Digital Commons Network^™

Science First, Formatting Second: Is It Feasible To Adopt A Free-Format Submission Policy?, Anas Alyazidi

Neurosciences

No abstract provided.

Neuroinflammation At The Crossroads Of Neurodegeneration: The Roles Of Microglia And Astrocytes In Parkinson's Disease, Alzheimer's Disease, And Multiple Sclerosis, Mohannad A. Almikhlafi

Neurosciences

Neuroinflammation plays a critical role in the pathogenesis of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. This review explores the underlying mechanisms of neuroinflammation, with a focus on the roles of microglia, astrocytes, peripheral immune cell infiltration, and cytokine release. The complex interplay between oxidative stress and chronic inflammation accelerates neurodegeneration, contributing to disease progression. Microglial activation, initially protective, becomes harmful when sustained over time, driving chronic inflammation. Similarly, astrocytes once considered passive are now recognized for their active involvement in both inflammatory and neuroprotective responses, depending on their activation state. Prolonged activation of microglia and …

Protein Intake In Children With Cerebral Palsy: A Narrative Review Highlighting The Implications Of Protein Intake On Muscle Mass, Growth, And Overall Nutritional Status, Manar Waleed Simbawa, Sheikha Nasser Alqahtnai

Neurosciences

Children with cerebral palsy experience nutritional challenges that affect protein intake and may contribute to poor muscle mass and growth faltering. Since protein plays a major role in preserving muscle mass and supporting growth, ensuring adequate intake is critical. A comprehensive literature search was conducted for observational studies published between 2006 and 2025. The reviewed studies results were grouped into: [1] Protein intake, with values ranging from 0.66 to 4.1 g/kg/day, with higher intake observed among ambulatory or orally fed children, [2] Nutritional Status and Body Composition, as reduced muscle was reported in children with severe motor impairment, and [3] …

Role Of Bevacizumab In Multiple Glioblastomas: A Retrospective Single-Center Analysis, Yongrui Zhao, Yidong Chen, Leiming Wang, Ye Cheng, Feng Yan, Jiankun Xu

Neurosciences

Objective: To explore the prognostic factors of multiple glioblastomas (M-GBMs) and the role of bevacizumab (BEV) in M-GBMs. Methods: 162 patients treated for primary glioblastoma (GBM) from 2020 to 2024 were retrospectively reviewed. Kaplan–Meier analysis was performed to compare progression-free survival (PFS) and overall survival (OS) between the single glioblastoma (S-GBM) group and the M-GBMs group. Independent predictors of OS among M-GBMs patients were evaluated via multivariable Cox regression analysis. Results: 116 patients had S-GBM, and 46 had M-GBMs. Compared with S-GBM patients, M-GBMs patients had poorer PFS (6.5 vs. 11 months, p<0.001) and OS (15.5 vs. 21 months, p=0.005). In the M-GBMs group, based on the RANO resection criteria, both univariable analysis and multivariable Cox models confirmed that the extent of resection, use of radiotherapy and chemotherapy, p53 overexpression, and use of BEV were all factors that significantly influenced OS. Specifically, the use of BEV prolonged OS from 12 months to 19.5 months (p = 0.017). From the initiation of BEV therapy, the median PFS was 5.5 months (95% CI 4.45–6.56 months), and the median survival was significantly longer than in those who did not received BEV (10 vs. 3 months, p = 0.021). Conclusion: The extent of resection, radiotherapy/chemotherapy, p53 …

Catalyzing Learner-Centered Ecosystems In Pennsylvania For A Future Of Human Thriving, Danielle S. Shylit

Graduate Theses & Dissertations

School-centric education has failed to produce equitable outcomes for Pennsylvania's learners. Declining student engagement, widening opportunity gaps, and the demoralization of educators and leaders escalate an urgent need to shift systems, mindsets, and praxis from a school-centric to a learner-centric paradigm. This action research dissertation elevates what is learned at individual, group, and system levels through disciplined inquiry with aligned district public education leaders in Pennsylvania willing to co-create learner-centered ecosystems with community stakeholders for a future of human thriving. Grounded in Education Reimagined's definition of Learner-Centered Ecosystems, and the theoretical frameworks of Bryk et al.'s Networked Improvement Communities and …

