Digital Commons Network^™

Serinc5 Restricts Hiv Membrane Fusion By Altering Lipid Order And Heterogeneity In The Viral Membrane, Amanda E Ward, Daria Sokovikova, Melvin Neal Waxham, Frederick A Heberle, Ilya Levental, Kandice R Levental, Volker Kiessling, Judith M White, Lukas K Tamm

Faculty, Staff and Student Publications

The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their infection by an incompletely understood mechanism. We have previously reported that Serinc5 but not its paralogue, Serinc2, blocks HIV cell entry by membrane fusion, specifically by inhibiting fusion pore formation and dilation. A body of work suggests that Serinc5 may alter the conformation and clustering of the HIV fusion protein, Env. To contribute an additional perspective to the developing model of Serinc5 restriction, we assessed Serinc2 and Serinc5's effects on HIV pseudoviral membranes. By measuring pseudoviral membrane thickness via cryo-electron microscopy and order via the fluorescent dye, …

Methodological Guidelines For Focus Groups With Children From Developing Regions, María J. Peñaherrera-Vélez, Angélica Ochoa Avilés Phd, Nancy Arpi, Elisabeth Rodas, Gabriela Zúñiga, Elena Jerves

The Qualitative Report

Qualitative research with children has gained recognition in recent years. Nevertheless, special considerations should be analyzed before conducting focus groups with children from developing countries where methodological guidelines are scarce. This article provides methodological guidelines for conducting focus groups with children from developing countries based on an extensive literature review and our experience in urban and rural areas in Ecuador. Peculiarities of urban and rural contexts are highlighted, and child-friendly strategies are proposed. We conclude that focus groups can be conducted successfully with urban and rural children from low-and-middle-income countries if their specific circumstances, such as language and cultural diversity, …

Do Automated Legal Threats Reduce Freedom Of Expression Online? Results From A Natural Experiment, J. Nathan Matias, Merry Ember Mou, Jonathon W. Penney, Maximilian Klein, Lucas Wright

All Papers

Automated law enforcement systems support privately-operated enforcement bots to take legal action in hundreds of millions of cases a year. In the area of copyright, legal scholars have hypothesized the existence of “chilling effects” that harm public discourse by influencing people to self-censor protected speech. We test this hypothesis in a large-scale quasi-experiment with 9,818 accounts on Twitter that made 5,171,111 tweets. In a confirmatory interrupted time-series analysis, we find evidence that people reduce how much they post online after receiving a take-down notice from a copyright enforcement bot. On average, accounts sent fewer tweets after enforcement (p<0.001). Accounts also changed from a daily increase in public tweets to a decline on average (p<0.001). We also report on novel software that conducts third-party monitoring of the behavioral outcomes of automated law-enforcement systems. Since automated law enforcement can influence public discourse, third-party monitoring like this report will be essential to governing the power of enforcement algorithms in society.

Facing Famine: Justice And The Case Of Unilateral Intervention, Tanner R. Brooks

Honors Theses

Through the course of this year, 900 thousand people will have to struggle through conditions of famine, and a total of 345.2 million will experience food insecurity of some kind. These concerning figures represent an over twofold increase since 2020.1 This presents a serious problem, as access to food is so plainly vital to every aspect of an individual’s existence. It should therefore be uncontroversial to assert the grave nature of the occurrence of famine and other food emergencies faced by so many today. Food emergencies are not merely a result of insufficient food, but rather the institutional policies enacted …

Considering The Social-Emotional Well-Being Of Multilingual Learners: A Comparative Case Study Across Program Models, Amy J. Heineke, Elizabeth M. Vera, Wenjin Guo, Joseph Kaye, Joseph Elliott

Education: School of Education Faculty Publications and Other Works

This multiple-case study probes the social-emotional well-being of elementary and middle-grade students labeled as English learners who were enrolled in different bilingual program models in the midwestern United States. Using ecological systems theory, this qualitative study probes students’ social-emotional well-being across schools and within different bilingual program models, seeking to determine the structures and practices that nurture positive facets or perpetuate negative facets of student well-being. Findings indicate that interactions with peers and adults in schools influence students’ social-emotional well-being, with program-model variations, community demographics, and societal discourse shaping these in-school experiences, relationships, and sentiments. Implications center on critical consideration …

