Digital Commons Network^™

Navigating Life And Death: A Moral Critique Of Euthanasia Practices Worldwide, Brooke Fuzie, Rachel Joseph

Wisdom & Compassion: The LUSON Journal

Euthanasia and physician-assisted death remain deeply debated ethical issues shaped by history, law, and cultural values. This narrative review explores how diverse ethical frameworks, shifting global legislation, and cultural perspectives inform current discourse, with special attention to the role of nurses guided by the American Nurses Association (ANA) Code of Ethics. Drawing on peer-reviewed studies, legal documents, and recent case analyses published between 2013 and 2025, the review identifies three key insights. Ethical frameworks influence whether society accepts or opposes euthanasia; robust legal safeguards are needed to protect autonomy and prevent misuse; and palliative care and advance care planning, including …

Perceived Knowledge, Attitude, Practice, And Barriers Of Jordanian Nursing Faculty To Integrate Genomic Concepts In The Curriculum: A Cross-Sectional Descriptive Study, Rachel Joseph

Wisdom & Compassion: The LUSON Journal

Background: Rapid advances in genomics knowledge and the expansion of precision medicine have amplified expectations for nurses to integrate genomic concepts into education and clinical practice. Evidence regarding genomic knowledge, attitudes, practices, and barriers among nursing faculty in the Middle East is limited. To equip practicing and emerging nurses, faculty must be equipped. Faculty preparedness is critical to successful curriculum integration and to preparing future nurses for genomic-informed care.

Purpose: This study examined the perceived knowledge, attitudes, practices, and barriers related to integrating genomic concepts in the nursing curriculum among nursing faculty in Jordan.

Methods: A cross-sectional descriptive design was …

More Than Machines: Our Identity In Christ, Jerrod A. Boggs

Wisdom & Compassion: The LUSON Journal

No abstract provided.

From The Leadership Desk, Elizabeth Whorley

Wisdom & Compassion: The LUSON Journal

No abstract provided.

Volume 3, Issue 2 - Complete Issue

Wisdom & Compassion: The LUSON Journal

No abstract provided.

Multi-Omics Systems-Guided Insights Of Withanolide And Other Bioactives Contributions To Anti-Stress And Endurance Outcomes In Withania Somnifera, Deepak Mundkinajeddu

Oxford ICSB

Conventional Ashwagandha standardization is largely focused on total withanolide quantification, without insights on the functional contribution of other phytochemical fractions. In this discovery-driven development program, orthogonal array–based model combined with predictive transcriptomics was used to delineate the relative biological roles of withanolide and other bioactive components within Withania somnifera extracts. Validated animal models showed that withanolide-enriched fractions significantly reduced serum cortisol (p< 0.05), while other bioactive-enriched fractions significantly increased run-time to exhaustion (p< 0.05), confirming anti-stress and endurance mechanisms. By linking the phytochemical profile with predicted biological pathway activity, the composition of the extract is rationally optimized for the development of a standardized extract (Ashwa.30), designed to deliver both anti-stress and endurance benefits at a dose of 30 mg. Clinical evaluation of the Ashwagandha extract demonstrated significant reductions in perceived stress scores and circulating cortisol levels, alongside measurable improvements in endurance parameters compared to placebo (p< 0.05), confirming translational alignment from preclinical discovery to human outcomes. Untargeted metabolomic profiling revealed enrichment of glycine and serine metabolism, methionine metabolism, phenylalanine and tyrosine metabolism, and homocysteine degradation pathways. These integrated metabolic changes worked together to improve energy production, support mitochondrial repair, maintain antioxidant balance, and help reset the body’s stress response system. This work presents a systems-biology–based approach to holistic Ashwagandha standardization, integrating withanolides and complementary bioactivities. It establishes a precision-driven framework for clinically validated adaptogenic efficacy.

