons Day Posters

No abstract provided.

The Interplay Of Conflicting And Complementing Institutional Logics In Sustainability Practices, Ivana Milosevic, A. Erin Bass, Benjamin Schulte

Management Faculty Publications

The impact of institutional environments on sustainability is well documented in the international business literature. However, how multiple and occasionally conficting institutional logics shape sustainability as it is practiced by individuals across countries remains undertheorized. Our study contributes to this line of research by examining how multiple institutional logics inform the comprehension of sustainability practices in two high-hazard organizations in the Republic of Serbia and Canada. In doing so, our fndings explicate three multi-level mechanisms – pulling down (1st level), relating (2nd level), and aligning (2nd level) – through which individuals in these organizations across two countries construct a localized …

A Gene Regulatory Network Approach Harmonizes Genetic And Epigenetic Signals And Reveals Repurposable Drug Candidates For Multiple Sclerosis, Astrid M Manuel, Yulin Dai, Peilin Jia, Leorah A Freeman, Zhongming Zhao

Faculty, Staff and Student Publications

Multiple sclerosis (MS) is a complex dysimmune disorder of the central nervous system. Genome-wide association studies (GWAS) have identified 233 genetic variations associated with MS at the genome-wide significant level. Epigenetic studies have pinpointed differentially methylated CpG sites in MS patients. However, the interplay between genetic risk factors and epigenetic regulation remains elusive. Here, we employed a network model to integrate GWAS summary statistics of 14 802 MS cases and 26 703 controls with DNA methylation profiles from 140 MS cases and 139 controls and the human interactome. We identified differentially methylated genes by aggregating additive effects of differentially methylated …

Political Strategy Of Women’S Legislative Members Of The Republic Of Indonesia From National Mandate Party (Pan) And National Awakening Party (Pkb) In The 2019 General Elections, Suryani Suryani, Ana Sabhana Azmy

Jurnal Wacana Politik

Women have an important role in politics, where their representation becomes a role model for other women. PAN and PKB are the two parties that won quite a large number of votes in the 2019 elections. However, the percentage of elected women legislators from these two parties does not represent the fulfillment of the 30% quota. This paper analyzes the strategy for selecting women members of PAN and PKB in the 2019 elections, using qualitative research methods. Through interviews and literature searches in the form of books and journals as well as other supporting references, this research yielded several important …

Print And Online News Reviews During 2021 That Influence The Indonesian Democracy Index In Blitar City, Zainal Abidin Achmad, Syifa Syarifah Alamiyah, Agus Wahyudi, Dinda Rizki Anita

Jurnal Wacana Politik

This study aims to analyze news content in print and online media during 2021, which affects the Indonesian Democracy Index in Blitar City. The research subjects are news from January 1 to December 31, 2021, from the print media Radar Blitar and Memorandum, as well as online media from Bhirawa.com and Mayangkaranews.com. These four media have the highest number of readers in Blitar City. This study uses a qualitative method with a textual analysis approach and collects data through virtual searches, clippings, focus group discussions, and in-depth interviews. All Informants were determined based on the representation of the institutions contained …

Zooming In: Analyzing Annual Meeting Format Changes Amidst A Global Pandemic, Mark T. Wilhelm, Danielle Clifford

Washington and Lee Law Review Online

Beginning in March of 2020, public companies in the United States were forced to take unprecedented measures to observe corporate formalities while following the government-mandated health and safety measures resulting from the COVID-19 pandemic. Those measures made in-person activities and meetings either incredibly challenging or, in certain jurisdictions, illegal. Because “proxy season,” the time when public companies typically hold their annual meetings of stockholders, followed shortly after the mass implementation of COVID-19 lockdowns and quarantines, public companies that had historically held these meetings in-person were left scrambling to find an alternative means to meet. Nearly overnight, the pandemic caused an …

It Runs In The Family: Pincince Household Sends Seven Siblings To Unh, Keith Testa

UNH Today Archive

No abstract provided.

Contraception Use Among Individuals With Substance Use Disorder Increases Tenfold With Patient-Centered, Mobile Services: A Quasi-Experimental Study., Emily A. Hurley, Kathy Goggin, Kimberly Pina, Janelle R. Noel-Macdonnell Phd, Andrea Allen, Sarah Finocchario-Kessler, Melissa K. Miller

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Individuals with substance use disorders (SUD) have disproportionately high rates of unintended pregnancy. Reducing harm associated with this risk and its biopsychosocial consequences requires evidence-based, non-coercive interventions that ensure access to contraception for individuals who choose to prevent pregnancy. We examined feasibility and impact of SexHealth Mobile, a mobile unit-based intervention that aimed to increase access to patient-centered contraceptive care for individuals in SUD recovery programs.

