Digital Commons Network^™

Key Strategies For Preparing Your Students For The Next Gen Nclex®, Rhonda Lawes

Nursing Faculty Prep Webinars (Sigma and Lecturio)

As a nursing faculty member, you already know about the new NGN question formats. However, would you like to learn how to teach your students key strategies to help them succeed on these new types of questions? Let a veteran NCLEX® educator show you how you can best prepare your students for encountering case studies, bow-ties, and trend items. We are excited to invite you to an interactive and practical session that will equip you to prepare your students to face the NGN.

Communication Theory Analysis Of Coda Movie, Lindsay Casey

Honors Theses

This undergraduate honors thesis addresses how the hearing community views and treats the d/Deaf community. The contents of this thesis include a literature review, communication theory, and qualitative analysis of the film, CODA (2021). Findings leave the hearing community with three main suggestions to implement when interacting with the d/Deaf community. These suggestions include acknowledging the daily communication struggle amongst members of the d/Deaf community, maintenance in a conversation may lead to exploitation and finally, due to different speech codes we should enact cultural respect towards others.

The literature review consists of an overview of the d/Deaf community’s history including …

Inhibiting Effects Of Methyllycaconitine (Mla) On Pnu-282987 Induced Neurogenesis In Blast-Exposed Mouse Retinas, Nastia Zhiyew Chan

Honors Theses

Irreversible vision loss can be caused by retinal damage, disease, or aging. In recent years, the prevalence of ocular damage due to blast trauma has been increasing due to the modernization of warfare. Adult mammalian retinal neurons were previously thought to lack the capacity for regeneration to reverse vision loss, which deemed the effects of many ocular damages permanent. However, recent studies from this lab have shown that PNU-282987, an agonist to the alpha 7 subtype of neural nicotinic acetylcholine receptors, will result in neural regeneration in adult mammalian cells. For this research project, I will be using Methyllycaconitine (MLA), …

The Colby Echo (2023-04-13), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.

The Effect Of Callery Pear (Pyrus Calleryana) On Soil Macrofauna (Diplopoda And Oligochaeta), Joseph M. Mcgee

Biology Theses

Callery pear (Pyrus calleryana) is a relatively recent invader of North America. Its ecological effects are still being explored, including those affecting soil macrofauna such as millipedes (Diplopoda) and earthworms (Clitellata: Oligochaeta). These animals play important roles in many soil processes so understanding how they respond to invasive species is vital to soil health. A previous study exploring potential herbicide control was completed in 2019, however as of 2022 there are still treatment zones with little to no Callery pear alongside fully invaded plots, providing an optimal habitat mosaic for comparison. This allowed us to pursue two research …

Overview: Bias In-Bias Out In Data Science, Allison C. Augustus-Wallace

School of Medicine Faculty Publications

DiscoverBMB, March 25 - 28, 2023, Seattle, WA

Precision Medicine, Ancestry, Genetics And Race, Lucio Miele

School of Medicine Faculty Publications

DiscoverBMB, March 25 - 28, 2023, Seattle, WA

The Kenyon Collegian - April 13, 2023

The Kenyon Collegian

No abstract provided.

Benefits Of Probiotics In Autism Spectrum Disorders : A Meta-Analysis Of Rcts, Sharanabasayyaswamy B. Hiremath, Srinivas L. Devendrappa

Pharmacology and Clinical Pharmacy Research

Using probiotics as a pharmaceutical intervention is based on the fact that dysbiosis affects many people with autism spectrum disorders (ASD). This study aimed to quantify various probiotics’ overall and individualized benefits in treating ASD. Randomized or cross-over trials comparing the efficacy of placebo or active control vs. probiotics in patients of any age diagnosed with ASD based on DSM IV/V criteria were considered under inclusion criteria. An electronic database search in PUBMED and Cochrane Library was conducted using MeSH search terms “probiotics” AND “Autism.” Mean change in the total score of clinical parameters used to assess ASD symptom severity …

Hochberg, Herbert, Sophia Maier Garcia

Bronx Jewish History Project

Herbert Hochberg, born in 1930, spent the first 10 years of his life in economic hardship because of the Great Depression. Both his parents migrated from Western Ukraine and lived in the Bronx since their marriage in 1928. They took in an infant to make end’s meet, and after the war his father went into the business of building two-family homes in the Bronx, while his mother stayed at home. Hochberg grew up across from Bronx Park until 1939 when his family moved to the newly developed Northeast Bronx near Allerton Avenue and Pelham Parkway. He describes the area as …

