Digital Commons Network^™

Identifying Signatures Of Ev Secretion In Metastatic Breast Cancer Through Functional Single-Cell Profiling, Mohsen Fathi, Melisa Martinez-Paniagua, Ali Rezvan, Melisa J Montalvo, Vakul Mohanty, Sendurai A Mani

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) regulate the tumor microenvironment by facilitating transport of biomolecules. Despite extensive investigation, heterogeneity in EV secretion among cancer cells and the mechanisms that support EV secretion are not well characterized. We developed an integrated method to identify individual cells with differences in EV secretion and performed linked single-cell RNA-sequencing on cloned single cells from the metastatic breast cancer cells. Differential gene expression analyses identified a four-gene signature of breast cancer EV secretion: HSP90AA1, HSPH1, EIF5, and DIAPH3. We functionally validated this gene signature by testing it across cell lines with different metastatic potential …

Comparative Study Of Adenosine Analogs As Inhibitors Of Protein Arginine Methyltransferases And A Clostridioides Difficile- Specific Dna Adenine Methyltransferase, Jujun Zhou, Youchao Deng, Iredia D Iyamu, John R Horton, Dan Yu, Masoud Vedadi, Antonello Mai, Robert M Blumenthal, Xing Zhang, Rong Huang, Xiaodong Cheng

Faculty, Staff and Student Publications

S-Adenosyl-l-methionine (SAM) analogs are adaptable tools for studying and therapeutically inhibiting SAM-dependent methyltransferases (MTases). Some MTases play significant roles in host–pathogen interactions, one of which is Clostridioides difficile-specific DNA adenine MTase (CamA). CamA is needed for efficient sporulation and alters persistence in the colon. To discover potent and selective CamA inhibitors, we explored modifications of the solvent-exposed edge of the SAM adenosine moiety. Starting from the two parental compounds (6e and 7), we designed an adenosine analog (11a) carrying a 3-phenylpropyl moiety at the adenine N6-amino group, and a 3-(cyclohexylmethyl guanidine)-ethyl moiety at the …

Synaptic Scaling Of Corticostriatal Circuits Underlies Hyperactivity In Gaba Transporter-1 Deficient Mice, Qin Jiang, Wei-Guang Li, Tian-Le Xu

Faculty, Staff and Student Publications

Homeostatic synaptic scaling entails adjustment of synaptic strength on a cell to prolonged changes of neuronal activity, which is postulated to participate in neuropsychiatric disorders in vivo. Here, we find that sustained elevation in ambient GABA levels, by either genetic deletion or pharmacological blockade of GABA transporter-1 (GAT1), leads to synaptic scaling up of corticostriatal pathways, which underlies locomotor hyperactivity. Meanwhile, medium spiny neurons of the dorsal striatum exhibit an aberrant increase in excitatory synaptic transmission and corresponding structural changes in dendritic spines. Mechanistically, GAT1 deficiency dampens the expression and function of metabotropic glutamate receptors (mGluRs) and endocannabinoid (eCB)-dependent …

Moderate To Vigorous-Intensity Continuous Training Versus High-Intensity Interval Training For Improving Vo2max In Women: A Systematic Review And Meta-Analysis, Robert Lindner, Isaac Selva Raj, Angela W. H. Yang, Shadman Zaman, Brianna Larsen, Joshua Denham

Research outputs 2022 to 2026

Traditional continuous training and high-intensity interval training (HIIT) can increase maximal oxygen uptake (VO2max). However, there is conflicting evidence regarding which form of training demonstrates the greatest improvements to VO2max, and data in women is sparse. We conducted a systematic review and meta-analyses to assess whether moderate to vigorous-intensity continuous training (MVICT) or HIIT was superior at improving VO2max in women. Randomised controlled and parallel studies examined the influence of MVICT and/or HIIT on VO2max in women. There was no statistical difference in VO2max improvements after training between women in the MVICT and HIIT cohorts (mean difference [MD]: −0.42, 95%CI: …

Source And Release Law Of Fluorine In Water-Rock System Of Coal Mine Goaf In Contiguous Area Of Shaanxi And Inner Mongolia, Wang Tiantian, Jin Dewu, Xue Jiankun, Ji Hongying, Shang Hongbo, Zhou Zhenfang, Yang Jian, Cao Yu

Coal Geology & Exploration

The coal mine goaf is the key area for the formation of high-fluoride mine water, and the source and release of fluorine in goaf water-rock system determines the enrichment or depletion of fluorine in mine water. Aiming at the unclear source and release rule of fluorine in the mine water of 3-1 coal goaf in the contiguous area of Shaaxi and Inner Mongolia, hydrochemical test, mineral composition analysis, mineral scanning electron microscopy and energy spectrum detection, as well as laboratory water-rock simulation experiment, were conducted to determine the source and occurrence carrier of fluorine in coal mine water, and to …

