Digital Commons Network^™

Early Diagnosis Of Celiac Disease In Pediatric Patients, Nicole Gertsberg

Nursing | Student Research Posters

Celiac disease affects about 1% of the population; however, the indistinct symptoms make it difficult to diagnose. Children are vulnerable populations who are able to experience this disease, but go severely undiagnosed. As a result, when this population matures, additional health issues arise such as other autoimmune diseases. Different studies were done regarding diet modifications, gaps in research, and treatment options for Celiac disease. This is the reason to investigate whether early diagnosis in childhood will achieve better health outcomes through diet modifications. A cohort study will be performed on Celiac disease patients, ages 5 to 15 years old at …

Loss-Of-Function Variants In Mycbp2 Cause Neurobehavioural Phenotypes And Corpus Callosum Defects, Lama Alabdi, Muriel Desbois, Domniţa-Valeria Rusnac, Raashda A Sulaiman, Jill A Rosenfeld, Seema Lalani, David R Murdock, Lindsay C Burrage, Ping Yee Billie Au, Shelley Towner, William G Wilson, Lawrence Wong, Theresa Brunet, Gertrud Strobl-Wildemann, Jennifer E Burton, George Hoganson, Kirsty Mcwalter, Amber Begtrup, Yuri A Zarate, Elyse L Christensen, Karla J Opperman, Andrew C Giles, Rana Helaby, Artur Kania, Ning Zheng, Brock Grill, Fowzan S Alkuraya

Faculty, Staff and Student Publications

The corpus callosum is a bundle of axon fibres that connects the two hemispheres of the brain. Neurodevelopmental disorders that feature dysgenesis of the corpus callosum as a core phenotype offer a valuable window into pathology derived from abnormal axon development. Here, we describe a cohort of eight patients with a neurodevelopmental disorder characterized by a range of deficits including corpus callosum abnormalities, developmental delay, intellectual disability, epilepsy and autistic features. Each patient harboured a distinct de novo variant in MYCBP2, a gene encoding an atypical really interesting new gene (RING) ubiquitin ligase and signalling hub with evolutionarily conserved functions …

The Data Behind Climate Investing: An Earth Day Q&A With Jack Dewaard, Jack Dewaard

Climate and Environmental Changes

No abstract provided.

Building Credibility, Trust, And Safety On Video-Sharing Platforms, Shuo Niu, Zhicong Lu, Amy X. Zhang, Jie Cai, Carla F. Griggio, Hendrick Heuer

Computer Science

Video-sharing platforms (VSPs) such as YouTube, TikTok, and Twitch attract millions of users and have become influential information sources, especially among the young generation. Video creators and live streamers make videos to engage viewers and form online communities. VSP celebrities obtain monetary benefits through monetization programs and affiliated markets. However, there is a growing concern that user-generated videos are becoming a vehicle for spreading misinformation and controversial content. Creators may make inappropriate content for attention and financial benefits. Some other creators also face harassment and attack. This workshop seeks to bring together a group of HCI scholars to brainstorm technical …

Emergency Medicine In-Training Examination Scores Are Not Associated With Burnout And Not Affected By The Introduction Of A Wellness Curriculum, Kelly Williamson Md, Patrick M. Lank, Nicholas Hartman, Nathan Olson, Elise O. Lovell

Journal of Wellness

Introduction: There is little research examining the relationship between burnout and medical knowledge. Study Objectives: The authors sought to determine if emergency medicine (EM) resident performance on the In-Training Examination (EM-ITE) is associated with burnout and if EM-ITE scores are affected by the implementation of a wellness curriculum.

Methods: As part of a multi-institution prospective education intervention trial, the Maslach Burnout Inventory, a valuable tool in the assessment of physician burnout, was administered at 10 EM residencies in February 2017. Then, five intervention sites introduced a year-long wellness curriculum. The MBI was re-administered at all sites in August 2017 and …

Evidence-Based Change To Address Newborn Pain During Painful Procedures, Amy M. Hines

MSN Capstone Projects

This evidenced-based practice project sought to provide evidence to change a hospital policy on addressing pain during painful procedures on newborns with the use of nonpharmacological interventions. A literature search was conducted on three databases: PubMed, Cumulated Index to Nursing and Allied Health Literature, and Cochrane. Twelve pieces of literature were included: nine randomized control trials, one systemic review, one meta-analysis, and one correlational study. The literature reviewed showed a strong positive correlation between using nonpharmacological interventions and lower pain scores of newborns during painful procedures.