Factors Influencing The Development Of Advanced Practice Nursing In Singapore, Madrean M. Schober

Dissertations

The development of advanced practice nursing (APN) roles has become a worldwide trend as healthcare planners explore innovative options for the provision of healthcare services. The integration of these new nursing roles presents a dynamic change for healthcare professionals and the systems in which they practice. Suitable policies should ideally support the inclusion of APN roles and their practice potential, however, a review of the literature found no evidence that demonstrated relevant policymaking, these policy processes and subsequent implementation of the intent of policy. The aim of the research was to investigate APN policy development from the beginning periods of …

Explicit Social And Emotional Learning In Elementary Education In The Post-Covid-19 Era, Mitch Mox

Masters Projects

The COVID-19 pandemic has exacerbated already dire situations in schools regarding students' social and emotional well-being. A growing body of research within the last five years supports the implementation of social emotional learning (SEL) in schools to better the academic and emotional growth of students, especially in the wake of a global pandemic that disrupted their social lives. Research not only suggests that students need increased exposure to explicit SEL curricula, but that states need to do more to educate districts and teachers on the importance of SEL. Additionally, studies suggest that districts need to develop ways of assessing and …

The Grizzly, April 13, 2023, Layla Halterman, Georgia Gardner, Marie Sykes, Erin Corcoran, Kate Horan, Samantha Kiessling, Laura Rothschild, Brian Tague, Katie Cressman

Ursinus College Grizzly Newspaper, 1978 to Present

Photo Essay: Spring Has Sprung! • Escape Velocity: "Avenge"[ance] in the Air • Ursinus Installs New Sustainable Rain Garden • GSA: Creating a Safe Space on Campus • Senior Honors Projects • Opinions: What Renovations Do You Want to See in Lower Wismer? • Playing Ball Like a Girl • "Raising the Bar": Ursinus College Women's Lacrosse Team

Editorial: Effects Of Radiation Therapies On Brain Metastases, Rupesh Kotecha, Minesh Mehta

All Publications

No abstract provided.

Pancreatic Cancer: Advances And Challenges, Christopher J Halbrook, Costas A Lyssiotis, Marina Pasca Di Magliano, Anirban Maitra

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche. In this review, we highlight the foundational studies that have driven our understanding of these processes. We further discuss the recent technological advances that continue to expand our understanding of PDAC complexity. We posit that the clinical translation of these research endeavors will enhance the currently dismal survival rate of this recalcitrant …

Targeting Of Epigenetic Co-Dependencies Enhances Anti-Aml Efficacy Of Menin Inhibitor In Aml With Mll1-R Or Mutant Npm1, Warren Fiskus, Christopher P Mill, Christine Birdwell, John A Davis, Kaberi Das, Steffen Boettcher, Tapan M Kadia, Courtney D Dinardo, Koichi Takahashi, Sanam Loghavi, Michael J Soth, Tim Heffernan, Gerard M Mcgeehan, Xinjia Ruan, Xiaoping Su, Christopher R Vakoc, Naval Daver, Kapil N Bhalla

Faculty, Staff and Student Publications

Monotherapy with Menin inhibitor (MI), e.g., SNDX-5613, induces clinical remissions in patients with relapsed/refractory AML harboring MLL1-r or mtNPM1, but most patients either fail to respond or eventually relapse. Utilizing single-cell RNA-Seq, ChiP-Seq, ATAC-Seq, RNA-Seq, RPPA, and mass cytometry (CyTOF) analyses, present pre-clinical studies elucidate gene-expression correlates of MI efficacy in AML cells harboring MLL1-r or mtNPM1. Notably, MI-mediated genome-wide, concordant, log2 fold-perturbations in ATAC-Seq and RNA-Seq peaks were observed at the loci of MLL-FP target genes, with upregulation of mRNAs associated with AML differentiation. MI treatment also reduced the number of AML cells expressing the stem/progenitor cell signature. A …

A Reduced Pancreatic Polypeptide Response Is Associated With New-Onset Pancreatogenic Diabetes Versus Type 2 Diabetes, Phil A Hart, Yogish C Kudva, Dhiraj Yadav, Dana K Andersen, Yisheng Li, Frederico G S Toledo, Fuchenchu Wang, Melena D Bellin, David Bradley, Randall E Brand, Kenneth Cusi, William Fisher, Kieren Mather, Walter G Park, Zeb Saeed, Robert V Considine, Sarah C Graham, Jo Ann Rinaudo, Jose Serrano, Mark O Goodarzi

Faculty, Staff and Student Publications

PURPOSE: Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polypeptide (PP) can differentiate these DM subtypes from type 2 DM (T2DM).

