Digital Commons Network^™

Survival Of The Fittest: Extremophilic Actinomycetes As The Future Of Antibiotic Treatment, Kyley Nelson, Ben Reddan

Celebrating Scholarship and Creativity Day (2018-)

The antibiotic resistance crisis is an emerging global health threat. In 2019 alone, 1.27 million deaths were attributed to antibiotic-resistant pathogens, and researchers predict the problem will worsen without intervention. Methicillin-Resistant Staphylococcus aureus (MRSA) has become a primary model for this crisis because it utilizes genomic adaptations to bypass β-lactam antibiotics. Although temperate actinomycetes have historically provided the majority of clinical antibiotics, recent bioprospecting has revealed that extremophilic actinomycetes represent a critical untapped resource. These organisms exhibit several adaptations to thrive in extreme environments, which results in the production of novel secondary metabolites and resilient extracellular enzymes. This literature review …

Beyond The Brain: Environmental Forces Driving Α-Synuclein Misfolding And Toxic Aggregation In Parkinson's Disease, Emily Mccarthy

Celebrating Scholarship and Creativity Day (2018-)

Parkinson's disease (PD) is an advanced neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the proliferation of protein aggregates within the brain. This capstone thesis investigates the unique biochemical environment of the gastrointestinal tract and whether it contributes to the formation of distinctive α-Synuclein (αSyn) aggregates affecting PD. Key promoters of αSyn aggregation include genetic mutations, oxidative stress, post-translational modifications, interactions with metal ions, and dopamine (DA) oxidation. These factors result in diverse structures such as oligomers, protofibrils, and fibrils, which result in unique functional outcomes, with oligomeric conformations leading to the highest level of neuronal toxicity. Evidence …

Abdominal Aortic Pseudoaneurysms: Etiology, Diagnostic Challenges, And Evolving Management Strategies, Jorge Jacob, Amanda Paes, Parnavi Singh, Joshua Baker, Eric Saunders, Raul Herrera, Brian Schiro

2026 Baptist Health Academic Conference: The Art and Science of Interprofessional Collaborations

No abstract provided.

The Pressure Is On For Pediatric Primary Lymphedema (Ple): Guiding Future Occupational Therapy Clinicians To Address The Unmet Needs And Enhance Care At An Academic Health Center, Ginger A. Kohler

Post-Professional Occupational Therapy Doctorate - Innovations in OT Symposium: Transforming Possibilities into Practice

Objective: Pediatric primary lymphedema (PLE) in adolescents is a rare, chronic condition frequently associated with delayed diagnosis and limited healthcare provider awareness. The purpose of this capstone project was to enhance Entry‑Level Doctor of Occupational Therapy (OTD) Students’ knowledge of the characteristics, management strategies, and available resources for PLE in adolescents, while increasing awareness of the critical role of occupational therapists certified in lymphedema therapy.

Methods: A hybrid educational module consisting of two one‑hour sessions, one asynchronous and one in‑person, was developed and delivered to Residential Entry-Level OTD Students at the Medical University of South Carolina (MUSC). Module content included …

Cuidarte También Es Trabajar: Hábitos Saludables Para Una Vida Laboral Plena, Lady Carolina Díaz Jurado, Francisco Javier Laguna Polanía

Ciencias de la Salud

El sedentarismo se ha convertido en un problema recurrente en la salud, especialmente en el ámbito laboral donde predomina la ausencia de actividad física prolongada. Diversos estudios indican que pasar mucho tiempo sentado aumenta notablemente las probabilidades de desarrollar enfermedades cardíacas, metabólicas y del sistema musculoesquelético. Ante esta problemática, surge esta publicación a modo de guía práctica y educativa sobre cómo implementar, de forma segura y progresiva, rutinas de HIIT y MISS, basada en el macroproyecto de investigación “Entrenamiento HIIT vs MISS, una mirada desde la salud ocupacional y los efectos cardiovasculares dirigido al personal administrativo de la Universidad de …

Applying Lean Six Sigma To Optimize Pediatric Liver Transplant Workflows: An Investigational Quality Improvement Initiative And Process Improvement Framework, Sarah E. Auletta

Online/Hybrid MPH Integrative Learning Experience (capstone projects)

For children with end-stage liver disease, liver transplantation is the only cure. While organ scarcity is a national challenge, internal pre-listing processes remain within an institution's control. This quality improvement initiative applied Lean Six Sigma and mixed-methods process mapping to the pediatric deceased donor liver transplant pathway at Boston Children's Hospital. By integrating five years of electronic health record data with multidisciplinary interviews, the project developed a comprehensive process map and performance dashboard.