Technological Path And Geological Guarantee For Energy Storage In Underground Space Formed By Coal Mining, Sun Qiang, Zhang Weiqiang, Geng Jishi, Hu Jianjun, Zhang Yuliang, Lyu Chao, Ge Zhenlong, Li Pengfei, Jia Hailiang, Liu Yabin, Li Yuxiang

Coal Geology & Exploration

Coal resource is still in the main position of China’s energy structure, but the development of coal industry is facing the new challenge of “carbon peaking and carbon neutrality”. Actively developing coal underground space energy storage technology is an effective means to promote low-carbon and clean energy utilization, and also a key measure to ensure China’s energy strategic security. This study discussed the potential utilization of underground space formed by coal mining based on the current energy storage technologies. Focusing on new energy storage technologies such as underground pumped storage hydropower plants in coal mines (UPSHCM), thermal energy storage (TES), …

Evaluation On Spatiaotemporal Variations Of Mine Water Quality And Water Source Identification Based On Key Dominant Factors In Loess Hilly And Gully Region, Shi Longqing, Qu Xingyue, Han Jin

Coal Geology & Exploration

It is difficult to accurately identify the sources of water inrush between sandstone-mudstone interbedded overburden in loess hilly and gully region, and these proportions of different water sources cannot be quantified. For this reason. Based on the systematic collection of surface water and groundwater samples from Zhujiamao Coal Mine in northern Shaanxi. This study revealed the hydrochemical evolution laws of water quality and the recharge relationship of various aquifer systems by mathematical statistics, Piper (trilinear) diagram, Gibbs diagram and the conventional hydrochemical characteristic method. Meanwhile, this study analyzed the evolution characteristics of stable isotopic composition in water, clarified the spatial …

Progress And Typical Case Analysis Of Demonstration Projects Of The Geological Sequestration And Utilization Of Co2, Liu Shiqi, Huang Fansheng, Du Ruibin, Chen Shiheng, Guan Yiting, Liu Yinghai, Wang Tao

Coal Geology & Exploration

The implementation of the geological sequestration and utilization of CO₂ (CGSU) has considerable effects on CO₂ emission reduction and is of great significance for the mitigation of global warming and the execution of the sustainable development strategy in China. Therefore, this study sorted the major methods for CGSU, made statistics of the global demonstration projects of CGSU, and primarily introduced the typical demonstration projects of CGSU in China. Furthermore, this study proposed prospects for the development trend of the CGSU technologies, which primarily include CO₂ enhanced oil recovery (CO₂-EOR), CO₂ enhanced coalbed methane recovery …

The Toxicology Of Particulate Matter Emitted From Coal Combustion And The Geological Origin Of Lung Cancer Epidemic In Xuanwei City, Yunan Province, China, Shao Longyi, Zhang Mengyuan, Feng Xiaolei, Jiao Jiewei, Wang Wenhua, Zhou Yiping

Coal Geology & Exploration

Xuanwei City in Yunnan Province is the area struck by the most severe lung cancer in China, with the incidence and mortality of lung cancer ranking first in the world. The study of genomics of lung cancer patients has shown that lung cancer in Xuanwei City has distinctive genetic characteristics and a unique incidence mode related to the environment. This study reviewed the epidemiological characteristics of the lung cancer epidemic in Xuanwei, as well as the level of pollution and toxicological characteristics of emissions from coal combustion. Moreover, this study discussed the geological origins of the lung cancer epidemic in …

Geothermal Energy Exploitation And Storage In Coal Field Under The Dual Carbon Goal, Wang Jiyang, Kong Yanlong, Duan Zhongfeng, Zhang Jixiong, Luo Xilian, Huang Yonghui, Luo Naning, Cheng Yuanzhi, Zhou Nan, Zhang Weizun, Pang Zhonghe

Coal Geology & Exploration

The development of geothermal energy in coalfield can not only improve the temperature environment of coal mining, but also turn waste into treasure through the clean utilization of geothermal energy. Especially, it is of great prospect to store energy in the mined-out area of coalfield under the “dual carbon” goal at present. Herein, in this paper, it was estimated that the geothermal reserves in the main coal-bearing areas of China were 1.12 × 10¹⁹ kJ, equivalent to 379.539 billion tons of standard coal, and the recoverable geothermal reserves were 1.71 × 10¹⁸ kJ, equivalent to 56.931 billion tons …

Toward A Narnian Valuation Of Nature: Participatory Ontology, Jeff Sellars

Sehnsucht: The C. S. Lewis Journal

Lewis’ appreciation of nature begs the question: from where does the natural world gain its purpose and meaning? Lewis’ valuation of nature can be understood perhaps best through participatory ontology: the immanent world is valued and saved only through the participation of the divine; the lower life is brought up into the higher life. This view can be seen very openly and unmistakably throughout The Chronicles of Narnia, where the natural Narnian world of plants, animals, trees, and creatures of all kinds are celebrated, and some are eventually included in the New Narnia.