Facilitating Student Success Through Scholar Programs, Jenna Heath, Isabella Shenouda

College of Liberal Arts Faculty Research

This poster features a series of career highlights from the UNLV Engelstad Scholars Program. This document profiles four exceptional current and former students—Fyona Mortel, Nikki Adams, Jordan Paul Guimarey, and Haydee Herrera—who demonstrate how the program's unique blend of mentorship, financial support, and community engagement accelerates career readiness. Through hands-on internships, leadership roles, and diverse professional networking opportunities, these scholars have cultivated essential competencies such as leadership, critical thinking, empathy, and professional branding, effectively preparing them for future success in their respective fields.

Virtual Rape In Indonesian Criminal Law: Legal Reality Or Conceptual Challenge?, Moh. Raihan Rizaldi Sutran

Indonesia Law Review

Current technological developments have brought humanity into a new era called the metaverse, a virtual world that allows people to interact through digital avatars. However, this progress has also presented new problems, one of which is virtual rape – rape committed by players through their avatars. Even though there is no direct physical contact, victims can still experience real psychological effects such as trauma, anxiety, and fear. The main problem is there are no regulations in Indonesia that can address this phenomenon yet. Therefore, this article examines the extent to which the phenomenon of “virtual rape” can be considered equivalent …

Patients With Opioid Use Disorder Report Compassionate Care But Missed Support Opportunity, Chloe Veilleux, William Dykes, J Richard, Wendy Craig, Liz Scharnetzki, A Wurcel, Aurora Quaye

Costas T. Lambrew Research Retreat 2026

Introduction: Results Hospitalizations involving opioid use disorder (OUD) have risen steadily over the past five years. Patients with OUD experience higher rates of self-directed discharge, readmission, and post-discharge mortality than those without OUD. These disparities are often driven by stigma and inadequate management of pain and withdrawal, which can lead to continued substance use following discharge.

Examining The Psychometric Structure Of An Instrument To Measure Students’ Interests And Motivation In Science Learning: Factor Analysis And Measurement Invariance, Fuhui Tong, Shifang Tang, Zhuoying Wang, Beverly J. Irby

Faculty Publications

In this study, we examined the psychometric properties (reliability, validity, and underlying factor structure) and measurement invariance of a researcher-developed instrument: Motivated Strategies for Science Learning (MSSL). Data were collected from 2765 fifth-grade students across [state withheld] school districts. Results from exploratory and confirmatory factor analyses suggested satisfactory psychometric properties of MSSL. We further identified strong evidence to support configural, metric, scalar, and strict invariance across school location groups (i.e., rural and non-rural), confirming that the instrument can accurately capture the construct of science learning motivation among fifth-grade students from both rural and non-rural Texas schools. The study provides the …

Strategies To Improve Caregiver Satisfaction With Telehealth In Autism Care, Navid Dezhnabadi

Walden Dissertations and Doctoral Studies

The increasing use of telehealth in autism care has created opportunities to improve caregiver satisfaction as it remains a critical challenge in pediatric specialty settings. The purpose of this integrative review was to identify strategies that healthcare administrators can implement to improve caregiver satisfaction with telehealth platforms and optimize care delivery for autism patients. Using an integrative review methodology and viewed from the lens of the unified theory of acceptance and use of technology framework, evidence from 20 research and non-research sources published between 2018 and 2025 were analyzed, using the Johns Hopkins nursing evidence-based practice model and synthesized. The …

Clustering Digestive Tract Tumors Using Transcriptomic And Mutation Data, Dwayne G Tally, Polina Bombina, Jake Reed, Jeffrey Kinne, Lynne V Abruzzo, Kevin R Coombes, Zachary B Abrams

2020-Current year OA Pubs

BACKGROUND: Digestive tract cancers, like most other cancers, are usually categorized based on cell or tissue of origin. Molecular clustering based on the transcriptome often produces the same classification.

