Digital Commons Network^™

Final 2021 Unreclaimed Sites Sampling Ur-40 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Integrated Transcriptomics Contrasts Fatty Acid Metabolism With Hypoxia Response In Β-Cell Subpopulations Associated With Glycemic Control, Mario A Miranda, Juan F Macias-Velasco, Heather Schmidt, Heather A Lawson

2020-Current year OA Pubs

BACKGROUND: Understanding how heterogeneous β-cell function impacts diabetes is imperative for therapy development. Standard single-cell RNA sequencing analysis illuminates some factors driving heterogeneity, but new strategies are required to enhance information capture.

RESULTS: We integrate pancreatic islet single-cell and bulk RNA sequencing data to identify β-cell subpopulations based on gene expression and characterize genetic networks associated with β-cell function in obese SM/J mice. We identify β-cell subpopulations associated with basal insulin secretion, hypoxia response, cell polarity, and stress response. Network analysis associates fatty acid metabolism and basal insulin secretion with hyperglycemic-obesity, while expression of Pdyn and hypoxia response is associated …

Single-Cell Rna Sequencing Reveals Immunosuppressive Myeloid Cell Diversity During Malignant Progression In A Murine Model Of Glioma, Sakthi Rajendran, Yang Hu, Alessandro Canella, Clayton Peterson, Amy Gross, Maren Cam, Matthew Nazzaro, Abigail Haffey, Akdes Serin-Harmanci, Rosario Distefano, Giovanni Nigita, Wesley Wang, Daniel Kreatsoulas, Zihai Li, Jesse A Sepeda, Andrew Sas, Mark E Hester, Katherine E Miller, Olivier Elemento, Ryan D Roberts, Eric C Holland, Ganesh Rao, Elaine R Mardis, Prajwal Rajappa

Faculty, Staff and Students Publications

Recent studies have shown the importance of the dynamic tumor microenvironment (TME) in high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate immunosuppression in glioma; however, it is still unclear if myeloid cells play a role in low-grade glioma (LGG) malignant progression. Here, we investigate the cellular heterogeneity of the TME using single-cell RNA sequencing in a murine glioma model that recapitulates the malignant progression of LGG to HGG. LGGs show increased infiltrating CD4+ and CD8+ T cells and natural killer (NK) cells in the TME, whereas HGGs abrogate this infiltration. Our study identifies distinct macrophage clusters in …

Pediatric Bowel Management Options And Organizational Aspects., Elizaveta Bokova, Wendy Jo Svetanoff, Marc Aaron Levitt, Rebecca M. Rentea

Manuscripts, Articles, Book Chapters and Other Papers

A bowel management program (BMP) to treat fecal incontinence and severe constipation is utilized for patients with anorectal malformations, Hirschsprung disease, spinal anomalies, and functional constipation, decreasing the rate of emergency department visits, and hospital admissions. This review is part of a manuscript series and focuses on updates in the use of antegrade flushes for bowel management, as well as organizational aspects, collaborative approach, telemedicine, the importance of family education, and one-year outcomes of the bowel management program. Implementation of a multidisciplinary program involving physicians, nurses, advanced practice providers, coordinators, psychologists, and social workers leads to rapid center growth and …

Anti-Inflammatory And Anti-Thrombogenic Properties Of Arterial Elastic Laminae, Jeremy Goldman, Shu Q. Liu, Brandon J. Tefft

Michigan Tech Publications, Part 1

Elastic laminae, an elastin-based, layered extracellular matrix structure in the media of arteries, can inhibit leukocyte adhesion and vascular smooth muscle cell proliferation and migration, exhibiting anti-inflammatory and anti-thrombogenic properties. These properties prevent inflammatory and thrombogenic activities in the arterial media, constituting a mechanism for the maintenance of the structural integrity of the arterial wall in vascular disorders. The biological basis for these properties is the elastin-induced activation of inhibitory signaling pathways, involving the inhibitory cell receptor signal regulatory protein α (SIRPα) and Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1). The activation of these molecules causes deactivation of …

