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The Polymerized Protein Response (Ppr) Is Activated By Genetic Variants That Polymerize In The Er And Is Mediated By Nfκbp50, Admire Munanairi, David A Rudnick, Jiansheng Huang, David H Perlmutter

2020-Current year OA Pubs

In previous studies we have shown that accumulation of the polymerogenic variant ATZ that causes α1-antitrypsin deficiency (ATD) activates NFκB DNA binding. Here we discovered that this response, which we are naming the polymerized protein response (PPR), is characterized by NFκB p50 homodimers, distinct from the p50/p65 heterodimers in the canonical NFκB inflammatory response and the unfolded protein response (UPR). The PPR is also activated by other disease associated variants that polymerize in the ER whereas disease-associated variants that do not form polymers activate p50/p65 heterodimers and UPR. The PPR elicits a unique gene expression profile, including changes that stabilize …

Interval Appendectomy Practices For Complicated Appendicitis In Children: A Systematic Review From The Apsa Outcomes And Evidence-Based Practice Committee., Jason P. Sulkowski, Carlos T. Huerta, Jun Tashiro, Diana L. Diesen, Brian C. Gulack, Emily Christison-Lagay, Katie W. Russell, Hanna Alemayehu, Stephanie F. Polites, Matthew T. Hey, Henry L. Chang, Alana L. Beres, Romeo C. Ignacio, Donald J. Lucas, Sandra K. Kabagambe, Robert Baird, Afif N. Kulaylat, Sara A. Mansfield, Rebecca M. Rentea, Christopher Pennell, Barrie S. Rich, Yasmine Yousef, Robert Ricca, Lorraine Kelley-Quon, Tamar L. Levene, American Pediatric Surgical Association Outcomes And Evidence-Based Practice Committee

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: This review summarizes considerations within the existing recent literature that guide the practice of interval appendectomy (IA) after initial non-operative management (NOM) of complicated appendicitis (CA) in children.

METHODS: A systematic review of English language articles published from 2000 to 2025 was conducted in Medline, Embase, and Cochrane Central Register of Controlled Trials to address four elements which could impact the decision for IA after NOM of CA: (1) the incidence of recurrent appendicitis; (2) the time period in which recurrence occurs; (3) the patient or disease-related risk factors which increase recurrence; and (4) the incidence of appendiceal neoplasms …

Early Neurologic Red Flags In Pediatrics: What Primary Care Providers Need To Know, Bob Underwood, Justin Coogle

Pediatrics in Practice: A CME Podcast

Subtle neurologic symptoms can be easy to miss in primary care. Pediatric neurologist Justin Coogle, MD, reviews early red flags, age‑specific warning signs and referral considerations to help pediatricians identify neurologic disorders earlier and optimize care.

Click here to stream the podcast episode.

Front Matter

DePaul Business & Commercial Law Journal

No abstract provided.

The Risk Of Risk, Julia Sinclair-Palm, Lj Slovin

Journal of Queer and Trans Studies in Education

For decades, research centered on risk narratives as a strategy to compel safety interventions in schools. In this report, we query the left’s continued attachment to this discursive positioning of trans youth and ask: what are the implications of relying on an articulation of trans youths’ right to exist in relation to risk in order to advocate for resistance? Drawing on queer and trans theory, we argue that research about trans youth is trapped in an understanding of trans youth as victims in need of saving. We desire responses from the left that are not mired in conservative narratives, and …

Why Keep The Lgbtqia+ Acronym Together – "Wouldn't It Just Be Best To Split The Acronym?", Kim Andreassen, Bri Mckenzie, Julian Chen, Wendy Cumming-Potvin

Journal of Queer and Trans Studies in Education

Drawing on the authors' reflections after hosting a community launch event that shared outcomes from research about LGBTQIA+ inclusion in K-12 education in Western Australia, this report examines the importance of keeping the LGBTQIA+ acronym together, emphasizing its role in promoting inclusion, intersectionality, and equitable education. Global legislative actions targeting gender-diverse and queer youth, such as recent restrictive laws in the United States, threaten the fundamental right to education and undermine efforts toward achieving the United Nations' Sustainable Development Goal 4 of quality education for all. Utilizing relevant education literature, researchers' reflections and introspective questions, this report stressed the interconnectedness …

From The Field: Lessons From Saskatchewan, J Wallace Skelton, Ashlee Sandiford, Alex Schmidt, Hannah Paul

Journal of Queer and Trans Studies in Education

Just before the 2023-2024 school year, Saskatchewan enacted transphobic school policy and then legislation. Four Saskatchewan educators describe the ways this legislation has impacted them, their students and their colleagues, and ways they are engaging in resistance through activism, pedagogy and research.