How Is The Use Of Ai Impacting Nursing Students Education?, Lorna H. Strain

GS4 Student Scholars Symposium

The use of Artificial Intelligence (AI) in education is rapidly increasing and reshaping how nursing students learn and engage with content. This thesis proposal takes a look at the impact of AI on the education of nursing students and explores students' perceptions of its use in their learning and education. As AI becomes more prevalent, many students are using it for study aids and content personalization, while schools are using it in simulations and textbook platforms. Many recognize its benefits, such as enhanced critical thinking, improved accessibility of materials, and more immersive learning. Concerns persist around ethical use, academic integrity, …

The Role Of Mentorship In Reducing Burnout In New Nurses And Nursing Students, Omari Andry

GS4 Student Scholars Symposium

Burnout among new nurses and nursing students is a consistent issue affecting the healthcare system by adding to early career turnover, emotional exhaustion, and decreased quality of patient care. Structured mentorship programs have emerged as a promising intervention to alleviate burnout by giving emotional support, professional development, and coping strategies. This proposal explores the role of mentorship in reducing burnout symptoms, improving job satisfaction, and promoting emotional resilience among new nurses and nursing students alike. Based on existing scholarly articles, the project will investigate how structured versus informal mentorship affects burnout rates, the qualities of effective mentors, and the outcomes …

Alkaloid Profiling Of Narcissus Poeticus L. Bulbs And Their Inhibitory Activity Of Cholinesterases, Maël Gainche, Isabelle Ripoche, Elodie Jagu

Oxford ICSB

The Amaryllidaceae family is well known for its rich diversity of alkaloids, including lycorine- and galantamine-type structures with potent cholinesterase inhibitory properties. In this study, we investigated the phytochemical composition and cholinesterase inhibitory activity of alkaloids isolated from Narcissus poeticus L., a species native to the botanically rich Auvergne region of France. Phytochemical analysis and bioguided fractionation of bulb extracts led to the identification of three known alkaloids, pseudolycorine, norgalantamine, and 2-O-(3’-hydroxybutanoyl)-lycorine, as well as a newly characterized tetrahydroquinoline derivative, poeticine A. The inhibitory activities of these compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were assessed using both a standard …

Evaluation Of Fasted And Fed Gastrointestinal Transformation Of Withania Somnifera Plant Extracts And Bioactive Compounds Via Uplc-Ms/Ms And Untargeted Metabolomics, Sarah Barr, Wendy Strangman, R. Thomas Williamson, Amala Soumyanath, Melissa Bollen

Oxford ICSB

Ashwagandha (Withania somnifera) is a widely consumed botanical supplement recognized for its anti-inflammatory, antioxidant, and anti-aging properties. Despite its extensive use, limited information exists on how its complex chemical composition changes during gastrointestinal digestion. An untargeted UPLC-MS/MS-based metabolomics approach enables analysis of discrete changes in complex mixtures. Previous in vitro studies of W. somnifera relied on simulated gastric and intestinal models composed primarily of buffers and digestive enzymes. This study advances those methods by incorporating bile salts and phospholipids under fasted and fed conditions to better simulate physiological digestion of aqueous and ethanolic extracts of W. somnifera root and leaf. …

Whole-Brain Emotional Processing Through The Meld Framework: A Music-Based Trauma-Informed Intervention, Janita Daggy, Arij Abdul, Tammy Griffin

Liberty University Research Week

The MELD Framework integrates music, emotion, language, and dialogue as a trauma-informed intervention supporting emotional regulation and self-expression. Grounded in neurobiology and trauma theory, this approach recognizes that traumatic experiences are stored in nonverbal, right-hemisphere systems and require embodied processing before verbal integration occurs. Using music and lyric analysis, the framework facilitates safe access to emotional states while promoting bilateral brain integration and narrative coherence. This mixed-methods study examines the impact of a single 20–25 minute MELD session on participants' emotional regulation, self-expression, and integration through pre- and post-intervention self-report measures and qualitative reflective writing prompts. Analysis focuses on shifts …

Unmasking Ashwagandha Controversy: Safety, Toxicity, And Adulteration, Tahir Maqbool Mir

Oxford ICSB

Ashwagandha (Withania somnifera) is an adaptogenic shrub valued for its roots, which support systemic health. Increasing use has raised safety concerns about adulteration and hepatotoxicity. The roots of ashwagandha are primarily preferred for systemic health, while the leaves were traditionally reserved for topical applications to treat joint inflammation and promote wound healing.  Although generally considered safe, ashwagandha supplements have been linked to drug-induced liver injury, including cholestasis, jaundice, and pruritus. Reports from various organizations like LARB in the Netherlands indicate a rise in liver toxicity cases, possibly due to cytotoxic withafrin A and DNA-damaging withanone. A major concern is widespread …

Advancements In Botanical Toxicology, Characterization, And Regulatory Frameworks, Paula Brown

Oxford ICSB

No abstract provided.