Language: Its Origin And Ongoing Evolution, Ilia Markov, Kseniia Kharitonova, Elena L Grigorenko

Faculty, Staff and Students Publications

With the present paper, we sought to use research findings to illustrate the following thesis: the evolution of language follows the principles of human evolution. We argued that language does not exist for its own sake, it is one of a multitude of skills that developed to achieve a shared communicative goal, and all its features are reflective of this. Ongoing emerging language adaptations strive to better fit the present state of the human species. Theories of language have evolved from a single-modality to multimodal, from human-specific to usage-based and goal-driven. We proposed that language should be viewed as a …

Relationships Among Biochemical Measures In Children With Diabetic Ketoacidosis, Nicole S Glaser, Michael J Stoner, Maria Y Kwok, Kimberly S Quayle, Kathleen M Brown, Jeff E Schunk, Jennifer L Trainor, Julie K Mcmanemy, Leah Tzimenatos, Arleta Rewers, Lise E Nigrovic, Jonathan E Bennett, Sage R Myers, Mckenna Smith, T Charles Casper, Nathan Kuppermann

Faculty, Staff and Students Publications

OBJECTIVES: Investigating empirical relationships among laboratory measures in children with diabetic ketoacidosis (DKA) can provide insights into physiological alterations occurring during DKA. We determined whether alterations in laboratory measures during DKA conform to theoretical predictions.

METHODS: We used Pearson correlation statistics and linear regression to investigate correlations between blood glucose, electrolytes, pH and PCO2 at emergency department presentation in 1,681 pediatric DKA episodes. Among children with repeat DKA episodes, we also assessed correlations between laboratory measures at the first vs. second episode.

RESULTS: pH and bicarbonate levels were strongly correlated (r=0.64), however, pH and PCO2 were only loosely correlated (r=0.17). …

Projected Effects Of Climate Change On Marine Ecosystems In Southeast Asian Seas, Susan Kay, Arlene L Avillanosa, Vikki Cheung, Hung N Dao, Benjamin Jareta Gonzales, Herminie P Palla, Radisti A Praptiwi, Ana M Queirós, Sévrine F Sailley, Joel D C Sumeldan, Wan Mohd Syazwan, Amy Yee-Hui Then, Hin Boo Wee

School of Biological and Marine Sciences

No abstract provided.

Mfge8 Links Absorption Of Dietary Fatty Acids With Catabolism Of Enterocyte Lipid Stores Through Hnf4Γ-Dependent Transcription Of Ces Enzymes, Ritwik Datta, Mohammad A Gholampour, Christopher D Yang, Regan Volk, Sinan Lin, Michael J Podolsky, Thomas Arnold, Florian Rieder, Balyn W Zaro, Michael Verzi, Richard Lehner, Nada Abumrad, Carlos O Lizama, Kamran Atabai

2020-Current year OA Pubs

Enterocytes modulate the extent of postprandial lipemia by storing dietary fats in cytoplasmic lipid droplets (cLDs). We have previously shown that the integrin ligand MFGE8 links absorption of dietary fats with activation of triglyceride (TG) hydrolases that catabolize cLDs for chylomicron production. Here, we identify CES1D as the key hydrolase downstream of the MFGE8-αvβ5 integrin pathway that regulates catabolism of diet-derived cLDs. Mfge8 knockout (KO) enterocytes have reduced CES1D transcript and protein levels and reduced protein levels of the transcription factor HNF4γ. Both Ces1d and Hnf4γ KO mice have decreased enterocyte TG hydrolase activity coupled with retention of TG in …

Alzheimer's Disease Genetic Risk And Cognitive Reserve In Relationship To Long-Term Cognitive Trajectories Among Cognitively Normal Individuals, Corinne Pettigrew, John C Morris, Jason Hassenstab, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

BACKGROUND: Both Alzheimer's disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR index score modifies the relationship between AD genetic risk factors and long-term cognitive trajectories in a large sample of individuals with normal cognition.