METHODS: We conducted a quasi-experimental study (enhanced usual care [EUC] followed by intervention) at three recovery centers with participants (n = 98) at risk for unintended pregnancy. EUC participants were offered printed information …

Lo Bueno Y Lo Malo – Assessing Admissions Staff And Practices Supporting Undocumented Students At Illinois’ Four-Year Public Universities, Dave Marcial

Theses and Dissertations

Illinois has enacted legislative policies to provide access to higher education and state funding opportunities for undocumented students. Public Act 093-0007, Illinois RISE Act, and Illinois House Bill 3438 all have implications for Illinois four-year public universities and community colleges.

This dissertation focused on understanding the training, knowledge, and support of the admissions staff at all twelve public four-year universities. A survey was created with the assistance of content experts to gauge admissions staff institutional training and knowledge as it pertains to supporting undocumented students. Approximately 90 admissions staff were identified for the study and 57 participants responded from all …

Engaging Gen Z Through Humor, Wendy Gillis, Fred Pozin

AMTP Proceedings 2023

ABSTRACT

The current generation of undergraduate students in the classroom (Gen Z) is the loneliest generation in the U.S. (Twenge, 2017), and they know it. What are they spending time on? Their phones. What are they not spending time on? Time with friends (Twenge, 2017). Gen Z has more of a life online versus offline, yet Gen Z yearns for in-person interaction, and the pandemic has only made it worse. The authors’ advice? Tell a joke. By combining theories from psychology, management, and marketing, this conceptual paper explores the relationship between humor, trust, and persuasion.

Advertising Sports Nutrition Practices To Adolescent Athletes: A Poster Series, Emma Hansen

Honors Program: Senior Projects (Public)

Sports nutrition is an important aspect of an athlete’s training and improvement, yet it is often overlooked when it comes to younger competitors. Four posters were created with the intent of providing adolescent athletes, their parents, and their coaches with information about important topics in sports nutrition including a general overview of nutrition goals, hydration strategies, recovery nutrition, and nutritional considerations for vegetarian and vegan youth athletes. The posters were designed to appeal to adolescents from the ages of 13 to 18, and each poster covers its designated topic in detail appropriate for middle and high school-aged athletes. The accompanying …

Intouch Week Of March 6, 2023, New York Medical College

InTouch

• The Family Health Center Celebrates Three Years at NYMC
• NYMC and Union Community Health Center Partner for Clinical and Allied Health Profession Training Program
• NYMC Forms Academic Affiliation with St. Mary’s General Hospital and Saint Clare’s Hospitals

Proximate Composition, Retained Water, And Bacterial Load For Two Sizes Of Hybrid Catfish (Ictalurus Furcatus × Ictalurus Punctatus) Fillets At Different Process Steps, Manirul Haque, Juan L. Silva

Department of Food Science and Technology: Faculty Publications

The catfish processors in the US are required to state the maximum percentage of retained water content (RWC) on the product label. The objectives of our study were to quantify the RWC of processed hybrid catfish fillets from proximate composition and the bacterial load at different processing points. Water content was determined using oven-dry (AOAC950.46,1990) and Near-infrared (NIR) spectroscopy. Protein and fat content were determined by NIR spectrometer. Psychrotrophic (PPC) and Total Coliform (TCC) counts were enumerated using 3MPetrifilmTM. The fillets’ overall baseline water, protein, and fat content were 77.8, 16.7 and 5.7%, respectively. The RWC of final fresh and …

Risk Of Diabetic Retinopathy Between Sodium-Glucose Cotransporter-2 Inhibitors And Glucagon-Like Peptide-1 Receptor Agonists, Tzu-Yi Lin, Eugene Yu-Chuan Kang, Shih-Chieh Shao, Edward Chia-Cheng Lai, Sunir J. Garg, Kuan-Jen Chen, Je-Ho Kang, Wei-Chi Wu, Chi-Chun Lai, Yih-Shiou Hwang

Wills Eye Hospital Papers

BACKGROUND: To compare risk of diabetic retinopathy (DR) between patients taking sodium-glucose cotransporter-2 inhibitors (SGLT2is) and those taking glucagon-like peptide-1 receptor agonists (GLP1-RAs) in routine care.

METHODS: This retrospective cohort study emulating a target trial included patient data from the multi-institutional Chang Gung Research Database in Taiwan. Totally, 33,021 patients with type 2 diabetes mellitus using SGLT2is and GLP1-RAs between 2016 and 2019 were identified. 3,249 patients were excluded due to missing demographics, age <40 >years, prior use of any study drug, a diagnosis of retinal disorders, a history of receiving vitreoretinal procedure, no baseline glycosylated hemoglobin, or no follow-up data. …

West Farms Estates Company, L.P. V. Rodriguez

All Decisions

No abstract provided.