The study revealed a median of 65 days elapsed between referral and waitlist activation—a timeline entirely within internal operational control. This delay was concentrated in two specific …

Igg4-Related Disease As An Uncommon Cause Of Myocarditis: A Case Report., Emily Ellis, Sarah Grebennikov, Rodolfo Jose Denadai Benatti

Heart and Vascular Articles

BACKGROUND: IgG-4-related disease (IgG4-RD) is a systemic fibroinflammatory disease that can affect any organ system. Myocarditis is a rare manifestation.

CASE SUMMARY: A 65-year-old woman with clinically diagnosed IgG4-RD, who had recently completed corticosteroid taper, presented with multiple admissions for recurrent chest pain and myocardial injury. Coronary angiography repeatedly showed preserved coronary anatomy, and initial transthoracic echocardiography showed preserved left ventricular systolic function. Subsequent transthoracic echocardiography showed rapid decline in ejection fraction, and cardiac magnetic resonance imaging (MRI) showed myocardial oedema, infarct scar, and patchy non-ischaemic fibrosis. A probable diagnosis of IgG4-RD myocarditis was made clinically based on medical history, …

Case Report Of Mixed Liver Injury Following Five Days Exposure To Cefepime In Young Adults, Widyati Widyati, Pandu Harijono, Gunady Wibowo Rencong

Pharmaceutical Sciences and Research

Drug-induced liver injury (DILI) remains a challenge in clinical practice and is still a diagnosis of exclusion. Although it has a low incidence amongst the general population, DILI accounts for most cases of acute liver failure with a fatality rate of up to 50%.

Case : A 56-year-old male was transferred to the Intensive Care Unit (ICU) with fever and severe thrombocytopenia,17,000. The patient was diagnosed with suspected sepsis and potential disseminated intravascular coagulation (DIC). Consequently, the patient was put on cefepime, administered 2g three times daily for over 30 minutes, and combined with amikacin at 1500 mg to be …

Allergy/Immunology Care Among Pediatric Patients With Food And Drug Allergy, Liana Osgood, Anya K. Cutler, James C. Bohnhoff

Costas T. Lambrew Research Retreat 2026

Specialty care was low overall for food and drug allergy patients: Food allergy: 48.2% children seeing an allergist/immunologist within one year of recorded diagnosis.

Addressing Diaper Need In Southern Maine: A Qualitative Study, Annie Batten Md, Amy Buczkowski

Costas T. Lambrew Research Retreat 2026

Overview

• Diaper insecurity (DI) is a prevalent and underrecognized need for patients

• Few studies have explored the systems that address DI

• Our study seeks to explore the landscape of DI mitigation in Southern Maine to identify opportunities for improved diaper access

A Two-Stage, Stakeholder-Integrated Model For Developing And Piloting Summative Osce Cases, Sara Nelson Md, Mhpe, Laura K. Snydman, Christine Mallar, Mike Shepherd Bs, Chse, Michael Carver-Simmons, Laura Baecher-Lind

Costas T. Lambrew Research Retreat 2026

Goal: To design an efficient, reproducible, and evidence-informed process to develop summative EOB OSCE cases for Internal Medicine, Obstetrics & Gynecology, and Psychiatry clerkships.

Knowledge Gaps In High-Energy Sacral Fracture Treatment And Management, Ashraf N. El Naga, Marko H. Neva, Ahmed Abdelazim Hassan, Gregory D. Schroeder, Mohammad El-Sharkawi, Sebastian F. Bigdon, Andrei F. Joaquim, Klaus Schnake, Richard Bransford, Emre Yilmaz

Rothman Institute Papers

High-energy sacral fractures (HESF) are often challenging injuries due to the location of the sacrum at the junction of the spine and pelvis, the complex biomechanics of the pelvic ring and the wide spectrum of injury patterns, which make treatment standardization challenging. Despite advances in classification systems - particularly the AOSpine Sacral Injury Classification - significant gaps remain in understanding optimal management. To review and discuss the management and identify knowledge gaps related to HESF. A narrative review of the literature was conducted, focusing on five domains: 1. Relative instability and biomechanics affected in different injury patterns; 2. The significance …

Intelligent Manufacturing Of Edible Oil: From Smart Sensing To Big Data Platform, Ru Jiang, Nadirbek Yusupbekov

