Digital Commons Network^™

Challenging The Nuances Of Pain Assessment With Co-Designed Audio-Visual Simulations In Nursing Education: A Descriptive Study, Michelle A. Kelly, Susan Slatyer, Naomi Tutticci, Joanne Ramsbotham, Sandra Johnston, Irene Ngune, Karen A. Theobald

Research outputs 2022 to 2026

Background: Appropriate management of pain remains a challenging issue. Surfacing nurses’ inherent assumptions about pain may lead to better pain management. This study developed and evaluated new audio-visual (AV) simulations for nursing students showcasing patient characteristics that may influence pain assessment. Methods: Descriptive pre/post intervention study informed by the STROBE framework. Participants were drawn from two Australian universities. Three AV simulations were codesigned by clinicians, educators, and health consumers. Data included: demographics, previous experiences of pain assessment; compassion scale, feasibility, and relevance of AV simulations. Quantile regression and content analyses were applied. Results: Full data sets of 491 participants (314 …

"We Need A Little Strength As Well": Examining The Social Context Of Informal Caregivers For Black Women With Breast Cancer, Tess Thompson, Jacquelyn Coats, Merriah Croston, Robert O Motley Jr, Vetta Sanders Thompson, Aimee S James, Lashaune P Johnson

2020-Current year OA Pubs

BACKGROUND: Informal caregivers (e.g., partners, other family members, friends) often provide social support to Black women with breast cancer, and caregivers find both benefits and challenges in their caregiving role.

METHODS: In this qualitative study, twenty-four caregivers for Black women with breast cancer participated in focus groups and interviews. Participants responded to a brief close-ended questionnaire as well as semi-structured questions about their experiences as cancer caregivers. Demographic information was collected, and relationship satisfaction was measured by the Relationship Assessment Scale-General scale (RAS-G). Focus groups and interviews were recorded, transcribed verbatim, and coded by two independent coders. Using an iterative, …

Nanoparticles For Applications In Specific Diagnostics And Precision Medicine, Naxhije Berisha

Dissertations, Theses, and Capstone Projects

Heterogeneity is common in the expression of cancer and treatment response. Precision medicine enables healthcare providers to tailor medical care to an individual's distinct genetic and environmental makeup. This customization has the potential to result in more efficient treatments while minimizing side effects. We believe that by studying the interface of nanotechnology and cancer medicine we can elucidate innovative solutions that address the challenges of disease heterogeneity. This includes advancements in drug delivery, formulations development, and diagnostic sensing. We highlight three studies that use nanotechnology for applications in precision medicine. In Chapter 2, we highlight design optimization of drug formulations …

A Candidate Needs Approach To Job Advertisements, Yuliya M. Cheban-Gore

Dissertations, Theses, and Capstone Projects

Organizations currently lack research-based best practice guidance on what information is most helpful for job seekers when deciding which jobs and organizations to apply to. This lack of guidance is a detriment because, typically, recruitment strategies are designed from the perspective of the organization’s needs –which is effective when the job market is organization, rather than candidate-driven. When the market is candidate-driven, it would benefit organizations to view the recruitment process through the lens of job seekers. The current studies focus on understanding one of the beginning stages of recruitment through the lens of job seekers: job advertisements. Through a …

The Construction Of Victimhood In Human Trafficking Intervention Courts, Lauren Moton

Dissertations, Theses, and Capstone Projects

Human trafficking intervention courts (HTICs), specialty courts in the US designed to connect trafficking victims to services when they are arrested, require defendants to identify as victims of human trafficking in order to qualify for HTICs' services and other social supports. However, some defendants may be autonomously trading sex, thereby raising questions about the meaning of the term "victim" within HTICs. Therefore, my study asks the following: a) at the institutional level, how do HTICs’ rules, norms, procedures, and stakeholders implement and give meaning to the “victim” label, and why?; and b) at the individual level, how do people who …

Trees In Urban Environments: How Soil Quality Impacts Tree Performance, Saidan Qi

Dissertations, Theses, and Capstone Projects

Cities around the world are increasingly investing in reforestation and afforestation efforts to mitigate impacts from climate change and population growth. However, urban soil conditions can be unfavorable for tree growth. Street trees are widely known to suffer from poor soil quality, but there has been no comprehensive review of this topic so far. Clean soils can be transported from nonurban areas to support cities’ green projects, but this approach is not sustainable. Artificial (constructed) soils can be created from various materials and have been proposed as an alternative medium for urban tree growth, but no research has been done …

