Digital Commons Network^™

Cardiovascular Disease And Dyslipidemia In Pediatric Type 1 Diabetes, Grace K Kim, Preneet Cheema Brar, Nidhi Bansal

Faculty, Staff and Students Publications

Purpose of review

Despite advances in type 1 diabetes (T1D) management, mortality is still increased, with cardiovascular disease (CVD) as the leading cause. Dyslipidemia is a highly prevalent modifiable CVD risk factor. We reviewed the existing literature on CVD mortality in T1D to highlight CVD risk in pediatric patients with T1D.

Recent findings

Pathophysiology of T1D and premature CVD risk is still not fully understood. Dyslipidemia remains a highly prevalent and undertreated CV risk factor in T1D. Statins have been shown to be safe and effective to improve CVD risk in adults with T1D, and in children with familial hypercholesterolemia, …

Designing Next-Generation Cardiometabolic Outcome Trials For Obesity Medicines, Elke Platz, Alexander Peikert, Biykem Bozkurt, Bart Van Der Schueren, Javed Butler, Ildiko Lingvay, Darren K Mcguire, Faiez Zannad, Naveed Sattar

Faculty, Staff and Students Publications

The prevalence of obesity has reached pandemic proportions and is having enormous public health effects. Obesity increases the risk of type 2 diabetes, hypertension, chronic kidney disease, and cardiovascular (CV) disease including coronary artery disease, heart failure, atrial fibrillation, and stroke. Although initial randomized clinical trials of weight-loss strategies through diet and exercise or early medical therapies did not lead to improved CV outcomes, more recent trials using glucagon-like peptide-1 (GLP-1) receptor agonists in individuals with obesity have demonstrated CV benefits. At present, there are multiple cardiovascular outcome trials (CVOTs) of novel GLP-1 receptor agonists and investigational products targeting multiple …

Obstructive Sleep Apnea Treatment Modifies The Effectiveness Of Catheter Ablation For Atrial Fibrillation: Post Hoc Analysis Of The Cabana Trial, Matthew W Segar, Kaleb D Lambeth, Brett Doliner, Joshua R Hirsch, Abdi Rasekh, Mehdi Razavi

Faculty, Staff and Students Publications

No abstract provided.

Rhesus Macaques With An Opa1 Mutation Demonstrate Features Of Autosomal Dominant Optic Atrophy, Tracy N Jaggers, Ana Ripolles-Garcia, Ala Moshiri, Brett D Story, Jun Wang, Rui Chen, Lucy G Moore, Leandro B C Teixeira, Jaeho Shim, Ana C Raposo, Maria Isabel Casanova, Sophie M Le, Sangwan Park, Laura J Young, Soohyun Kim, Karolina P Roszak, Vanessa Ureno, Paige M Karpinen, Nayeli Echeverria, Monica Ardon, Brian C Leonard, Marguerite Knipe, Eliza Bliss-Moreau, Brad Fortune, J Timothy Stout, Jeffrey Rogers, Nicholas Marsh-Armstrong, Sara M Thomasy

Faculty, Staff and Students Publications

Autosomal dominant optic atrophy (ADOA) is an inherited optic neuropathy primarily caused by mutations in OPA1. We identified and defined a spontaneous nonhuman primate (NHP) model of ADOA using rhesus macaques heterozygous for a missense mutation (OPA1A8S). With ocular examinations, ophthalmic imaging, electroretinography, histopathology, immunohistochemistry, and transmission electron microscopy (TEM), we documented retinal nerve fiber layer (RNFL) thinning, retinal ganglion cell (RGC) loss and dysfunction, OPA1 mislocalization, and reduced axonal mitochondrial density in affected macaques. Our investigation revealed substantial phenotypic variability among affected macaques, shedding light on the pathogenesis of ADOA. The retinas were evaluated using techniques …

Development Of Telenutrition Education And Counseling Protocol To Improve Diet Quality In Individuals With Spinal Cord Injury, Adrianne Widaman, Benjamin Dirlikov, Ramya Gopalan, Shelley Wood, Maria Sol Casas, Kazuko Shem