METHODS: We developed a new method, Newmanization, to reduce underlying tissue signals from transcriptomic analysis. To test our method, we downloaded data on 1635 samples of digestive tract cancers from The Cancer Genome Atlas. The available data includes transcriptomic data by RNA-Seq, as well as binary mutation allele frequency data by whole exome sequencing. We compared, using silhouette widths and visualization by dimension reduction plots, the effectiveness of Newmanized transcriptome and …

Child-Centered User Interface Design For Early Language Learning Applications: A Qualitative Comparative Study, Fenie Fedora Wijaya, Shienny Megawati Sutanto

Jurnal Pendidikan dan Pembelajaran

Background: In the digital learning era, user interface (UI) design plays an important role in shaping how children engage with educational applications, particularly in early language learning contexts. however, many applications are not fully aligned with children’s cognitive, emotional, and developmental needs. Objective: This study aims to examine how UI design in child-centered language learning applications can be optimized to support children’s cognitive and emotional needs while enhancing learning outcomes. Method: This study adopts a qualitative comparative approach, integrating a literature review, visual analysis of two English-language learning applications (Duolingo ABC and BOOKR Class), semi-structured interviews with three design experts, …

Age-Dependent Effects Of Mkp-2 Deletion On Glucose Homeostasis In Female Mice, Laura Rain Chambliss

Honors Capstone Projects and Theses

No abstract provided.

Socializing Stem: Analyzing The Effects Of Stem Pedagogy, Communication, And Culture On Stem Student's Holistic Development, Jalynn B. Whitfield

Honors Capstone Projects and Theses

No abstract provided.

Jtc 26: Twenty Years In The Making, Staff Report

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Between Care And Compliance: A Mixed-Methods Examination Of Social Workers' Perspectives On Behavior Contracts In Healthcare, Katelyn E. Murphy

Social Work Doctoral Dissertations

Behavior contracts are frequently used in healthcare environments to manage behaviors labeled as disruptive; however, their use presents many ethical, legal, and practical concerns. This mixed-methods study examined behavior contracts through a social work lens, with particular attention to their impact on patient-centered care, professional ethics, and the patient–provider relationship. Based on the Person-in-Environment theory and core bioethical principles, the quantitative aspect of the study assessed healthcare social workers’ attitudes regarding the ethical implications of behavior contracts and their alignment with patient-centered care. The study looked further at how these perceptions differed based on years of professional experience as a …

2025 Annual Report, Tennessee. Bureau Of Investigation.

Annual Report

No abstract provided.

Building Sustainable Competitive Advantage Through Customer Centricity: Evidence From Fmcg Firms In Indonesia, Oskar Fajar Damanik, Elliot Simangunsong, Fathony Rahman, Eka Ardianto

The South East Asian Journal of Management

Research Aims: This study aims to develop a comprehensive model that leverages customer-centric strategies to build sustainable competitive advantage within the dynamic and complex context of changing consumer behaviour.

Design/Methodology/Approach: Data were obtained from 235 sales and marketing managers across 63 Fast Moving Consumer Goods (FMCG) firms using a convenience sampling method. A structured questionnaire employing Likert-scale items was distributed via Google Forms. The data were analysed using Partial Least Squares Structural Equation Modelling (PLS-SEM) in SmartPLS 3 and further validated through semi-structured interviews with top management practitioners.

Research Findings: The findings of the study indicate that a customer-centric strategy …

The Influence Of Top Management Commitment On Competitive Advantage Through Supply Chain Resilience, Supply Chain Digitalisation, And Supply Chain Responsiveness, Hotlan Siagian, Sautma Ronni Basana, Widjojo Suprapto, Zeplin Jiwa Husada Tarigan

The South East Asian Journal of Management

Research Aims: This study aims to analyse the influence of top management's commitment on competitive advantage through supply chain digitalisation, responsiveness, and resiliency.

