Digital Commons Network^™

Abnormal Trafficking And Processing Of Multiple Matrix Metalloproteinases Drive Cartilage Defects In Congenital Disorders Of Glycosylation, Chia-Lun Wu

All Dissertations

Congenital Disorders of Glycosylation (CDG) are rare metabolic diseases caused by defects in glycosylation. Despite identification of over 200 CDG types, the mechanisms linking glycosylation defects to diverse clinical phenotypes remain unclear. This dissertation uses zebrafish models of PMM2-CDG and STT3-CDG to redefine CDG pathogenesis, shifting from a simple glycan deficiency model to one involving disrupted cellular spatial organization.

We identify a protease-dependent pathway underlying craniofacial cartilage defects. Specifically, defective proteolytic processing of N-cadherin, a key adhesion molecule in chondrogenesis, is a central driver of pathology. We further uncover an unconventional trafficking mechanism in which ER stress and altered secretory …

Reimagining Access: Gentrification, Race And Youth Engagement In Outdoor Recreation, Cameron Smith

All Dissertations

Outdoor recreation has proven beneficial for youth, providing mental, social, and physical health benefits that last a lifetime. However, there is a gap in Black and Brown youth's participation in structured outdoor activities due to a multitude of structural factors. An overarching systemic factor that has affected these youths' participation in outdoor recreation is Gentrification, and its derivative, Green Gentrification, which specifically refers to how green amenities and infrastructure drive displacement of long-term communities. As a result of the displacement, Black and Brown youth are placed in a society where they are forced to navigate spaces that were intentionally designed …

The Impact Of Label Material On Perceived Value And Environmental-Friendliness Of Beverages In Returnable Glass Bottles Versus Actual Environmental Impact Via Life Cycle Assessment, Toni Sharp

All Dissertations

With guidance from the EPA to reduce virgin packaging use and alternatively increase reuse, the concept of reusable packaging has re-emerged as a potential sustainable alternative to single-use and recyclable packaging. For businesses, an understanding of the potential environmental benefits of switching from single-use packaging to reusable packaging, along with consumer willingness to pay for sustainable packaging are paramount. Existing literature on willingness to pay (WTP) for ethical or sustainable products typically relies on consumers’ stated preferences found through surveys using hypothetical products and prices. It has been revealed that sustainability claims printed on the label or products in glass …

Assessing Neurodiverse Inclusion In Zoos, Aquariums, And Nature Centers: A Secondary Analysis Of The Mozaics Project, Jennifer N.K. Garcia

All Dissertations

Playful experiences are found to promote positive youth development (Burdette & Whitaker, 2005; Gray, 2011; Sobel, 2018; Watchman & Spencer-Cavaliere, 2017). Additionally, playing in nature can improve attention and mood and reduce stress (Greenleaf, 2014; Kaplan & Kaplan, 1989; Shin & Swank, 2018; Ulrich ,1991). Unfortunately, neurodiverse youth, especially those with autism, can often experience barriers that limit access to play (Pynn et al., 2018; Stern, 2003) specifically play in nature (Barnes, 2007; Wolfberg, 2009). Yet, community organizations that offer playful experiences in nature, such as zoos, aquariums, and nature centers, could be uniquely positioned in the community to support …

Baseline Cervical Intervertebral Disc Biomechanics And Implications For Allograft Preservation, Nathan F. Buchweitz

All Dissertations

Neck pain has become an increasingly common orthopaedic healthcare issue. Evidence shows that degeneration of cervical intervertebral discs (the cartilage between the spinal vertebrae in the neck) may be associated. While disc degeneration in the lumbar spine has been extensively studied in relation to low back pain, it has received less attention in the cervical spine. Biomechanically, the cervical (neck) and lumbar (lower back) regions of the spine differ in function. Lumbar discs resist a greater burden of body weight, whereas cervical discs are adapted for mobility to aid flexible head orientation. Despite these key differences, disc injury and degeneration …

Diffuse Radiation Controls On Southern Pine Forest Ecosystem Functioning, Jeremy Forsythe