Faculty Research, Scholarly, and Creative Activity

Background: Cardiometabolic disease (CMD) is a leading cause of death for individuals living with chronic spinal cord injury (SCI), with a mortality rate due to CMD being higher than individuals without SCI. Telenutrition (TN) interventions tailored to health and accessibility needs of individuals with SCI may mitigate cardiometabolic risks. Objectives: To describe the development and validation of a telehealth-based medical nutrition therapy (MNT) within a clinical trial investigating the effectiveness of modifying diets to improve cardiometabolic health in persons with chronic SCI. Methods: The adaptive module-based MNT education content was developed in 3 phases by a multidisciplinary team. The first …

Enhancing Inference Of Differential Gene Expression In Metatranscriptomes From Human Microbial Communities, Evan M Lee, Nathan P Mcnulty, Matthew C Hibberd, Jiye Cheng, Kazi Ahsan, Hao-Wei Chang, Barak A Cohen, Jeffrey I Gordon

2020-Current year OA Pubs

Metatranscriptomic (MTX) sequencing quantifies gene expression from the collective genomes of microbial communities (microbiomes), enabling assessment of functional activity rather than functional potential. While differential expression testing is essential for RNA-sequencing analysis, current metatranscriptomic approaches have only been benchmarked on simulated data, resulting in a lack of standard practices for analysis of real datasets. Here, we use mock communities (defined mixtures of microbial cells with known properties) to quantitatively assess robustness and susceptibility of current approaches to various confounders including organisms' low relative abundance, differential abundance, low prevalence, global transcriptional output changes, and compositional effects. We show that no current …

Genetic Predispositions To Cancer: What Pediatricians Need To Know, Sarah Gubara, Nicole Wood

Pediatrics in Practice: A CME Podcast

Pediatric hematology/oncology physician Nikki Wood, DO, explains how pediatricians can recognize genetic cancer risk, refer to genetics appropriately, and support families through long‑term surveillance.

Click here to stream the podcast episode.

Laboratory Charter School V. M. S.

2026 Decisions

USDC for the Eastern District of Pennsylvania

Construction And Characterization Of Novel Mycobacterium Tuberculosis-Derived Triple And Quadruple Knockout Vaccines Against Tuberculosis, Omar Garnica, Raja Veerapandian, Kishore Das, Abhishek Mishra, Varsha Rawat, Areanna Carmona, Vivek Chauhan, Rakesh Kumar, Jessica Chacon, Shrikanth S. Gadad, Subramanian Dhandayuthapani

School of Medicine Publications

Tuberculosis (TB) is a deadly disease that claims the lives of over a million people each year worldwide. The Bacille Calmette-Guérin vaccine has long been used to protect against TB, but it produces variable effects across different populations and fails to protect against adult pulmonary TB. Therefore, there is an urgent need for alternative vaccines that can offer better protection. We have developed a strategy for the rational deletion of virulence-related genes in Mycobacterium tuberculosis (Mtb) to create hyperattenuation that also enhances immunogenicity. Previously, we generated both single (∆fbpA) and double knockout (DKO) (∆fbpA-∆sapM) mutants of …

Intensive Versus Standard Blood Pressure Control After Endovascular Thrombectomy In Acute Ischemic Stroke: A Meta‐Analysis Of Randomized Controlled Trials, Tallal Mushtaq Hashmi, Mushood Ahmed, Hadiah Ashraf, Muhammad Shakir, Ibrahim Ahmad Bhatti, Faizan Ahmed, Ahmad Alareed, Ali Hasan, Gregg C. Fonarow, Ameer E. Hassan

School of Medicine Publications

Background: The optimal strategy for blood pressure management following mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion remains a subject of ongoing research.

Methods: We comprehensively searched PubMed, Embase, and the Cochrane Library from inception to June 20, 2025. Randomized controlled trials comparing intensive versus standard blood pressure control following mechanical thrombectomy for acute ischemic stroke were included. The primary outcomes were excellent functional outcome (modified Rankin Scale score 0-1 at 90 days) and good functional outcome (modified Rankin Scale score 0-2 at 90 days). Pooled odds ratios (ORs) with 95% CIs were calculated using a random-effects …

Sowing Imbalance From The Start: Power, Role Socialization, And Graduate Assistants In Ncaa Division I Power Four Athletic Departments, Kaitlin Pericak, Daniel Springer, Brittany Washington, Rachel Silva

