Digital Commons Network^™

Synthetic Lethality Of Decitabine Plus Atr Inhibition For Tp53-Mutated Aml, Jeremy T Baeten, Sumedha Agashe, Imene Tabet, Jack T Wooldridge, Amber Carter, Jamie N Butler, Christopher A Miller, Nicole Helton, Annabel Quinet, Kimberly B Johansson, Yichan Yang, Geoffrey L Uy, Alessandro Vindigni, Daniel C Link

2020-Current year OA Pubs

TP53 mutations are found in 10% to 15% of myeloid neoplasms and are associated with a dismal prognosis. Although hypomethylating agents (HMAs), such as decitabine, are active in TP53-mutated myeloid neoplasms (TP53-MN), mutation clearance is rarely complete and nearly all patients relapse. Molecular determinants of response to HMAs in TP53-MN are poorly understood. Here, we show that decitabine induces replicative stress with decreased replication fork progression, induction of single-strand DNA breaks, and activation of the ataxia telangiectasia mutated-Rad3-related (ATR) pathway. Resolution of decitabine-induced replication stress is impaired in TP53-mutated acute myeloid leukemia (AML) cells, representing a potential therapeutic vulnerability. Indeed, …

Prognostic Significance And Clinicopathological Associations Of Tumor Budding And Poorly Differentiated Clusters In Endometrioid Endometrial Carcinoma ​, Hani̇fe Seda Mavi̇li̇, Ömer Atmiş, Fatma Seher Pehli̇van, Fatma Sezen Çavdaroğlu Deveci̇, Ali̇ Riza Kandi̇loğlu

Turkish Journal of Medical Sciences

Background/aim: Tumor budding (TB) and poorly differentiated clusters (PDCs) are histopathological parameters that have been associated with poor prognosis in various malignancies, particularly colorectal carcinoma. Although numerous studies have demonstrated an association between the microcystic, elongated, and fragmented (MELF) pattern in endometrial carcinomas and lymphovascular invasion as well as lymph node metastasis, the literature regarding TB and PDCs in this context remains limited. This study aimed to investigate the potential associations of the MELF pattern, TB, and PDCs with overall survival, progression-free survival, and clinicopathological parameters in cases of endometrioid endometrial carcinoma (EEC).

Materials and methods: A total of 190 …

Academic Senate - Agenda, 04/14/2026, Academic Senate

Academic Senate Agendas

No abstract provided.

Acute Compartment Syndrome Following Lower Leg Vascular Injury: A Big-Data Approach To Estimating Incidence And Risk Factors, Harry Moroz, Edward J. Harvey, Yasser C. Bouklouch

Journal of Shock and Hemodynamics

Acute Compartment Syndrome (ACS) is a limb- and life-threatening complication of lower leg fractures. Rapid recognition and fasciotomy can prevent irreversible ischemic injury, but ACS is often under-recognized. Vascular injury may increase the risk of ACS by impairing perfusion and exacerbating swelling. This study aimed to determine the incidence, risk factors, and outcomes of ACS in patients with lower leg fractures, with particular emphasis on the impact of vascular injury. This retrospective cohort study used data from the 2017 American College of Surgeons Trauma Quality Programs database to perform a multicenter analysis of patients with lower leg fractures. Patients were …

South Carolina Teacher Workforce Profile For 2024–25, Svetlana Dmitrieva, Brian Cartiff, Angela Starrett

Reports

This report provides a comprehensive analysis of South Carolina’s public school teacher workforce in 2024–25. Aligned with SC TEACHER’s mission, it offers data to support decision-making at both state and district levels. Using teacher-level information for 55,634 educators, this report describes key workforce characteristics and trends of classroom teachers (PK–12), special education teachers, and retired educators who have returned to the classroom.

In addition to exploring broad workforce patterns, the report highlights age profiles across different facets of the teacher workforce. Understanding the distribution of early-, mid-, and late-career educators is essential for anticipating retirement trends, identifying support needs for …

Automated Land Surface Temperature Estimation And Prediction Using Multispectral And Multi-Temporal Indices In Google Earth Engine: Bizerte Study Case, Northern Tunisia, Fatma Ezzahra Ben Cheikh, Mohamed Hafedh Hamza

Journal of King Abdulaziz University: Meteorology, Environment and Arid Land Agriculture

This study analyzes the spatiotemporal evolution and near-future trajectory of land surface temperature (LST) in Bizerte, a rapidly urbanizing Tunisian coastal governorate. Using multi-temporal Landsat imagery (2009–2024) processed in Google Earth Engine, we quantify bi-seasonal warming and project thermal conditions to 2029. Over 2009–2024, mean summer LST rose by 2.8 °C (to 41.7 °C) and winter LST by 2.5 °C (to 18.9 °C), with urban and bare-soil areas warming most intensely (+5.3 °C). This coincided with increased built-up density and marked declines in vegetation and moisture indices. A Random Forest regression model, trained on 2009–2019 data and validated on 2024 …

Steering Minutes 04/14/2026, Steering Committee

Steering Committee

No abstract provided.