Chemical Technology, Control and Management

With the rapid advancement of Industry 4.0 technologies, intelligent manufacturing and big data platforms are profoundly transforming the production models of the traditional edible oil industry. The edible oil production process involves multiple complex unit operations such as refining, decolorization, and deodorization, which impose high requirements on process control and product quality monitoring. This paper presents a systematic review of key technological advances in the field of intelligent manufacturing of edible oil, establishing a comprehensive technical framework encompassing four dimensions: smart sensing, artificial intelligence applications, IoT communication, and big data platforms. The review begins by analyzing the global background and …

Growth Of Vanilla Cuttings Under Modified Acid Soil Media And Application Of Several Plant Growth Regulators, Rifqi Raditya Kurniawan, Yugi Rahayu Ahadiyat, Etik Wukir Tini

Jurnal Kultivasi

This research aimed to optimize the growth of vanilla (Vanilla planifolia) cuttings in acid soils by modifying the growing media and applying several types of plant growth regulators (PGRs). Several types of PGRs, including synthetic compounds such as indole-3-acetic acid (IAA) and 6-benzylaminopurine (BAP), as well as natural extracts from shallot (Allium ascalonicum L.) and moringa leaves (Moringa oleifera), were tested to enhance plant performance in acid-growing conditions. The primary objectives were to determine the optimal soil amendment formula and the most effective PGR type for promoting vanilla growth, and to develop a measurable, easy-to-use PGR formulation accessible to farmers. …

The Effect Of Liquid Foliar Fertilizer And Pruning Combinations On The Growth Of Productive Phase Arabica Coffee Plants (Coffea Arabica L.), Syifa Djuita Putri, Alvito Krishna Balapradhana, Mira Ariyanti, Intan Ratna Dewi Anjarsari, Yudithia Maxiselly

Jurnal Kultivasi

In recent years, productivity decline in arabica coffee has become a real issue in Indonesia. This decay has been brought about by various external and internal factors that are beyond human control. Various factors, including suboptimal cultivation practices, take part in this process. The objective of the present study was to evaluate the effect of pruning combined with foliar fertilizer application (coconut water and sugarcane molasses) and 6-benzylaminopurine (BAP) on the vegetative growth of arabica coffee plants during the production phase. The research was conducted at Ciparanje Experimental Field, Universitas Padjadjaran, using a randomized complete block design with seven treatments …

Morphology And Bioactive Compounds Of Gurmar (Gymnema Sylvestre) With Potential As Antidiabetics, Neny Novita Yuliany, Abdillah Maulana Farhan, Putry Lazimatu Ziyaroh, Edia Fitri Dwinianti, Husnatun Nihayah, Mukhamad Su'udi

Jurnal Kultivasi

The medicinal plant Gymnema sylvestre is widely known for its ability to lower blood sugar levels. This study reviewed the physical characteristics and bioactive compounds of G. sylvestre sourced from different regions, emphasizing its potential as an antidiabetic agent. Morphological analysis includes leaf structure, trichome presence, and other anatomical features, which can influence the plant's chemical profile. Phytochemical analysis, performed using techniques like GC-MS, identifies key bioactive compounds such as saponins, flavonoids, and gymnemic acids, which contribute to its hypoglycemic effect. The findings indicate that regional variations can affect the concentration and presence of these compounds, suggesting that environmental factors …

Optimization Of Physalis Angulata L. Callus Induction And Salinity-Induced Antioxidant Production, Firstian Naufal Sistyananda, Erni Suminar, Anne Nuraini, Muhamad Kadapi, Murgayanti, Syariful Mubarok, Rahmat Budiarto, Eddy Renaldi, Kusumiyati

Jurnal Kultivasi

Groundcherry (Physalis angulata L.) is a plant with many medicinal potentials due to its rich secondary metabolites such as phenolic and flavonoid. However, conventional agriculture practices are still limited, especially in Indonesia. This study was divided into two stages. The first stage was conducted to determine optimal 6-BAP and 2,4-D combination for callus induction, while the second stage was conducted to determine callus phenolic, flavonoid, and antioxidant response to salinity stress. The first stage was arranged in factorial completely randomized design with two factors: 6-BAP (0, 2, and 4 mg/L) and 2,4-D (0, 0.5, 1, and 1.5 mg/L). The second …

Growth And Yield Response Of Shallots To Npk, Nk, And Humic Acid Under Different Mycorrhiza Application, Alfu Laila, Endang Sulistyorini

