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Penilaian Domain Pengkajian Paripurna Pasien Geriatri (P3g) Sebagai Faktor Yang Berpengaruh Terhadap Kejadian Pneumonia Nosokomial Pada Pasien Usia Lanjut Yang Dirawat Di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Hildebrand Hanoch Victor, Edy Rizal Wahyudi, C. Martin Rumende, C. H. Soejono, A. G. Rooshoeroe, Hamzah Shatri, Leonard Nainggolan, Cosphiadi Irawan

Jurnal Penyakit Dalam Indonesia

Introduction. Nosocomial pneumonia is a lung infection that occurs after the patient is hospitalized for more than 48 hours, without any signs of pulmonary infection at the time of treatment. When compared with young individuals, elderly individuals are more likely to have community-sourced and nosocomial infections with worse outcomes. Comprehensive Geriatric Assessment (CGA) domains are expected to explain the factors that contribute to nosocomial pneumonia in elderly patients. This study aimed to determine the proportion of elderly treated at Dr. Cipto Mangunkusumo National Central General Hospital who experienced nosocomial pneumonia and whether the CGA domains influence the occurrence of nosocomial …

Gambaran Risiko Post-Traumatic Stress Disorder (Ptsd) Pada Penyintas Covid-19 Di Rumah Sakit Universitas Andalas, Sri Wahyuni, Arina Widya Murni, Beni Indra, Rini Gusya Liza, Isnindiah Koerniati, Eldi Sauma

Jurnal Penyakit Dalam Indonesia

Introduction. The COVID-19 pandemic has a negative impact on life where sufferers can experience emotional problems such as despair, deep sadness, helplessness, anxiety, and depressive symptoms. Especially in hospitalized COVID-19 survivors, there are sequelae in the form of anxiety, depression, and Post-traumatic Stress Disorder (PTSD). PTSD experienced by COVID-19 survivors will affect the patient’s quality of life in the future. This study aimed to assess the risk of PTSD in COVID-19 survivors who had been hospitalized at Andalas University Hospital.

Methods. A cross-sectional descriptive study was conducted among COVID-19 survivors aged ≥15 years who had been hospitalized at Andalas University …

Modulasi Mikrobiota Untuk Memperbaiki Laju Filtrasi Glomerulus, Toksin Uremik, Dan Penanda Inflamasi Pada Gagal Ginjal Kronik: Telaah Sistematik Dan Meta-Analisis, Burhan Gunawan, Raymond Sebastian Purwata, Syarif Hidayat, Roy Akur Pandapotan, Jennifer Jennifer

Jurnal Penyakit Dalam Indonesia

Introduction. Dysbiosis microbiota is considered as one of the consequences and impacts of high uremic toxins in patients with Chronic Kidney Disease (CKD), which can lead to an increased risk of progression and mortality. The aim of this systematic review and meta-analysis was to perform quantitative effect of microbiota modulation for estimated Glomerular Filtration Rate (eGFR), uremic toxin (total-p cresyl/total pCS), and inflammatory marker (hs-CRP) outcome among CKD patients.

Methods. Article searches were conducted from PubMed, ScienceDirect, and Cochrane Library data sources from 2010-2022. Assessment of article quality follows the rules of PRISMA (Preferred Reporting Items in Systematic …

Efektivitas Ekstrak Strobilanthes Crispus Terhadap Kadar Glukosa Darah Puasa Dan Pasca Tes Toleransi Glukosa Oral Pada Rattus Norvegicus Diabetes Melitus, Alvin Gunawan, Laura Wihanto, Ari Christy Muliono

Jurnal Penyakit Dalam Indonesia

Introduction. The 2018 Riskesdas data shows that the prevalence of diabetes mellitus is increasing each year. Strobilanthes crispus leaves are known for lowering blood glucose levels. This study aimed to determine the difference in the effectiveness of S. crispus leaves ethanolic extract on fasting blood glucose (FBG) and post-oral glucose tolerance test (OGTT).