Effect Of Phacoemulsification On Intraocular Pressure In Eyes With Functioning Tube Shunts, Wesam Shamseldin Shalaby, Sonali Patel, Sophia Lam, Allen Ganjei, Aakriti Garg Shukla, Natasha Kolomeyer, Daniel Lee, L. Jay Katz, Marlene Moster, Jonathan Myers, Reza Razeghinejad

Wills Eye Hospital Papers

Purpose: To evaluate the effect of phacoemulsification on intraocular pressure (IOP) in eyes with functioning tube shunts.

Methods: This was a retrospective chart review of primary open-angle glaucoma (POAG) patients with a functioning tube who underwent phacoemulsification and had ≥24 months of follow-up. The primary end point was defined as surgical failure (IOP > 21 mmHg) at month 24, progression to no light perception (NLP) vision, glaucoma reoperation, or implant removal. Surgical failure defined as IOP >18 and >15 mmHg, changes in visual acuity (VA), IOP, and number of medications were assessed.

Results: Twenty-seven eyes of 27 patients with moderate or …

Development Of A Valid And Reliable Survey To Assess Personal, Behavioral, And Environmental Factors Surrounding Food Insecurity In A College Population, Jennette Kilgrow

Theses and Dissertations

Objective: The aims of our present study were to develop a valid and reliable survey framed around the social cognitive theory, which would evaluate internal and external factors associated with food insecurity from the student's perspective, and to test the survey with a multi-state population. Design: The College Perspectives around Food Insecurity (CPFI) survey was developed through several revision and improvement steps using a mixed methods approach. In Phase 1 (2018-2019), data were translated into survey items and assigned to a theoretical concept (personal, behavioral, or environmental) in the social cognitive theory. In Phase 2 (2019-2020), content validity testing occurred …

Transition From Clinician To Academician: A Heuristic Inquiry Of Role Change, Work-Role Conflict And Identity Development In Occupational Therapy, Theresa Rhett-Davis

Theses and Dissertations

Transitioning can be a daunting experience for occupational therapists shifting to an academic job as new faculty with new roles, responsibilities, and expectations. As newcomers to academia, occupational therapists can become overwhelmed by meeting the demands of the academic roles of teaching, scholarship, and service. Through a heuristic approach, I explored the lived experiences of occupational therapists who transitioned to academia from the clinical setting to better understand role change, work-role conflict, and academic identity development during the transition process. The person-environment-occupation-performance model provided a framework to understand the findings and give meaning to the OT faculty transition experience. The …

On The Road Lending Program Evaluation: Final Report, Michael E. Swack, Jolan Rivera, Sanjeev Sharma

Carsey Publications

In this report, Michael Swack, Jolan Rivera, and Sanjeev Sharma discuss the results of the On The Road Lending (OTRL) program evaluation.

OTRL and its sister CDFI, On the Road Sustainability Funds (OTRSF), share a common mission to promote prosperity within America’s working families through transportation and financial innovation. While OTRL and OTRDF measure and report on many environmental, social, and financial outcomes, the most important are economic mobility measures and improvements in quality of life, namely, greater agency, and control of options through more wealth and time (OTRL, 2021).

OTRL clients work with a coach who provides vehicle purchase …

Kruppel-Like Factor 8 Regulates Triple Negative Breast Cancer Stem Cell-Like Activity, Giang Le Minh, Emily M Esquea, Tejsi T Dhameliya, Jessica Merzy, Mi-Hye Lee, Lauren E Ball, Mauricio J Reginato

Kimmel Cancer Center Faculty Papers

INTRODUCTION: Breast tumor development is regulated by a sub-population of breast cancer cells, termed cancer stem-like cells (CSC), which are capable of self-renewing and differentiating, and are involved in promoting breast cancer invasion, metastasis, drug resistance and relapse. CSCs are highly adaptable, capable of reprogramming their own metabolism and signaling activity in response to stimuli within the tumor microenvironment. Recently, the nutrient sensor O-GlcNAc transferase (OGT) and O-GlcNAcylation was shown to be enriched in CSC populations, where it promotes the stemness and tumorigenesis of breast cancer cells in vitro and in vivo. This enrichment was associated with upregulation of the …

2023-April-19-Inaugural Conference For Center For Pharmacy Education, Advocacy, And Outreach Slated For May 8, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY, Tenn. (April 19, 2023) – Ballad Health and East Tennessee State University Bill Gatton College of Pharmacy are hosting the inaugural conference for the Center for Pharmacy Education, Advocacy and Outreach on May 8 at Ballad’s Bristol Regional Medical Center in Bristol, Tennessee. The event is aimed at pharmacists and pharmacy technicians and will focus primarily on the topics of substance use disorder (SUD) and the opioid epidemic. Continuing education credit is being offered for each presentation during the program. 