“No (My Parents Can’T Know I’M Trans)…For Now:" Resisting Anti-Transgender Backlash In Schools Through A Policy Experiment, Lee Airton, Mik Turje

Journal of Queer and Trans Studies in Education

This From the Field account describes an intervention we and our colleagues offered in the Canadian culture war surrounding transgender children and youth, as clinical and research experts on K-12 education policy and supports for transgender youth and their parents. In 2023, following comprehensive review by K-12 school administrators, lawyers and experts in child welfare, we released No For Now (NFN). NFN responded to the impending passage of laws which directly harm transgender youth by essentially forcing them to be outed to potentially unsupportive parents. We suggest that NFN enacts an experimental kind of policy-based resistance to these laws and …

Pride On The Prairie: Resistance As Pedagogy In Oklahoma, Madelyn D. Evans, Ashley Herndon, Sage A. Mauldin

Journal of Queer and Trans Studies in Education

With an increasing number of attacks on two-spirit, transgender, queer, and gender non-conforming (2STQGNC) students, it is critical to critique the intersecting systems of oppression that work in tandem to eradicate anyone who does not conform to ‘regimes of normalcy,’ particularly cisheteronormativity. In Oklahoma, legislative assaults are taking place to erase 2STQGNC identities and limit civil rights and civil liberties within K-12 schools. This report examines various oppressive policies, highlights student-led resistance as a pedagogical tool, discusses the reciprocal relationship between student activism and community support, and concludes with recommendations for K-12 Educators and 2STQGNC Students.

Pedagogies Of Heart/Break: Nurturing Trans Resistance Through Beloved Witnessing, Page Valentine Regan

Journal of Queer and Trans Studies in Education

This article calls for spiritual activism on behalf of trans young people. Drawing from the narratives and perspectives of a group of trans young adults of Color situated in the Southeastern United States, the author encourages pedagogies of heart/break. Such a pedagogical position requires a service-based orientation to education, rooted in beloved witnessing. Rather than affinity spaces, political action, or cerebral understanding, beloved witnessing may prove to be a more reliable condition for healing and self-actualization, especially in support of a trans of Color future in educational research, practice and places of learning.

Rural School Counselors Supporting Queer Students In The Southeastern United States, Harley Devon Locklear, Damaris Bates

Journal of Queer and Trans Studies in Education

This article aims to explore the storied experiences of school counselors who actively, overtly and covertly resist the oppression of queer students within rural schools throughout the Southeastern United States. Narrative Inquiry was the research methodology utilized to collect, interpret, and reconstruct these stories, culminating in the synthesization of six overarching themes capturing the factors contributing to and limiting the advocacy efforts of rural school counselors: View of Role, Counselor Self-Efficacy, Stakeholder Push-back, Services Offered, Advocacy Efforts, and Training and University Support. Implications for school counselors, counselor education program, and school administers are also discussed in relation to improving …

Engines For Activism: Gsa Advisors Sparking Student Activism For Lgbtq+ Equity, Elizabeth J. Meyer, Rebecca Grace Kaplan, Erin Kurtz

Journal of Queer and Trans Studies in Education

This article reports on a study on educators supporting student activism for LGBTQ+ equity in schools. The research questions we address are: What impacts do activist-educators have on the activities of the students in their GSA (Genders & Sexualities Alliance)? In what ways do activist-educators support student activism for LGBTQ+ equity? Based on in-depth interviews with seven educators in Colorado, we use grounded theory to present a conceptual model called “Engines for Activism” (EFA). We share data that explain how student and educator interactions within the space of a student club led by an educator-activist can drive advocacy and activism …

