Digital Commons Network^™

Changing The Narrative: Exploring Post-Traumatic Growth In African American Women Who Identify As Transformational Leaders After Experiencing The Foster Care System, Leah Angel Vance-Daniel

Education Doctoral

The purpose of this qualitative study was to examine the lived experiences of African American women who identified as transformational leaders and who successfully navigated adulthood after experiencing the foster care system. Post-traumatic growth (PTG) theory served as the theoretical framework for this study, which reflects a positive mental shift brought about by struggling with at least one extremely difficult life circumstance. Semi-structured interviews were conducted with eight African American women, and five themes emerged from the data analysis: (a) Journey to Transformational Leadership: Self-Awareness, Vulnerability, and Self Acceptance; (b) From Repeating to Repairing; (c) You Either Have to Lie …

Teacher Perceptions In Early Childhood Classrooms: Understanding The Disproportionate Suspension Of Black Girls In Preschool, Lachelle Dionne Walker

Education Doctoral

The purpose of this interpretive qualitative study was to examine eight preschool lead teachers’ perceptions of the behaviors of Black girls, with a specific focus on those leading instruction in classrooms of 3- and 4-year-old learners, to assess if their perceptions of the behaviors of Black preschool-aged girls influenced their discipline practices and behavior management. The findings of this study revealed that preschool lead teachers held positive perceptions and early adultified views, also known as adultification bias, of Black girls in preschool settings. Furthermore, early adultified views of preschool lead teachers toward Black preschool-aged girls did not correlate with discriminatory …

Beyond The Bell: Young Black Male Reflections On Teacher Expectations And Postsecondary Outcomes, Raina Lewis

Education Doctoral

The purpose of this qualitative study was to examine the lived experiences of seven young Black males after their graduation from high school, focusing on how they recalled and interpreted their high school teachers’ expectations. Using semi-structured interviews with the Black males, aged 18–25, this study sought to understand how participants made meaning of these experiences and the lasting impact on their identity development. Grounded in Tichnor-Wagner’s culture of care theory, this study looked through the lens of culturally responsive, emotionally supportive, and equity-driven educational environments. This culture of care theory framework is particularly relevant for young Black males who …

The Impact Of Place-Based Education Professional Development On Faculty Identity And Perceptions Of Nature-Culture Dichotomies, Reyt Middleton

Master's Theses

This qualitative study analyzes how implementing place-based education (PBE) in undergraduate coursework shapes faculty identity narratives and nature–culture positionalities across conceptual lenses of past, present, and future. Three faculty members at a regional Mississippi university engaged in a PBE professional development program; narratively driven pre- and post-implementation interviews were given to participants, then examined via thematic analysis. Framed primarily through lenses of constructivism, with support from critical pedagogy of place, relational and ecological epistemologies, and scholarship on faculty identity, this study posits two research questions—1: How does teaching PBE influence faculty identity narratives across past, present, and future temporalities? 2: …

Modeling The Effects Of Low-Pressure Atmospheric Fronts On Sediment Transport Through Mississippi Sound Barrier Island Inlets, Nicholas J. Gagliano

Master's Theses

Coastal sediment dynamics in the Mississippi Sound are strongly influenced by tropical cyclones and the more frequent passage of low-pressure atmospheric fronts. While hurricanes are well recognized for reshaping barrier islands and altering sediment budgets, the cumulative role of recurrent fronts remains poorly quantified. This thesis investigates the impacts of six low-pressure atmospheric fronts (2015–2017) on sediment flux through six barrier island inlets in the Mississippi Sound.