Design/Methodology/Approach: Data were collected using a five-point Likert-scale questionnaire distributed to manufacturing practitioners with a minimum supervisory position. A total of 203 valid questionnaires were analysed. Data processing was performed using SmartPLS version 4.0 to test measurement and structural models.

Research Findings: The study results indicate that eight hypotheses are accepted and one is rejected. Top management commitment positively impacts supply chain digitalisation, responsiveness, and resilience. Furthermore, supply chain digitalisation and supply chain resilience both positively impact …

The Path To Impulse: A Cognitive-Affective-Conative Model Of Live E-Commerce Behaviour Across Southeast Asia, Any Urwatul Wusko, Aminullah Aminullah

The South East Asian Journal of Management

Research Aims: This study investigates how cognitive and affective mechanisms jointly shape impulse buying intentions in live e-commerce environments, using the Cognitive-Affective-Conative (CAC) model, with a focus on Southeast Asian consumers.

Design/Methodology/Approach: A quantitative, cross-sectional survey was conducted with 430 respondents from Indonesia, Malaysia, Thailand, Vietnam, and the Philippines. Data were gathered from participants with recent live-shopping experience on platforms such as TikTok Shop and Shopee Live. Structural Equation Modelling (SEM) using SmartPLS was employed to test the proposed relationships.

Research Findings: Perceived authenticity and interactivity significantly influence emotional arousal and fear of missing out, which in turn predicted impulse …

The Digitalisation Of Administrative Processes And Institutional Agility In Sucs Cebu City: The Mediating Role Of Employee Digital Readiness, Leovigilda L. Bithay

The South East Asian Journal of Management

Research Aims: This study examines how the digitalisation of administrative processes influences institutional agility in SUCs in Cebu City, Philippines, and explicitly investigates employee digital readiness as a mediating capability that translates digital investments into organisational adaptability.

Design/Methodology/Approach: A quantitative predictive research design was employed using a structured survey administered to 300 administrative employees selected through purposive sampling. PLS-SEM was used to test direct and indirect relationships.

Research Findings: The digitalisation of administrative processes has a significant positive effect on institutional agility. Employee digital readiness partially mediates this relationship, indicating that technological modernisation alone yields limited gains in agility unless …

April 30, 2026, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Vulnerability Of Bass Populations To Our Changing Climate In The Mississippi River, Cameron Schreifels

Celebrating Scholarship and Creativity Day (2018-)

Climate change is altering habitats and damaging bass populations throughout the Mississippi. The main factors of climate change affecting bass are shifts in water quality and significant weather events, which have increased bass vulnerability. With rising temperatures and eutrophication changing the way these bass hunt for their prey, it has made it easier for other non-native species to encroach on their habitat, which has led to bass further encroaching on other species due to climate change.  Given their economic importance and cultural significance, better management practices are needed to find new ways to protect them and ensure they remain a …

The Big Picture Of The Small Intestine, Reagan Kangas

Celebrating Scholarship and Creativity Day (2018-)

Histology is the study of microscopic tissue structures and is used to understand the function of tissues and visualize the cellular organization within them. It is an important tool in biology and medicine, used for diagnosing disease (i.e., cancers, infections, inflammatory diseases, etc.) and studying organ structure and function. The goal of this poster is to compare preparation and staining techniques, specifically paraffin versus frozen sectioning methods, along with Masson’s trichrome versus hematoxylin and eosin (H&E) staining. These methods differ in processing time, tissue preservation, and the level of detail they reveal under a microscope. This project uses small intestines …

The Love We Risk, Dylan Murphy

Celebrating Scholarship and Creativity Day (2018-)

This personal narrative reflects on the loss of childhood pets and the lessons learned through grief, love, and healing. It explores the deep bond formed with two family dogs, the heartbreak of losing them to illness, and the emotional struggle of moving forward afterward. Through welcoming another dog into the family, the story reveals how love can continue without replacing the past. Ultimately, the piece conveys the idea that although loving a pet comes with the pain of eventual loss, the joy, companionship, and memories they bring make that love worthwhile.