Visualizing Ancient Empire In Tudor England: Imperial Monarchy, Reformation, And The Antique Soldier In The Title Page To Richard Grafton’S Large Chronicle (1569), Peter Nicholas Otis

Dissertations, Theses, and Capstone Projects

This thesis analyzes the iconography and visual sources of the title page to the first volume of A chronicle at large and meere history of the affayres of Englande (1569) by the Tudor author Richard Grafton. Representing the visual synthesis of several distinct but interrelated currents that developed in the preceding century, the title page to the Large Chronicle offers a rare glimpse into a transitional moment in the middle Tudor perception and visual representation of the British past. These currents include imperializing royal iconography, with origins in antecedent representations in the late fifteenth century; the entry of the ‘classicizing’ …

Cancer In Pajamas: Radio, Podcasts, And The Politics Of Free Time In The Digital Age, Daniel Grjonko

Dissertations, Theses, and Capstone Projects

The podcast, an extremely potent fermentation of the radio which was so central to many of the Frankfurt School thinkers, is an important political subject to consider in light of rekindled social discussions concerning a society straddling the line between fascism and socialism. Especially the political podcast, which has become a pulse of intellectual discussion and historical analysis, promises itself simultaneously as a medium of entertainment, pedagogy, and translation into real-world organizing for a different world, true for both the left and the right. The truth, I propose, is a sinister other experience, one which maintains the status quo …

Containerization Of Seafarers In The International Shipping Industry: Contemporary Seamanship, Maritime Social Infrastructures, And Mobility Politics Of Global Logistics, Liang Wu

Dissertations, Theses, and Capstone Projects

This dissertation discusses the mobility politics of container shipping and argues that technological development, political-economic order, and social infrastructure co-produce one another. Containerization, the use of standardized containers to carry cargo across modes of transportation that is said to have revolutionized and globalized international trade since the late 1950s, has served to expand and extend the power of international coalitions of states and corporations to control the movements of commodities (shipments) and labor (seafarers). The advent and development of containerization was driven by a sociotechnical imaginary and international social contract of seamless shipping and cargo flows. In practice, this liberal, …

Migrant Children And Legislation: Integrating Knowledge About Trauma Into Policy, Yolennys E. Albornoz

Dissertations, Theses, and Capstone Projects

This study seeks to integrate some knowledge about trauma into migration policies in the U.S. regarding children. Migration is not a novel concept; it is a dynamic phenomenon that experiences continuous changes and constantly increases in numbers. Globally, the United States has been the primary destination for foreign migrants for a long time, and most of them are Latinos who cross the U.S. and Mexico border. Here, I explore how children face trauma in their home country, which forces them to migrate. Also, while they migrate and after they have migrated, exposing the three stages of trauma for migrant children. …

The Role Of The Infralimbic-Basal Forebrain Pathway In Fear Extinction, Carolina Maria Fernandes Henriques

Dissertations, Theses, and Capstone Projects

The medial prefrontal cortex (mPFC) is a key region for emotion regulation, and its failure to regulate extinction of aversive memories is associated with Post Traumatic Stress Disorder. Study of how the Infralimbic cortex (IL), a subregion of the mPFC, directly communicates with the Basolateral Amygdala (IL-BLA), has thus far failed to uncover the circuit mechanisms that lead to mPFC-mediated amygdala suppression of firing and diminished fear responses during extinction retrieval. One problem of this model is that it doesn’t incorporate indirect IL communication with the BLA. A key region to help understand how IL modulates extinction is the basal …

‘The Power Of Three Will Set Us Free': Witchy Womanist Readings Of Toni Morrison’S Sula, Opal Palmer Adisa’S It Begins With Tears, And Migdalia Cruz’S The Have-Little And Miriam’S Flowers, Anamaría Flores

Dissertations, Theses, and Capstone Projects

Witchy womanism is a critical methodology for reading, teaching, and writing about literature in order to generate emancipatory knowledge, activate Queer, Black, and Indigenous consciousnesses, contribute to 21^st century women’s, Black, and Indigenous liberation movements, and foster (re)connections to ancestral rituals and knowledge. Born at the intersections of Black Studies, BIPOC Queer and Gender Studies, Caribbean Studies, English, Hip-Hop Studies and Latinx Studies, “‘The Power of Three Will Set Us Free’: Witchy Womanist Readings of Toni Morrison's Sula, Opal Palmer Adisa's It Begins With Tears, and Migdalia Cruz's The Have-Little and Miriam's Flowers" is a multidisciplinary …

Fashion, Freedom, And Feminism: The Transcendent Work Of Rosa Genoni And Her "Tanagra Dress" Reimagined, Christina Trupiano

Dissertations, Theses, and Capstone Projects

The fashion industry itself is broad in scope and dependent upon numerous sub-industries to produce its garments. It is heavily dependent upon machinery of all kinds, yet unlike many industries today, it is still also largely reliant on manual labor, specifically minority women labor. This dependance upon manual labor correlates with its long history of worker exploitation and sweated labor. The concentration of exploitative labor practices in the fashion industry have made it a focal point in the ongoing struggle between workers and the downward pressure capitalism and industrialization placed on worker compensation, quality of life and job security.