Further Development Of A Low-Energy Arc-Ignition System For Nytrox/Abs Hybrid Propulsion Systems, Stephen A. Whitmore, Jared S. Coen, Ryan J. Thibaudeau

Mechanical and Aerospace Engineering Faculty Publications

Utah State University has developed a high-performance “green” hybrid propulsion technology based on the unique electrical breakdown properties of 3D-printed acrylonitrile butadiene styrene. Using 3D-printed ABS as fuel, typical startup sequences require approximately 5–15 joules and, once started, the system can be sequentially fired with no additional energy inputs required. The number of possible ignitions is limited only by the amount of fuel. The most technologically mature version uses gaseous oxygen (GOX) as oxidizer and 3D-printed ABS as fuel. While GOX is mass-efficient, it lacks volumetric efficiency unless highly pressurized. Nytrox, a blend of GOX and nitrous oxide, improves propellant …

Predictive Analytics In Oncology And Ophthalmology: Machine Learning Applications For Diabetic Retinopathy And Breast Cancer, Ali Abidalkareem

Electronic Theses and Dissertations

The convergence of artificial intelligence and healthcare represents one of the most transformative developments in modern medicine, with deep learning technologies emerging as powerful tools for addressing complex diagnostic challenges. This dissertation develops and validates machine learning frameworks that address critical challenges in medical diagnosis through innovative approaches to data augmentation, feature learning, and classification, focusing on two fundamental problems: Diabetic Retinopathy (DR) severity classification using multi-model convolutional neural networks (CNNs), and breast cancer stage identification using microRNA (miRNA) gene expression biomarkers. For diabetic retinopathy classification, this work proposes an ensemble deep learning framework that integrates Diffusion-based data augmentation for …

Integrating Multi-Source Data With Machine Learning Techniques To Upscale Wetland Carbon Dioxide Fluxes, Abdullah Sulaiman Abdullah Al Fazari

Electronic Theses and Dissertations

Accurate quantification of atmospheric carbon dioxide (CO₂) fluxes in wetland ecosystems is essential for understanding their role in both regional and global carbon dynamics, particularly in the context of climate change. However, the spatial and temporal heterogeneity of wetlands presents major challenges for developing reliable upscaling models. This research developed and validated a comprehensive framework to upscale CO₂ fluxes across the Everglades National Park (ENP) and Big Cypress National Preserve (BCNP) in South Florida through the integration of multi-source datasets, including AmeriFlux eddy covariance (EC) tower measurements, NASA’s BlueFlux airborne CO₂ data, and multispectral satellite imagery from Landsat 8 OLI …

Trading Precarities: How Bangladeshi Freelancers Leverage The Digital Economy Amid Local Insecurity And Ai Disruption, Naim Bin Hasan

Electronic Theses and Dissertations

This study examines how Bangladeshi freelancers use digital platform work to cope with precarious local labor markets and how this strategy both mitigates and reproduces insecurity. In this form of work, freelancers compete for short-term, skill-based remote jobs posted by global clients. Drawing on 30 in-depth interviews and virtual ethnography, this study challenges dominant Western understandings of the precariat that assume workers fall from stable employment into insecure work. Instead, the findings show that many freelancers enter platform labor strategically as a way out of already unstable and limited local opportunities. While freelancing carries a promise of foreign income, flexibility, …

Semiochemicals And Odorant Receptors Underlying Potato Cultivar Susceptibility And Resistance To Potato Tuber Moth, Ruipeng Chen, Wangtao Hu, Qin Hu, Junjie Yan, Jiao Yin, Fathiya M. Khamis, Yulin Gao, Walter S. Leal

All Peer-Reviewed Publications

Infestation of potato by the potato tuber moth (Phthorimaea operculella) varies markedly among cultivars, yet the chemical and molecular mechanisms underlying this variation remain poorly understood. Here, we combine field surveys, chemical ecology, functional genomics, and structural modeling to reveal how cultivar-specific volatile profiles shape moth oviposition behavior and pest outcomes. Field and laboratory assays identified marked differences in adult attraction, oviposition, and larval damage among potato cultivars, which correlated with distinct blends of emitted volatile organic compounds (VOCs). Behavioral analyses revealed that among other VOCs, trans-nerolidol and β-ionone act as attractants, whereas 3-carene and benzyl tiglate function as oviposition …