International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis – 2023, Sarah K. Wise, Cecelia C. Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Helene J. Krouse

School of Medicine Publications

Background

In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document.

Methods

ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus …

Ensuring Equitable Treatment For People Of Color Receiving Audiology Care, Isabel Guidotti, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Abstract 1- Introduction: As health care providers, serving patients equitably may require concurrent caring for the concerns and demands of family members as well. When striving to provide equitable care to patients of all backgrounds, familial participation throughout an appointment can play a substantial role. Case Presentation: An older adult male patient who used English as a second language presented with moderate, sloping to severe, mixed hearing loss, bilaterally. Hearing aid options were counseled and discussed in detail with the patient and his spouse. Discussion: The patient’s wife played an active role throughout the appointment and served as a valuable …

Paraquat, Parkinson's Disease, And Agnotology, Amit Ray, E. Ray Dorsey

Articles

This commentary examines the controversial relationship between paraquat, a widely used herbicide, and Parkinson's disease through the lens of agnotology—the deliberate production of ignorance for commercial gain. Despite numerous animal and epidemiological studies linking paraquat to Parkinson's disease, its use in the United States doubled from 2013 to 2018. The authors reveal how the manufacturer allegedly employed tactics similar to the tobacco industry, including attempts to discredit scientific researchers and suppress unfavorable findings. While over 30 countries have banned paraquat due to health risks, the EPA reauthorized its use in 2021. The paper argues that internal company documents and emerging …

Immortalized B Cells Transfected With Mrna Of Antigen Fused To Mitd (Ibmam): An Effective Tool For Antigen-Specific T-Cell Expansion And Tcr Validation, Zhe Wang, Tiantian Zhang, Aaron Anderson, Vincent Lee, Szymon Szymura, Zhenyuan Dong, Benjamin Kuang, Elizabeth Oh, Jingwei Liu, Sattva S Neelapu, Larry Kwak, Soung-Chul Cha

Faculty, Staff and Student Publications

Peripheral mononuclear blood cells (PBMCs) are the most widely used study materials for immunomonitoring and antigen-specific T-cell identification. However, limited patient PBMCs and low-frequency antigen-specific T cells remain as significant technical challenges. To address these limitations, we established a novel platform comprised of optimized HLA-matched immortalized B cells transfected with mRNA of a prototype viral or tumor antigen conjugated to MHC class-I trafficking domain protein (MITD) to increase the efficiency of epitope expression in antigen-presenting cells (APCs) essential to expanding antigen-specific T cells. When applied to CMV as a model, the IBMAM platform could successfully expand CMV-specific T cells from …

Mmu: 03/06/23–03/12/23, Student Bar Association

Monday Morning Update

This Week @ NDLS

Mass Times

Commons Daily Menu

General Announcements

NDLS Faculty & Staff Spotlights

1L of the Week: Jennifer Lee

2Ls Taking Ls: Kathleen Ryan

Ask a 3L: Matt Delfino

Sport Report by Stephen Nugent

Jackie's Corner

Child Care Investments And Policies In The Upper Valley, In The Pandemic And Beyond: “People Have To Hurry Because This Arpa Funding Isn’T Going To Last Forever”, Sarah Boege, Jess Carson, Kamala Nasirova

Carsey Publications

In this brief, the authors illustrate New Hampshire and Vermont’s different responses to supporting the early childhood education and care sector during the COVID-19 pandemic and examine the limited publicly available data on pandemic relief funds through the lens of the interstate Upper Valley region. While data limitations preclude the authors from identifying which child care pandemic relief programs worked best and for whom, the authors find spatial and program type differences in relief receipt. Using data from interviews with early childhood educators in the Upper Valley, the authors identify the role that temporary relief funds have played in keeping …

Phenotypic Plasticity In Circulating Tumor Cells Is Associated With Poor Response To Therapy In Metastatic Breast Cancer Patients, Evan N Cohen, Gitanjali Jayachandran, Hui Gao, Phillip Peabody, Heather B Mcbride, Franklin D Alvarez, Megumi Kai, Juhee Song, Yu Shen, Jie S Willey, Bora Lim, Vicente Valero, Naoto T Ueno, James M Reuben

Faculty, Staff and Student Publications

Circulating tumor cells (CTCs) are indicators of metastatic spread and progression. In a longitudinal, single-center trial of patients with metastatic breast cancer starting a new line of treatment, a microcavity array was used to enrich CTCs from 184 patients at up to 9 timepoints at 3-month intervals. CTCs were analyzed in parallel samples from the same blood draw by imaging and by gene expression profiling to capture CTC phenotypic plasticity. Enumeration of CTCs by image analysis relying primarily on epithelial markers from samples obtained before therapy or at 3-month follow-up identified the patients at the highest risk of progression. CTC …