Methods. True experimental study using post-test only control group design and Rattus norvegicus as experimental animals. Rattus norvegicus were selected by random sampling which were then divided into 4 groups (K, P1, P2, P3), each group consisted of 5 animals. The animals were subsequently induced with diabetes …

Profilaksis Pasca Paparan Virus Hiv Pada Petugas Kesehatan, Teguh Harjono Karjadi

Jurnal Penyakit Dalam Indonesia

Health workers (HCWs) are prone to get infected by HIV infection when carrying out their duties. The injuries can be caused by needle sticks, sharp objects (scalpels, lancets, or other) that have been exposed to body fluids or splashes of body fluids onto the body’s mucosa (eyes, nose, mouth) and non-intact skin have the potential to transmit the HIV infection. Post-exposure transmission due to contamination of body fluids to health workers can be prevented by providing post-exposure prophylaxis therapy. Post-exposure prophylaxis (PEP) is given as soon as possible and no later than 72 hours after exposure. Prophylaxis is given to …

Vaksinasi Influenza Sebagai Prediktor Terjadinya Kejadian Rawat Inap Akibat Kejadian Kardiovaskular Pada Pasien Dengan Riwayat Penyakit Jantung Koroner: Suatu Laporan Kasus Berbasis Bukti, Sukamto Koesnoe, Alvin Johan, Widhi Dewanta, Nabilla Gita Ekanara, Muhammad Ikrar Hermanadi

Jurnal Penyakit Dalam Indonesia

Influenza is known to worsen cardiovascular events in patients with a history of coronary heart disease. However, the effectiveness of influenza vaccination in reducing hospitalization due to cardiovascular disease is not clearly known. We aim to determine the effect of influenza vaccination on hospitalization rates due to cardiovascular disease in patients with a history of coronary heart disease. Relevant literature was searched on four electronic databases: MEDLINE, EMBASE, SCOPUS, and Cochrane Library, using predetermined keywords. Critical review of the studies was done using the Center of Evidence Based Medicine (CEBM) University of Oxford assessment tool. The search yielded six articles, …

Substance Use Disorders And The Behavioral Effects Of Novel And Existing Compounds, Sarah Uribe

Theses and Dissertations

These investigations aimed to study the effects of experimental compounds for use in treating and preventing substance use disorders, particularly opioid use disorder (OUD) and alcohol use disorder (AUD). Identifying and testing potential medications for these two diseases is critical since current FDA-approved medications are only modestly effective, and addiction continues to spread. We previously demonstrated that co-administration of morphine and MP-III-024 produced synergistic effects in hot plate and von Frey assays. This study evaluated whether MP-III-024 also produced synergistic effects in behavioral tests sensitive to the side effects of morphine. Our findings suggest that co-administration of morphine and MP-III-024 …

Retraction, N. Kinoshita, M. Paul, Y. Kashiv, P. Collon, C. M. Deibel, B. Digiovine, J. P. Greene, C. L. Jiang, S. T. Marley, R. C. Pardo, K. E. Rehm, D. Robertson, R. Scott, C. Schmitt, X. D. Tang, R. Vondrasek, A. Yokoyama

Faculty Publications

No abstract provided.

Pandemics And The Protection Of Privacy And Personal Information: Issues Concerning The Restriction On The Right To Privacy In Emergencies, Fumio Shimpo

Japanese Society and Culture

This article focuses on issues which need to be considered in aiming to ensure both the effectiveness of infectious disease control measures and the protection of the right to privacy from the following perspectives.

(1) Issues regarding the restriction of the right to privacy in emergency situations, including (i) the types of measures taken in emergency situations and issues with respect to the restriction of the right to privacy in emergency situations, (ii) the normalisation, constancy and fixation of exceptional measures in emergency situations, (iii) dual-use and use for purposes different from those originally intended, (iv) acquisition of secondary information …

The Policy Of Plastic Waste Reduction: A Case Of Kanagawa Zero Plastic Waste Declaration, Yoshiyuki Nobusawa

Japanese Society and Culture

Marine plastics and microplastics become the global problem. In Japan the mandatory charge for a plastic bag was introduced as the plastic measure. Kanagawa Prefecture, located in Japan's metropolitan area, has implemented advanced plastic measures. Therefore, this paper considers Kanagawa zero plastic waste declaration and the efforts of local governments concurring with the approved. Therefore, this paper considers Kanagawa zero plastic waste declaration and the efforts of the local government approving．Kanagawa is divided into four areas: urban areas, coastal areas, inland, and mountainous region. This paper analyzes the method for zero plastic waste.

