Digital Commons Network^™

Challenges In The Ethical Review Process Of Covid-19 Related Research At Hrec-Tumed, Thailand, Wilaiwan Chimkhong, Thana Khawcharoenporn, Pacharapan Surapolchai

Asian Medical Journal and Alternative Medicine

Objective: To explore the challenges encountered in the ethical review process and timeline of COVID-19 related research at the Human Research Ethics Committee of Thammasat University (Medicine) (HREC-TUMED), Thailand, focusing on submission characteristics, review outcomes, and committee adaptations.

Materials and Methods: This retrospective descriptive study analyzed COVID-19 research protocols submitted to HREC-TUMED between June 2020 and July 2022. Protocols were evaluated for research types, investigator affiliations, funding sources, review types, and timeline metrics, using descriptive statistics.

Results: A total of 89 COVID-19 related research protocols were submitted to HREC-TUMED, with the majority originating from faculty investigators (64%). Most protocols underwent …

Ckd-Associated Osteoporosis: A Comprehensive Clinical Update, Suthiya Anumas, Midori Sakashita, Waroot Pholsawatchai

Asian Medical Journal and Alternative Medicine

Objective: To provide an updated overview of the pathophysiology, diagnostic strategies, and treatment options for chronic kidney disease (CKD)-associated osteoporosis.

Methods: A narrative review of recent literature and guideline recommendations, including KDIGO 2017 and 2025, with emphasis on bone health assessment and pharmacologic interventions in CKD.

Results: CKD impairs bone quantity and quality through mechanisms involving uremic toxins, hormonal imbalances, metabolic acidosis, medications, and secondary hyperparathyroidism. While dual-energy X-ray absorptiometry (DXA) remains the standard for assessing bone mineral density, additional insights are provided by bone turnover markers, high-resolution peripheral quantitative computed tomography (HR-pQCT), and bone biopsy. Both antiresorptive and anabolic …

Exploring The Perceptions Of Black Nurse Educators Regarding Antiracist Pedagogy In Nursing Education, Deborah Ann Stallworth

Walden Dissertations and Doctoral Studies

Racism remains a persistent issue in nursing, prompting calls to create more inclusive educational environments and confront racial disparities. Guided by an intersectionality and critical realism framework, this generic qualitative study examined how Black nursing educators perceive antiracist pedagogy, how they implement it, and what they believe is needed to strengthen its adoption in nursing education. Twelve Black undergraduate nursing educators participated in in‑depth, one‑on‑one interviews. Thematic analysis generated four themes: (a) implementing antiracist pedagogy in the classroom; (b) challenges and resistance within school environments; (c) racial marginalization norms in nursing education, and (d) advocacy and vision for institutional reform …

Convergence Education In A Stem-Focused University: An Ethnographic Study Of A Cross-College Design And Innovation Program, Greg J. Strimel, Sherylyn Briller, Jackson Otto, Rebecca Martinez, Douglas Pruim, Todd R. Kelley

School of Engineering Technology Faculty Publications

Background

Innovation often transcends the bounds of individual disciplines, yet undergraduate teaching is still largely organized today within single disciplines and respective academic units. Convergence education offers a promising organizational approach to bring transdisciplinary teaching and learning into undergraduate education by aligning institutional structures, pedagogy, and partnerships around meaningful, innovation experiences to address contemporary problems. However, longstanding academic silos in higher education hinder the adoption of convergence-focused pedagogies. Therefore, this study examined the three-year implementation of a novel convergence education initiative developed to foster design and innovation capabilities across multiple academic disciplines. By integrating faculty from the university’s engineering technology, …

Current Status Of Msk Diagnostic Ultrasound Education In Doctorate Of Physical Therapy Programs In The United States: A Survey, Lesley Parrish Dr., Heather E. Mount, Casey Charlebois

Innovations in Health Sciences Education Journal

Musculoskeletal ultrasound (MSK-US) is a dynamic, cost-effective imaging modality increasingly integrated into Doctor of Physical Therapy (DPT) curricula. Despite growing interest, variability exists in the integration and implementation of MSK-US in entry-level DPT programs. This study aimed to assess the current status of MSK-US education in accredited DPT programs across the United States. A cross-sectional survey was distributed to all 294 accredited DPT programs in the U.S. via email. The survey consisted of 32 questions that addressed curriculum content, instructional methods, faculty qualifications, and barriers to implementation. Participation was voluntary, and 44 programs responded. No experimental interventions were applied. The …

Social Workers’ Perceptions Of The Prevalence Of Cyberbullying Among Post-Primary Education Students In The Sultanate Of Oman, Fawziya Al Saidi, Saif Bin Naser Al-Maamri, Rahma Al Badawi