A high-resolution application of the Regional Ocean Modeling System with the Community Sediment Transport Modeling System was developed to simulate tidal circulation, wind-driven currents, and sediment dynamics. Waves were excluded from the simulations. …

Volunteer Spotlighting: Costly Signaling To Promote Volunteerism, Clyde A. Raible V

Master's Theses

Prosocial behaviors, because they are initially costly and do not guarantee a direct benefit to the actor, can nonetheless increase social status by signaling a willingness to incur cost on behalf of another. Given this signal value, nonprofit organizations may be able to leverage this knowledge to increase donations, such as through the provisioning of attention to, and recognition of, volunteers through social media. I predicted that the costliness of spotlighted behavior and the target signal clarity (i.e., individual vs. group spotlight) would interact with participants’ dispositional dominance and prestige-based status motives to influence volunteerism interest. To explore these associations, …

A Covalent Allosteric Molecular Glue Suppresses Nrf2-Dependent Cancer Growth, Nilotpal Roy, Ilah Bok, Harit Panda, Dhaval P Bhatt, Emily M Wilkerson, Soma Saeidi, Paul Zolkind, Michael B Major, Et Al.

2020-Current year OA Pubs

UNLABELLED: The NRF2 transcription factor is constitutively active in cancer, in which it functions to maintain oxidative homeostasis and reprogram cellular metabolism. NRF2-active tumors exhibit NRF2 dependency and resistance to chemotherapy/radiotherapy (RT). In this study, we characterize VVD-065, a first-in-class NRF2 inhibitor that acts via an unprecedented allosteric molecular glue mechanism. In the absence of stress or mutation, NRF2 is rapidly degraded by the Kelch-like ECH-associated protein 1 (KEAP1)-cullin3 (CUL3) ubiquitin-ligase complex. VVD-065 specifically and covalently engages Cys151 on KEAP1, which in turn promotes KEAP1-CUL3 complex formation, leading to enhancement of NRF2 degradation. Previously reported Cys151-directed compounds decrease KEAP1-CUL3 interactions …

Computational Fluid Dynamics-Based Risk Stratification Of Modified Blalock-Taussig-Thomas Shunt Thrombogenicity, Yi Qiao, Ethan Penn, Jacob Miller, Scott Bugenhagen, Ram Rohatgi, Kelsey Mercer, Blaire Kulp, Jinli Wang, Pirooz Eghtesady, Guy M Genin, Edon J Rabinowitz, David Bark

2020-Current year OA Pubs

BACKGROUND: The modified Blalock-Taussig-Thomas shunt (mBTTS) is a critical palliative procedure for infants with single-ventricle physiology, but thrombosis-related occlusion affects 8% to 12% of infants and carries nearly 50% mortality. Meanwhile, existing antithrombotic strategies fail to address the hemodynamic factors driving thrombosis, highlighting the need for a deeper understanding of flow dynamics in shunt failure.

OBJECTIVES: This study aims to identify how mBTTS geometry influences hemodynamics and thrombosis risk, providing quantitative guidance for surgical planning and shunt design optimization.

METHODS: We used patient-specific imaging data to test 54 idealized mBTTS configurations, systematically varying key geometric factors: pulmonary artery diameter, shunt …

Sustainment Of Hydroxyurea Adherence In Patients With Sickle Cell Disease, Andrew M Heitzer, Zachary Wooten, Guangjin Luo, Marsha Treadwell, Allison A King, Victor R Gordeuk, Nirmish Shah, Christina M Abrams, Sarah Mccuskee, Siera Gollan, Jennifer Longoria, Jane S Hankins, Sickle Cell Disease Implementation Consortium

2020-Current year OA Pubs

IMPORTANCE: Despite established treatment guidelines and strong therapeutic benefit, hydroxyurea remains underused among patients with sickle cell disease.

OBJECTIVE: To assess the change in self-reported hydroxyurea use (ie, taking the medication at all) and adherence (ie, the number of days taken per week) over time and to examine factors associated with the trajectory of hydroxyurea use and adherence.

DESIGN, SETTING, AND PARTICIPANTS: Data were collected through the Sickle Cell Disease Implementation Consortium, a longitudinal, multicenter, observational cohort study that recruited patients from 8 centers across the US. Data collection occurred from 2017 to 2022, and analyses were performed from January …

Cognitive Behavioral Therapy For Individuals With Low Literacy And Perinatal Depression: A Randomized Clinical Trial, Eliza Kleban, Ashleen Lee, Aminata Koroma, D Taylor Hendrixson, Joshua Duncan, Mark J Manary, Kevin B Stephenson

2020-Current year OA Pubs

IMPORTANCE: Perinatal depression is common in sub-Saharan Africa, yet treatment gaps are substantial. Cognitive behavioral therapy (CBT) is effective but relies on written materials.