Essay On The Revitalization Of Local Communities, Hiroshi Saito

Japanese Society and Culture

It is difficult to theorize regional revitalization due to the differences in the characteristics of each local government. However, it may be possible to generalize its basic features: “regional management” and “financial surplus.” The problem of regional revitalization is conventionally discussed from a perspective of public administration. However, this paper reexamines the problem from a management theory perspective. Considering the starting point of regional revitalization is the surplus of public finances, attention is focused on the local tax law, especially on the importance of inhabitant tax, fixed property tax, and resident population policy. The paper also shows that the attraction …

March 31, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

New Census Data Reflect The Continuing Impact Of Covid On U.S. Demographic Trends, Kenneth M. Johnson

Carsey Publications

In this brief, Senior Demographer Kenneth Johnson reports that, according to recent Census Bureau estimates, the U.S. population has grown at the slowest rate in history in the past two years due to the impact of Covid. Deaths exceeded births in 75 percent of all U.S. counties, far more than at any point in the past. Most of the modest population gain was due to migration, and its extent varied along the rural-urban continuum. Looking ahead, the size and distribution of future population gains remain uncertain. As the impact of the pandemic wanes, the excess of births over deaths is …

Covid-19 Crisis: Shifting Educational Leadership Toward A New Normal - A Case Study, Emily C. R. Ellwood

Doctor of Education in Educational Leadership Dissertations

This study examines the lived experiences of educational leaders during the COVID-19 pandemic. Research has often pointed to the role of educational leadership and its relationship to the quality and well-being of a school’s culture and climate. Recently the coronavirus has created a crisis on a magnitude the world has never seen that has globally altered human interactions and created an educational new normal. Literature is quickly seeking to examine the impact on education, and while much of its effect is yet to be seen, this study advances the understanding of crisis leadership, distinct from crisis management, during the …

Teaching Behavioral Contingencies To Young Children With Asd Using Contingency Mapping, Marqueline Cenatus

USF Tampa Graduate Theses and Dissertations

Children with autism spectrum disorder (ASD) often exhibit problem behavior in schools, which negatively impacts their educational outcomes. Unfortunately, teachers continue to have difficulty addressing problem behavior in the classroom. Contingency mapping is a visual representation of the contingencies for engaging in a desired and undesired behaviors, which has been found to improve student behavior in the classroom setting. The current study examined the use of the contingency mapping intervention for young children with ASD. Specifically, the study examined the extent to which the contingency mapping intervention result in a decrease of off-task behavior during natural classroom activities. Three young …

Decellularized Heart Extracellular Matrix As A Biomimetic Substrate For Alleviating Hipsc-Cardiac Fibroblast Activation And Enhancing Isogenic Cardiac Organoids, Charles Kerr

MUSC Theses and Dissertations

Cardiovascular disease is the constant leading cause of death worldwide. While substantial efforts have been undertaken to improve disease outcomes, the lack of adequate human cardiac tissue models exacerbates research and development costs and clinical trial failures, hampering novel therapeutic discovery. To address this, human engineered cardiac microtissues composed of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) show potential in recapitulating hallmark qualities of natural human myocardium for novel therapeutic testing, disease modeling and cardiotoxicity screening. However, as these models are engineered in vitro, they are limited in their capacity to fully recapitulate myocardium and are vulnerable to influences …

The Minutes Of The Marshall University Graduate Council Meeting, March 31, 2023, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.

Development And Evaluation Of Interactive Computerized Training To Teach Practitioners To Implement Safety Skills Training, Rasha R. Baruni

USF Tampa Graduate Theses and Dissertations

Children can experience unintentional injuries due to safety threats found in their environments (Centers for Disease Control and Prevention, 2008). Researchers have shown that children can be taught safety responses using behavioral skills training (BST) and in situ training (IST). Within the safety skills literature, there is evidence that manualized interventions are effective for teaching parents and teachers to deliver BST (Gross et al., 2007; Novotny et al., 2020). An approach that has not been evaluated for teaching safety skills is interactive computerized training (ICT). The ICT approach employs technology to deliver trainings in the absence of a trainer (Gerencser …

Pamam- Cyclodextrin Conjugate Upregulates Brain-Derived Neurotropic Factor In Arpe-19 Cells, Gopika Ashokan