Soil Nutrient And Invertase-Producing Bacteria Relation Impact On Cilembu Sweet Potato (Ipomoea Batatas L.) Growth: A Study Based On Upland And Wetland Cultivation In Cilembu Village Sumedang District, Eso Solihin, Syaiful Anwar, Dwi Andreas Santoso, Budi Nugroho, Purwono, Rija Sudirja, Haris Maulana, Nadia Nuraniya Kamaluddin, Agung Karuniawan

Jurnal Kultivasi

Environment is one important factors that must be considered in supporting sweet potato productivity. Environmental factors can be biotic and abiotic, including the availability of nutrients and microbes in the soil. This study aimed to identify the nutrient content of the soil in paddy fields and dry fields, identify the total invertase microorganisms in paddy fields and dry fields, and identify the relationship between soil nutrients and microorganisms during the growth of Cilembu sweet potato in dry and paddy fields agroecosystems. This research was conducted on dry fields and paddy fields in Cilembu Village, Sumedang Regency. The experimental design used …

Atherosclerotic Plaque In Individuals Without Known Cardiovascular Disease But With Established Obstructive Sleep Apnea And At High Risk Of Obstructive Sleep Apnea, Harneet Walia, Atulya Khosla, Anshul Saxena, Shozab Ali, Theodore Feldman, Jonathan Fialkow, Khurram Nasir

All Publications

Objectives: In a large U.S. cohort free of CVD evaluated by coronary computed CT angiography, we aimed to assess the association between established / high risk of Obstructive Sleep Apnea (OSA) and coronary plaque.

Background: There are limited data available depicting the association between established / high risk of OSA and the presence of coronary plaque in a population-based sample free from CVD.

Methods: Cross-sectional data from 2359 participants enrolled in the Miami Heart Study (MiHeart) who underwent coronary CT angiography was used for this study. The Berlin questionnaire was used to stratify patients as having high or low risk …

27th Annual Alumni Awards Dinner, Black Law Students Association

Student Organizations

APRIL 14, 2023

Sleep Apnea And Substance Use Disorders Associated With Co-Occurrence Of Anxiety Disorder And Depression Among U.S. Adults: Findings From The Nsduh 2008–2014, Chun Xu, Priscila Acevedo, Liang Wang, Nianyang Wang, Kaysie Ozuna, Saima Shafique, Annu Karithara, Victoria I. Padilla, Chunxiang Mao, Xin Xie, Kesheng Wang

Health & Biomedical Sciences Faculty Publications

Few studies have focused on sleep apnea and substance use disorders with co-occurrence of anxiety disorder and depression. This study included a total of 270,227 adults, 9268 with co-occurrence of anxiety disorder and depression in the past year, from the combined 2008–2014 National Survey on Drug Use and Health (NSDUH) data, which are the latest datasets with measures of anxiety disorder and sleep apnea. Weighted multinomial logistic regression analyses were used to estimate the associations between anxiety disorder and depression and their co-occurrence. Comorbidity was highly prevalent: 40.4% of those with depression also met the criteria for anxiety disorder, whereas …

Exploring The Impact Of School Connectedness On Students’ Mental Health And Academic Achievement, Matthew Scott Posthuma

Masters Projects

Abstract

Research and relevant literature have shown that school connectedness is not only associated with but has a profound impact on students’ mental health and academic achievement. School connectedness is a factor that can be influenced directly by the school environment and by interventions aimed at helping students that take place during school. School counselors carry out many of these interventions and have a responsibility to promote safe and protective environments for all students. Through the use of data and screening tools, school counselors are able to identify students that could benefit from participating in interventions. Interventions regarding school connectedness …

Development Of An Advanced Practice Provider Diagnostic Clinic Within An Oncology Practice, Abigail Jean Voss

Masters Projects

Background: The process of diagnosing cancer and the time to treatment can influence a patient’s experience with diagnosis of cancer at a later stage being associated with poorer cancer outcomes and decreased quality of life post-treatment. With increasingly complex oncologic imaging and pathology findings, effective interventions for early diagnosis of cancer requires a cohesive approach including referral, diagnosis, staging, and treatment phases. Objectives: The aim of this article is to outline the program development efforts initiated to apply current literature findings and organizational assessment to create a program development toolkit and business plan for an Advanced Practice Provider …