Journal of Arts and Social Sciences

The current study addressed one of the most important problems facing human societies, which is the phenomenon of cyberbullying, applied to the Sultanate of Oman. The study followed a mixed approach, represented by the documentary and qualitative approaches - the grounded theory method. The study community represented documents related to cyberbullying in terms of its nature, forms, parties, effects, and strategies to confront it. A sample of experts in basic education schools, numbering 8 experts, and semi-standardized interview questions were used as a tool to monitor their perceptions, while verifying the necessary values of objectivity and reliability. The results of …

Educational Transformation Through Aligning With Oman Vision 2040, Rabie A. Ramadan

Journal of Arts and Social Sciences

This paper investigates the role of Artificial Intelligence (AI) in revolutionizing the education sector under the Oman 2040 vision. The vision aspires to economic sustainability, and education is a cornerstone for achieving this vision. The paper evaluates the present landscape of AI in Oman's educational system, exploring the current initiatives and how AI can be extended in education and be part of its practices. Based on the nature of the study, the methodology employed involves a comprehensive review of available literature and internet resources related to AI applications in education globally and within Oman. This secondary research approach allows for …

Career Adaptability Of Prospective Teachers With Disabilities In Indonesia: A Phenomenological Study, Rr Dwi Umi Badriyah, Erfan Ramadhani, Ramtia Darma Putri, Syska Purnama Sari, Amândio De Araújo Sarmento, Kadek Suhardita

Jurnal Kajian Bimbingan dan Konseling

Pre-service teachers with disabilities face career transitions shaped by personal aspirations, accessibility barriers, stigma, and limited role models. In Indonesia, little is known about how they build career readiness for teaching within inclusive unequal educational contexts. This study explores the career adaptability of pre-service teachers with disabilities in Indonesia. Grounded in Career Construction Theory, it examines concern, control, curiosity, and confidence, while extending the framework by considering resilience and flexibility as relevant dimensions. A qualitative phenomenological design was used. Twenty-five students with disabilities enrolled in Primary School Teacher Education and Special Education programs at an Indonesian university participated in semi-structured …

A Rare Case Of Cutaneous Extramedullary Hematopoiesis In Chronic Myeloid Leukemia, Bennett Christie-Nguyen, Hanadi El Achi, Levani Iashvili, Amer Wahed, Brenda Mai, Jacob Armstrong

Faculty, Staff and Student Publications

Cutaneous extramedullary hematopoiesis (CEH) is a rare manifestation of extramedullary hematopoiesis (EMH), a process typically associated with fetal development or myeloproliferative neoplasms. EMH most commonly involves the spleen, liver, and lymph nodes, with CEH being exceedingly rare in chronic myeloid leukemia (CML). Here, we present a 34-year-old Hispanic male with multiple bilateral lower extremity lesions, right buttock and leg pain, fatigue, and splenomegaly, who was found to have chronic-phase CML. Punch biopsy of one of the skin lesions demonstrated dermal infiltration by maturing hematopoietic elements, including granulocytes, megakaryocytes, and erythroid precursors, with fluorescence in situ hybridization (FISH) testing confirming a …

A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink

Faculty, Staff and Student Publications

While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor responses. Cyclic dinucleotides (CDNs) are STING agonists that hold promise in combination approaches, but they require frequent intratumoral administration when used in both preclinical models of HNSCC and clinical trials. To reduce administration frequency, we have created a peptide hydrogel–liposome composite system, K2-Lip(CDN), for local and prolonged availability of CDN. We investigated the loading limits of cationic liposomes in both …

Therapeutic Potential Of Glp-1 Receptor Agonists For Smoking Cessation, Christian S Hendershot, W Kyle Simmons, Manish K Jha, Sherry A Mckee, Luba Yammine

Faculty, Staff and Student Publications

Glucagon-like peptide-1 (GLP-1) therapies are under investigation for a growing number of neuropsychiatric conditions, including substance use disorders. Cigarette smoking accounts for the largest proportion of substance use-related morbidity and mortality, in part reflecting increased risk for cardiometabolic disease among people who smoke. Given modest quit rates with approved smoking cessation therapies, medications with novel mechanisms of action are needed to expand the available monotherapy and combination treatment options. Treatments that prevent post-cessation weight gain could further reduce relapse and cardiometabolic risks following smoking cessation. Preclinical findings show that GLP-1 receptor agonists (GLP-1RA) modulate nicotine reward, reduce nicotine self-administration, and …

