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Targeting Efferocytosis In Inflammaging, Ivan K H Poon, Kodi S Ravichandran

2020-Current year OA Pubs

Rapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for the maintenance of tissue homeostasis, the resolution of inflammation, and tissue repair. However, impaired efferocytosis can result in the accumulation of apoptotic cells, subsequently triggering sterile inflammation through the release of endogenous factors such as DNA and nuclear proteins from membrane permeabilized dying cells. Here, we review the molecular basis of the three key phases of efferocytosis, that is, the detection, uptake, and degradation of apoptotic materials by phagocytes. We also discuss how defects in efferocytosis due to the alteration of phagocytes and dying cells …

Teacher Professionalism, Expertise And The Jurisdictional Struggle, Jim Hordern

School of Law, Humanities and Social Sciences

In this paper, the relationship between teacher professionalism, expertise and educational knowledge is examined via the sociology of the professions, studies of professional knowledge, and the philosophy of expertise. Drawing on the work of Abbott the jurisdictional context of teaching is foregrounded, with a focus on (i) how educational problems are defined; (ii) professional knowledge-in-use (or diagnosis, inference and “treatment” in teaching); and (iii) the potential of systematically organised abstract knowledge base for teaching. It is suggested that teaching is a profession particularly vulnerable to external jurisdictional challenge, with little opportunity for protection against forms of what Abbott terms “advisory” …

B Cells Mediate Lung Ischemia/Reperfusion Injury By Recruiting Classical Monocytes Via Synergistic B Cell Receptor/Tlr4 Signaling, Khashayar Farahnak, Yun Zhu Bai, Yuhei Yokoyama, Deniz B. Morkan, Zhiyi Liu, Junedh M. Amrute, Alejandro De Filippis Falcon, Yuriko Terada, Fuyi Liao, Wenjun Li, Hailey M. Shepherd, Ramsey R. Hachem, Varun Puri, Kory J. Lavine, Andrew E. Gelman, Ankit Bharat, Daniel Kreisel, Ruben G. Nava

2020-Current year OA Pubs

Ischemia/reperfusion injury-mediated (IRI-mediated) primary graft dysfunction (PGD) adversely affects both short- and long-term outcomes after lung transplantation, a procedure that remains the only treatment option for patients suffering from end-stage respiratory failure. While B cells are known to regulate adaptive immune responses, their role in lung IRI is not well understood. Here, we demonstrated by intravital imaging that B cells are rapidly recruited to injured lungs, where they extravasate into the parenchyma. Using hilar clamping and transplant models, we observed that lung-infiltrating B cells produce the monocyte chemokine CCL7 in a TLR4-TRIF-dependent fashion, a critical step contributing to classical monocyte …

Cpsa Mediates Infection Of Recruited Lung Myeloid Cells By Mycobacterium Tuberculosis, Steven J Grigsby, G V R Krishna Prasad, Joshua B Wallach, Ekansh Mittal, Fong-Fu Hsu, Dirk Schnappinger, Jennifer A Philips

2020-Current year OA Pubs

Mycobacterium tuberculosis (Mtb) possesses an arsenal of virulence factors to evade host immunity. Previously, we showed that the Mtb protein CpsA, which protects Mtb against the host NADPH oxidase, is required in mice during the first 3 weeks of infection but is thereafter dispensable for full virulence. Using flow cytometry, we find that ΔcpsA Mtb is retained in alveolar macrophages, impaired in recruiting and disseminating into monocyte-derived cells, and more likely to be localized in airway cells than wild-type Mtb. The lungs of ΔcpsA-infected mice also have markedly fewer antigen-specific T cells, indicating a delay in adaptive immunity. Thus, we …

Impact Of Type Of K Fertilizer On Dcad Of Fen Grassland In Northeast Germany, A. Behrendt, J. Pickert, F. Eulenstein, B. Kroschewski

IGC Proceedings (1977-2023)

A lower DCAD is required in the diet fed during the prepartum period, but increasing the DCAD of diets fed during lactation increased milk yield and dry matter intake (Overton 2020). We conducted 3 cutting date/type of fertilizer trials, harvested with 5, 4 and 3 cuts per year over 3 years. Compared to the chloride based K fertilizer, the application of a sulphate based K fertilizer did not change dry matter yield and fodder quality (NEL-, XP-content) but led to significant higher DCAD in the grass in cut 1 - 3 of all trials over 3 years. The increase of …

Breeding Small Grains As A Forage, Silage And Cover Crop For The Southern Coastal Plain (Usa) In A Changing Climatic Environment, A. Blount, Marcelo O. Wallau, S. A. Harrison, Cheryl L. Mackowiak, A. Babar, José C. B. Dubeux Jr.