Determinants Of Opioid-Relevant Exposure From 7-Hydroxymitragynine Products In The Evolving U.S. Marketplace, Igor Koturbash, Scott Alsbrook, George Pro

Oxford ICSB

Kratom’s U.S. market has rapidly evolved from largely botanical powders and capsules to products enriched in 7-hydroxymitragynine (7-OH), a potent mu-opioid receptor agonist that is typically present only at trace levels in leaf material. To quantify downstream behavioral health burden and contextualize it with real-world signals of product diffusion, we analyzed National Survey on Drug Use and Health (NSDUH) data (2021-2023) alongside public health alert trends and systematic online product surveillance. In NSDUH, 5.8% of adults met criteria for serious mental illness (SMI). SMI increased by 150% among adults with combined opioid use disorder (OUD) and kratom use between 2021 …

Naturally Derived Kratom Extracts: Toxicological Evaluation In Humans And Rodents, Sibyl Swift

Oxford ICSB

Peer-reviewed literature provides limited toxicological data on the consumption of naturally derived kratom extracts. Given the increasing use of kratom products, understanding their safety profile is critical for public health and regulatory decision-making. To address this gap, we conducted a rodent toxicology assessment and a controlled human clinical study. Human Clinical Study: Healthy male and female participants consumed specified kratom extracts daily for 14 consecutive days under controlled conditions. Clinical observations and biochemical markers were monitored throughout the study. Rodent Toxicology Study: Equivalent extract doses were administered to rodents for 90 days to evaluate subchronic exposure. Assessments included body weight, …

Detection Of 17Α Ethynylestradiol And 17Β Estradiol In Wastewater, Kezia J. Lemke

Research & Creative Achievement Day

Environmental estrogens act as endocrine disrupting chemicals, thereby affecting the metabolism, synthesis, and receptors of hormones. For this reason, estrogens can have serious health consequences for aquatic wildlife by negatively affecting their reproductive abilities. Synthetic estrogens, such as 17α ethynylestradiol, the synthetic analog of 17β estradiol, are particularly potent, and are shown to have more harmful effects at lower concentrations. This illustrates the importance of developing sensitive and efficient methods for 17α ethynylestradiol and 17β estradiol detection, so that areas of high concentration can be recognized and methods to decrease the estrogen concentrations can be put in place. To this …

Characterization Of Bacteria In Cattle Specimens, Jacob D. Hanson, Josie M. Tieskoetter

Research & Creative Achievement Day

Cattle nasal cavities provide a favorable environment for microbial colonization and can habit a wide population of bacteria, including opportunistic and pathogenic species. The objective of this research was to isolate, characterize, and identify bacteria present is nasal swap specimen collected from multiple calves. Samples were cultured and analyzed using selective and differential media, Gram staining, spore staining, and a range of biochemical assays. Several bacterial species were identified including the genus Corynebacterium and Streptococcus while some isolates could not be identified using classical biochemical methods alone. These results demonstrate that calf nasal specimens commonly contain diverse bacterial populations, some …

Effects Of Parental Communication On Alcohol Use And Self-Esteem As A Mediating Variable, Alanna Hartman

Research & Creative Achievement Day

Alcohol abuse has become a problematic phenomenon among young adults. Previous studies have found that parental communication with low warmth leads to greater risk for alcohol abuse later in life. We predict there is going to be a positive correlation between negative parental communication and alcohol abuse. Self-esteem has also been shown to have a relationship with alcohol abuse in previous research. We hypothesize that self-esteem would negatively correlate with alcohol abuse in the current study. Additionally, the literature suggests a relationship between self-esteem and parental communication. Given the relationships among these variables, we predict that self-esteem would partially or …

Beyond Caseloads And Calendars: Measuring Staff Satisfaction In Treatment Court, Ariana R. Huntington

Research & Creative Achievement Day

Background and Purpose: Treatment courts are specialized programs designed to divert individuals from incarceration while supporting recovery and rehabilitation. With more than 4,000 treatment courts operating nationwide and serving over 150,000 individuals annually, they represent a critical component of the criminal justice system. Treatment court staff may be particularly vulnerable to stress due to sustained exposure to complex substance use cases and systemic, administrative, and team-related demands. Assessing staff well-being is therefore essential, as it has implications for court effectiveness, workforce stability, and overall system functioning. Despite this importance, limited research has examined the experiences of treatment court professionals. The …