Modelling The Temporal Dynamics Of Microsporidia Mb Prevalence In Anopheles Mosquitoes Under Environmental Variability, Charlène N. Mfangnia, Matteo Pedercini, Henri E. Tonnang, Jeremy K. Herren

All Peer-Reviewed Publications

Releasing Microsporidia MB-positive mosquitoes is being investigated as a promising component of Integrated Vector Management (IVM) strategies for malaria control. In this study, we developed a System Dynamics model to replicate the observed interactions between humans, mosquitoes, the Plasmodium parasite, and the symbiont MB. The model accounts for the impact of environmental variables - such as humidity, rainfall, and temperature - on mosquitoes, Plasmodium, and MB, using exogenous inputs derived from daily climatic observations (rainfall, relative humidity, and temperature) recorded during the mosquito field surveys. We calibrate the model using data collected from Ahero in Kenya, available for 3 years …

A Machine-Learning-Based Tool For Stroke Risk Prediction In Blunt Cerebrovascular Injury: Development And Preliminary Evaluation, Victoria Wagner, Joshua D Preston, Alejandro De Leon Castro, William F Mueller, Jonathan Nguyen, Manuel Garcia-Toca, Elizabeth R Benjamin, S Rob Todd, Jason D Sciarretta

Faculty, Staff and Student Publications

Purpose: Stroke risk correlates with the Biffl grading system in blunt cerebrovascular injury (BCVI). Although anti-thrombotic therapy is the mainstay of stroke prevention, no point-of-care clinical decision-support tool exists to guide timing for therapy. We sought to develop an interactive online calculator that incorporates patient-specific demographic and injury characteristics to estimate stroke risk and risk reduction with anti-thrombotic (AT) administration.

Methods: Data from BCVI patients (n = 1,197) at a Level I Trauma Center were retrospectively collected. Six machine learning methods were employed to predict stroke risk with and without AT therapy. Class imbalance was addressed using downsampling and/or class …

Exploring How Long-Term Residents Influence Environmental Policy Decisions In The Takushara Settlement In Abuja, Nigeria, Agbanusi Uchechukwu Jonathan

Walden Dissertations and Doctoral Studies

Rapid urbanization of Nigeria’s Federal Capital Territory (FCT) has increasingly marginalized indigenous communities, creating a significant disconnect between top-down environmental governance and how it affects residents. Previous research has found that this land swap displaces indigenous stewards and erodes their traditional ecological knowledge, endangering local livelihoods, food security, and sustainable management of natural resources. The purpose of this narrative qualitative study was to explore how long-term residents perceive and experience their influence in environmental policy decisions through the lens of the social-ecological systems framework and the theory of resilience. This study examined the systematic exclusion of long-term residents of the …

"Deep In The Trenches": A Multi-Perspective Interpretive Phenomenological Analysis Of Student Mothers Navigating The Hidden Realities Of Postpartum Anxiety, Rhonda Harris

Theses and Dissertations

Despite availability of effective treatments women with postpartum anxiety (PPA) commonly go untreated because of barriers to care. Student mothers are a particularly vulnerable subgroup of women as they tend to be younger, are less likely to be married, and have lower incomes than non-student mothers. As anxiety rates in college women are higher than the general population and higher than college men, student mothers are at high risk of the adverse effects of untreated PPA. There is a paucity of existing literature about student mothers and mental health. The aim of the current study is to understand the help-seeking …

Butte Priority Soils Operable Unit (Bpsou) 2026 Monthly Progress Report. Consent Decree For The Butte Priority Soils Operable Unit. Civil Action No. Cv 89-039-Bu-Seh, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Emotional Intelligence Training In Physician Assistant Education: Comparing Workshops Alone To Workshops Plus Coaching, Mickey Lebowitz, William Holmes

Innovations in Health Sciences Education Journal

Introduction

Clinicians and health care students with higher emotional intelligence (EQ) are more likely to experience positive outcomes for themselves and their patients. Given these benefits and EQ’s learnability, teaching EQ to health care students has been suggested. Therefore, we aimed to assess the impact of workshops combined with coaching (W+C) relative to workshops only (WO) on PA students’ EQ, and, as an outcome measure, their feelings of success. Additionally, we investigated whether these impacts depend on students’ baseline EQ.

Method

Using the Six Seconds Emotional Intelligence Inventory, we retrospectively tracked first- and second-year changes in EQ and success scores …

Elliott’S Embodied Inclusion 360 Framework: A Holistic Approach To Supporting Neurodiverse Individuals, Niki Elliott Ph.D.