IGC Proceedings (1977-2023)

Forage breeding of small grains in the southern Coastal Plains region of the U.S. mimic many other countries experiencing climate changes and breeding strategies should be similar for improving small grains grown for forage, silage or as cover crops. Significant focus on improvements in stress-adaptation has encouraged members of the SunGrains cooperative to cross, evaluate and develop experimental lines with inherent adaptation to climatic conditions including heat stress, drought tolerance, short-day and long-day forage production periods, and flooded conditions for events with storm-related, short-term durations. Many new cultivars, grown throughout the southeastern U.S. have resulted from breeding selection under abiotic …

The Future Of Clovers In Forage Systems And As Cover Crops, J. H. Bouton, John R. Caradus

IGC Proceedings (1977-2023)

Clovers (Trifolium spp.) are the most widely used genera of legumes in forage systems, although only a limited number of the hundreds of perennial and annual species are commercially available. The number of varieties available within each of the main commercial species can be high and demonstrates past breeding achievements. Success relates to any clover’s ability to persist in mixtures with other forage species, across a range of soil types, management systems, and climates, while providing animal nutrition and biologically fixed nitrogen benefits. Uses range from traditional pasture mixtures with grasses to inclusion in multi-species mixtures, and as cover …

3rd Annual Hu Research Symposium Program 2021, Akeisha Belgrave, Erica Ward, Rebekah Harriger

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

3rd Annual HU Research Symposium program and schedule of presenters. Presentations were held April 21st, 2021 virtually on the Teams platform.

Effectiveness And Cost Of Shrub Removal Methods In Degraded Woodlands Being Converted To Silvopasture, S. Cartoni-Casamitjana, M. J. Renz

IGC Proceedings (1977-2023)

Transforming degraded woodlands to silvopasture is of interest in the Midwestern USA as it increases profitability of farms and benefits animal health. Invasive shrubs within woodlands, however, are a major obstacle to silvopasture establishment. Research was undertaken to evaluate the effectiveness, cost and resulting herbaceous canopy light interception of common brush-control methods when used alone or integrated over a two-year timeframe. Five treatments were established in a randomized complete block design. In the first year, treatments were either forestry mowed (mow) or rotationally grazed by goats (goats) at a stocking density of 5700 to 6000 kg per hectare. In the …

Grass Vegetation Dynamics In Wetlands With Different Utilization, Dorai Pandian Kannan

IGC Proceedings (1977-2023)

The land-use patterns, combined with the biotic interactions, are likely to substantially affect the grass community of tropical wetlands. However, we need more information to understand the vegetation cover and, particularly, the diversity of grasses in the protected sites, where the naturally occurring interactions with extreme complexity. Hence a thorough understanding of these interactive effects on grass dynamics would help develop wildlife management guidelines to predict the grass-woody herbs and other associated vegetation. In light of this, a beta vegetation survey and diversity analysis in two varying wetland ecosystems of natural mountain streams and temporary ponds. Grass communities occurred along …

Weed Management Affects Pasture Productivity And Animal Performance, José C. B. Dubeux Jr., I. L. Brêtas, L. M. D. Queiroz, H. A. Koury

IGC Proceedings (1977-2023)

Weed can be defined as any plant growing in undesirable locations. Weeds are considered one of the main challenges in agricultural fields. Weeds affect pasture productivity mainly because of the competition for limited resources such as nutrients, water, and light with forage plants. Weeds encroach pastures spontaneously and spread quickly through the farm and neighboring areas, making their control difficult. In addition, weeds can affect forage nutritive value, grazing behaviour, voluntary forage intake, animal health, and consequently animal performance. The low efficiency of mechanical weeding and the global concern about indiscriminate use of herbicides impose challenges for producers in grazing …