Check in will take place between 8:30-9 a.m., with the conference starting at 9 a.m. in the Monarch …

Promoting Neurodiversity Across The Lifespan, Erika Chavez, Karen Park

Spring 2023 Virtual OTD Capstone Symposium

A poster to assess the overall needs of neurodiverse populations who participate in adult day programs and have opportunities to engage within their community. The purpose was to empower neurodiverse populations throughout adulthood to be themselves and engage with others and in occupations as they see fit.

Special Needs In Pediatric Dentistry, Emma Kail

Health Sciences Presentations

Over the summer of 2022 I got the chance to work on my internship at a special needs and non special needs focused dentistry. Through this presentation I focus mainly on the pediatric special needs aspect of the dental care given to patients. Throughout the poster I speak about the importance of special needs care within dentistry and the field of dental health itself, where I worked and how they accommodated and worked with those with special needs to give the best care possible, and finally how this experience has changed my goals set for my future, especially within the …

The Impact Of The War In Gaza On Pediatric Mental Health, Noura Warsi

Honors Theses

Due to the military occupation and numerous violent wars that occur in the Gaza Strip, current research depicts that these occurrences not only suscept children to physical harm, but are also detrimental to children’s mental health, causing lasting consequences if left untreated. The purpose of this project is to understand and analyze the impact of the wars, specifically the 2021 war, and the military occupation on Gaza’s pediatric mental health. Unfortunately, children in Gaza, as well as parents, teachers, health care providers, and mental health counselors have the unique problem of navigating mental health crises in children who experience continuous …

A Review Of Pre-Clinical Studies On Meth-Induced Gut Microbiome Alterations, Payton Brabant

Honors Theses

Substance use disorder (SUD) is a chronic, pervasive disease that affects approximately 40.3 million people aged 12 and over within the United States (SAMHSA, 2021). Recent investigations have emphasized preventive measures targeting the development of SUDs and the occurrence of relapse. However, to date, FDA-approved medications are only available for those with alcohol (AUD) and opioid use disorders (OUD) (Forouzan et al., 2021). Given that about 964,000 people have methamphetamine use disorder (MUD) within the United States, investigation of novel treatment approaches for psychostimulant abuse is warranted (Forouzan, Hoffman, and Kosten, 2020). Several negative effects can occur after using methamphetamine …

Analysis Of Firefighters’ Psychological Trauma And Interrupted Domains, Alyssa Garcia, Pam Kasyan-Howe, Kristin Domville, Kristian Llaca

Student Capstone Papers

Firefighters are at a high risk of experiencing posttraumatic stress, anxiety, depression (Teoh et al., 2019), suicidality, substance abuse (Bing-Canar et al., 2019), and burnout (Teoh et al., 2019). Firefighters are regularly exposed to traumatic events on calls which results in their decreased mental health; and associated decreased participation in meaningful occupations, routines, and roles (Edgelow & Cramm, 2020; Edgelow et al., 2021; Wittwer et al., 2021). This project contains both research and a program. The purpose of this research was to understand how firefighter demographics interact with interrupted occupations, routines, and roles and at what frequency when faced with …

There Is No Single Gold Standard Study Design (Rcts Are Not The Gold Standard), B. Burt Gerstman

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Data: Y-Serve Participants Notes, Yoshihiko Ariizumi

Spiritual Proficiency

This data of 500 plus notes originally hand-written by the participants in the Y-Serve programs is a great resource to know their experiences in service learning. The compiler wishes that this document assists those who write essays or do extended research projects to illuminate and promote service learning in our educational settings.

From The Garden: A Fun Cookery Book For Young Chefs, Mandie Rekaby, Luna Fox

Publications

As the crops were growing this year at Togher Community Garden children and indeed adults often asked us what we were going to do with the produce? It was partly in response to their inquiry that we came up with the idea of cooking classes for children and subsequently this little book.

We are very lucky to have a chef amongst our community gardeners. Mandie Rekaby is not only a chef but a wonderful communicator who loves children, she designed and ran the classes. For four weeks in August we relied on a simple camping stove and our novel smoothie …

Ay 2022/2023 Fs Meeting Minutes, 2023-04-19, Faculty Senate

Faculty Senate Archives

No abstract provided.

Uab Medicine Named The Official Medical Provider For Talladega Superspeedway, Alicia Rohan

Browse All News

No abstract provided.