All Dissertations

Diffuse solar radiation, sunlight scattered by atmospheric aerosols and/or clouds, enhances plant photosynthesis through the diffuse fertilization effect (DFE), increasing ecosystem gross primary productivity (GPP) per unit of incoming radiation. Despite this known effect, pine forests of the southeastern United States remain comparatively understudied in the diffuse light literature. This is a critical knowledge gap, as the southeastern United States sequesters more carbon than any other region of the conterminous country (approximately 176 ± 26 Tg C yr⁻¹, or roughly 56% of national forest net carbon exchange), and the region experiences some of the highest biogenic aerosol loads in North …

Neurobiological Mechanisms Of Attention In Adolescents, Virginia Clark

All Dissertations

Adolescence is a transformative developmental period characterized by profound biological, neurological, and behavioral changes. This dissertation investigates the neurobiological underpinnings of attention in adolescents, emphasizing how internal mechanisms influence and individually shape cognitive development through the endosystem. Rooted in the intersection of human development, learning sciences, and cognitive neuroscience, this work argues for a more integrated understanding of attention as a fundamental cognitive function for learning, one that is behaviorally seen but also biologically and neurologically driven. While developmental science has often emphasized external influences such as family, culture, and environment, this work centers on the adolescent’s internal biological systems …

El Leñador, May 2026, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

From Synapse To Circuit: Mechanisms Of Behavioral Flexibility And Its Restoration After Prenatal Alcohol Exposure, Jayapriya Chandrasekaran

Biomedical Sciences ETDs

Behavioral flexibility—the ability to adapt behavior when contingencies change—is a fundamental executive function supported by orbitofrontal–striatal circuitry. This dissertation examined molecular, motivational, and circuit mechanisms underlying flexibility and its restoration after prenatal alcohol exposure (PAE). In healthy mice, GluN2B-containing NMDA receptors in the orbitofrontal cortex increased during outcome updating, while AMPA receptor subunits in the dorsal striatum rose during new learning, defining temporally distinct plasticity processes. PAE impaired reversal learning under low-reward conditions, but not when motivation was high, indicating altered thresholds for circuit engagement rather than permanent loss. Finally, optogenetic stimulation of OFC→dorsal striatum projections rescued flexibility in PAE …

The Eviction Caste System, Allison Freedman

Faculty Scholarship

The United States is facing a dire housing crisis, and most Americans agree that housing is a universal necessity. Yet under current Supreme Court jurisprudence, housing is not a fundamental right, and individuals facing housing insecurity from an eviction are generally not members of a suspect class. This is because eviction is often viewed as an individual problem and a symptom of poverty, which the Supreme Court has repeatedly affirmed is not a suspect classification. This Article disrupts the superficial narrative that eviction is an individualistic symptom of poverty, and instead views evictions from a systemic and historical perspective. It …

Without Their Consent: The History Of Involuntary Sterilization Of Women Of Color In The United States, Guadalupe Cataldo

Women's, Gender, and Sexuality Studies

Throughout the history of the United States, there is a continuous theme of women of color and immigrant women experiencing violations of their reproductive rights, including sterilization abuse. Under eugenics laws and initiatives, these women have been sterilized to prevent the reproduction of people that those in power deemed “unfit.” Due to intersecting gender, racial, and socioeconomic statuses, women of color have been more vulnerable to involuntary sterilization than their more privileged peers. Through the review of research articles, analysis of documentary interviews, collection of relevant news articles, and archival research of materials produced by organizations fighting sterilization abuse, this …

How Academic Pressure Is Declining The Mental Health Of South Korean Students, Lilyanne Boyland

East Asian Studies

South Korea’s education system is widely recognized for its academic excellence; however, this may highly impact students’ mental health and overall well-being, which can hinder their academic performance. Students are known to dedicate long hours of their day to their education, in addition to their daily academic schedules. This study focuses on how academic pressure, that is mostly driven by parents and educators, as well as traditional cultural values on education, affects the mental health of South Korean students. This thesis is divided into three sections: Historical and Cultural Contexts, South Korea’s Current Educational Environment, and Next Steps for South …