USF Tampa Graduate Theses and Dissertations

Background: Traumatic Brain Injury (TBI) is a major contributor to death and disability due to motorvehicle accidents, sports, physical abuse, and battlefield injuries. The primary insult to the brain leads to inflammation, vascular dysfunction, and oxidative stress in the brain as well as in the eye. This leads to loss of Retinal Ganglion Cells (RGCs) and downregulation of Brain derived Neurotopic Factor (BDNF). BDNF is a neurotrophic factor that binds to Tropomyosin Receptor Kinase B (TrkB) receptor to promote cell growth, survival, and differentiation. Current treatment strategies do not promote neuronal regeneration. Therefore, novel treatments are needed to restore vision …

Job Perspectives Of University Students Aspiring To Become Civil Servants Using Q Sort: Based On The 2020 Toyo University Student Survey, Masatoshi Minowa

Japanese Society and Culture

This study questioned what kind of gap in perceptions of work perspectives exists between current and aspiring civil servants in the first place, and whether there are differences in perceptions of work perspectives between students who aspire to become civil servants and those who aspire to work in the private sector. This was examined in an exploratory approach by using data from Q Sort, a Q methodology study, to capture the value perceptions surrounding work perspectives, particularly among students who aspire to become civil servants. The data compared were students aspiring to become civil servants, students aspiring to work in …

Development Of Regional Revitalization Policy By Roadside Stations: From Its Birth To A New Response In Post-Covid World, Ryusaku Matsuo

Japanese Society and Culture

The Roadside Station is expected to serve as the base facilities for the regional revitalization, with functions for rest, information transmission and regional alliance. In this study, the reason why the Roadside Station has developed as it is today examined from the social background and institutional characteristics, and future issues are considered. First, the institutional characteristics of Roadside Stations are theoretically examined, and the original system supporting them is examined and analyzed. The case analysis on the effort of Priority "Roadside Station" is carried out. Second, a case study is conducted on the new development of Roadside Stations, and the …

Analysis Of Factors Affecting Child Poverty Rates In Prefectures, Takahiro Suzuki, Kazutoshi Tanabe

Japanese Society and Culture

The Japanese government enacted the “[A1] "Act to Accelerate Policies for Disadvantaged Kids”" in 2013, in the face of a society where one in seven children are faced withare in financial difficulties. The enforcement of this law requiresd local governments to formulate and implement measures to address child poverty. However, it is evident that various factors have an impact on the child poverty rate, and the relative impact of these factors is not yet known yet. Consequently, local governments face[A2] there are many challenges in the implementing[A3] implementation of poverty-[A4] reduction measures by local governments. In …

Quarterly Report - 3rd Quarter, January 1 - March 31 2023, Etsu Foundation, East Tennessee State University

ETSU Foundation Quarterly Reports

No abstract provided.

Differential Contributions Of Glun2a- And Glun2b- Containing Nmda Receptors To Tissue Recovery After Sd, Jordan E. Weisend, C W. Shuttleworth

Brain & Behavioral Health Research Day

Spreading depolarizations (SDs) are now recognized as a principal source of excessive glutamate accumulation in stroke. It is not yet known whether different NMDA receptor (NMDAR) subtypes contribute to progression of SD or damaging effects of SD in vulnerable tissues. We examined possible contributions of GluN2A- and GluN2B-containing NMDARs to SDs in healthy and vulnerable tissues. Focal microinjection of KCl was used to initiate SDs in the hippocampal CA1 subregion of murine brain slices. Intrinsic optical signals (iOS) monitored SD propagation and tissue swelling. Extracellular potential changes (“DC shifts”) were used to examine prolonged depolarizations previously linked to neuronal injury. …

Peer Support Model To Address Substance Use Disorders Treatment Engagement In Rural Communities, Justine L. Saavedra, A S. Crisanti, Chole Caswell, Alyssa J. Jaramillo, Sttep Research Group

Brain & Behavioral Health Research Day

Background: New Mexico (NM) leads the nation in alcohol-related and drug overdose deaths. This project aims to implement and test a model of telehealth-substance use disorder (TH-SUD) treatment to reach underserved rural, Hispanic, and Native American (NA) populations in Sandoval, San Juan, McKinley, Cibola, Valencia, and Santa Fe Counties. The overall goal is to reduce the consequences of substance use in culturally relevant ways. Our population of focus is rural, Hispanic, and NA adult patients with an SUD presenting to the emergency department (ED) or inpatient units of the University of New Mexico Sandoval Regional Medical Center located in Sandoval …