Front Matter (Volume 2, Issue 1), Grayson Carter

Sehnsucht: The C. S. Lewis Journal

No abstract provided.

Go Forth With Wisdom & Leadership, Kristen Montgomery

Epsilon Sigma at-Large Research Conference

see attached pp

Toxic Positivity: A Concept Analysis, Hannah G. Shipp, Katherine C. Hall

Epsilon Sigma at-Large Research Conference

Purpose: Post-COVID-19 workforce issues have pushed terms like resilience and burnout further into the forefront of professional discourse. Strategies aimed to improve resilience, decrease burnout, and increase retention appear to be less effective in the current climate. One potential unexplored contributor is toxic positivity. The purpose of this research is to analyze the concept of toxic positivity and its relevance to nursing.

Aims: Research questions; “1) How is toxic positivity used across contexts?; 2) Whose perspectives are represented and whose are not?; 3) What are the dimensions of toxic positivity?; 4) How are the dimensions related?; and 5) How is …

Implementing An Acute Stress Disorder Screening Tool In The Trauma Intensive Care Unit Setting, Sierra Bridgers

Epsilon Sigma at-Large Research Conference

This is a quality improvement project that focuses on implementing screening for acute stress disorder using the Acute Stress Disorder Structured Interview–DSM-IV tool in a Trauma Intensive Care Unit (ICU) at a Level 2 Trauma Center in Nashville, TN. Currently, at this hospital there is not a screening process implemented for these patients. Every trauma patient meets the criteria for acute stress disorder. Starting the process early aims for patients to be properly educated about their trauma and gets them the resources they need to heal mentally from the trauma.

During the 6-week implementation period of this project, the trauma …

The Relationship Between Test-Anxiety, Test Performance, Metacognitive Beliefs And Self-Esteem In College Students, Amie Shelley

Campus Research Month

Test anxiety and low self-esteem could affect the validity of certain academic examinations especially if it limits students from performing successfully. There is a need to ensure that students, whose future is often tied to academic success, are adequately educated and assisted in understanding the many layers of internal and external influence that can be in effect. This research will be based on the following question: How are metacognitive beliefs and self-esteem related to test anxiety and academic performance? Essentially, the research is focused on better understanding the tenuous relationship observed from previous research between test-anxiety and academic performance by …

Open Data Indicates That Collegedale Could Be A Bluezone, Tristan Deschamps, Alva Johnson

Campus Research Month

A blue zone is an indicator of exceptional health in a community. Adventists have a blue zone community in Loma Linda, but there has been little research into other Adventist populated areas that could be blue zones. Therefore, our goal is to show that open data suggests that a blue zone may exist near Southern Adventist University, specifically in Collegedale. This data has been gathered from different federal sources, including, the CDC, the US Census Bureau, the Tennessee Department of Health, official state records, and federal documents that are available to the public.

Interactive Dashboard Of Diabetes In The Us, Marc Butler

Campus Research Month

The contribution of this research project is the construction and interactive dashboard in order to facilitate the visualization of diabetes-related data to the public

Mitigating Peer-To-Peer Housing Impacts: Toward A Rational Nexus P2p Housing Impact Mitigation Strategy, Arthur C. Nelson

Journal of Comparative Urban Law and Policy

Traveler lodging has been around since humans created tribes and certainly since they invented civilization. The internet and the rise of peer-to-peer, short-term housing has accelerated traveler and lodging opportunities. Today, Airbnb alone has nearly three million hosts offering more than seven million listings. This article explores the rise of “peer-to-peer,” or P2P housing, and offers economic, planning, and public policy perspectives.

Lisbon: Pelos Frutos Conhece-Se A Arvore: Food Waste In The Land Of Plenty, Becky Jacobs

Journal of Comparative Urban Law and Policy

According to the Food and Agriculture Organization of the United Nations, one-third of all food produced for human consumption, approximately 1.3 billion tons per year, is wasted or lost globally. Data as of March 1, 2020 indicates that Europe produces 88 million tons of food waste annually, of which approximately one million tons is food waste from Portugal. Portugal has, and Lisbon in particular has, been a leader on food loss and waste policy issues. This article will detail Portugal’s efforts to reduce food waste as well as other countries efforts.

Mental Health In Sexual And Ethnic Minorities, Aaliyah Bailey, Ashlyn Bowers, Ashley Clark, Cassidy Paquette, Garrett Bassham

Epsilon Sigma at-Large Research Conference

Evidence Based Health Promotion Scientific Abstract

Introduction & Background:

Mental Health resources are scarce in rural areas. In 2020, suicide was the third leading cause of death for African Americans ages 15 to 24; this is only one example of the mental health disparities experienced by minority groups.