Intersectionality And Belonging: Higher Education Mathematics, Ashley Natalie

Mathematics and Statistics

Students with intersecting marginalized identities (such as race, gender, socioeconomic status, disability, or first-generation background) often face unique challenges in advanced mathematics that affect confidence, participation, amounting to a sense of belonging. These experiences remain underrepresented in mathematics education research. This qualitative, narrative-based study examines how these students experience classroom dynamics and belonging in upper-level mathematics courses. Semi-structured interviews will be analyzed thematically to identify patterns related to identity, classroom culture, instructor behavior, and peer interactions. Findings aim to highlight barriers and supportive practices, informing more inclusive teaching strategies and equitable learning environments in advanced mathematics.

Intersectionality And Belonging: Higher Education Mathematics, Ashley Williams

Mathematics and Statistics

Students with intersecting marginalized identities (such as race, gender, socioeconomic status, disability, or first-generation background) often face unique challenges in advanced mathematics that affect confidence, participation, amounting to a sense of belonging. These experiences remain underrepresented in mathematics education research. This qualitative, narrative-based study examines how these students experience classroom dynamics and belonging in upper-level mathematics courses. Semi-structured interviews will be analyzed thematically to identify patterns related to identity, classroom culture, instructor behavior, and peer interactions. Findings aim to highlight barriers and supportive practices, informing more inclusive teaching strategies and equitable learning environments in advanced mathematics.

Youth In Leadership Positions: A Mediation Program Proposal, Abigail Horn

Sociology

Encountering the justice system can have harmful impacts on a child’s well-being and can lead to negative outcomes in the future, such as missing school and reoffending. This paper proposes a program to combat these impacts by creating infrastructure for schools to handle low level offenses within schools through a mentoring program. After a review of the literature on the current justice system in the United States, rehabilitative and restorative justice practices, and the effects of youth leadership positions, the “Re-Mentoring Program” is proposed. A play on the words "restorative" and "rehabilitative," this program involves youth who have offended, victims, …

The Human Touch: Lawyer Leadership In The Age Of Generative Ai, Kathleen Elliott Vinson

Suffolk University Law School Faculty Works

No abstract provided.

Rethinking The Scope Of State Power: Territorial Jurisdiction, Popular Sovereignty, And Extraterritorial Legislation, Jeffrey Schmitt

William & Mary Law Review

The Supreme Court applies the territorial framework of international law to resolve disputes over the reach of state power. Under this framework, a state’s power is coterminous with its borders, such that a state’s regulatory power within its territory is limited only by federal law. The Court recently used this framework to overrule an obscure line of Dormant Commerce Clause cases that held that a state regulation of local conduct could have impermissible extraterritorial effects.

This Article argues that the territorial model of state power from international law does not account for the division of sovereignty within our federal system. …

Belonging, Ver Ikeseh

Masters Theses, 2020-current

This thesis explores belonging as the core of my artistic practice, developed through public murals and participatory installations in shared spaces. Grounded in a studio practice that engages directly with communities, the work positions art within everyday environments rather than separate from them. Through murals created across James Madison University and within surrounding communities, I examine how public art can generate moments of connection, visibility, and reflection. The thesis culminates in the participatory mural Belonging, created in the Duke Hall Gallery at James Madison University, where these ideas are brought together through direct public engagement. Developed through collaboration, the …

Statutory Backups For Endangered Constitutional Rights, Aaron-Andrew P. Bruhl

Faculty Publications

This Article concerns the phenomenon of “statutory backup rights,” or statutes that provide protections parallel to constitutional rights that are believed to be at risk of judicial abrogation. Proposals for backup rights gained attention in the aftermath of the Supreme Court’s 2022 decision in Dobbs v. Jackson Women’s Health Organization, which not only eliminated the constitutional right to abortion but called into question some other constitutional rights as well. Shortly after Dobbs, Congress enacted a limited statutory backup for same-sex marriage. States have created backup rights across a range of topics, some of which appeal mostly to those …