Service Through Empowerment, Samantha Oritz, Emma Schuele, Faith Robak

Celebrating Scholarship and Creativity Day (2018-)

This community-engaged learning project explored the impact of community support on the reintegration of previously incarcerated men through our volunteer work at the Overcomers International Fellowship (OIF) Dream Center. The Dream Center is a nonprofit organization that provides residents with housing, mental health support, education, and employment resources to help them transition back into society. As volunteers, we conducted empowerment interviews, reviewed case studies, and supported daily operations while building meaningful relationships with residents. Through these interactions, we not only learned about their individual experiences but also saw how having a strong support system can influence personal growth and overall …

Aquatic Invasive Species Control: Minnesota’S Herbicide Problem, Adam Novak

Celebrating Scholarship and Creativity Day (2018-)

Minnesota lakes have an invasive species problem: invasives are outcompeting our native plants and causing ecological degradation. Herbicides are used in Minnesota to help alleviate the stress that invasive plants put on the ecosystem, but continued use of herbicides has its own environmental downside. An analysis of five common aquatic herbicides including, diquat, endothall, 2,4-D, fluridone, and copper-based solutions was completed to find specific ecological downsides. Sediment degradation, effects on various fish life stages, zooplankton, and other non-target organisms were analyzed. This study offers alternative managements strategies and presents a decision tree to help lake associations manage invasive plants.

Effect Of Music Therapy And Music Focused Interventions On Fall Rates In A Memory Care Unit, Emily Spanier, Cassie Howe, Hannah Reiter, Paige Mauer

Celebrating Scholarship and Creativity Day (2018-)

This quality improvement project examined the effect of music therapy and activity-focused interventions on fall rates in a memory care unit at a long-term care facility. The project was developed after staff identified falls as a major safety concern, with the memory care unit accounting for a disproportionate number of facility-wide falls. Through audits and observations, the team found that boredom, wandering, restlessness, and lack of meaningful engagement were common contributing factors to falls among residents with dementia. To address this issue, the team implemented low-cost, person-centered interventions including playing familiar music through Alexa, encouraging participation in simple arts and …

Survival Of The Fittest: Extremophilic Actinomycetes As The Future Of Antibiotic Treatment, Ben Reddan, Kyley Nelson

Celebrating Scholarship and Creativity Day (2018-)

The antibiotic resistance crisis is an emerging global health threat. In 2019 alone, 1.27 million deaths were attributed to antibiotic-resistant pathogens, and researchers predict the problem will worsen without intervention. Methicillin-Resistant Staphylococcus aureus (MRSA) has become a primary model for this crisis because it utilizes genomic adaptations to bypass β-lactam antibiotics. Although temperate actinomycetes have historically provided the majority of clinical antibiotics, recent bioprospecting has revealed that extremophilic actinomycetes represent a critical untapped resource. These organisms exhibit several adaptations to thrive in extreme environments, which results in the production of novel secondary metabolites and resilient extracellular enzymes. This literature review …

Food Insecurity On College Campus, Erika Islao, Izzy Green, Rachel Stone, Ariana Messer

Celebrating Scholarship and Creativity Day (2018-)

Food Insecurity can affect certain groups more than others. At the College of Saint Benedict and Saint John's University we've observed it in international students, student-athletes, and those without transportation. Although CSBSJU offers several dining options, it can still be difficult for students to access meals due to limited availability during breaks, limited dining hours for student-athletes, and transportation barriers. This paper examines how food insecurity and nutrition insecurity impact students’ overall well-being while also exploring how these challenges appear within the CSBSJU community. Research shows that students experiencing food insecurity often report higher stress levels, and lower academic engagement. …