METHODS: Subjects with new-onset DM (<3 >years' duration) in the setting of PDAC (PDAC-DM, n = 28), CP (CP-DM, n = 38), or T2DM (n = 99) completed a standardized mixed meal tolerance test, then serum PP concentrations were subsequently measured at a central laboratory. Two-way comparisons of …

Targeting Mirnas And Other Non-Coding Rnas As A Therapeutic Approach: An Update, Emine Bayraktar, Recep Bayraktar, Hulya Oztatlici, Gabriel Lopez-Berestein, Paola Amero, Cristian Rodriguez-Aguayo

Faculty, Staff and Student Publications

Since the discovery of the first microRNAs (miRNAs, miRs), the understanding of miRNA biology has expanded substantially. miRNAs are involved and described as master regulators of the major hallmarks of cancer, including cell differentiation, proliferation, survival, the cell cycle, invasion, and metastasis. Experimental data indicate that cancer phenotypes can be modified by targeting miRNA expression, and because miRNAs act as tumor suppressors or oncogenes (oncomiRs), they have emerged as attractive tools and, more importantly, as a new class of targets for drug development in cancer therapeutics. With the use of miRNA mimics or molecules targeting miRNAs (i.e., small-molecule inhibitors such …

Experiential Exposure As The Key To Recruiting Medical Students Into Pathology, Ashley M. Holloman, Mary P. Berg, Bronwyn Bryant, Lisa Ross Dixson, Melissa R. George, Julie Katz Karp, Barbara E.C. Knollmann-Ritschel, Victor Gerardo Prieto, Charles F. Timmons, John Michael Childs, Amanda Lofgreen, Kristen Johnson, Cindy B. Mccloskey

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Medical student interest and pursuit of a career in pathology have been steadily declining since 2015. We conducted three separate surveys of medical students to better understand these trends. In our first survey, we focused on assessing U.S. allopathic medical students understanding and perceptions of pathology. We later surveyed U.S. osteopathic medical students as a companion to the allopathic medical student survey, in which many similarities were discovered with some key differences. In our final survey, we specifically looked at curriculum differences between the U.S. allopathic medical schools that graduate the most students who enter pathology training programs (Group 1) …

How Influential Are Medical School Curriculum And Other Medical School Characteristics In Students’ Selecting Pathology As A Specialty?, Cindy B. Mccloskey, Mark Brissette, John Michael Childs, Amanda Lofgreen, Kristen Johnson, Melissa R. George, Ashley M. Holloman, Bronwyn Bryant, Mary P. Berg, Lisa Ross Dixon, Julie Katz Karp, Barbara E.C. Knollmann-Ritschel, Victor Gerardo Prieto, Charles F. Timmons, Robert D. Hoffman

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

There has been a significant decline in the number of United States allopathic medical students matching to pathology residency programs. Data acquired from the American Association of Medical Colleges (AAMC) show sustained variation in the medical school production of students who go on to pathology residency. When divided into groups based on the medical school's historical volume of graduates entering pathology, the schools in groups labeled Group 1 and Group 2 produced significantly higher and lower proportions of pathology residents, respectively. This study aimed to identify what medical school curriculum elements and other medical school characteristics might explain the differences …

Navigating The Unfamiliar: The Lived Experience Of Elementary School Teachers As They Navigate The Use Of New Literacies During A Global Pandemic, Sydney Boyer

Theses and Dissertations

New literacies within schools is supported by both education policy and research; despite this, new literacies have yet to enter and transform the classroom. The COVID-19 pandemic offered an unprecedented opportunity to study teachers' experiences as they are required to navigate new literacies while teaching online. Therefore, the purpose of this phenomenological study was to explore the lived experience of three upper elementary school teachers as they navigated the use of new literacies in a Title I school during a global pandemic. Data sources included three in-depth interviews and were analyzed through a thematic approach. Data analysis resulted in identifying …

A Qualitative Exploration Of The Strategies Used By Patients And Nurses When Navigating A Standardised Care Programme, Dominic Roche, Aled Jones

School of Nursing and Midwifery

No abstract provided.