Purpose Statement and Research Question:

We saught to answer: “Are there greater mental health disparities among sexual and ethnic minorities, such as LGBTQ+ groups or Middle Eastern women, compared to their heterosexual, majority counterparts; if so, is there anything we can do about the issue as nurses?”

Literature Review:

To match the …

Mental Health Disparities In Minorities And Their Relation To Nursing Practice, Aaliyah Bailey, Ashley Clark, Ashlyn Bowers, Cassidy Paquette, Garrett Bassham

Epsilon Sigma at-Large Research Conference

Evidence Based Health Promotion Scientific Abstract

Introduction & Background:

Mental Health resources are scarce in rural areas. In 2020, suicide was the third leading cause of death for African Americans ages 15 to 24; this is only one example of the mental health disparities experienced by minority groups.

Purpose Statement and Research Question:

We saught to answer: “Are there greater mental health disparities among sexual and ethnic minorities, such as LGBTQ+ groups or Middle Eastern women, compared to their heterosexual, majority counterparts; if so, is there anything we can do about the issue as nurses?”

Literature Review:

To match the …

The Prevelence And Effect Of Pornea In Culture, Bryce Bengtson

Liberty University Research Week

Undergraduate

Three Minute Thesis

Crispr: The Double-Edged Sword Of Genetic Engineering, Grace Spade

Liberty University Research Week

Undergraduate

Three Minute Thesis

Martha's Vineyard: The Island With The Flying Hands, Kaitlyn Misirian

Liberty University Research Week

Undergraduate

Textual or Investigative

How Lifestyle Implementations Affect The Health Of Obese Women Compared To Women Who Are Not Obese, Chloe Hensley, Callie Marshall, Adela Robles, Adrianna Winseman

Epsilon Sigma at-Large Research Conference

Obesity is a major risk factor for many health problems, including cardiovascular disease and diabetes. It is anticipated that the prevalence of obesity in the United States will grow as time passes. The objective of this study is to compare the health of obese women who engage in regular exercise to that of nonobese women. This literature review is drawn from eight library-based research articles at East Tennessee State University (ETSU). The search engine covers topics such as obesity, postmenopausal women, physical activity, nutrition, health, fitness, and lifestyle. Taking nutritional supplements and increased physical exercise minimizes the likelihood of health …

Prevention And Education In Medication Assisted Treatment Facilities, Lindsey Mccartt

Epsilon Sigma at-Large Research Conference

Introduction and Background: Between 1999 and 2014 the number of patients in the labor and delivery that were on medication for opioid use disorder (MOUD) quadrupled. The rate of unintended pregnancies in pregnant patients of mOUD is at a tremendous high due to inconsistencies in the use of reliable contraception in this population.

Purpose Statement: To reduce the number of unintended pregnancies and infants born with neonatal abstinence syndrome there is a need for prevention and required education for men and women in medication-assisted facilities.

Literature Review: Twenty research studies were reviewed and evaluated. These articles were …

Effects Of Same Sex Parenting, Erin Hermann

Epsilon Sigma at-Large Research Conference

Ensuring the safety and welfare of children has a lasting effect on society. As we progress to a more inclusive concept of what constitutes a family, the effect of same sex parenting (SSP) must be considered.

Health related outcomes describing the advantages, disadvantages and unique challenges experienced by this population is surprisingly robust.

Dexcom & Other Continuous Glucose Monitors Impact Toward Diabetic Care Management & Convenience, Lacey Beyer, Tori Buckler, Colleen Rypkema, Dr. Pam Hulstein

Celebration of Research

Continuous glucose monitor devices, such as the Dexcom, plays a huge role in lowering A1C, advancing individual diabetic management, and preventing diabetic complications. Through the following research, connections have been made between the goal of continuous glucose monitoring devices being more convenient for patients and the positive impact towards managing glucose trends and hemoglobin A1C levels.

Slide Preparation For Dna Attachment For Use In Optical Tweezers, Dylan J. Kirkeby, Karissa Carlson, Emily Grace, Eric Jones

Celebration of Research

Our research team, ISLAND CURE, is a multidisciplinary team of professors and undergraduate students with the goal to design and build instruments to make biological measurements on a limited budget. One of the apparatuses we are designing, is optical tweezers, which are a Nobel Prize-winning technology capable of trapping microscopic and sub-microscopic particles using a laser beam. Using a 1064 nm beam, we will trap a single strand of DNA using beads and this will enable us to exert minute forces upon the DNA. This experiment will give us a better understanding of the forces on damaged DNA; specifically, the …