Longitudinal Variations In Antibody Responses Against Sars-Cov-2 Spike Epitopes Upon Serial Vaccinations, Dicle Yalcin, Sydney J. Bennett, Jared Sheehan, Amber J. Trauth, For Yue Tso, John T. West, Michael E. Hagensee, Alistair J. Ramsay, Charles Wood

LSU-LCMC Cancer Center Faculty Publications

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impacted healthcare, the workforce, and worldwide socioeconomics. Multi-dose mono- or bivalent mRNA vaccine regimens have shown high efficacy in protection against SARS-CoV-2 and its emerging variants with varying degrees of efficacy. Amino acid changes, primarily in the receptor-binding domain (RBD), result in selection for viral infectivity, disease severity, and immune evasion. Therefore, many studies have centered around neutralizing antibodies that target the RBD and their generation achieved through infection or vaccination. Here, we conducted a unique longitudinal study, analyzing the effects of a three-dose mRNA vaccine regimen …

Residential Metals Abatement Program Investigation Summary Report (Non-Residential Parcels – Indoor Dust) Emerson Elementary School, Environmental Resource Management (Erm)

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

An Evaluation Of The Effectiveness Of Innovation Ecosystems In Facilitating The Adoption Of Sustainable Entrepreneurship, Dana Sami Bakry

Dissertations and Theses

Sustainable entrepreneurship has a substantial role of a steadily growing economy and advanced industrial economies. Several strategies have been formed and employed to support the adoption of innovation and technologies in the sustainable entrepreneurship sector. However, the successful outcome of these strategies in achieving their goals depends on how effective they are in satisfying their objectives and thus increasing innovation adoption. One measurement for effectiveness of ecosystem implements can be their support to the input of the process of innovation and technologies adoption and their impact on satisfying regional goals.

The objective of this research is evaluating the effectiveness of …

Feature Selection For Support Vector Regression Using A Genetic Algorithm, Shannon B Mckearnan, David M Vock, G Elisabeta Marai, Guadalupe Canahuate, Clifton D Fuller, Julian Wolfson

Faculty, Staff and Student Publications

Support vector regression (SVR) is particularly beneficial when the outcome and predictors are nonlinearly related. However, when many covariates are available, the method's flexibility can lead to overfitting and an overall loss in predictive accuracy. To overcome this drawback, we develop a feature selection method for SVR based on a genetic algorithm that iteratively searches across potential subsets of covariates to find those that yield the best performance according to a user-defined fitness function. We evaluate the performance of our feature selection method for SVR, comparing it to alternate methods including LASSO and random forest, in a simulation study. We …

Contribution Of Glaciers To Water, Energy And Food Security In Mountain Regions: Current Perspectives And Future Priorities, C Clason, S Rangecroft, Pn Owens, E Łokas, G Baccolo, N Selmes, D Beard, J Kitch, Rm Dextre, S Morera, W Blake

School of Geography, Earth and Environmental Sciences

Mountain glaciers are crucial sources of fresh water, contributing directly and indirectly to water, energy and food supplies for hundreds of millions of people. Assessing the impact of diminishing glacial meltwater contributions to the security of this resource is critical as we seek to manage and adapt to changing freshwater dynamics in a warming world. Both water quantity and quality influence water (in)security, so understanding the fluxes of water, sediment and contaminants through glacial and proglacial systems is required for holistic assessment of meltwater contribution to downstream resource security. In this paper we consider the socio-environmental role of and pressures …

Phase Ii Study Of Palbociclib (Pd-0332991) In Ccnd1, 2, Or 3 Amplification: Results From The Nci-Match Ecog-Acrin Trial (Eay131) Subprotocol Z1b, Amy S Clark, Fangxin Hong, Richard S Finn, Angela M Demichele, Edith P. Mitchell, James Zwiebel, Fernanda I Arnaldez, Robert J Gray, Victoria Wang, Lisa M Mcshane, Larry V Rubinstein, David Patton, P Mickey Williams, Stanley R Hamilton, Mehmet S Copur, Samer S Kasbari, Ravneet Thind, Barbara A Conley, Carlos L Arteaga, Peter J O'Dwyer, Lyndsay N Harris, Alice P Chen, Keith T Flaherty

Department of Medical Oncology Faculty Papers

Purpose: Cyclin D/CDK4/6 is critical in controlling the G1 to S checkpoint. CCND, the gene encoding cyclin D, is known to be amplified in a variety of solid tumors. Palbociclib is an oral CDK4/6 inhibitor, approved in advanced breast cancer in combination with endocrine therapy. We explored the efficacy of palbociclib in patients with nonbreast solid tumors containing an amplification in CCND1, 2, or 3.