Development Of Seed Production Of Important Grass And Legume Species In Poland In Relation To The European Market, Barbara Golińska, Piotr Goliński

IGC Proceedings (1977-2023)

An analysis was carried out on the status of seed production of most important grass and legume species in Poland in terms of the area of seed crops and their seed yield on the background of the European market. Particular attention in the analysis was paid to the dominant species in the reproductive area of varieties of forage and turfgrasses and small-seeded legumes in Poland and in Europe, i.e. Lolium perenne L., Lolium multiflorum Lam., Festuca rubra L. and Trifolium pratense L. For analysis the ESCAA and Polish Main Inspectorate of Plant Health and Seed Inspection data from 2004‒2021 were …

A Comparison Of Four Methods Of Botanical Analysis In Kentucky Cattle Pastures, Echo Elizabeth Gotsick, S. Ray Smith, Jimmy C. Henning, Christopher D. Teutsch

IGC Proceedings (1977-2023)

Throughout the many decades of grassland and forage research, practitioners have used many different methods to assess botanical composition. While a few of these methods have proven to be accurate and efficient, there has been limited direct comparison between methods. The objective of this study was to determine an accurate and efficient method to determine botanical composition for researchers, practitioners, and students. Six farms with two pastures each were monitored across the state of Kentucky. Sampling started fall 2020 and continued through fall 2022 with measurements taken three times a year using the following measurement techniques: step point, visual estimation, …

Short-Term Effect Of Forage Grasses On Carbon Sustainability, Fodder Security, And Soil Properties In Poor Soils Of Semi-Arid India, H. M. Halli, P. Govindasamy, M. Choudhary, R. Srinivasan, M. Prasad, Vinod K. Wasnik, Vijay Kumar Yadav, A. K. Singh, S. Kumar, D. Vijay

IGC Proceedings (1977-2023)

Grasses are essential sources of fodder for livestock and provide options for climate resilience due to their broad range of adoption. They are also valuable resources for soil quality enhancement. Therefore, a six-year field study using nine grasses (2013 to 2019) was initiated in a semi-arid region of central India. The study aimed to assess the short-term impact of these nine grasses on soil carbon stock, selected soil physiochemical and biological properties, and green fodder yield. Results (after six years) revealed that a greater carbon stock (7.0 and 7.2 Mg ha^–1), carbon sustainability index (71.6 and 89.3), and …

Improvement In The Nitrogen Use Efficiency And Uptake Of Perennial Ryegrass (Lolium Perenne) Caused By The Epichloë Fungal Endophyte Ar37, M. A. Harmer

IGC Proceedings (1977-2023)

The forage yield and pasture persistence benefits of Epichloë fungal endophyte strain AR37 (AR37) in high rainfall perennial ryegrass (Lolium perenne) pastures in Australia and New Zealand are recognised. However, the effect of beneficial endophytes on nitrogen (N) use efficiency, yield response to applied N and N uptake had not been determined.

To investigate this, a replicated trial was managed for three years under irrigation in southern Australia. Five N application rates (0, 20, 40, 80 and 160 kg N/ha) were applied every second harvest to a tetraploid perennial ryegrass variety with and without AR37. Ryegrass biomass was …

Using A Radiometric Method To Determine The Silage Density In Bunker Silos, Thomas Hoffmann, Andree Jacobs

IGC Proceedings (1977-2023)

Certain minimum densities should be targeted when storing silage in bunker silos. Often the minimum density is not reached. As a result, high losses can occur. This study aims to develop a measuring device for online density measurement. The basis of the measuring device is a source of caesium radiation with an activity of 37 MBq and a sodium iodide scintillation detector. The measuring device uses the backscattering method. Source and detector are arranged in a measuring wheel, which is connected with the tractor via the rear three-point linkage. Both, the current density as well as the density increase in …

Stability And Purity Of Epichloë Endophyte Infection In New Zealand Ryegrass Pastures, David E. Hume, Grant M. Rennie, W. Mcg. King, A. L. Taylor, Marty J. Faville, D. Luo, Katherine N. Tozer

IGC Proceedings (1977-2023)