Neuroinclusion

The embodied inclusion (EI) 360 framework asserts that authentic inclusion requires adapting environments in support of neurodiverse learners. The EI 360 model offers an urgently needed synthesis of intersecting theories and practices that are too often addressed in silos: educational neuroscience, trauma-informed teaching, social–emotional learning, inclusive education, and culturally responsive pedagogy. The framework identifies five core domains (i.e., physiological, relational, environmental, instructional, and transcendental) that form a cohesive lens through which to understand and respond to learner needs. Each domain contributes valuable insight into neurodiverse learner neurobiology, replacing fragmented, incomplete support plans with an integrated, individualized profile of a learner’s …

Loss Of Znrf3/Rnf43 Unleashes Egrfr In Cancer, Fei Yue, Amy T Ku, Payton D Stevens, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng, Galen Hostetter, Xiangwei Wu, Shixia Huang, Noah F Shroyer, Bing Zhang, Bart O Williams, Qingyun Liu, Xia Lin, Yi Li

Faculty, Staff and Students Publications

ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination and degradation. However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with ZNRF3/RNF43 mRNA levels in multiple human cancers. Through biochemical investigations, we demonstrate that ZNRF3/RNF43 interact with EGFR via their extracellular domains, leading to EGFR ubiquitination and subsequent degradation facilitated by the E3 ligase RING domain. Overexpression of ZNRF3 reduces EGFR levels and suppresses cancer cell growth in vitro and in vivo, whereas knockout of …

Single-Cell Tcr Mapping Reveals Spatially Coordinated T Cell States In Head And Neck Cancer, Kelli A Mccord, Emerald Kan, Sean Hyslop, Amanda Y Xia, Colby J Hofferek, James S Lewis, Andreas Wieland, David J Hernandez, Vlad C Sandulache, William H Hudson

Faculty, Staff and Students Publications

Current spatial T cell receptor (TCR) profiling approaches lack the resolution needed to link clonal identity, transcriptional state, and spatial positioning of individual T cells in the tumor microenvironment. Here, we introduce a spatial TCR profiling strategy that resolves individual T cell clones together with their transcriptional states at single-cell resolution and applied the method to human head and neck squamous cell carcinoma. Presumed tumor-specific T cells were broadly dispersed throughout the tumor microenvironment, and cells of the same clone occupied distinct transcriptional states in different locations: Immune-rich regions contained more plastic or progenitor cells, whereas tumor-dense regions were enriched …

A Tv-Bm3d Iterative Algorithm For Vmat-Ct Reconstruction, Chia-Lung Chien, Beibei Guo, Rui Zhang

Faculty, Staff and Students Publications

Volumetric modulated arc therapy-computed tomography (VMAT-CT), which is the CT reconstructed using the portal images collected during VMAT, can potentially be an effective onsite imaging tool. The goal of this study was to propose an iterative reconstruction algorithm that can further improve the image quality of VMAT-CT and reduce the number of failed reconstructions. An iterative algorithm combining total variation (TV) with block-matching and 3D filtering (BM3D) was proposed, addressing the L1-L2 regularization problem using the split Bregman method. We collected portal images from 67 VMAT cases including 50 phantom and 17 real-patient cases. Both Feldkamp-Davis-Kress (FDK) and TV-BM3D iterative …

Constitutive Ampk Activation Prevents Hepatocellular Carcinoma Development Through Inhibition Of Hnf4Α Activity, Zhen Sun, Bernard Linares, Cassidy Urdiales, Fiyad Alsarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L Van Nostrand

Faculty, Staff and Students Publications

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality and is largely driven by metabolic disorders such as obesity and type 2 diabetes. The AMP-activated protein kinase (AMPK) is a master regulator of metabolism, and its activation has been proposed as a therapeutic strategy for treating metabolic disorders. However, although AMPK activity is down-regulated in HCC, the precise role of AMPK in HCC development has not been clearly delineated. Here, we investigated the ability of constitutive AMPK activation to prevent HCC development using a constitutively active AMPK transgenic mouse model and a pharmacological AMPK activator. We observed that AMPK …

Association Between Dietary Self-Perception And Sugar-Sweetened Beverage Consumption Among Young Adults Latinas, Mi Zhou, A. Susana Ramirez, Angela Xu, Jacqueline Bergman

Faculty Research, Scholarly, and Creative Activity

Objective: To investigate the relationship between self-perceived overall dietary healthfulness and self-reported sugar-sweetened beverage (SSB) consumption among young adult Latinas, accounting for socioeconomic and acculturation-related factors. Design: Cross-sectional analysis using survey data. SSB intake was assessed using the BEVQ-15, and dietary self-perception was measured via a two-item scale. Multiple linear regression models examined associations between self-perception and total daily SSB intake, adjusting for income, education, and two validated acculturation indicators. Setting: Participants were recruited from a national online panel across the United States. Participants: A total of 881 Latina women aged 18–29 years participated. After removing cases with invalid outcome …