OBJECTIVE: To evaluate the efficacy of a culturally adapted CBT intervention delivered by lay counselors to women with perinatal depression in rural Sierra Leone.

DESIGN, SETTING, AND PARTICIPANTS: This study was an individually randomized, outcomes assessor- and investigator-blinded, clinical trial of an adapted CBT intervention vs enhanced usual care. The trial was conducted in 6 government-run antenatal clinics in Pujehun District, Sierra Leone, which has limited infrastructure, low literacy, high maternal undernutrition, and no perinatal mental …

Hematopoietic Cell Transplant Access And Patient Diversity, Rachel Cusatis, Ramzi Abboud, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Allogeneic hematopoietic cell transplant (HCT) is curative for hematologic cancers, yet access remains inequitable for racially and ethnically underrepresented and socioeconomically disadvantaged populations, making the goal of having a suitable donor for every patient who needs a transplant challenging. The ACCESS trial broadened access by enrolling patients without matched donors, who instead received an HCT from a mismatched unrelated donor.

OBJECTIVE: To compare baseline characteristics of ACCESS trial participants with participants enrolled in a similar clinical trial and a patient-reported outcome (PRO) protocol cohort.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included adult participants (aged ≥18 years) from 3 …

Androgen Loss Accelerates Brain Tumour Growth Via Hpa Axis Activation, Juyeun Lee, Joshua B Rubin, Et Al.

2020-Current year OA Pubs

Many cancers, including glioblastoma (GBM), show a male-biased incidence and associated worse outcomes

Adaptive Evolution Of Gene Regulatory Networks In Mammalian Neocortex, Zhuo Li, Linda J Richards, Et Al.

2020-Current year OA Pubs

Mammals have evolved a more complex brain, exemplified by the transformation of the single-layer dorsal cortex of excitatory projection neurons (ExNs) in ancestors into a multilayered cerebral neocortex

Single-Cell Spatiotemporal Dissection Of The Human Maternal-Fetal Interface, Cheng Wang, Sarah K England, David K Stevenson, Gary M Shaw, Et Al.

2020-Current year OA Pubs

The human maternal-fetal interface is characterized by mosaic intermingling of maternal and fetal cells

Synovial Fluid Biomarkers Associated With Anterior Cruciate Ligament Injury And Reconstruction: A Systematic Review, Daniel C Touhey, Derrick M Knapik, Sina Tartibi, Varun Gopinatth, Tanya Boghosian, Matthew J Matava, Matthew V Smith, Robert H Brophy

2020-Current year OA Pubs

BACKGROUND: Synovial fluid biomarkers reflect the inflammatory response after joint injury and surgery. Previous studies have identified synovial fluid biomarker concentrations in the knee after both anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR).

PURPOSE: To systematically review the literature to summarize reported changes in synovial fluid biomarkers and their concentrations after acute ACL injury/ACLR.

STUDY DESIGN: Systematic review; Level of evidence, 4.

METHODS: Studies published in the PubMed, EMBASE, and the Cochrane Library databases reporting in English on humans sustaining ACL tears and undergoing ACLR from inception to August 2025 were identified and included if postinjury/preoperative and/or postoperative …

Adapt-On-Demand: Enabling Flexible And Scalable Adaptive Radiotherapy Through Workflow Automation, Sean Domal, Min Geon Choi, Justin Visak, Ruiqi Li, Taoran Li, Boon-Keng Kevin Teo, Xiaodong Zhao, Matthew Schmidt, Eric Laugeman, David Parsons, Yang Kyun Park, Shahed Badiyan, David Sher, Mu-Han Lin

2020-Current year OA Pubs

PURPOSE: CT-guided adaptive radiotherapy (CTgART) offers significant clinical benefits, but its utilization is often limited by resource demands and rigid workflows. This study presents a flexible and scalable "Adapt-on-Demand" (AOD) framework that integrates the adaptive capabilities of the Varian Ethos platform with the high-throughput IGRT delivery of the Varian Halcyon, supported by automated scripting.