The Prescription Drug Monitoring Program In A Multifactorial Approach To The Opioid Crisis: Pdmp Data, Pennsylvania, 2016–2020, Jenna R. Adalbert, Amit Syal, Karan Varshney, Brandon George, Jeffrey Hom, Asif M. Ilyas

College of Population Health Faculty Papers

Background: Prescription opioids remain an important contributor to the United States opioid crisis and to the development of opioid use disorder for opioid-naïve individuals. Recent legislative actions, such as the implementation of state prescription drug monitoring programs (PDMPs), aim to reduce opioid morbidity and mortality through enhanced tracking and reporting of prescription data. The primary objective of our study was to describe the opioid prescribing trends in the state of Pennsylvania (PA) as recorded by the PA PDMP following legislative changes in reporting guidelines, and discuss the PDMP's role in a multifactorial approach to opioid harm reduction.

Methods: State-level opioid …

Butte Priority Soils Operable Unit (Bpsou) 2022 Final Insufficiently Reclaimed Sites Quality Assurance Project Plan (Qapp) And 2022 Final Unreclaimed Sites Qapp Request For Change, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Iowa Conference On Communicative Disorders [Program, 2023], Iowa Conference On Communicative Disorders

Iowa Conference on Communicative Disorders Programs

The Iowa Conference on Communicative Disorders provides continuing education activities in speech- language pathology that are acceptable to the State of Iowa and the American Speech-Language and Hearing Association. Areas of emphasis include adults and pediatrics.

Approval For: Berkeley Pit And Discharge Pilot Project, Quarterly Pilot Project Report, Third Quarter 2022, Dated December 23, 2022, Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Role Of Extracellular Vesicles In Cancer, Raghu Kalluri, Kathleen M Mcandrews

Faculty, Staff and Student Publications

Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent studies have identified EVs as key mediators of cell-cell communication via packaging and transfer of bioactive constituents to impact the biology and function of cancer cells and cells of the tumor microenvironment. Here, we review recent advances in understanding the functional contribution of EVs to cancer progression and metastasis, as cancer biomarkers, and the development of cancer therapeutics.

“You Feel A Sense Of Accomplishment”: Outdoor Adventure Experiences Of Youths With Visual Impairments During A One-Week Sports Camp, Lauren J. Lieberman, Katie Ericson, Melanie Perreault, Pamela Beach, Kelsey Williams

Department of Special Education and Communication Disorders: Faculty Publications

There are many cognitive, physical, and social–emotional benefits for youths from participating in outdoor adventure activities. However, youths with visual impairments are not given the same opportunities to participate in outdoor adventure activities as their peers without disabilities. The purpose of this study was to examine the outdoor adventure experiences of youths with visual impairments participating in a week-long sports camp. Thirty-seven youths with visual impairment (ages 9–19 years) attending a one-week sports camp participated in this study. Participants engaged in a variety of outdoor adventure activities throughout the week of camp (e.g., sailing, hiking, rock climbing, biking, kayaking). Participants …

Diego Beekman Mutual Housing Association Housing Development Fund Corp. V. Larkins

All Decisions

ERAP Case.

Low And Differential Polygenic Score Generalizability Among African Populations Due Largely To Genetic Diversity, Lerato Majara, Allan Kalungi, Nastassja Koen, Kristin Tsuo, Ying Wang, Rahul Gupta, Lethukuthula L Nkambule, Heather Zar, Dan J Stein, Eugene Kinyanda, Elizabeth G Atkinson, Alicia R Martin

Faculty, Staff and Students Publications

African populations are vastly underrepresented in genetic studies but have the most genetic variation and face wide-ranging environmental exposures globally. Because systematic evaluations of genetic prediction had not yet been conducted in ancestries that span African diversity, we calculated polygenic risk scores (PRSs) in simulations across Africa and in empirical data from South Africa, Uganda, and the United Kingdom to better understand the generalizability of genetic studies. PRS accuracy improves with ancestry-matched discovery cohorts more than from ancestry-mismatched studies. Within ancestrally and ethnically diverse South African individuals, we find that PRS accuracy is low for all traits but varies across …