Molecularly Targeted Therapy In Acute Myeloid Leukemia: Current Treatment Landscape And Mechanisms Of Response And Resistance, Curtis A Lachowiez, Courtney D Dinardo, Sanam Loghavi

Faculty, Staff and Student Publications

Treatment for acute myeloid leukemia (AML) has evolved rapidly over the last decade as improved understanding of cytogenetic and molecular drivers of leukemogenesis refined survival prognostication and enabled development of targeted therapeutics. Molecularly targeted therapies are now approved for the treatment of FLT3 and IDH1/2-mutated AML and additional molecularly and cellularly targeted therapeutics are in development for defined patient subgroups. Alongside these welcome therapeutic advancements, increased understanding of leukemic biology and treatment resistance has resulted in clinical trials investigating combinations of cytotoxic, cellular, and molecularly targeted therapeutics resulting in improved response and survival outcomes in patients with AML. Herein, …

Treatment Outcomes For Newly Diagnosed, Treatment-Naïve Tp53-Mutated Acute Myeloid Leukemia: A Systematic Review And Meta-Analysis, Naval G Daver, Shahed Iqbal, Camille Renard, Rebecca J Chan, Ken Hasegawa, Hao Hu, Preston Tse, Jiajun Yan, Michael J Zoratti, Feng Xie, Giridharan Ramsingh

Faculty, Staff and Student Publications

Background: TP53 mutations, which are present in 5% to 10% of patients with acute myeloid leukemia (AML), are associated with treatment resistance and poor outcomes. First-line therapies for TP53-mutated (TP53m) AML consist of intensive chemotherapy (IC), hypomethylating agents (HMA), or venetoclax combined with HMA (VEN + HMA).

Methods: We conducted a systematic review and meta-analysis to describe and compare treatment outcomes in newly diagnosed treatment-naïve patients with TP53m AML. Randomized controlled trials, single-arm trials, prospective observational studies, and retrospective studies were included that reported on complete remission (CR), CR with incomplete hematologic recovery (CRi), overall survival (OS), event-free survival (EFS), …

Microbiome Influencers Of Checkpoint Blockade-Associated Toxicity, Yinghong Wang, Robert R Jenq, Jennifer A Wargo, Stephanie S Watowich

Faculty, Staff and Student Publications

Immunotherapy has greatly improved cancer outcomes, yet variability in response and off-target tissue damage can occur with these treatments, including immune checkpoint inhibitors (ICIs). Multiple lines of evidence indicate the host microbiome influences ICI response and risk of immune-related adverse events (irAEs). As the microbiome is modifiable, these advances indicate the potential to manipulate microbiome components to increase ICI success. We discuss microbiome features associated with ICI response, with focus on bacterial taxa and potential immune mechanisms involved in irAEs, and the overall goal of driving novel approaches to manipulate the microbiome to improve ICI efficacy while avoiding irAE risk.

Qualification Of Hemophilia Treatment Centers To Enable Multi-Center Studies Of Gene Expression Signatures In Blood Cells From Pediatric Patients, Birgit M Reipert, Christoph J Hofbauer, Bagirath Gangadharan, Verena Berg, Elizabeth Donnachie, Shannon Meeks, Maria Elisa Mancuso, Joel Bowen, Deborah L Brown

Faculty, Staff and Student Publications

Hemophilia A is a rare congenital bleeding disorder caused by a deficiency of functionally active coagulation factor VIII (FVIII). Most patients with the severe form of the disease require FVIII replacement therapies, which are often associated with the development of neutralizing antibodies against FVIII. Why some patients develop neutralizing antibodies while others do not is not fully understood. Previously, we could demonstrate that the analysis of FVIII-induced gene expression signatures in peripheral blood mononuclear cells (PBMC) obtained from patients exposed to FVIII replacement therapies provides novel insights into underlying immune mechanisms regulating the development of different populations of FVIII-specific antibodies. …

Mechanosensitive Membrane Proteins: Usual And Unusual Suspects In Mediating Mechanotransduction, Miriam B Goodman, Elizabeth S Haswell, Valeria Vásquez

Faculty, Staff and Student Publications

This Viewpoint, which accompanies a Special Issue focusing on membrane mechanosensors, discusses unifying and unique features of both established and emerging mechanosensitive (MS) membrane proteins, their distribution across protein families and phyla, and current and future challenges in the study of these important proteins and their partners. MS membrane proteins are essential for tissue development, cellular motion, osmotic homeostasis, and sensing external and self-generated mechanical cues like those responsible for touch and proprioception. Though researchers' attention and this Viewpoint focus on a few famous ion channels that are considered the usual suspects as MS mechanosensors, we also discuss some of …