Mastery By Mistakes: Reframing Failure In Higher Education Skill-Based Teaching And Assessment, Maura Metheny

JWU Dissertations & Theses

Experiencing a mistake, error or failure while learning generates an additional inquiry process that activates prior knowledge and increases retention of subsequent feedback and new material (Kapur, 2008). The use of errors to guide practice has been shown to lead to skill-mastery and expertise (Ericsson et al., 1993). When classrooms are psychologically safe environments where penalty-free exploration and knowledge application are encouraged, students gain a deeper understanding of the content (Tulis, 2013). This qualitative exploratory descriptive study aimed to understand the ways that undergraduate faculty in skill-based disciplines involve errors, mistakes and failures in teaching and …

From Beauty To Burden: Mapping The Health And Psychosocial Impacts Of Fragrances And Cosmetic Products Use In The Uae, Sharifa Alblooshi, Mariam Al Ali, Dana N. Abdelrahim, Suheir Awadalla

All Works

Background The dynamic beauty care sector in the Middle East is on an upward trend in the UAE; however, concerns persist about the side effects of this industry, attributed to chemical exposure, which is believed to contribute to skin problems and other health issues. In the UAE, there is a lack of data on consumer usage, awareness, and the health effects associated with it.Methods This study presents the results of an online survey administered to 461 female subjects in the United Arab Emirates as part of a cross-sectional study. The survey consisted of 55 questions on product use, knowledge, attitudes, …

Knowledge, Attitude And Practice Towards Sarcopenia Among Diabetic Patients Attending Outpatient Department Of A Tertiary Care Centre In Kerala, India, Vysakh Ts, Ajas Sn, Asha Raby N

Muthanna Medical Journal

Background: Sarcopenia is a progressive skeletal muscle disorder increasingly seen in individuals with diabetes, leading to functional decline and poor quality of life. Despite Kerala's high diabetes burden, sarcopenia remains underrecognized. This study assessed knowledge, attitude, and practice (KAP) regarding sarcopenia among diabetic patients and examined inter-domain relationships. Methods: A 6-month institutional cross-sectional study was conducted in the Family Medicine outpatient department of St. Joseph's Hospital Trust, Kochi. Using consecutive sampling, 154 diabetic patients (type 1 or 2) aged ≥ 40 years were enrolled. Data were collected using a pilot-tested questionnaire covering sociodemographic and clinical details, knowledge (12 items), attitude …

Regulatory Role Of Il-1Β And Cxcl8 In Inflammatory Cell Dynamics And Gingival Inflammation In Gingivitis, Dhuha Mahmood Ali

Muthanna Medical Journal

Background: Gingivitis is a common inflammatory disease of the periodontal tissues characterized by immune responses triggered by microbial biofilm. The inflammatory process involves the release of several cytokines and chemokines, including interleukin-1 beta (IL-1β ) and chemokine CXCL8, which play crucial roles in regulating leukocyte recruitment and inflammatory signaling within the gingival tissues. These biomarkers are considered important indicators of periodontal inflammation and may reflect the progression of periodontal diseases.

Aim: This study aimed to evaluate the levels of inflammatory biomarkers IL-1β and CXCL8 and investigate their role in gingival inflammation.

Materials and Methods: This case-control study included subjects diagnosed …

Ucc Minutes 4-14-26, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Approved Courses 4-14-26, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Global Impact Of Germline Structural Variation On The Cancer Proteome, Fengju Chen, Yiqun Zhang, Luis F Paulin, Darshan S Chandrashekar, Sooryanarayana Varambally, Fritz J Sedlazeck, Chad J Creighton

Faculty, Staff and Students Publications

Proteome and transcriptome data combined can help assess the relevance of non-coding germline variants. Here, we combine germline Structural Variants (SVs) with mass spectrometry-based proteomics on tumors from 1637 cancer patients spanning various tumor tissues of origin to determine the extent SV breakpoint patterns involve differential protein expression of nearby genes. Rare and singleton SVs disrupting protein expression of known cancer susceptibility genes collectively involve 6% of patients. About 24% of the hundreds of genes with SV-associated non-coding cis-regulatory alterations at the mRNA level are similarly associated at the protein level. Both rare and common SVs may associate with differential …

Dapk2 Regulates Pkm2 Phosphorylation At Threonine 45 To Facilitate Disturbed Flow-Induced Atherosclerosis, Shuai Guo, Long Xu, Yixin Chen, Yuan Zhao, Yuting Zhang, Runfa Yu, Kaixiang Cao, Litao Wang, Wenjia Ai, Jiang-Yun Luo, Lu Lu, Jun He, Yuan Zhou, Li Wang, Andrew H Baker, Yuqing Huo, Yiming Xu

Faculty, Staff and Students Publications

Background: Oscillatory shear stress (OSS), resulting from disturbed blood flow, is implicated in atherosclerotic plaque formation by incompletely understood mechanisms. This study aims to elucidate the involvement of death-associated protein kinase (DAPK) 2 in OSS-induced endothelial cell (EC) activation and atherosclerosis.