Patients and methods: Patients with tumors containing a CCND1, 2, or 3 amplification and expression of the retinoblastoma protein were assigned to subprotocol Z1B and received palbociclib 125 mg once daily for 21 days of …

Herbicide Drift Vs. Crop Resilience – The Influence Of Micro-Rates, Milan Brankov, Bruno Canella Vieira, Miloš Rajković, Milena Simić, Vukadinović Jelena, Violeta Mandić, Vesna Dragičević

Department of Agronomy and Horticulture: Faculty Publications

A greenhouse study was conducted to test the effects of low herbicide dose exposure on different crops measuring visible damages, plant height, leaf area, and dry matter. Seven crops were tested: lettuce (Lactuca sativa L.) cv. Novosadska majska maslena, oil pumpkin (Cucurbita maxima Duch) cv. Olivija, oilseed rape (Brassica napus L.) cv. NS Ras, pepper (Capsicum annuum L.) cv. Kurtovska kapija, soybean (Glycine max (L.) Merr) cv. ZP Laura, sunflower (Helianthus annuus L.) cv. NS Kruna, and tomato (Solanum lycopersicum L.) cv. Dunavski Rubin. Herbicide dicamba in the range of 0.14 to 1 …

Rest And Remember: Falls R Preventable, Joy Mason, Halyna Matiyash

Nursing

Background or Significance: Through evidence based research an audit to identify the reasons for falls was initiated. The top six indications were (1) sedative medications (2) Connection to an IV, (3) impulsive behavior (4) previous falls (5) mobility, vision or balance issues (6) sudden change in condition. This six point assessment lead to identifying and tracking high fall risk patients, as well as utilizing appropriate safety measures.

Purpose of the project or study: In response to a high fall rate on a General Medicine Unit, two bedside nurses, both members of the High Reliability Unit (HRU) team, implemented an innovative …

Exploring The Dynamics Of Negotiating Everyday Sexism In India: A Daily Diary Study, Sudha Shashwati, Parul Gupta, Preeti Kapur

The Qualitative Report

This study was undertaken to investigate the negotiation of everyday sexism encountered by college going young adult women in India in an urban context. An open-ended daily diary form was constructed, and 185 such forms were filled by 58 women enrolled in various colleges of a central university located in Delhi, India. These were analysed by content analysis with the help of NVivo software with a focus on target and type of sexism reported as well as response to sexist incident faced. The findings of this study reveal that participants chose inaction (53%) more than confronting sexism (47%), and reasons …

Barriers And Facilitators To The Adoption And Use Of Assistive Technology For Adults With An Intellectual Disability Who Live In Supported Accommodation: A Mixed Methods Systematic Review Protocol, Benjamin Morris, Alison Warren, Hannah Bradwell, Miriam Noonan

School of Health Professions

Objective: This review will identify the barriers and facilitators of assistive technology adoption and use in adults with intellectual disabilities living in supported accommodation. This will inform the development of an assistive technology adoption framework for these settings. Introduction: Assistive technology has the potential to increase the independence and well-being of people with intellectual disabilities; however, it is often not adopted. Generic models of technology adoption exist, and a recent systematic review has explored factors influencing access to assistive technology by people with intellectual disabilities. However, no review has presented a framework of adoption or use of technology specifically for …

Mmp9 Clears The Way For Metastatic Cell Penetration Across The Blood-Brain Barrier, Joseph H Mccarty

Faculty, Staff and Student Publications

Although brain metastases are 10-fold more prevalent than primary brain cancers, relatively little is understood about the genes and pathways that promote metastatic cell entry, growth, and survival in the brain. Hence, determining how metastatic tumors colonize the brain and thrive within the neural microenvironment is a topic of both fundamental importance and direct clinical relevance. In this issue, a report by Karreman and colleagues explores pathways that are exploited by metastatic tumor cells to arrest in the circulation, cross the endothelial blood-brain barrier (BBB), and thrive in the brain microenvironment. The authors used elegant imaging tools including intravital fluorescence …