Journal of Issues in Intercollegiate Athletics

Graduate assistantships represent early entry points into intercollegiate athletics and serve as critical sites of professional socialization. Guided by Mead’s (1934) role theory and Foucault’s (1975/1977) concept of power, this study examined how graduate assistants (GAs) negotiated their dual roles as students and employees within Division I Power Four athletic departments. Semi-structured interviews with 10 current GAs revealed how organizational expectations normalized overwork, positioned the master’s degree as a compulsory credential, and sowed imbalance that shaped participants’ identities and well-being. Findings demonstrate how GAs internalized structured constraints and reproduced organizational norms, framing overwork as a necessary rite of passage. These …

Identifying Skill Gaps And Upskilling Priorities For C-Level Executives Using The Analytic Hierarchy Process (Ahp) Analysis, Mohamed Riyazhkhan, Mohsin Aziz, Krishna Murthy, Abdul Azeez K M, George Anthony Fernando

Journal of Global Management Research

C-level executives, or chief-level executives, play a significant role in corporate development, and their roles and responsibilities are essential for sustaining organizational effectiveness in an increasingly competitive business environment. They also constitute a fundamental component of organizational management systems (Julie & Emory, 2006). In this research, data were collected exclusively from C-level or C-suite executives (CEO, CFO, COO, and CHRO) from leading corporations in Oman and India. This study investigates three representative cases related to managerial functions across various corporate organizations. The first case examines the job descriptions associated with C-level executives, the second case explores the identification of skill …

Book Review Of Suburban Refugees: Class And Resistance In Little Saigon, Phoebe T. Pham

Journal of Southeast Asian American Education and Advancement

In Suburban Refugees: Class and Resistance in Little Saigon, Jennifer Huynh challenges the common view that refugee resettlement follows a straightforward path toward assimilation, stability, and upward mobility. Focusing on Vietnamese refugees in Little Saigon, Orange County, California, Huynh examines how refugees navigate displacement, housing insecurity, and political exclusion in suburban spaces often idealized as homogenous and prosperous. Drawing on extensive data, the book presents suburban resettlement as a prolonged process shaped by structural forces and community resistance. Huynh situates her analysis within growing suburban inequality and enduring racialized policies that limit refugee opportunities long after formal resettlement. Her …

Using Natural Products In Patients With Cancer: More Than Chemotherapy, Gailen D. Marshall

Oxford ICSB

The fundamental goal of cancer therapy is to cure the cancer. However, the approach to that goal is complicated and varies depending upon the type and stage of the tumor as well as the clinical characteristics of the patient. Cancer treatment focused on killing the tumor has considerable comorbidities associated with each therapy. Common side effects such as systemic immunosuppression, bleeding, anemia and specific organ-based pathologies each have their own significant morbidity/mortality risk. The use of natural products, both as direct antitumor agents and as moderators/mitigators of side effects of antitumor agents has a long history. Recent studies seek to …

Socio-Legal Framework For Vulnerability: Using Public-Private Partnerships As A Tool For Disaster Management, Latisha Nixon-Jones

Pepperdine Law Review

As disasters continue to grow in size and intensity, the question arises: can governments effectively meet local and regional disaster response and recovery needs? This Article examines the history of utilizing public-private partnerships (PPPs) to enhance government functions in disaster management. The primary objective of this Article is to assess whether involving private entities in governmental roles is an effective strategy for building resilient communities and ensuring public safety, particularly for vulnerable populations. Existing literature focuses on the financial and logistical aspects of PPPs with mere mentions of legal importance. To address these failures, this Article proposes a novel socio-legal …

The Impact Of Computer-Based Memory Screening Administration On Variables Associated With Cardiovascular Functioning In A Sample Of Young Adults: A Pilot Study, Kanaan Hurst, Haley Hughes

Liberty University Research Week

With the rising number of individuals diagnosed with dementia, Alzheimer's and related neurodegenerative disorders, research shows that there is a grand need to understand such impairments. Our team examined cognitive function using a previously developed memory screening computer-based test. In addition to screening for cognitive function, Blood Pressure was recorded 3 times (to ensure accuracy on average) preceding the computer-based assessment and immediately following completion. Blood pressure was monitored as having hightened pressure can indicate increased likelihood of developing cognitive impairment. Developed by clinical psychologist, Dr. Crews, CogniCheck is a computer-based screening tool that uses active recall tests to assess …

Create @ State 2026, Arkansas State University - Jonesboro

Create@State

Proceedings for 2026

The Putative Dash Complex Gene Dcm1 Influences Ph Adaptation And Virulence In Cryptococcus Neoformans, Cate Plaisance