Implementation Of Education Regarding Trafficking Among Healthcare Staff And Community Organizations, Anna M. Peterson, Kate E. Arndorfer

Research & Creative Achievement Day

Background: Over the past two decades, human trafficking has received increasing media attention and public awareness efforts. Despite this, significant gaps remain in the knowledge and preparedness of healthcare professionals, specifically nursing staff, to identify and respond to trafficking victims. Human trafficking includes the exploitation of individuals through the use of force, fraud, or coercion for labor or sexual acts. Survivors often experience acute injuries, chronic illness, psychological trauma, and long-term health complications. Healthcare settings, particularly emergency departments, may be one of the few opportunities for victims to have contact with professionals outside of trafficking situations. However, there is a …

The Impact Of Early Skin-To-Skin Contact On Neurodevelopmental Outcomes In Preterm Infants, Ashia Meister

Research & Creative Achievement Day

Preterm infants face significant neurodevelopmental risks due to the interruption of late gestation brain maturation. Early skin to skin contact has emerged as a low cost intervention that supports sensory regulation, physiological stability, and neural development. This honors project synthesizes current evidence on how early skin to skin contact influences cognitive, motor, language, and socio emotional outcomes in preterm infants and translates these findings into an educational presentation for pre licensure nursing students. Across studies, early and sustained skin to skin contact is associated with improved brain activity, behavioral organization, and developmental scores in infancy, with additional evidence of structural …

Analysis Of Ovarian Structure And Cell Health In Drosophila Melanogaster After Toxic Metal Treatment, Brooke E. Helling

Research & Creative Achievement Day

This project examines how the application of multiple histological and fluorescent stains can be used to visualize the structure of fruit fly (Drosophila melanogaster) ovaries, including how toxic metal exposure may affect ovarian tissue. Ovaries were dissected from adult female flies, and some flies were first treated with toxic metals to observe possible changes in cell structure. The samples were stained with DAPI to label nuclei, antibody stains to detect specific proteins within the ovary, and apoptosis stains to identify cells undergoing programmed cell death. After staining, the ovaries were imaged using a fluorescence microscope to compare how healthy and …

Photocatalysis Of Methyl Red Using Iron Oxide Nanoparticles, Mikayla A. Ertz, Bonnie Ni, Conner J. Lehner, Henry S. Gramann

Research & Creative Achievement Day

This study investigated the photodegradation of methyl red, an azo dye commonly used as a pH indicator and a known environmental pollutant, using synthesized Fe3O4 nanoparticles. Methyl red is resistant to degradation from simple environmental conditions such as heat and light. The goal of this project was to determine whether Fe3O4 nanoparticles could act as an effective catalyst for dye degradation under UV light and to analyze the reaction kinetics using UV-Vis spectroscopy. The Fe3O4 nanoparticles were synthesized, then confirmed to be magnetic and further characterized using IR spectroscopy. Photodegradation experiments were conducted by exposing 50 ppm methyl red solutions, …

Disaster Preparedness In Healthcare Workers, Helen Prow

Research & Creative Achievement Day

Disasters can negatively impact healthcare systems worldwide, with increased impacts on resource-limited communities. Nurses and other healthcare workers are often on the frontlines of disaster response; evidence shows that many healthcare workers worldwide are not adequately prepared to respond effectively. The purpose of this honors project is to analyze factors and interventions that influence healthcare workers, specifically nurses, in disaster preparedness in resource-limited settings globally. A review of peer-reviewed literature published within the past ten years was conducted using systems such as CINAHL, PubMed, Google Scholar, and Open Evidence. Articles were selected based on relevance to disaster preparedness among healthcare …

Molecular Basis Of 24-Methyl Cholesterol As An Anti-Renal Clear Cell Carcinoma Agent In The Context Of Altered Cellular Glucose Metabolism, Josiah Chung, Merritt Smith, Zachary Wang