METHODS: We developed an end-to-end dual-platform workflow that dynamically transitions between ART and IGRT delivery based on patient needs. Key components include Eclipse Scripting API (ESAPI) automation to streamline adapted plan ingestion from the Ethos Treatment Planning and Management System (TPMS) export directory, compatibility conversion for …

Preterm Birth Increases Susceptibility To Hyperglycemia-Induced Kidney Injury With Sex-Specific Differences In Structural And Molecular Responses, Rachel K Dailey, Aleksandra Cwiek, Logan C Hamil, Sage Timberline, Ayyappa Kumar Sista Kameshwar, Masako Suzuki, Jaya Isaac, Kimberly Deronde, Mark Conaway, Kevin M Bennett, Edwin J Baldelomar, Matthew R Hoch, Kimberly J Reidy, Jennifer R Charlton

2020-Current year OA Pubs

BACKGROUND: Preterm birth increases the long-term risk of diabetes and chronic kidney disease (CKD), yet its impact on diabetic kidney disease (DKD) is unclear. We previously showed that male preterm mice with diabetes develop early features of DKD, including reduced podocyte density, decreased renin expression, activation of angiogenesis pathways, and impaired endothelial-podocyte signaling. Here, we examine whether preterm birth similarly accelerates DKD progression in female mice and compare structural and transcriptomic outcomes in the females to the prior male cohort to assess sex-specific differences.

METHODS: Preterm mice were delivered by Caesarean section at 19 days post conception (dpc) and term …

A Prospective, Multi-Center, Observational Study Of The Safety, Tolerability And Effectiveness Of Nusinersen In Adult Patients With Spinal Muscular Atrophy, Craig M Zaidman, Crystal Proud, Bing Liao, Nassim Rad, Doreen Ho, Mary-Lynn Chu, Shafeeq Ladha, Thomas O Crawford, Shakti Nayar, Angela Genge, Margaret Frey, Chad Heatwole, Daphne Lew

2020-Current year OA Pubs

Nusinersen, an antisense oligonucleotide, modulates pre-mRNA splicing to produce full length survival motor neuron protein in spinal muscular atrophy (SMA). It was approved in the US for SMA in all ages based on evidence in children. In adults, studies of nusinersen rely on real-world observational data and show stability or small improvements over time. We performed a prospective, 30 month longitudinal, observational multi-center study of adults initiating nusinersen with SMA types II/III to examine its safety, tolerability, and effectiveness. 43 participants (20 female; 14 ambulatory; 3, 17, and 23 with 2, 3, and ≥4 SMN2 copies, respectively), mean (SD) age …

Adventitial Macrophage Accumulation Impairs Perivascular Nerve Function In Mesenteric Arteries With Inflammatory Bowel Disease, Elizabeth A. Grunz, Benjamin W. Jones, Olubodun Michael Lateef, Sidharth Sen, Katie Wilkinson, Trupti Joshi, Erika M. Boerman

Biomedical Sciences

Introduction: Inflammatory bowel disease involves aberrant immune responses and is associated with both cardiovascular disease risk and altered intestinal blood flow. However, little is known about how inflammatory bowel disease affects regulation of perivascular nerves that mediate blood flow. Previous work found perivascular nerve function is impaired in mesenteric arteries with Inflammatory bowel disease. The purpose of this study was to determine the mechanism of impaired perivascular nerve function.

Methods: RNA sequencing was performed on mesenteric arteries from IL10−/− mice treated with H. hepaticus to induce disease (inflammatory bowel disease) or left non-gavaged (Control). For all other studies, Control and …

Optimization-Based Power Management For Hybrid Towing Vessels: A Comparative Framework Toward Mission-Aware Control, Rachel K. Burchill