This …

Matr3 Pathogenic Variants Differentially Impair Its Cryptic Splicing Repression Function, Mashiat Khan, Xiao Xiao Lily Chen, Michelle Dias, Jhune Rizsan Santos, Sukhleen Kour, Justin You, Rebekah Van Bruggen, Mohieldin M M Youssef, Ying-Wooi Wan, Zhandong Liu, Jill A Rosenfeld, Qiumin Tan, Udai Bhan Pandey, Hari Krishna Yalamanchili, Jeehye Park

Duncan NRI Faculty and Staff Publications

Matrin-3 (MATR3) is an RNA-binding protein implicated in neurodegenerative and neurodevelopmental diseases. However, little is known regarding the role of MATR3 in cryptic splicing within the context of functional genes and how disease-associated variants impact this function. We show that loss of MATR3 leads to cryptic exon inclusion in many transcripts. We reveal that ALS-linked S85C pathogenic variant reduces MATR3 solubility but does not impair RNA binding. In parallel, we report a novel neurodevelopmental disease-associated M548T variant, located in the RRM2 domain, which reduces protein solubility and impairs RNA binding and cryptic splicing repression functions of MATR3. Altogether, our research …

2024 4-H Volunteer Leader Conference Workshop Descriptions, Nh 4h Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Mousetrap Cars, Mentor Guide, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

Mental Health Resource Guide Sullivan County, Suzanne Meattey

UNH Cooperative Extension

No abstract provided.

Mental Health Resource Guide Strafford County, Suzanne Meattey

UNH Cooperative Extension

No abstract provided.

Mental Health Resource Guide Merrimack County, Suzanne Meattey

UNH Cooperative Extension

No abstract provided.

Mental Health Resource Guide Cheshire County, Suzanne Meattey

UNH Cooperative Extension

No abstract provided.

Mental Health Resource Guide Coös County, Suzanne Meattey

UNH Cooperative Extension

No abstract provided.

Mental Health Resource Guide Rockingham County, Suzanne Meattey

UNH Cooperative Extension

No abstract provided.

Mental Health Resource Guide Hillsborough County, Suzanne Meattey

UNH Cooperative Extension

No abstract provided.

Evaluating The Impact Of Desk Appearance Ticket Reform In New York State, Olive Lu, Michael Rempel

Publications and Research

This report addresses the extent to which reform led more people charged with low-level offenses to return home swiftly after an arrest, avoid overnight detention, and limit unnecessary system contact. We focused solely on misdemeanors and Class E felonies where the specific charge is subject to a mandatory DAT (excluding domestic violence, sex offenses, and select other charges) and the individual has not failed to appear in the past two years. Thus, we excluded most cases where police officers retained discretion; however, the data could not isolate all carve-outs, such as people who cannot prove their identity, appear to need …

Ubiquitous Filter Feeders Shape Open Ocean Microbial Community Structure And Function, Anne W. Thompson, Györgyi Nyerges, Kylee M. Brevick, Kelly Sutherland

Biology Faculty Publications and Presentations

The mechanism of mortality plays a large role in how microorganisms in the open ocean contribute to global energy and nutrient cycling. Salps are ubiquitous pelagic tunicates that are a well-known mortality source for large phototrophic microorganisms in coastal and high-latitude systems, but their impact on the immense populations of smaller prokaryotes in the tropical and subtropical open ocean gyres is not well quantified. We used robustly quantitative techniques to measure salp clearance and enrichment of specific microbial functional groups in the North Pacific Subtropical Gyre, one of the largest ecosystems on Earth. We discovered that salps are a previously …

Bintrafusp Alfa With Ccrt Followed By Bintrafusp Alfa Versus Placebo With Ccrt Followed By Durvalumab In Patients With Unresectable Stage Iii Nsclc: A Phase 2 Randomized Study, Everett E Vokes, Clifford G Robinson, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Preclinical evaluation of bintrafusp alfa (BA) combined with radiotherapy revealed greater antitumor effects than BA or radiotherapy alone. In a phase 1 study, BA exhibited encouraging clinical activity in patients with stage IIIB or IV NSCLC who had received previous treatment.