Knowledgemaking As Resistance For Queer Youth, Katie Clonan-Roy, Shereen Naser, Daylun Armstrong, Mars Bonilla-Gilgenbach, Thomas Haynes, Rae Jackson, Liz Goncy, Kimberly Anne Fuller

Journal of Queer and Trans Studies in Education

In an era of increasing anti-LGBTQ+ legislation, queer youth continue to resist oppressive systems through knowledge-making and collective action. In this paper, we explore the transformative nature of liberatory knowledge making for sexual and gender diverse (SGD) youth, which can foster youth’s capacity for resistance work against systems that would otherwise harm them. The paper focuses on a program called Youth Research for Social Change (YRSC) program, where youth and adult co-conspirators engaged in participatory action research to challenge dominant narratives, develop critical consciousness, and foster a sense of community. We explore key tenets of liberatory knowledgemaking—community and solidarity, criticality, …

“You Can’T Ban That!”: Lgbtq+ Youth Of Color Speak Back To Book Bans In Utah, Sonny Partola, Leticia Alvarez Gutiérrez

Journal of Queer and Trans Studies in Education

This article explores how LGBTQ+ youth of color (LGBTQ+ YOC) in Utah perceive anti-LGBTQ+ book bans amid a hostile sociopolitical climate. Drawing from a critical ethnographic study at a public high school, and guided by Queer of Color Critique, we examine how censorship, heteronormativity, and White Christian nationalism shape book bans. Youth participants described such bans as mechanisms of erasure and harm that restrict access to affirming literature and reinforce marginalization, while also revealing contradictions in schools’ promotion of literacy alongside censorship. Despite these harms, participants resisted erasure—asserting visibility, belonging, and intellectual freedom. This study contributes to scholarship on censorship …

Numeracy-Based Civic Education Model: Needs Analysis Through An Explanatory Sequential Design, Sulkipani Sulkipani, Kokom Komalasari, Sapriya Sapriya, Susan Fitriasari, Vina Amilia Suganda Makenun

Numeracy

The United Nations Sustainable Development Goals emphasize numeracy as essential for quality education, and require its integration across the curriculum, including into civic education (CE). However, the integration of numeracy in CE in Indonesian universities has not yet been clearly mapped out. This study aims to analyze the need for numeracy integration in CE as a basis for developing a numeracy-based CE learning model. Using a mixed method with an explanatory sequential design, the study involved a convenience sample of 225 students and 10 lecturers from various universities through surveys, interviews, observations, and documentation studies. Quantitative findings show that numeracy …

Investigating How Caffeine Affects Perceived Exertion And To What Extent Young Adults Consumers Are Aware Of The Active Ingredients, Brianna Richter

Honors Projects

BACKGROUND: Caffeine is one of the most widely consumed substances in the world, often used to increase energy and alertness. From morning coffee to pre-workout and energy drinks, caffeine has become a daily staple for students, athletes, and working professionals. In recent years, caffeine consumption has increased significantly, with the energy drink and pre-workout industries rapidly expanding. Research has been conducted on the effects of caffeine; however, there is limited research examining how consumer awareness of caffeine products and their additional active ingredients influence perceived exertion and exercise in young adults. PURPOSE: This study investigated the perceived effect of …

Intouch Week Of April 27, 2026, New York Medical College

InTouch

• Tracey Milligan, M.D., FAAN, and Sarah Parauda, M.D., Honored on National Stage with Top Neurology Awards
• White Coat Ceremony Ushers SLP Class of 2027 into Clinical Training
• D.P.T. Class of 2028 Steps into Clinical Education
• SOM Class of 2028 Marks Milestone as Clinical Training Begins
• NYMC Celebrates Earth Day with Campus Sustainability Initiatives
• A Pawsitive Break for the NYMC Community
• Student Spotlight: Ashley Abing-Mesropyan Follows a Path Towards Meaningful Care

The Intersection Of Discrimination Between People Of Color And The Queer Community, Zaniya M. Howell