LSU New Orleans Theses and Dissertations

This thesis presents an optimization-based framework for power management in hybrid towing vessels operating under dynamic mission conditions. A physically consistent modeling approach is developed, incorporating battery state-of-charge dynamics (SOC), unified power flow, and operational constraints. The framework evaluates rule-based control using fixed heuristic thresholds, Particle Swarm Optimization (PSO), Genetic Algorithm (GA), and multi-objective Non-Dominated Sorting Genetic Algorithm II (NSGA-II) under a representative harbor-assist mission profile. Results show that optimization-based methods significantly outperform rule-based control. PSO achieves the lowest fuel consumption and near-perfect tracking with minimal battery use, while GA provides balanced performance with moderate battery utilization. NSGA-II reveals a …

Careers That Feel Like Plinko And A Labor Of Love: A Phenomenology Of Full-Time Contingent Faculty’S Development As Instructors At A University In Transition, Anne Ogburn

LSU New Orleans Theses and Dissertations

Instructors in higher education often do not study or practice teaching before entering the classroom (Flaherty, 2019; McMurtie, 2021). Instead, instructors may develop their teaching knowledge and skills in a variety of ways (Hora & Smolarek, 2018; Kennedy, 2016; McCrickerd, 2012; Oleson & Hora, 2014). Despite this haphazard approach, instructor development is particularly important in higher education given that effective teaching practices improve success outcomes for students (Kilgo et al., 2015; Loes et al., 2019; Umbach & Wawrzynski, 2005). Researchers have focused on the impact of introductory courses on students’ long-term success in a given subject or major (Xu, 2019). …

Understanding The Lived Experiences Of Title Ix Coordinators At Higher Education Institutions In Louisiana, Amanda Robbins

LSU New Orleans Theses and Dissertations

Higher education professionals employed as Title IX Coordinators in Louisiana are tasked with managing their university’s response to sexual misconduct occurring within their campus community. The role’s responsibilities have increased with guidance from every presidential administration since 2014 and often include case management, training of investigators, hearing board members, and mandated reporters as well as completing reports, community education and more (U.S. Department of Education, 2020; Exec. Order No 14021). Scholarly research over the past two decades has informed a body of literature about the experiences of survivors (Baker et al, 2016; Bolger, 2016), the experiences of the accused (Cruz, …

What We Want The Decision Makers To Know About First-Generation College Student Success: Insights From Students’ Perspectives, Monique N. Legendre

LSU New Orleans Theses and Dissertations

One-third of all undergraduates in the U.S. are first-generation college students (FGCS) (Center for First-Generation Student Success, 2020). Due to barriers such as inequitable access to rigorous college preparatory programs and coursework, limited resources and access to college and career counseling, financial constraints, and a lack of college knowledge such as the expectations, norms, and language of higher education, FGCS often arrive less prepared for college than continuing-generation students, impacting first-generation student success and persistence in post-secondary education (Broadhurst et al., 2023; Campoverdi, 2023; Cataldi et al., 2018; Hamilton et al., 2016; Katrevich & Aruguete, 2017; Osborne, 2023; Pratt et …

Exploring The Training Experiences Of Adult Taekwondo Practitioners: A Case Study Of A Martial Arts Program In The Southern United States, Nicholas Daniel Ryburn

Graduate Theses and Dissertations

Taekwondo has gained increasing prominence among adult practitioners in the United States, offering both physical and psychological benefits. However, despite its popularity, research on Taekwondo has predominantly emphasized youth populations, competitive contexts, or injury epidemiology, with limited attention to the lived experiences of adult practitioners. Adults present distinct needs and challenges in martial arts training, including variability in physical conditioning, age-related health considerations, and constraints associated with family and professional responsibilities. A deeper understanding of these factors is crucial for developing training programs that are both effective and sustainable for adult populations. This dissertation employs a qualitative case study design …

Ꭰꮎꮰꭶ (Missing): A Phenomenological Study Of Native American Student Experiences In The Law School Setting, Christina Allene Shaw

Graduate Theses and Dissertations

The legal landscape for Native American people in the United States is ever evolving and highly nuanced, with its historical foundation anchored into the classical pilasters of American legal jurisprudence. Federal Indian law scholars place that historical foundation within the written opinions of Chief Justice Marshall dating back to the 1820s and 1830s (Fletcher, 2024). Although few law students will likely find themselves closely examining the unassigned readings of the Marshall Trilogy or contemporary federal Indian law, there is one small group of students in law school doing exactly that: Native American law students. American Indians and Alaska Natives are …