Modeling Collective Cell Behavior In Cancer: Perspectives From An Interdisciplinary Conversation, Frederick R Adler, Alexander R A Anderson, Abhinav Bhushan, Paul Bogdan, Jose Javier Bravo-Cordero, Amy Brock, Yun Chen, Edna Cukierman, Kathleen E Delgiorno, Gerald V Denis, Meghan C Ferrall-Fairbanks, Zev Jordan Gartner, Ronald N Germain, Deborah M Gordon, Ginger Hunter, Mohit Kumar Jolly, Loukia Georgiou Karacosta, Karthikeyan Mythreye, Parag Katira, Rajan P Kulkarni, Matthew L Kutys, Arthur D Lander, Ashley M Laughney, Herbert Levine, Emil Lou, Pedro R Lowenstein, Kristyn S Masters, Dana Pe'er, Shelly R Peyton, Manu O Platt, Jeremy E Purvis, Gerald Quon, Jennifer K Richer, Nicole C Riddle, Analiz Rodriguez, Joshua C Snyder, Gregory Lee Szeto, Claire J Tomlin, Itai Yanai, Ioannis K Zervantonakis, Hannah Dueck

Faculty, Staff and Student Publications

Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.

Development And Characterization Of Inducible Astrocyte-Specific Aromatase Knockout Mice, Jing Wang, Uday P Pratap, Yujiao Lu, Gangadhara R Sareddy, Rajeshwar R Tekmal, Ratna K Vadlamudi, Darrell W Brann

Faculty, Staff and Student Publications

17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models. The aim of this study was to develop a tamoxifen (TMX)-inducible astrocyte-specific aromatase knockout mouse line (GFAP-ARO-iKO mice) to specifically deplete the E2 synthesis enzymes and aromatase in astrocytes after their development in adult mice. The characterization of the GFAP-ARO-iKO mice revealed a specific and robust depletion in the aromatase expressions of their astrocytes and a significant decrease in their hippocampal E2 levels after …

The Parthenon, April 19, 2023, Evan Green, Conner Woodruff, Matt Schaffer, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Scott Price, Charles Bowen

The Parthenon

No abstract provided.

2023 Imsaloquium, Illinois Mathematics And Science Academy

IMSAloquium Event Booklets

Welcome to IMSAloquium 2023. This is IMSA’s 36 th year of leading in educational
innovation, and the 35th year of the IMSA Student Inquiry and Research (SIR) Program.

Cross-Cultural Adjustment Factors Influencing International Collegiate Student Athletes, Samantha Young

Theses and Dissertations

The purpose of this study was to further investigate the experience of international student-athletes (ISA) studying and competing at the collegiate level in the United States. This mixed methods study used a survey and interviews to probe ISAs' challenges and support sources. ISAs attending a large private four-year university located in the western United States along with university athletic support staff participated in this study. In the survey comments and interviews the ISAs expressed that they are highly concerned with their ability to financially survive in this new environment. A demanding schedule requiring the balancing of athletics and academics does …

Damar Hamlin: Legal Implications Of An Nfl Injury, Evan Feder

Cardozo International & Comparative Law Review (CICLR) Blog

On January 2nd, 2023, in an NFL game played between the Cincinnati Bengals and the Buffalo Bills, Damar Hamlin, a Bills safety, tackled Bengals receiver Tee Higgins. After the collision, Hamlin stood up and began to walk, but after two steps he collapsed to the ground. He went into cardiac arrest and was given CPR and was later taken to the University of Cincinnati Medical Center in critical condition. On the following Monday, January 9th, Hamlin was released from the ICU, and he has continued to improve since then. It was an extremely rare injury; in fact, there has only …

Rethinking" Risk" In Algorithmic Systems Through A Computational Narrative Analysis Of Casenotes In Child-Welfare, Devansh Saxena, Erina Seh-Young Moon, Aryan Chaurasia, Yixin Guan, Shion Guha

Health Services and Informatics Research

No abstract provided.

Assessment And Prediction Of Glioblastoma Therapy Response: Challenges And Opportunities, Dan Qi, Jing Li, C Chad Quarles, Ekokobe Fonkem, Erxi Wu

Faculty, Staff and Student Publications

Glioblastoma is the most aggressive type of primary adult brain tumour. The median survival of patients with glioblastoma remains approximately 15 months, and the 5-year survival rate is < 10%. Current treatment options are limited, and the standard of care has remained relatively constant since 2011. Over the last decade, a range of different treatment regimens have been investigated with very limited success. Tumour recurrence is almost inevitable with the current treatment strategies, as glioblastoma tumours are highly heterogeneous and invasive. Additionally, another challenging issue facing patients with glioblastoma is how to distinguish between tumour progression and treatment effects, especially when relying on routine diagnostic imaging techniques in the clinic. The specificity of routine imaging for identifying tumour progression early or in a timely manner is poor due to the appearance similarity of post-treatment effects. Here, we concisely describe the current status and challenges in the assessment and early prediction of therapy response and the early detection of tumour progression or recurrence. We also summarize and discuss studies of advanced approaches such as quantitative imaging, liquid biomarker discovery and machine intelligence that hold exceptional potential to aid in the therapy monitoring of this malignancy and early prediction of therapy response, which may decisively transform the conventional detection methods in the era of precision medicine.