METHODS: Analyses used data from the Preclinical AD Consortium, including harmonized data from 5 longitudinal cohort studies. Participants were cognitively normal at baseline (M baseline age = 64 years, 59% female) and underwent 10 years of follow-up, on average. AD genetic risk was measured by …

Median Nerve Stimulation For Treatment Of Tics: A 4-Week Open Trial With Ecological Momentary Assessment, Ann M Iverson, Amanda L Arbuckle, David Y Song, Emily C Bihun, Kevin J. Black

2020-Current year OA Pubs

Median nerve stimulation (MNS) at 10-12 Hz was recently proposed as a treatment for Tourette syndrome and other chronic tic disorders (TS/CTD). We report on 31 participants ages 15-64 with TS/CTD in an open-label, comparative (within-group, several time points) study of MNS (ClinicalTrials.gov registration number NCT05016765). Participants were recruited from completers of a randomized controlled trial (RCT) of MNS and were given a transcutaneous electrical nerve stimulation (TENS) unit to use as desired for 12 Hz MNS for 4 weeks. Participants were instructed to complete surveys regarding tic symptoms and stimulation discomfort before and after stimulation, as well as twice …

The Effect Of High Fraction Of Inspired Oxygen On Human Motor Learning Processes, Zheng Wang

LSU Doctoral Dissertations

Human motor learning processes are fundamental for our daily activities and can be adversely affected by neurologic conditions. Motor learning largely depends on successfully integrating cognitive and motor-related sensory information. A simple, easily accessible treatment that could enhance these learning processes would be exciting and clinically impactful. In this dissertation, we explore the effect of normobaric 100% oxygen treatment (NbOxTr) during different motor learning tasks and investigate the brain oxygenation changes during the process. In the visuomotor adaptation task (VMA), when participants adapted to a visual distortion between visual feedback and hand movements, participants with NbOxTr exhibited better movement planning …

Role Of Nod2 Receptor In Immune Response To Staphylococcus Aureus, Precious Mckenzie, Aparna Palakodeti Ph.D

Research Days

Staphylococcus aureus, a gram-positive, commensal bacterium, causes several opportunistic diseases and infections in humans. Furthermore, some strains of S.aureus have developed resistance to antibiotics such as methicillin and pose a health risk. Pattern Recognition Receptors (PRRs) on host immune cells recognize specific components of S.aureus cell wall and mount an immune response against the bacteria. One such PRR is the Nuclear Oligomerization Domain 2 (NOD2) receptor which is present in the cytosol of host immune cells. NOD2 recognizes Muramyl-Dipeptide (MDP), a component of the peptidoglycan cell wall of several bacteria including S. aureus. The binding of MDP to NOD2 allows …

From Space To The Streets: Leveraging Satellite Data For Air Pollution, Health, And Justice, Gaige Kerr

Sustainability Seminar Series

Ambient air disproportionately affects marginalized and minoritized communities in the United States. Satellite remote sensing provides crucial data needed to assess air pollution at a high spatial resolution and further understand the drivers, extent, and impacts of this form of environmental injustice. I provide a few vignettes to highlight how recent advances in remote sensing can inform and improve our understanding of environment health. First, satellite measurements and datasets that incorporate satellite data demonstrate the inequitable distribution of traffic-related pollutants such as nitrogen dioxide and fine particulate matter and how disparities have changed during recent years, including during the COVID-19 …

The Effects Of Joint Angle And Anchoring Scheme On Performance Fatigability And Neuromuscular Responses Following Isometric Forearm Flexion Tasks To Failure, Jocelyn E. Arnett, Robert W. Smith, Tyler J. Neltner, John Paul V. Anders, Dolores G. Ortega, Terry J. Housh, Richard J. Schmidt, Glen O. Johnson