Methods: Publicly available resources, including genome-wide microarray, RNA sequencing, and single-cell RNA sequencing, were utilized to identify key OSS-sensitive regulatory factors. Techniques such as mass spectrometry, immunoprecipitation, proximity ligation assay, and RNA sequencing were employed to identify pyruvate kinase M2 (PKM2) as the binding protein of DAPK2 and determine the specific site of PKM2 phosphorylation by DAPK2. To assess …

International Consensus On The Evaluation And Management Of Hypothalamic Hamartomas: Results From A Modified Delphi Survey, Nathan T Cohen, Xiaotong Li, Madison M Berl, Chima O Oluigbo, Hiroshi Shirozu, Samuel F Berkovic, Margaret Zacharin, Wirginia Maixner, Andreas Schulze-Bonhage, Kerstin Klotz, Nicola Specchio, Sarah Ferrand-Sorbets, Christine Bulteau, Alexis A Arzimanoglou, Jean Regis, J Helen Cross, Martin M Tisdall, Hanna Richardson, Arthur Cukiert, Cristine Cukiert, Julia Jacobs, Elizabeth J Donner, Phillip L Pearl, John F Kerrigan, Angus A Wilfong, Kevin C J Yuen, Dennis J Dlugos, Daniel Curry, Irfan Ali, John Ragheb, Lisa Soeby, Erica Webster, William D Gaillard

Faculty, Staff and Students Publications

Background and objectives: Hypothalamic hamartomas (HH) are rare brain lesions associated with epilepsy and numerous comorbidities. Worldwide treatment is varied. There is a paucity of high-quality evidence to guide treatment. This study aimed to establish expert consensus on the evaluation and management of HH.

Methods: A modified Delphi survey was designed by the Medical Advisory Board of Hope for Hypothalamic Hamartomas and was conducted among 17 International League Against Epilepsy level II epilepsy surgery centers. The survey included 257 questions in round 1 and 81 refined questions in round 2, covering domains of diagnosis, imaging, medical and surgical treatment, neuropsychological …

Equitable Estimation Of Accurate High Injury Networks (Hins) For Vulnerable Road Users, Anurag Pande, Anandamayee Majumdar, Lucas Roman Kantorowski

Mineta Transportation Institute

To improve traffic safety, communities first need to know where serious crashes are actually happening. High-Injury Networks are designed to identify these locations, but they are usually built using only police-reported crash data. This research asks: Are we missing crashes—and injuries—by relying on police data alone? The research team first demonstrates that data from Emergency Medical Services and those from official databases differ substantially, and neither data set captures the full extent of collisions in a community. Following that analysis, the research team concluded that a new data source may help complete this. Toward that end, the research team scraped …

Advancing Hand Therapy Practice Through Specialized Clinical Reasoning And Patient Education, Candace Heinlein

Capstone Projects

This doctoral capstone experience (DCE) was completed at Corewell Health Grand Rapids Hospitals Hand Therapy Clinic and focused on two ACOTE concentration areas including advanced clinical practice skills and education. The experience combined hands-on clinical practice in a specialized outpatient hand therapy setting with the development of high-quality client education materials and home exercise programs (HEPs). Objectives were created to address identified needs through the creation of client education handouts, development of diagnosis-specific Medbridge HEP templates, and creation of training resources to improve therapist efficiency with Medbridge use. Outcomes of the project included improved access to evidence-based educational materials, reduced …

Artificial Intelligence In Low-Dose Computed Tomography Lung Cancer Screening: Clinical Integration, Validation, And Translational Challenges, Valeria Vanessa Varela Betancourt, Archana Acharya, Nusrat Jahan, Udit Kapahi, Insharah Khalid, Syed Maaz Shah, Hassan Ibrahim, Bushra Nawaz, Shazma Shayan, Maia Valls Palacios Reese, Sheeza Nadeem, Manju Rai