Liberty University Research Week

Cancer remains a major global cause of mortality, with kidney cancer representing a significant portion of newly diagnosed cases each year worldwide and in the United States. In Virginia alone, more than one thousand new kidney cancer cases are reported annually. The majority of these cancers are classified as renal cell carcinoma (RCC), with clear cell renal cell carcinoma (ccRCC) accounting for roughly 70% of diagnoses. ccRCC tumors exhibit substantial metabolic reprogramming that supports rapid proliferation and survival under fluctuating nutrient conditions. Because of this metabolic dependence, targeting pathways involved in glucose uptake and cellular energy production has emerged as …

Understanding Factors Associated With Mental Health Among Collegiate Athletes, Kaidin S. Barnes, Paige Christianson, Kylie Buck, Kyra Nelson

Research & Creative Achievement Day

Understanding factors associated with mental health among collegiate athletes may help inform targeted support and reduce barriers to care. This study examined relationships among athletic identity, perceived stigma, psychological distress, and sport participation in college students. Participants (N = 312) reported varsity or club sport involvement, with 28.2% identifying as varsity or club athletes. Variables measured included athletic identity, perceived stigma, and symptoms of anxiety, depression, and stress. A subset of participants also reported injury history. Data were analyzed using correlations and independent samples t-tests. Athletic identity was moderately and positively associated with stigma, indicating that students who identified more …

Exploring How Virtual Reality Affects The Client-Recreational Therapist Relationship, Ellie Barker, Sophia M. Young, Natalia C. Miller, Lindsay J. Bergan

Research & Creative Achievement Day

Virtual Reality (VR) is an electronic recreation of reality, depicting environments, and enabling clients to interact with instantaneous simulations that provide an immersive experience (Guttentag, 2010;  McGovern, 1994). Adopting VR as an intervention could be a breakthrough innovation to overcome obstacles while connecting with clients. Current research on VR used in Recreational Therapy (RT) holds inconsistencies in its findings, specifically across various populations and VR tools. The purpose of this study was to gain insights from professionals about the therapeutic relationship between clients and therapists when using VR as an intervention. This study examined how the relationship between the therapist …

Comparison Of Total Distance And Sprint Distance Between Positions Of Division Ii Female Soccer Players, Tamas Sebestyen, Jonathan P. Bayer

Research & Creative Achievement Day

Introduction: To manage player health, minimize injury, and optimize performance in NCAA Division II soccer, this study analyzed positional demands using GPS technology. The findings provide insights into enhancing training plans and recovery based on specific positions. Methods: NCAA Division II female soccer players were tracked during sixteen in-season competitions using 10 Hz GPS wearable technology. Players were grouped into tactical roles including Wing Backs (WB), Center Backs (CB), Defensive Midfielders (6), Attacking Midfielders (10), and Forwards (9). Key metrics analyzed included Total Distance (TD), Total Sprint Distance (TSD), and Distance per Minute (D/M). Results: Forwards (9) and attacking midfielders …

Care, Capitalism, And Croissants: Interprofessional Students Take On Business Of Healthcare In Paris, Beth A. Komay, Phoebe S. Enebechi, Selma Dzamalija, Nicole A. Sharp

Research & Creative Achievement Day

The Business of Healthcare in Paris is a faculty-led study-away program that unites business, nursing, and other healthcare students in an immersive experience of global healthcare systems. The primary design of this course is around interprofessional learning that integrates coursework and cultural experiences from within the Midwest United States (US) and France. Students begin the course by visiting healthcare facilities and small alternative-therapy businesses in the US, gaining initial exposure to diverse care environments. They then travel to Paris and surrounding areas to explore comparable sites, including hospitals, an art therapy center, a residential rehabilitation facility, and small businesses providing …

Project Akira: Data Mining And Merging, And Training A Custom-Built Gpt To Produce Therapist-Like, Ethically Coherent Responses, Rocco Moore, Joshua Farara

GS4 Student Scholars Symposium

Numerous artificial intelligence GPT models are trained on various language dataset types, including ethical and mental health dialogue, to produce ethically coherent responses, and these datasets are opened and merged together via the efficient processes of data mining and data merging. To explore how companies such as OpenAI and Microsoft achieve these goals, we implemented our own custom-built GPT, named AkiraGPT, which has recently and historically had issues generating ethical responses, simulating self awareness, and has sometimes generated incomprehensible, contextually irrelevant responses. In addition to that, AkiraGPT would sometimes have it's responses be "cut off." 

Our goal with our research …