Attitudes Toward Harm Reduction Among Criminal Legal Staff, Diamond Meadows

Electronic Theses and Dissertations

Substance use disorders (SUDs) are prevalent among individuals interacting with the criminal legal system (Moore et al., 2019). Despite the high rates of individuals with SUDs interacting with the criminal legal system, there continue to be barriers to integrating harm reduction approaches within the system. Harm reduction approaches (i.e., medication assisted treatment) are effective in reducing the negative consequences associated with substance use and the pathway to recovery for many. The purposes of this study are to: 1. examine the psychometric properties of the Harm Reduction Acceptability Scale (HRAS) among criminal legal staff, 2. explore individual differences in staff attitudes …

Rationalizing Atrocity: Vindicatory Careerism And Mass Murder As A Career Path, 1939-1943, Bethany G. Bare

Electronic Theses and Dissertations

This study examines members of the Nazi Schutzstaffel from an occupational perspective, focusing on how professional roles shaped their participation in systematic mass murder. As National Socialism gained influence in interwar Germany, it coincided with the rise of a generation of ambitious and embittered men eager to distinguish themselves. The transition from the T4 Program (1939-1941), the involuntary euthanasia of disabled Germans, to Operation Reinhard (1942-1943), the extermination of Polish Jews, demonstrates how mass murder evolved into a career path, as each of the men examined served as T4 personnel before transferring to Poland to assume positions as extermination camp …

Mechanism Of Formation Of Guanine-Guanine Crosslinks As Products Of One-Electron Oxidation Of 1-Methylguanosine In Acidic Medium, Ibrahim Braimah Mr

Electronic Theses and Dissertations

Reactive oxygen species (ROS) from normal metabolism and environmental exposure may cause oxidative DNA damage. Guanine (G) is the most oxidizable nucleobase. One-electron oxidation (OEO) of G in produces guanine radical cation (G•⁺), which deprotonates to form guanyl radical G(-H)•.This radical exists in two tautomeric forms: G(N1-H)• and G(N2-H)•. Dimerization of guanyl radical yields G-G cross-links (D1/D2); a tautomeric form for dimer formation remains elusive. This study presents the first characterization of G• dimerization products from the OEO of 1-MeGuo in acidic medium. Photolysis at 470 nm in the presence of S₂O₈²⁻ and Ru(II)(bpy)₃²⁺ generates two major stereoisomers (D1AW* and …

Academic And Demographic Predictors Of Retention And Persistence In Business Programs: Post-Covid Cohorts Of Traditional And Ncccs Transfer Students, Matthew K. Crump

Electronic Theses and Dissertations

This quantitative study examined academic and demographic predictors of first-year retention and major persistence among traditional first-year and North Carolina community college transfer students enrolled in undergraduate business programs. Guided by Tinto’s 1993 Model of Student Retention and Astin’s 1984 Theory of Student Involvement, the research focused on students who entered two AACSB-accredited institutions within the UNC System during Fall 2021, Fall 2022, and Fall 2023 as traditional first-year students or as transfer students from North Carolina community colleges.

Institutional data from the Banner Student Information System provided the basis for logistic regression analyses that examined predictors including high school …

Durable, Distributed Llm Inference On Cots Devices, Brycen E. Dunn

Electronic Theses and Dissertations

The advancement of Large Language Models (LLMs) has fundamentally changed the nature of natural language processing. The substantial memory requirements of frontier models creates a significant barrier to entry, centralizing inference. This thesis presents the design and implementation of a distributed inference framework designed to democratize LLMs by leveraging commodity devices. The framework combines the resources of heterogeneous COTS devices into a unified compute pool, enabling the inference of models exceeding a single device's memory capacity. A novel Task Partitioning Engine (TPE) analyzes model architectures, profiles node capabilities, and supports pipeline and expert parallelism strategies. The primary contribution is a …

Look, I Finished My Pem Sticker Chart!, Kimberly L. Fugok Do, Sarah Fish Do, Kira Galeano, Kyle S Wilson Md, Dawn M. Yenser, Bryan G. Kane Md

Department of Emergency Medicine

No abstract provided.