Journal for Sports Neuroscience

Purpose: The purpose of this study was to examine the effects of joint angle on MVIC and neuromuscular responses at task failure following sustained, isometric forearm flexion tasks anchored to a rating of perceived exertion (RPE) of 8 (RPE = 8) and anchored to the initial torque that corresponded to RPE = 8 (TRQ). Methods: Ten women (age: 21.0 ± 2.8 yrs; height: 168.5 ± 7.2 cm; body mass: 68.0 ± 7.2 kg) performed 2, 3 s MVICs at joint angles (JA) of 75°, 100°, and 125° (randomized order) before and after sustained, isometric forearm flexion tasks to failure at …

Talk Debt To Me: An Applied Linguistics Approach To Exploring College Student Preferences For Student Loan Debt Letters, Zachary W. Taylor, Elizabeth A. Rainey, Chelseaia Charran, Gretchen Holthaus, Linda Eguiluz, Ada Horne, Myra Francisco, Karla Weber-Wandel

Journal of Student Financial Aid

Although student loan debt has been rigorously studied over the past several decades, scant research has investigated how institutions of higher education communicate debt to current and former student borrowers. As COVID-19 forced the United States Department of Education to cancel the Annual Student Loan Acknowledgement as part of a student’s signing of the master promissory note (MPN), there are no other mechanisms for students to be aware of their student loan debt beyond a debt letter from their institution or reviewing their National Student Loan Debt System (NSLDS) portal. This applied linguistics study surveyed 2,030 current student loan borrowers …

Indebted To My Education: Examining College Graduates’ Perceptions Of Student Loan Repayment, Vincent D. Carales, Mauricio Molina

Journal of Student Financial Aid

In this paper, we examine college graduates’ perceptions of entering student loan repayment and how they navigated this process. Findings highlight the importance of helping students make informed borrowing decisions, particularly as they begin repaying their student loan debt. Policy makers wishing to hold institutions accountable for keeping college affordable while enhancing financial aid policy will gain further insight.

An Assessment Of Effective Serials Management In Selected Academic Libraries In Niger State, Nigeria., Muhammad Kasim Bala, Yahaya Abdullahi Isah, Amina Ibrahim

Library Philosophy and Practice (e-journal)

This paper reports an examination of effective serials management practices in some academic libraries in Niger state. The study specifically investigated the types of serial materials in the libraries. It also examined the acquisition methods as well as methods applied in organizing serial materials in the studied libraries. Challenges bedeviling effective management of serial information sources also form the objective. The study further made a review from different sources on management of serials in libraries. The population of the study consisted of twenty three (23) staff manning the serials units of the affected libraries. Questionnaire and observation check-list were used …

De-Class-Ifying Microtargeted Political Advertising, Jacob Kovacs-Goodman

Fordham Law Voting Rights and Democracy Forum

In contemporary American politics, Big Tech companies provide sophisticated advertising interfaces that enable anyone to target specific voters by demographic. These companies defend their tools as “neutral” to evade culpability for discriminatory ads. Yet, such microtargeted advertising presents a significant threat to democracy. This Article advances a possible two-pronged solution to bar online platforms from targeting political ads based on a user’s protected class. First, this Article promotes a largely unexplored tactic: extending Title II of the Civil Rights Act into the digital space so that behavior that would be impermissibly discriminatory offline is not permitted online. Second, this Article …

A Constitutional Right To Early Voting, David Schultz

Fordham Law Voting Rights and Democracy Forum

Voting is a cost-benefit decision. Individuals are more likely to vote if the benefits of doing so outweigh the disadvantages. With early voting laws eased due to the COVID-19 pandemic, the 2020 election demonstrated that turnout increases when elected officials reduce voting costs. Despite all the benefits of early voting, there is no constitutional right, and it remains a privilege that state legislatures can revoke at will.

Since the 2020 election, state legislatures have proposed—and enacted—hundreds of bills to change voting rules. But with the intense partisan disagreement over voting, coupled with political polarization reaching an apex, these acts restricting …

Citizen Enforcement Laws Threaten Democracy, David A. Carrillo, Stephen M. Duvernay

Fordham Law Voting Rights and Democracy Forum

No abstract provided.