Jurnal Kultivasi

One strategy to increase shallot production is the utilization of microorganisms in the soil, such as arbuscular mycorrhizal fungi (AMF), which is applied together with fertilizer. This research aimed to investigate the effects of different nutrient inputs and mycorrhizal association on the growth and yield of shallots. This study used a split-plot design with three replications as blocks. The main plot included four treatments: no nutrient inputs, NPK fertilizer, NK fertilizer, and humic acid, while the subplot involved the mycorrhiza application (with or without). The measured variables included growth (plant height and number of leaves) and yield (fresh weight and …

Promoting Climate Justice Through Smr Licensing In The United States And Canada: Legal Comparison And Lessons For Vietnam And Developing Countries, Nhut Le Minh, Tran Quang Huy, Tran Vu Thien An

Indonesia Law Review

Climate justice is an issue raised in Vietnam and many developing countries around the world due to the increasing number of serious climate change events in recent years. For this reason, energy transition is chosen as one of the solutions for climate justice promotion in Vietnam, as well as in other developing countries. Across the options, Small modular reactor (SMR) investment is under significant consideration for climate justice promotion in Vietnam and the developing countries. SMR can ensure that every person has access to clean energy while protecting the environment. However, developing SMR requires the harmonisation between innovation and nuclear …

Children Facing The Law: Addressing Narcotics Offenses Through Restorative Justice, Nashriana Nashriana, Desia R. Banjarani

Indonesia Law Review

In recent years, the increasing number of children involved in narcotics-related crimes in Indonesia has raised concerns about the effectiveness of the current juvenile justice system. While the Juvenile Criminal Justice System Law promotes the use of diversion and restorative justice, in practice, punitive measures such as imprisonment remain the dominant approach. This gap between normative ideals and legal reality highlights the need for reform. Drawing from comparative legal frameworks in countries such as the United States, Germany, and Spain, this study explores the potential of therapeutic treatment as a more humane and effective response to juvenile narcotics offenses. Therapeutic …

The Rodrigo Duterte Case At The International Criminal Court: Towards The Erosion Of States’ Right To Withdraw From The Rome Statute?, Giovanni Chiarini Dr

Indonesia Law Review

The Rodrigo Duterte case raises complex questions concerning the interpretation of Article 127 of the Rome Statute (RS), particularly regarding its statutory limits relating to the one-year window governing the effects of withdrawal, as well as the interpretation of the procedural identity of the preliminary examination. This paper is divided into two parts: the first briefly outlines the procedural history of the war on drugs case from 2016 to 2024; the second analyses the dissenting opinion concerning the interpretation of Article 127 RS and explores the key developments from 2025 to 2026, focusing on the main issues raised by the …

Cyanosis-Associated Coagulopathy In Neonates Undergoing Cardiopulmonary Bypass: A Scoping Review, Lily Crickmar

Student Works

2. Structured summary:

A. Background: Patients with cyanotic congenital heart disease exhibit coagulation abnormalities related to chronic hypoxemia, which may increase the risk of bleeding and thrombosis, particularly during cardiopulmonary bypass.

B. Objective: This scoping review mapped the existing literature on coagulation disturbances and perioperative hemostatic outcomes in pediatric patients with cyanotic congenital heart disease.

C. Methods: 14 studies meeting the inclusion criteria were identified through structured database searching. The data were collected and synthesized descriptively due to heterogeneity in study design, patient populations, and coagulation assessment methods.

D. Results: Across studies, cyanotic patient physiology was associated with platelet dysfunction, …

Intraoperative Aspiration Risk Reduction Of Diabetic Patients Through Gastric Ultrasound: A Scoping Review, Dakota Sellers Bsn, Rn, Kristy Speight Bsn, Rn, Ginger Chastain Bsn, Rn, Tyler Stone Bsn, Rn, Claudia Bursi Bsn, Rn, Laura Reed Dnp, Aprn, Fnp-Bc, Cne, Fnap, Margaret Harvey Phd, Acnp-Bc, Fhrs

Doctor of Nursing Practice Projects

Purpose/Background

Patients with diabetes mellitus are significantly more prone to delayed gastric emptying, which can increase their risk for aspiration events in the operating room despite following standard fasting guidelines set by the American Society of Anesthesiologists (ASA). Using point-of-care gastric ultrasound, trained providers can quickly and accurately evaluate gastric volumes and risk-stratify patients based on these findings. However, these methods have not been clearly assessed in the diabetic population. The purpose of this scoping review is to map the existing evidence on the use of gastric ultrasound findings among adult patients with diabetes undergoing anesthesia.