Ngc - Torch Test Ablation Stand Improvements And Upgrades, Sarah Nelson

Undergraduate Honors Capstone Projects

This capstone project is sponsored by Northrop Grumman (NGC). The goal of the project is to redesign an ablation torch testing system to improve usability, safety, and versatility. Northrop Grumman relies on their ablation torch testing system to conduct quantitative evaluations of materials and high stress and high temperature conditions. The system provides essential data that supports product development, safety validation, and compliance with performance standards. By improving usability, safety, and versatility, NGC will be able to streamline testing operations, increase accuracy of results, and reduce operator risk. The system must allow testing using both a bent and straight torch …

A Global Prospective Harmonization Framework For Suicidality, Anhedonia, And Obsessive-Compulsive Symptoms In Psychiatric Genetic Studies: A Cross-Continental Study Within The Ancestral Population Network, Ana Diaz-Zuluaga, Jacey Anderberg, Ana Ramirez-Diaz, Andrea Marques, Catherine Rast, Daniel Bustamante, Deborah Jonker, Johanna Valencia-Echeverry, Stella Gichuru, Lukoye Atwoli

Internal Medicine, East Africa

This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive-compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 27,500 individuals across diverse ancestries and clinical populations for genetic analysis within the NIMH Ancestral Population Network (APN). Five APN projects are participating in the current study (PUMAS-Paisa, PUMAS-NeuroGAP, KOMOGEN-D, LATINO, and SAX-II), spanning recruitment over 15 countries across the Americas, Africa, and Asia. Participants are being enrolled via the recruitment protocols specific to each participating project. The harmonized clinical battery includes the Columbia-Suicide Severity Scale, Snaith-Hamilton Pleasure Scale, and Florida Obsessive-Compulsive …

Beyond Moving Hands: Narratives Around Deaf Education, Sara Simpson

Theses and Dissertations

This qualitative narrative study explored the experiences and perspectives of deaf educators and educational interpreters working in high school settings. Participants shared narratives about their professional experiences, training, and roles in deaf education. By considering their professional histories, backgrounds, and cultural perspectives, this study examined how these experiences shaped participants’ perceptions of the current state of deaf education.

Using a qualitative narrative research design, three participants with experience working in high school deaf education settings were interviewed individually and later participated in a focus group discussion. The interviews and focus group centered on participants’ perspectives regarding key issues in deaf …

Examining The Effects Of Lateral Loading On Railroad Tapered Roller Bearings, Abel David Sanchez Trinidad

Theses and Dissertations

The loading conditions experienced by freight railcar bearings vary as a function of vehicle operating conditions. Under static conditions, bearings are primarily subjected to radial loads transmitted through the wheelset. During operation, however, track irregularities, braking events, railcar load imbalances, and curving introduce complex impact, longitudinal, and lateral forces in addition to the normal radial loading. These lateral forces increase friction within the bearing raceways, which could accelerate wear and potentially lead to premature spall initiation and propagation. While prior research at the University Transportation Center for Railway Safety (UTCRS) has demonstrated that vibration signatures can be used to detect …

Examining Professional Self-Doubt And Professional Quality Of Life Among Licensed Professional Counselors In Texas, Celia A. Ramos

Theses and Dissertations

Licensed Professional Counselors (LPCs) in Texas frequently navigate emotionally demanding work, including high caseloads, complex client needs, and sustained exposure to client distress. Over time, these professional demands can contribute to stress, emotional fatigue, and job strain, increasing vulnerability to burnout and reducing professional quality of life (Bardhoshi & Um, 2021; Maor & Hemi, 2021; McCarthy et al., 2010; Thompson et al., 2014). This quantitative research study examined the professional quality of life of LPCs in Texas using the Professional Quality of Life Scale (ProQOL) based on gender, ethnicity, age, licensure type, years of experience, does work setting induce compassion …