The Rpl/Rps Gene Signature Of Melanoma Ctcs Associates With Brain Metastasis, Tetiana Bowley, I Lagutina, C Francis, S Sivakumar, R Solwyn, E Taylor, Yan Guo, Bridget N. Fahy, Bernard Tawfik, Dario Marchetti

Brain & Behavioral Health Research Day

Melanoma brain metastasis (MBM) is linked to poor prognosis and low overall survival. We hypothesized that melanoma circulating tumor cells (CTCs) possess a gene signature significantly expressed and associated with MBM. Employing a multi-pronged approach, we provide first-time evidence identifying a common CTC gene signature for ribosomal protein large/small subunits (RPL/RPS) which associate with MBM onset and progression. Experimental strategies involved capturing, transcriptional profiling and interrogating CTCs, either directly isolated from blood of melanoma patients at distinct stages of MBM progression or from CTC-driven MBM in experimental animals. Second, we developed the first Magnetic Resonance Imaging (MRI) CTC-derived MBM xenograft …

Prenatal Alcohol Exposure And Placental Insufficiency Result In Altered Dendritic Complexity In Medial Frontal Cortical Neurons In Adult Rat Offspring, Brooke R. Dunn, Nathanie G. Pavlik, Clement Jose, Jessie C. Newville, Suzy Davies, Daniel D. Savage, Jessie R. Maxwell

Brain & Behavioral Health Research Day

Prenatal Alcohol Exposure (PAE) results in deficits in executive functioning. PAE is also associated with placental abnormalities in function and perfusion, deemed placental insufficiency (PI). PI independently contributes to neurodevelopmental deficits. The impact on the combined effects of PAE and PI is unknown. We hypothesized that voluntary moderate PAE+PI would result in decreased neuronal complexity within the medial frontal cortex, a region critical to executive functioning, assessed through use of a three-dimensional (3D) Sholl analysis.

To establish a model of moderate PAE and PI, pregnant Long-Evans rats voluntarily drank 5% ethanol or saccharin water until embryonic day 18 (E18). On …

Guidance On Methadone For Opioid Use Disorder In Older Adults: Current Practices, M E. Dankoscik, S H. Patel, A Viszolay, E W. Green, C Smith, V Jacobsohn

Brain & Behavioral Health Research Day

Introduction: Opioid use disorder is highly prevalent and treatment is becoming more complex with the emergence of fentanyl. Methadone is a highly effective medication and full agonist of the opioid receptor allowing treatment of patients with high opioid tolerance. The proportion of adults over 65 is increasing and will rise to 77 million by 2034. In geriatric populations up to 50% of Medicare recipients take at least five medications a day. This polypharmacy and physiologic changes of metabolism puts this population at a higher risk of adverse events. In this study, we aim to determine the current practice of methadone …

Post-Error Adjustment Enhances Task-Positive Visual Processing, Mark Lavelle, James F. Cavanagh

Brain & Behavioral Health Research Day

Our ability to discern multiple, simultaneous latent processes during the exertion of control is limited by rudimentary combinations of manifest behavior. We hypothesized that EEG could provide unique evidence that control can simultaneously alter behavioral output (i.e. decision threshold) as well as sensory gain (i.e. drift rate). This study includes EEG data from 21 young adults who completed a Flankers task where the luminance of the stimuli varied trial-wise against a black background. Conflict was associated with lower drift and lower threshold, as well as increased frontal midline theta power. Controlling for these effects, lower drift rate and threshold were …

Emotional Faces And Working Memory In Children With High Autistic And Anxiety Traits, Teagan Mullins, Jeremy Hogeveen

Brain & Behavioral Health Research Day

While the impact of anxiety and autism on working memory has been investigated, conflicting findings have been reported. For both conditions, working memory has been reported to be intact, impaired, or improved, or variously modulated by other factors, including emotional content of stimuli, and neuroimaging findings have been varied. When looking at the combined effect of comorbidity, the picture is even less clear. Here, we determined whether a classic finding in the cognitive neuroscience of anxiety—increased salience and attention to negative emotional stimuli—varies across children who do or do not also have elevated autistic traits. Specifically, we used the Adolescent …