Methods

A scoping review …

Dexmedetomidine As An Adjuvant In Intrathecal Anesthesia Vs. Opioids - Evaluating Adverse Events: A Scoping Review, Autumn Holloman Bsn, Rn, Paige Blackstock Bsn, Rn, Rasmia Ibrahim Bsn, Rn, Chase Logan Bsn, Rn, Hunter Turner Bsn, Rn, Dwayna Accardo Dnp. Crna, Faana, Laura Reed Dnp, Aprn, Fnp-Bc, Cne, Fnap

Doctor of Nursing Practice Projects

Purpose/Background 

Spinal anesthesia is widely used in surgical practice because it provides effective anesthesia and analgesia while reducing the need for intravenous anesthesia. Opioids are commonly used as intrathecal adjuvants; however, their use is associated with adverse effects such as pruritus, postoperative nausea and vomiting (PONV), urinary retention, and respiratory depression. Dexmedetomidine, a selective α2-adrenergic agonist, has gained attention as an alternative to opioids due to its sedative and analgesic properties without the opioid side effect profile. This scoping review evaluates current evidence comparing intrathecal Dexmedetomidine and opioids as adjuvants to spinal anesthesia in adult surgical patients.

Methods

A scoping …

The Scripted Body: A Historical Analysis Of How Vituperative Narratives Shaped Disparities In Women’S Healthcare, Eva Fava-Rodrigues

Gender, Sexuality and Women's Studies Student Scholarship

No abstract provided.

Cultural Perspectives On Work-Life Balance: A Literature Review Of Cultural Differences Relating To Work-Family Conflict And Occupational Well-Being, Emma Rosengartner

Honors Theses

The focus of this review is to explore four different cultural views on work-life balance (WLB) and work-family conflict (WFC). The terms WLB and WFC have become increasingly popular in the business world as people struggle to separate their home life and work life due to technology blurring the lines and women becoming an equal force in the workplace. When individuals experience high levels of WFC or do not have stable WLB, well-being is often negatively affected and work performance declines. This review explores literature on WLB and WFC in Japan, Mexico, Sweden, and the United States to make connections …

Investigating The Synthesis And Antibacterial Activity Of A Main-Chain Cationic Polymer, Emily Smith

Honors Theses

Antibiotic resistance is a growing threat to public health. Due to the overuse of antibiotics in agriculture, the overprescription of antibiotics, and the misuse of antibiotics by patients, antibiotic resistance is spreading at an alarming rate. As antibiotic resistance spreads, the antibiotics we depend on to treat common infections become ineffective. Therefore, it is imperative to develop novel treatments for infections that do not increase the prevalence of antibiotic resistance. One treatment being explored is the use of synthetic polymers with antibacterial properties. Synthetic polymers are advantageous because they can be synthesized from widely available precursors and their structure is …

Cleft Palate And The Coordination Of Wnt Signaling And Pax9 In Murine Palatogenesis, Landon Wyatt

Honors Theses

Cleft palate is a common craniofacial birth defect that arises when the molecular and morphogenetic events guiding secondary palate formation lose coordination during a narrow developmental window. In mice, successful palatogenesis requires the paired palatal shelves to grow vertically, elevate above the tongue, and fuse at the midline; disruption of any of these steps can result in clefting. Two important regulators of this process are canonical Wnt signaling and the transcription factor Pax9, both of which contribute to normal palatal mesenchymal growth and patterning during early development. This paper first examines whether altered Dkk1/Wnt signaling contributes to the Pax9-null palate …

“Under The Fig-Tree”: Post-Revolutionary Literature Influences American Government, Clara Kernodle

Honors Theses

The literary context of post-Revolutionary America developed a broad sense of the American character as virtuous, hardworking, and responsible. In the 1780s, three American writers, representing these three categories of literature, penned their perspectives on human character and society, to much commercial success. J. Hector St. John de Crèvecoeur, Royall Tyler, and Philip Freneau described their situations and opinions with candor and wit, helped spark a broad sense of the American character, and influenced the authors of the nation’s founding documents. At the end of that same decade, Anti-Federalist political philosophy drew from an established literary conception of the American …

Personal Tendencies And Traveler Preferences: A Study On Personality-Driven Travel Marketing, Evelyn Filleman

Honors Theses

This study examines the influence of personality typing (as outlined by the International Personality Item Pool test structure) on travel decision-making as it relates to marketing matrix strategies. Understanding the relationship between personality type and travel is crucial, as individuals will have different need hierarchies and place decision-making factors on different levels of priority. This study uses the theoretical frameworks of Clifford Geertz and Michael Pacanowsky (Cultural Approach to Organizational Communication) and Judee Burgoon (Expectancy Violations Theory) to inform, direct, and explain the results of the completed research. A total of 261 participants were asked to take a survey outlining …