Antibody-Drug Conjugates For Multiple Myeloma: Just The Beginning, Or The Beginning Of The End?, Upasana Ray, Robert Z Orlowski

Faculty, Staff and Student Publications

Multiple myeloma is a malignancy of immunoglobulin-secreting plasma cells that is now often treated in the newly diagnosed and relapsed and/or refractory settings with monoclonal antibodies targeting lineage-specific markers used either alone or in rationally designed combination regimens. Among these are the anti-CD38 antibodies daratumumab and isatuximab, and the anti-Signaling lymphocytic activation molecule family member 7 antibody elotuzumab, all of which are used in their unconjugated formats. Single-chain variable fragments from antibodies also form a key element of the chimeric antigen receptors (CARs) in the B-cell maturation antigen (BCMA)-targeted CAR T-cell products idecabtagene vicleucel and ciltacabtagene autoleucel, which are approved …

Experimental Study: Deep Learning-Based Fall Monitoring Among Older Adults With Skin-Wearable Electronics, Yongkuk Lee, Suresh Pokharel, Asra Al Muslim, Dukka Kc, Kyoung Hag Lee, Woon Hong Yeo

Michigan Tech Publications, Part 1

Older adults are more vulnerable to falling due to normal changes due to aging, and their falls are a serious medical risk with high healthcare and societal costs. However, there is a lack of automatic fall detection systems for older adults. This paper reports (1) a wireless, flexible, skin-wearable electronic device for both accurate motion sensing and user comfort, and (2) a deep learning-based classification algorithm for reliable fall detection of older adults. The cost-effective skin-wearable motion monitoring device is designed and fabricated using thin copper films. It includes a six-axis motion sensor and is directly laminated on the skin …

Facility Management System, Abdulla Talib Al Malik

Theses

Businesses nowadays are suffering due to high costs associated with energy consumption, maintenance, and overall lack of monitoring of assets. The downside of this is the negative impact high energy consumption has on the environment in terms of carbon emissions. To address this concern, this paper proposes a Facility Management System that details how a business can link all their assets to one central location for effective monitoring. This will allow any business to ensure that their maintenance costs are managed appropriately, all asset operations are in line with demand and not operating outside of when it Is required, and …

Investigating The Effects Of Work-Family Conflict On Turnover Intention Of Ict Employees In Malaysia, Lai Meng Lee, Su Wan Gan, Yong Sheng Chia

Makara Human Behavior Studies in Asia

With the intensified focus on information and communication technology (ICT) as a driver of the Malaysian economy, pressure will increase on the recruitment and retention of ICT employees. However, work overload and conflict with family roles may lead to a higher level of turnover intention among ICT employees. The objective of this study is to investigate the predicting effects of all forms of work-family conflict (time-based, strain-based and behavior-based) on turnover intentions. This quantitative cross-sectional study utilizes primary data collected from 200 employees from ICT companies in the Klang valley using purposive sampling. Various statistical analyses such as correlation and …

Understanding Involuntary Illegal Online Gamblers In The U.S.: Framing In Misleading Information By Online Casino Reviews, Sinyong Choi

UNLV Gaming Research & Review Journal

Although there are many illegal online gamblers in the United States who use offshore gambling sites while falsely believing that their activity is legitimate, few studies have focused on the role of online casino reviews (OCR) who facilitate this activity. These reviews, for a variety of reasons, may present misleading information designed to encourage U.S. players to use offshore gambling sites. Using framing theory and neutralization techniques, we conducted a content analysis of multiple OCR to examine how they present information and justifications regarding the use of offshore gambling sites in the U.S. The findings indicate that many OCR positively …

A Systematic Review On High Flux And Medium Cut Off Membranes – Benchmarking Using Simulation Models, Ahana Fatima Alex, R Vinoth, Ravishankar Dudhe

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Eben Cabs (Mobility As A Service), Asha Kumari

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Health Status In Gestational Diabetes And Oxidative Dna Damage, Nitu Basumatary, Vaishnavi Singh, Chamma Gupta, Pesona Grace Lucksom, Abhishek Byahut

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.