Liberty University Research Week

Cryptococcus neoformans is an opportunistic fungal pathogen that causes lethal cryptococcal meningitis in immunocompromised individuals, such as the AIDS community or those who are undergoing cancer treatment. The yeast is responsible for around 19% of all AIDS related deaths annually and has been classified among the highest ranked fungal pathogens on the World Health Organization’s (WHO) Fungal Priority Pathogens List (FPPL). Antifungal resistance has stimulated increasing concern with C. neoformans. The primary route of infection is the inhalation of basidiospores from environmental reservoirs such as bird droppings and tree detritus. Germination of the basidiospores and survival of yeasts within the …

Engaging The Non-Dominant Hand In Creative Tasks As A Pathway To Emotional Expression And Healing, Tiffany Spatz, Deepa Michelle Emmanuel, Janita Daggy

Liberty University Research Week

Traditional therapeutic approaches may not fully engage the brain's creative processing, limiting individuals' capacity to effectively manage stress and navigate emotional discomfort. Utilizing the non-dominant hand for creative tasks shows potential as a therapeutic approach to emotion regulation while helping individuals manage stress and improve self-control. The practice works to reduce stress by means of physiological and psychological processes while also establishing relaxation and emotional balance. These activities demand brain management of motor control tasks which form cognitive flexibility and mindfulness and create better self-control and impulse regulation. A case example is included for incorporating this intervention into counseling practice.

Music Enhances Theta Brainwave Activity Regardless Of Tuning Frequency, Robert Somerville, Davis Raz, Jettson Yarborough, Luc-Shalom Kouame

Liberty University Research Week

No abstract provided.

Application Of Aqbd Principles To Build A Robust Compendial Analytical Method For The Quantification Of Phytochemicals In Mate And Guayusa Leaf Dietary Ingredients, Maria Monagas, Salika Jeelani, Greg Winter, Natalia Kouznetsova

Oxford ICSB

Mate (Ilex paraguariensis) and Guayusa (Ilex guayusa), both members of the Aquifoliaceae family, have traditionally been consumed as herbal teas in South America. Their leaves are rich in methylxanthines and hydroxycinnamoylquinic acids—quinic acid derivatives of caffeic and gregrferulic acids—which provide stimulant and antioxidant properties. These compounds make them valuable for use in health and energy beverages as well as dietary supplements. We applied the Analytical Quality-by-Design (AQbD) approach to develop a robust UHPLC method for simultaneous quantification of methylxanthines and hydroxycinnamoylquinic acids. The method and sample preparation were designed in alignment with USP General Chapter < 1220> Analytical Procedure Life Cycle and …

Examining Racial And Ethnic Differences In Quality Of Care Between Home And In-Center Hemodialysis, Sukhman Bains

2026 Symposium

Home hemodialysis (HHD) offers improved flexibility and clinical outcomes compared to in-center hemodialysis. However, its use remains limited, particularly among racial and ethnic minority populations disproportionately affected by end-stage renal disease (ESRD). This systematic review analyzed seven retrospective cohort studies (2004–2025) to assess disparities in HHD utilization and outcomes. Minority patients were significantly less likely to initiate HHD, with adjusted odds ratios ranging from 0.45 to 0.70, while no disparities were observed within Canada’s universal healthcare system. Although HHD was associated with lower mortality, this finding is likely influenced by selection bias, as HHD patients tended to be younger and …

Optimizing Itpa R178c Assays Via Hplc, Jared J. Reisnouer, Wally D. Pines

2026 Symposium

Two of the major nucleotide bases in DNA and RNA (Adenine and Guanine) are derived from the purine Inosine Monophosphate (IMP). IMP may occasionally form the noncanonical nucleotide Inosine Triphosphate (ITP) within the cell and become incorporated into DNA during replication, leading to potentially lethal errors. To combat this, human cells produce the “housekeeping” enzyme Inosine Triphosphatase (ITPA) to revert ITP to IMP. A mutation of this protein that replaces the 178th amino acid Arginine with Cysteine (R178C) is associated with a fatal infantile encephalopathy. Previous assessments of enzyme-substrate binding and catalysis for ITPA variants have been run at a …

The Burden Of Neglect: Examining Environmental And Health Risks At Kiteezi Landfill, Uganda, Rebecca Martha Nantale, Nfn Dangpa Wandji Nana, Bright Agbotui, Maame Yaa Okrah, Emmanuel N. Clottey