METHODS: This multicenter, double-blind, controlled phase 2 study (NCT03840902) evaluated the safety and efficacy of BA with concurrent chemoradiotherapy (cCRT) followed by BA (BA group) versus placebo with cCRT followed by durvalumab (durvalumab group) in patients with unresectable stage III NSCLC. The primary end point was progression-free survival according to Response Evaluation Criteria in Solid Tumors version 1.1 …

Determinants Of Referral Network Size For Screening Colonoscopies In The Veterans Health Administration After The Implementation Of The Mission Act, Chase S Eck, Vivian Ho, Cheng Jiang, Laura A Petersen

Center for Medical Ethics and Health Policy Staff Publications

Objective: To measure key characteristics of the Veterans Health Administration's (VHA) Community Care (CC) referral network for screening colonoscopy and identify market and institutional factors associated with network size.

Data sources: VHA electronic health records, CC claim data, and National Plan and Provider Enumeration System.

Study design: In this retrospective cross-sectional study, we measure the size of the VHA's CC referral networks over time and by VHA parent facility (n = 137). We used a multivariable linear regression to identify factors associated with network size at the market-year level. Network size was measured as the number of physicians who performed …

Public Platform With 39,472 Exome Control Samples Enables Association Studies Without Genotype Sharing, Mykyta Artomov, Alexander A Loboda, Maxim N Artyomov, Mark J Daly

2020-Current year OA Pubs

Acquiring a sufficiently powered cohort of control samples matched to a case sample can be time-consuming or, in some cases, impossible. Accordingly, an ability to leverage genetic data from control samples that were already collected elsewhere could dramatically improve power in genetic association studies. Sharing of control samples can pose significant challenges, since most human genetic data are subject to strict sharing regulations. Here, using the properties of singular value decomposition and subsampling algorithm, we developed a method allowing selection of the best-matching controls in an external pool of samples compliant with personal data protection and eliminating the need for …

Gene-Specific Acmg/Amp Classification Criteria For Germline Apc Variants: Recommendations From The Clingen Insight Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel\, Isabel Spier, Xiaoyu Yin, Marcy Richardson, Marta Pineda, Andreas Laner, Deborah Ritter, Julie Boyle, Pilar Mur, Thomas V O Hansen, Xuemei Shi, Khalid Mahmood, John-Paul Plazzer, Elisabet Ognedal, Margareta Nordling, Susan M Farrington, Gou Yamamoto, Stéphanie Baert-Desurmont, Alexandra Martins, Ester Borras, Carli Tops, Erica Webb, Victoria Beshay, Maurizio Genuardi, Tina Pesaran, Gabriel Capellá, Sean V Tavtigian, Andrew Latchford, Ian M Frayling, Sharon E Plon, Marc Greenblatt, Finlay A Macrae, Stefan Aretz, Insight-Clingen Hereditary Colon Cancer/Polyposis Variant Curation Expert Panel

Center for Medical Ethics and Health Policy Staff Publications

Purpose: The Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel (VCEP) was established by the International Society for Gastrointestinal Hereditary Tumours and the Clinical Genome Resource, who set out to develop recommendations for the interpretation of germline APC variants underlying Familial Adenomatous Polyposis, the most frequent hereditary polyposis syndrome.

Methods: Through a rigorous process of database analysis, literature review, and expert elicitation, the APC VCEP derived gene-specific modifications to the ACMG/AMP (American College of Medical Genetics and Genomics and Association for Molecular Pathology) variant classification guidelines and validated such criteria through the pilot classification of 58 variants.

Results: The APC-specific criteria …

Risk Factors For Childhood Brain Tumours: A Systematic Review And Meta-Analysis Of Observational Studies From 1976 To 2022, Felix M Onyije, Roya Dolatkhah, Ann Olsson, Liacine Bouaoun, Isabelle Deltour, Friederike Erdmann, Audrey Bonaventure, Michael E Scheurer, Jacqueline Clavel, Joachim Schüz

Center for Medical Ethics and Health Policy Staff Publications

BACKGROUND: Childhood brain tumours (CBTs) are the leading cause of cancer death in children under the age of 20 years globally. Though the aetiology of CBT remains poorly understood, it is thought to be multifactorial. We aimed to synthesize potential risk factors for CBT to inform primary prevention.

METHODS: We conducted a systematic review and meta-analysis of epidemiological studies indexed in the PubMed, Web of Science, and Embase databases from the start of those resources through 27 July 2023. We included data from case-control or cohort studies that reported effect estimates for each risk factor around the time of conception, …