Honors Theses

This thesis examines the mental health experiences of Queer People of Color (QPOC) through an intersectional infrastructure, highlighting how intersecting systems of sexuality/gender-based and racial oppression influence psychological outcomes. QPOC experience disproportionate levels of systemic violence, trauma, and chronic stress in comparison to both heterosexual people of color and white LGBTQ+ counterparts, leading to elevated risks of anxiety, depression, and other mental health concerns. Prior research often separates race from sexual and gender identity, restricting a thorough understanding of this community’s experiences. Drawing on original survey data and existing literature, this study illustrates the aggravating effects of intersectional discrimination and …

265 Screens, Don Casper

Theses

265 Screens documents twenty-nine cinemas across six states which shut down since March 15, 2020. My project blends photography with cinematography set in a darkened space creating an alternative cinematic experience - reflecting on the changing film industry through the rise of digital technologies and what it means to lose these physical spaces that connect us. Digital streaming has made it possible to watch films at home or alone on a mobile device – creating more isolated viewing experiences. This body of work embodies this transition through the blending of the materials used to create the images themselves. The photographs …

Embedding Social Determinants Of Health Into Maternal Simulation Scenarios: Enhancing Nursing Staff Awareness Of Equity-Based Education, Sherina Evans

Doctor of Nursing Practice Projects

Despite growing evidence emphasizing the importance in addressing disparities in maternal health outcomes, maternal health simulations often lack integration of social determinants of health (SDOH) and cultural considerations. The purpose of this Doctor of Nursing Practice quality improvement project was to enhance nursing faculty cultural awareness through simulation scenarios that incorporate SDOH and culturally responsive elements. This project was guided by Lewin’s Change Theory and the Jeffries Simulation Framework. The aim was to strengthen faculty awareness and skills to support the development of culturally inclusive simulation experiences. Descriptive statistics were utilized to analyze results which was a limitation. Nursing faculty …

Cim221 Rainbow Tree: Example 6, Lily Hackett, Dillon Hudson, Kaden Matchett, Rees Muthee

Exemplars

For our project, our group was presented with the 89% project. The 89% project focuses on the 89% of people who want to make a change for our climate, but simply don't commit, essentially getting the route for climate change reduction nowhere.

We chose Behavioural Sciences as our theoretical lens. This means we would be putting time into researching exactly who our audience is, and what attitudes and reactions they hold in regards to climate change. We needed to figure out a way to inform the 89% of this issue, and convince them to join us in improving the way …

An Evaluation Of Total Navicular Implants: A Scoping Review, James Mcclure Hughes, Nicholas Belardo Obias, Amanda Killeen

School of Podiatric Medicine - Student Research

The aim of this study is to determine the efficacy and safety profile of total navicular implants based on current literature.

Navicular insults such as high-energy trauma, osteonecrosis, and Muller-Weiss syndrome may result in avascular necrosis or a critical sized bone defect, conditions that are highly difficult to manage given current treatment modalities. Total navicular implants may offer a solution to these problems. While 3D printing of implants remains investigational, its use in highly individualized cases involving the talus has had promising results with conditions like avascular necrosis, tumors, trauma, and arthritis. The navicular is unique in its attachments to …

A Novel Guide‑Free Internal Device Fixation For Transverse Tri‑Planar Distal Metatarsal Osteotomy: A Retrospective Review​, Maya D. Kaafarani, Brittney White, Graham A. Hamilton, Shannon M. Rush

School of Podiatric Medicine - Student Research

Introduction: Minimally invasive surgery (MIS) for bunion correction has gained popularity due to favorable outcomes and reduced recovery times. However, most MIS techniques rely on commercial instrumentation for osteotomy, reduction, and fixation. This retrospective study evaluates patients treated with a novel tri-planar distal metatarsal osteotomy performed without specialized MIS guides, using only standard surgical tools and a novel device.