Massive Septic Shock And Complex Survivorship In A Medically Complex Pediatric Patient Following Gastrostomy Tube Malposition With Operative Findings Of Feed Within The Retrorectus Space, Samira R. Haberman, Christopher M. Ahmad, Olivia R. Kaufman, Rae-Anne Kastle, Brett Dunbar

Student Publications

Gastrostomy tube (G-tube) replacement is often routine; however, in children with complex medical needs, misplacement can rapidly lead to life-threatening complications. We describe the case of a 16-year-old male patient with neuronal ceroid lipofuscinosis who developed fulminant septic shock after accidental G-tube dislodgement and malposition. At an outside hospital, reinsertion attempts required tract dilation; bloody aspirate and inconclusive radiographs were overlooked, and feeds were resumed at home. After 48 hours, the patient presented to a community hospital in profound shock (blood pressure 40/20 mmHg, lactate 7.8 mmol/L, procalcitonin >50 ng/mL) with extensive abdominal wall emphysema and feed extravasation into the …

Etalanetug (E2814) In Dominantly Inherited Alzheimer's Disease: An Open-Label Phase 1b/2 Study To Assess Safety And Target Engagement In Participants With Mild To Moderate Cognitive Impairment, Erica Andreozzi, Kanta Horie, Nicolas R Barthélemy, Brian A Gordon, Shaney Flores, Tammie L S Benzinger, Eric Mcdade, Randall J Bateman, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Etalanetug (E2814) is designed to delay the clinical progression of Alzheimer's disease (AD) by binding to the microtubule binding region (MTBR) of tau implicated in seeding and spreading of tau pathology. Dominantly inherited Alzheimer's disease (DIAD) is a rare form of the disease (<  1%), having similar changes in the tau distribution and pathology to sporadic AD. Herein, we report the safety, pharmacology and biomarker results of the etalanetug Study 103 in DIAD patients.

METHODS: Study 103 enrolled participants with mild-to-moderate cognitive impairment due to DIAD who received etalanetug intravenously every 4 weeks escalating from 750 mg, 1500 mg, 3000 mg, to 4500 mg. After ascending to 4500 mg, patients received 4500 mg for up to 108 weeks. Tau pathology biomarkers, ptau217 and MTBR-tau243 were measured in CSF. Additional …

Navigating A Delicate Balance: Antibiotic Allergy In The Setting Of Renal Infection And Diabetic Ketoacidosis, Aun Bangash, Muhammad Bangash, Ruben M. Martinez Meza

School of Medicine Publications

Acute pyelonephritis is a bacterial infection of the renal parenchyma that requires prompt recognition and antibiotic therapy to prevent complications such as sepsis and chronic renal inflammation. We present a case of a 26-year-old woman with poorly controlled type 1 diabetes mellitus and a documented beta-lactam allergy who presented with atypical symptoms, including flank pain without urinary complaints. Laboratory evaluation demonstrated leukocytosis with a negative urinalysis. CT of the abdomen revealed left lobar nephronia with early contralateral involvement of the right kidney. Given her allergy history, she was treated with levofloxacin. During her hospital stay, she developed nausea, vomiting, and …

A Comparative Analysis Of Data Privacy Laws In European Union And United States: A Need For Better Protections Of Marginalized Groups In Light Of Advances In Artificial Intelligence, Lauren Demchak

Journal of International Law and Comparative Studies

No abstract provided.

Lingkungan Sebagai Subyek Hukum Dan Kewenangan Publik Lsm Lingkungan, Dr. Daud Silalahi, S.H.

Jurnal Hukum & Pembangunan

Abstract

Genetic Secrets Unveiled: Unraveling Privacy Concerns In Direct-To- Consumer Genetic Testing Between The United States And The European Union, Sofia Marie Cabrera

Journal of International Law and Comparative Studies

No abstract provided.

A Case For Idaho And Other Western States Owning Their Own Land, Alisha Urrutia

Idaho Law Review

Idaho and other states in the western United States have struggled with federal ownership and management of public lands for decades. Since 1976, when the Federal Land Management and Policy Act was enacted and the Homestead Act was repealed, states in the west have challenged the constitutionality and legal authority of the BLM to hold onto and manage western lands in a myriad of ways. This article discusses some of the most recent challenges to this system, including a lawsuit filed by the State of Utah in August of 2024. This article expands on these challenges, citing legal and political …