Montview Journal of Research & Scholarship

The Kiteezi Landfill, located near Kampala, Uganda, exemplifies the severe environmental and health challenges arising from inadequate urban waste management. Established in 1996, the landfill was designed to handle the city's waste but has been operating beyond its capacity for years. By 2024, it had received between 1,500 and 2,000 tons of solid waste daily, far exceeding its intended limits by more than 200%. This study investigates the environmental and public health impacts of the Kiteezi Landfill in Uganda. The primary research question is: How has inadequate waste management at Kiteezi Landfill contributed to environmental degradation and public health crises? …

Exploring The Antimicrobial Properties Of Spotted Lanternfly Contaminated Honey, Davanna Mcclellan

Liberty University Research Week

This study aims to investigate how the antimicrobial properties of pure honey and spotted lanternfly contaminated honey differ. The spotted lanternfly (Lycorma delicatula) is an invasive species that has been in the U.S. since 2014. This species has wreaked havoc on many different industries, such as the agricultural and tobacco industries. However, the relationship between the lanternfly and the European honey bee (Apis mellifera) has not been researched. One facet of their relationship shows that honey bees will use lanternfly secretions called honeydew to make honey. Honey possesses antimicrobial and anti-inflammatory qualities due to the antimicrobial peptides present within honey …

Differential Effects Of Curcumin And C646 On Mitogenic And Metabolic Signaling In Insulin-Stimulated Hepg2 Cells, Davis Raz, Rachael De Klerk

Liberty University Research Week

No abstract provided.

Sub-Lethal Exposure Of Culcicidine Mosquitoes To Pyriproxyfen: A Gateway To Pyrethroid Resistance, Ava Luckey, Andrew Duncan

Liberty University Research Week

Mosquito borne diseases are a global health concern, requiring effective methods of vector control. Pyriproxyfen (PPF) is an insect growth regulator that prevents larvae from becoming adult mosquitoes. The adults exposed to PPF often have difficulties in reproduction. Pyrethroids, however, are an insecticide meant to kill mosquitoes. Oftentimes PPF and pyrethroids are used together and resistance has become an increasing concern. This study would investigate if a sublethal larval exposure to PPF will cause increased resistance to pyrethroids in adult Culcidine mosquitoes. Two separate mosquito groups would be reared with or without larval PPF exposure. The adults from both groups …

The Effects Of Ultra- Processed Foods On Metabolic Health Among Young Adults, Cynthia Ilechukwu, Atika Ali, Fadzai Nyarugwe, Ifeoluwanimi Shobayo, Krista Coipel, Naa Komley Commey, Tahirou Diallo

Liberty University Research Week

Introduction/Background

Ultra-processed foods (UPFs), as defined by the NOVA classification system, are industrially produced foods that are high in added sugar, sodium, unhealthy fats, and additives while being low in fiber and essential nutrients. Young adulthood is a crucial period for developing long-term dietary habits, yet many young adults consume a disproportionately high amount of UPFs. Evidence suggests that diets high in UPFs can negatively affect metabolic health, increasing the risk of obesity, insulin resistance, and type 2 diabetes mellitus (T2DM) at relatively early ages. Understanding the impact of UPFs in this age group is important for developing preventive strategies …

Barefoot Shoes: The Effect On Health And Wellness, Rebecca Hofheinz

Liberty University Research Week

The development of footwear from the outset of civilizations and the rise in popularity associated with their use in the Roman Empire has led to the diversification of styles and uses for shoes that we see today. While the first shoes were rudimentary, they fulfilled the basic need of protecting the wearer’s feet from the various abrasive textures and temperatures of the landscapes they lived in. Those initial shoes were consistently represented by layered fabrics or leather wrapped around the feet before they then progressed further into the leather sandals that were displayed by the gladiators of the Roman age. …

Mental Health Consequences Of Climate-Related Hazards: A Us Case Study., Perseverance Nothando, Fadzai Nyarugwe, Wuraola Awosan

Liberty University Research Week

Background: The planet has warmed considerably over the past four decades, leading to more extreme weather events like floods, fires, and hurricanes. In the U.S., the number of climate-related disasters has surged, affecting approximately 1.7 billion people between 2010 and 2020. Projections suggest that by 2050, the U.S. population impacted by climate-related disasters could double, with a quarter of the population affected annually. Research indicates that 25% to 50% of people exposed to extreme weather events are susceptible to negative mental health consequences, such as anxiety and PTSD. This underscores the urgent need to address the psychological impact of climate …