Methods: A retrospective review was conducted on 28 patients (31 procedures, including 3 bilateral cases) who underwent MIS bunion correction from 2021 to 2024. The technique involved a 2–3 cm medial incision, transverse osteotomy at the distal surgical neck of the …

Beyond A Backsplash, Emery Gowdy

Honors Projects

Tile often goes to waste before material failure, adding to the waste the construction industry creates. Ceramic tiles should be seen as a prized building material, especially in a time when conservation is essential for our planet's health. Yet our current building practices too often leave them buried in the millions of tons of construction waste we produce each year, well before they need to be. Which is why it is necessary to consider new ways of designing a system for adhering tiles that allows them to be preserved. In this paper, I developed a new tile system based on …

Improving Monitoring And Documentation Of Long-Acting Injectable Antipsychotic Adherence In Patients With Schizophrenia Through Staff Education And Refill History Review, Stacy Ann Bruce

Doctor of Nursing Practice Projects

Schizophrenia is a chronic psychiatric disorder associated with relapse, hospitalization, and poor outcomes when medication adherence is suboptimal. Nonadherence increases morbidity and healthcare utilization (World Health Organization, 2022; Zhao et al., 2025). Long-acting injectable (LAI) antipsychotics improve adherence and reduce hospitalization, but inconsistent monitoring and documentation in outpatient settings hinder early identification of missed doses (Lieslehto et al., 2022). This Doctor of Nursing Practice (DNP) quality improvement project aimed to evaluate whether staff education and structured refill-monitoring processes improve identification and documentation of nonadherence to LAI antipsychotics. Using Kotter’s Change Management Model and the Plan-Do-Study-Act framework, the project focused on …

Quality Improvement Project: Emergency Preparedness In Urgent Care: Impacting Competency Among Medical Assistants, Sarah Pettyjohn

Doctor of Nursing Practice Projects

Urgent care settings present significant challenges, including limited staffing and resources, unpredictable patient acuity, and training deficiencies. These factors contribute to a competency gap among medical assistants, limiting their ability to recognize and respond to medical emergencies. The purpose of this quality improvement project is to impact emergency medical preparedness through a formal educational intervention. Grounded in Lewin’s Change Model and the Kirkpatrick Model, the project aims to improve emergency medical competency, consistent with evidence supporting structured training approaches. Using American Heart Association guidelines, medical assistants participated in a six-week educational program implemented through the Plan-Do-Study-Act framework, with assessments administered …

Should There Be International Standards For Qualitative Social Work Research? A Commentary On Utility, Contradictions, And Reframing To Principles, Margaret Janse Van Rensburg

Faculty and Staff Publications

This commentary critically examines the promise and contradictions inherent in developing international standards for qualitative social work research. It contributes by proposing that ethics guided by epistemic freedom and epistemic justice can act as a foundation for flexible principles enhancing qualitative social work research on an international level.

Stability Without Support: Kinship Care And The Reproduction Of Inequality In Child Protection, Kiera Fischer

Senior Seminars and Capstones

This project examines child protection outcomes in Minnesota through a structural and inequality focused lens, analyzing how poverty, housing instability, racism, and system overlap shape family involvement with Child Protective Services (CPS). This literature review draws from sociology, anthropology, social work, and child welfare research, to examine how child protection systems disproportionately surveil and penalize low-income families and families of color, often framing structural disadvantage as an individual parental failure rather than a systemic or institutional issue. I specifically consider placement outcomes following child removal, with particular attention to differences between kinship care and non-relative foster care. Kinship placements are …

Cross-Sectional Associations Of Metabolically Healthy Obesity, Lifestyle Factors, And Steatotic Liver Disease In Adults From The Fels Longitudinal Study, Ariana L. Garza, Audrey C. Choh, John Blangero, Cici X. Bauer, Stefan A. Czerwinski, Miryoung Lee

School of Medicine Publications

Objective: To examine the associations of metabolic health and obesity phenotypes with liver fat accumulation and hepatic steatosis in adults. Methods: We analyzed 676 non-Hispanic white adults (18–95 years; 55.8% female) from the Fels Longitudinal Study using a cross-sectional design. Participants were classified into metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO) phenotypes. Metabolically unhealthy status was defined as the presence of ≥1 metabolic dysfunction, consistent with prior epidemiological definitions; secondary analyses using ≥2 were also performed. Obesity was defined using DXA-derived body fat percentage. Liver fat (%) was …

Vibration Health Monitoring System In Uah Senior Aircraft Design, Deklan Alexander Wilder

Honors Capstone Projects and Theses

No abstract provided.