Student Publications

Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis. Low-dose computed tomography (LDCT) screening has demonstrated significant mortality reduction in high-risk populations; however, its widespread implementation is limited by high false-positive rates, inter-reader variability, and substantial workflow burden. Artificial intelligence (AI) has emerged as a promising adjunct to address these challenges by enhancing diagnostic consistency, efficiency, and risk stratification in LDCT-based screening. This narrative review aims to synthesize current evidence on AI methodologies, clinical applications, validation studies, and translational challenges in LDCT-based lung cancer screening. A structured literature search was conducted across PubMed, Scopus, …

Herpes Simplex Virus Type 1 R-Loops Are Targets For Apobec-Mediated Mutagenesis, Márton Miskei, Dóra Varga, Lilla Hornyák, Éva Sipos, Éva Nagy, Qiuzhen Li, Zsolt Karányi, Zoltán Szabó, Rachel Deweerd, Abby M Green, Dávid Szüts, Eszter Csoma, Lóránt Székvölgyi

2020-Current year OA Pubs

APOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infection. APOBEC3 enzymes are recruited to viral R-loops, generating clustered C-to-T mutations in genes critical for viral assembly. Importantly, R-loops alone are not mutagenic, and APOBEC3 enzymes do not edit HSV-1 without an R-loop; mutagenesis occurs when R-loops and APOBEC3 enzymes interact. These findings identify endogenous R-loops formed during the HSV-1 life cycle as focal vulnerabilities and highlight R-loop-APOBEC3 coupling as a mechanism for antiviral mutagenesis.

Modeling The Combined Effects Of Forest Fire And Climate Change On Snow-Water Storage In The Oregon Cascades, Joseph D. Vigil

Dissertations and Theses

Forest fire and climate change are reshaping the snow hydrology of the Pacific Northwest of the United States, yet the combined effects of these disturbances on snow accumulation, storage, and melt timing remain poorly quantified in these Mediterranean mountain watersheds. This study integrates field-based snow and radiation observations with physically based modelling to evaluate how postfire forest structure, postfire snow albedo decay, and future climate change influence snow-water storage in the Breitenbush watershed of the western Oregon Cascades. This work was conducted as part of a broader U.S. Army Corps of Engineers effort to improve postfire hydrologic prediction and flood …

Lembaga Swadana Sebagai Model Pengelolaan Keuangan Negara, Arifin P. Soeria Atmadja

Jurnal Hukum & Pembangunan

Abstract

Forms Of Bullying That Affect The Academic Achievement Of Eighth-Grade Students According To Data From The Timss 2023 International Study: A Comparative Study Of Saudi Arabia, Japan, And Finland, Dr. Ali Hamoud Alharbi

University of Bisha Journal for Educational Sciences

This research aimed to identify the most common forms of bullying experienced by eighth-grade students, according to data from the TIMSS 2023, and those with the greatest impact on academic achievement, in Saudi Arabia, Japan, and Finland. The sample included all students who participated in the TIMSS 2023 study, totaling 15,667 students. The descriptive method, employing both causal-comparative and correlational approaches, was used to achieve the study’s objectives. The results showed that the most common form of bullying in Saudi Arabia, Japan, and Finland was “listening to hurtful things about one’s appearance,” with rates of 35.5%, 12.1%, and 24%, respectively. …

Performing Professional Persona On Whatsapp: Gendered Self-Presentation And Authority Negotiation Among Saudi Women At Work, Meshari Ali Al-Sairi

UB Journal for Humanities

Drawing on Goffman’s concept of persona as a strategic and situational performance, the study examines written responses elicited through guided workplace scenarios designed to simulate high-stakes professional interaction on WhatsApp. The study adopted a qualitative, interpretive, discourse-pragmatic research design. The sample of the study included 30 women and 10 men employed in academic or administrative roles at the University of Bisha, and data were collected through semi‑structured, DCT‑style guided written prompts tailored to WhatsApp communication. Findings outlined three recurring persona patterns in women’s responses which are not interpreted as individual communication styles, but as systematic and adaptive responses to the …

Drawing-Based Story Telling Influence On Children Language Development And Social Aspect, Hariddha Yuni Sulistyaningrum, Imanuel Hitipeuw, Triyono Triyono

Jurnal Pendidikan Humaniora

Language and social development of children plays an important role in influencing further development. The objectives of this research are to determine the effect of drawing based on story- telling toward language development and social development of children age 5–6 years. Single subject research with reversal design ABAB was used in this experimental research. Four kindergarten children identified having language and social problems became the subjects. The observation was used to col- lect data. In addition, the data were put into graphs to be analyzed by using visual inspection. The results showed that drawing activities based on story telling could …