Coloniality Disrupted: Critical Knowledge Interventions Shift Decolonial Attitudes Among White Americans Via Collective Responsibility & Moral Outrage, Mejdy Jabr

Graduate Theses and Dissertations

Epistemologies of ignorance and critical knowledge dialectically shape how individuals psychologically and politically orient themselves within oppressive social systems. Across three studies, I investigated the psychological mechanisms through which critical-historical knowledge about Indigenous peoples relates to and causally shifts support for (or opposition to) decolonization among America’s foremost settler population, White Americans. Study 1 utilized an Indigenous history test to assess the relationship between critical knowledge and support for decolonization (i.e., decolonial policies and practices; DCPPs), finding that critical-historical knowledge is positively associated with DCPP support and that this relationship is mediated by collective responsibility. Studies 2 and 3 built …

“Menopause Is Universal, But No One Prepared Us”: An Inductive Thematic Analysis Of R/Menopause, Alissa Lauren Hardwick

Graduate Theses and Dissertations

Menopause is a universal biological transition, yet women’s lived experiences of its emotional, cognitive, relational, and healthcare dimensions remain comparatively underrepresented in research. Guided by critical feminist theory and feminist standpoint epistemology, this study examined how women in the r/Menopause online community described experiences of depression and anxiety during the menopausal transition, how they narrated healthcare encounters, and how they made sense of shifting identity and social value. By treating self-authored online narratives as situated forms of knowledge, the study aimed to illuminate how menopausal distress is interpreted and negotiated in everyday discourse. An inductive qualitative reflexive thematic analysis was …

From Data Digitization To Personalized Care: Deep Learning And Decision Analytics In Healthcare Systems, Ahla Ko

Graduate Theses and Dissertations

This dissertation traces a progression from foundational data infrastructure to individualized clinical decision-making, developing and evaluating three computational frameworks that advance healthcare efficiency and personalization through deep learning and decision analytics. The first study presents an end-to-end pipeline for automated recognition of handwritten medical forms, addressing persistent challenges in health data digitization. Integrating a YOLO-based field detection model, a Convolutional Recurrent Neural Network (CRNN) for text transcription, and a confidence-based human-in-the-loop quality assurance framework, the system achieved 99.75\% Exact Match Accuracy and a 0.13\% Character Error Rate on medical forms collected from a tuberculosis research project in Moldova. A GPU-accelerated …

Assessing The Potential Of Taming Chicken Gut Commensal Bacteria Using Random Transposon Mutagenesis, Arjun Chapagain

Graduate Theses and Dissertations

The chicken gut microbiome comprises hundreds of bacterial species whose functional roles remain largely unknown, in part because the tools needed to experimentally manipulate these organisms in their native community context have not been systematically developed or validated. This dissertation addresses the gap through three connected research chapters that progressively build a framework for transposon-based genetic delivery in the chicken cecal microbiome, moving from community-wide accessibility mapping to vector optimization to library preparation refinement. In Chapter 2, we established the community-level insertion landscape in chicken cecal metagenome using Himar transposon delivery via RP4 conjugation and aligned Tn-seq reads to a …

Investigating The Influence Of Dietary Phytogenics And Postbiotics On Horizontal Transmission Of Histomonas Meleagridis In Commercial Turkey Poult Hens, Diego Fernando Cortes Velez

Graduate Theses and Dissertations

Histomonas meleagridis is a parabasalid protozoan and the causative agent of histomonosis, or blackhead disease, in turkeys. Withdrawal of the last remaining in-feed arsenical from the market in 2015 led to the re-emergence of the disease. As a result, there is a need to investigate alternatives, such as dietary inclusion of postbiotic and phytogenic compounds, to reduce H. meleagridis transmission and disease severity in commercial turkey flocks. The purpose of this project was to evaluate the influence of dietary inclusion of three different combinations of postbiotic and phytogenic compounds on H. meleagridis transmission in turkey poult hens. A thesis introduction …