Teaching And Learning Interventions Designed To Improve Cultural Competence In Health Profession Students: A Systematic Review, Gloria Nkhoma, Chiao Xin Lim, Gerard A. Kennedy, Ieva Stupans

Internet Journal of Allied Health Sciences and Practice

Purpose: Developing healthcare profession students’ cultural competency knowledge, skills and attributes is critical to meet the needs of culturally and linguistically diverse healthcare service consumers. The purpose of this systematic review was to identify effective cultural competence interventions for healthcare profession students. Methods: A systematic review of peer reviewed articles published from 2010-2021 using PRISMA guidelines was conducted by searching CINAHL, EMBASE, ERIC, PubMed, and Psych INFO databases. Article quality was assessed using the Evaluation Tool for Quantitative Research and Mixed Method Appraisal Tool. Results: The initial search identified 2,261 potentially relevant studies, 41 studies met the inclusion criteria in …

Athletic Trainers Value The Intrinsic Rewards Of Specialty Certifications More Than Barriers And Extrinsic Rewards, Michael B. Hudson, Eva M. Frank, Taylor Harper, Lyndsey Comer, Kelsey Lamont

Internet Journal of Allied Health Sciences and Practice

Purpose: Health care professionals may earn specialty certifications to recognize their advanced knowledge and skills. Athletic training has implemented specialties; however, it is unclear what athletic trainers (ATs) know and perceive about specialty certifications. We developed a survey to examine the following issues: (1) analyze what ATs know about specialty certifications; (2) rank the rewards and barriers ATs perceive to be associated with earning/pursuing specialty certifications; and (3) examine differences in these findings based on ATs state practice acts being more restrictive or less restrictive. Method: We utilized a nonequivalent group, cross-sectional survey design and collected data for one month …

Taylor Mathematics Adds Data Science Major, Taylor University

2023 Website News Stories

No abstract provided.

Lanthorn, Vol. 57, No. 26, March 27, 2023, Grand Valley State University

Volume 57, August 1, 2022 - April 10, 2023

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

The Utah Statesman, March 27, 2023, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

2023-03-27_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Usa Archaeology Museum Newsletter - March 2023, Archaeology Museum

Archaeology Museum Newsletters

In this edition of the museum's newsletter:

• Alabama Archaeology Society Southwest Chapter Talks:

1. "Artifacts for Dummies"
2. "The Navajo Water Project & Chapter House Work"

• Movie in the Park: Indiana Jones and the Last Crusade, Thursday, April 6th

Exploring Generational Trauma, Delanie Patterson, Brooke Mann, Will Stutterheim

SACAD: Scholarly Activities

Generational trauma is still a relatively new field of study that has gained immense popularity with various researchers and the rest of society. There are several contributing factors to generational trauma being explored and examined so researchers can reduce the effects on both parents and offspring. Centers for Disease Control and Prevention [CDC] (2021) describes Adverse Childhood Experiences (ACEs) as trauma or a significant stressor that occurs during childhood, and trauma in itself significantly impacts families and individual functioning. It is essential to continue the research on generational trauma to help families create a healthier living environment and a better …

Queer Psycho And The He Circus: Applying Queering, Magic, And More-Than-Human Theories To Immersive Visual Story Worlds As An Antidote To Late Capitalism, Eleanor Dare, Dylan Yamada-Rice

School of Art, Design and Architecture

Abstract Two immersive visual story worlds (IVS), Queer Psycho and HE Circus, are at the center of this article, one made by each of us. Individually we found our works necessitated the development of new frameworks for IVS construction, namely (1) Brechtian a-effect and queering, and (2) magic and more-than-human theories. These new framings were needed to realize our desire to use IVS to create spaces of active resistance from psychological harm imposed by political and ableist structures designed with rigid ways of seeing the world through straight/neoliberal lenses. When both story worlds and their frameworks are viewed side-by-side, they …