Perennial ryegrass (Lolium perenne) in New Zealand pastures is typically infected with the mutualist Epichloë fungal endophyte, which assists the plant in resisting biotic and abiotic stresses. Ryegrass that has naturalised in New Zealand is highly infected with the ‘Standard’ strain of endophyte. This strain provides good protection from a range of invertebrate pests but negatively impacts livestock productivity and health in the warmer seasons of the year. Grass-endophyte associations have been developed between elite perennial ryegrass cultivars and selected endophyte strains to provide protective properties to the host plant and lessen or eliminate the negative effects on …

A Global Perspective Of Epichloë Endophyte Toxicity In Sown Pastures, David E. Hume, S. C. Finch

IGC Proceedings (1977-2023)

The asexual Epichloë fungal endophytes that form mutualistic, obligate, asymptomatic associations with ryegrasses (Lolium spp.) and tall fescue (Festuca arundinacea) are critical components of pastures in the USA, Australia and New Zealand. Research has convincingly demonstrated that these endophytes enhance agronomic performance of their grass hosts, due to protection from biotic and abiotic stresses such as insect pests and drought. However, although beneficial in terms of enhancing forage quantity, the widespread occurrence of ‘common-toxic’ strains of endophyte negatively impacts the quality of forage for livestock. These bioprotective and anti-quality properties are due to endophyte-expressed secondary metabolites. It …

My Son Went Quiet; Shadow, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a review of two short films: My Son Went Quiet(2024), directed by Ian Bawa, and Shadow (2024), directed by Kamell Allaway

Bliss, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a film review of Bliss (2022), directed by Joe Maggio.

Dosh, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a film review of Dosh (2023), directed by Radha Mehta.

Eindis Ends It All, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a film review of Eindis Ends It All (2022), directed by Tamara Rosenfeld.

You Were Never Really Here, Monica Blizek

Journal of Religion & Film

This is a film review of You Were Never Really Here (2023), directed by Flor Portieri.

Demon Mineral, Brady Desanti

Journal of Religion & Film

This is a film review of Demon Mineral (2024), directed by Hadley Austin.

Leilani's Fortune, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a film review of Leilani's Fortune (2024), directed by Loveleen Kaur.

2018 2nd Place: Identifying The Effectiveness Of Plant Extracts For Treating Biofilms Of Escherichia Coli And Myxococcus Xanthus, Micah Burton

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

Antibiotic resistance is a topic that is of growing concern in the field of medicine. Antibiotics act as growth blockers or act as toxins, killing the organism they affect. These biological weapons generate selective pressure leading to the current antibiotic crisis. This selective pressure causes resistant organisms to begin to emerge and over generations antibiotic resistance can develop and be spread among a bacterial population.

One of the key factors contributing to antibiotic resistance in bacteria is the ability for some bacteria to form and shield themselves within biofilms. Biofilms are masses of bacteria protected by a polysaccharide/ extracellular DNA …

Common Ground, 1996, V1 N1, February, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Chicago, IL: First issue of "Common Ground", a publication from The Park Ridge Center for the Study of Health, Faith and Ethics, associated with Lutheran General Hospital. This initial issue is titled, "Clinical Ethics News", but the title is changed in the following issues after a naming competition is announced in this issue. This issue has a case study on a Jehovah's Witness patient, a review of the Home Care Ethics Committee, and other ethical news.

Common Ground, 1996, V1 N2, April, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Chicago, IL: Issue of "Common Ground", a publication from The Park Ridge Center for the Study of Health, Faith and Ethics, associated with Lutheran General Hospital. This issue has a case study on health care decisions for minors, updates from ethics committees at various Advocate hospitals, and other medical and bioethical news.

Common Ground, 1996, V1 N3, June, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Chicago, IL: Issue of "Common Ground", a publication from The Park Ridge Center for the Study of Health, Faith and Ethics, associated with Lutheran General Hospital. This issue has a case study on insurance, updates from ethics committees at various Advocate hospitals, and other medical and bioethical news.

Common Ground, 1996, V1 N4, August, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Chicago, IL: Issue of "Common Ground", a publication from The Park Ridge Center for the Study of Health, Faith and Ethics, associated with Lutheran General Hospital. This issue has a case study on placebos, updates from ethics committees at various Advocate hospitals, and other medical and bioethical news.