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A History Of Alternatives To The Use Of Animals In Research And Testing, John Parascandola

Tales of WellBeing

A medical historian investigates the social history of the development of alternatives to laboratory animals.

Student Senate Meeting Minutes January 23, 2024, Student Senate-Winona State University

Student Senate Meeting Minutes

This document is the official Winona State University Student Senate Minutes January 23, 2024.

Distinct Interactions Stabilize Egfr Dimers And Higher-Order Oligomers In Cell Membranes, Krishna C. Mudumbi, Eric A. Burns, David J. Schodt, Zaritza O. Petrova, Anatoly Kiyatkin, Lucy W. Kim, Emma M. Mangiacapre, Irais Ortiz-Caraveo, Hector Rivera Ortiz, Chun Hu, Kumar D. Ashtekar, Keith A. Lidke, Diane S. Lidke, Mark A. Lemmon

Pathology Research and Scholarship

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase with important roles in many cellular processes as well as in cancer and other diseases. EGF binding promotes EGFR dimerization and autophosphorylation through interactions that are well understood structurally. How these dimers relate to higher-order EGFR oligomers seen in cell membranes, however, remains unclear. Here, we used single-particle tracking (SPT) and Förster resonance energy transfer imaging to examine how each domain of EGFR contributes to receptor oligomerization and the rate of receptor diffusion in the cell membrane. Although the extracellular region of EGFR is sufficient to drive receptor dimerization, …

Lindenwood's Aj Surrell Crowned Miss Missouri Volunteer, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

Exploring Lgbtq+ Cultural Competency And Dei In Continuing Education: A Cross-Sectional Review Of U.S. Pharmacy Legislation, Jennifer Ko, Jeremy Carlos, Yvonne Nguyen

Pharmacy Faculty Articles and Research

Background

Lesbian, gay, bisexual, transgender, queer or questioning, intersex, asexual, or other sexual orientations or gender identities (LGBTQ+) cultural competency training is offered in pharmacy curricula to variable extents. State legislation directly dictates pharmacist training through continuing pharmacy education (CPE) requirements.

Objectives

This study aimed to identify the U.S. states and the District of Columbia (D.C.) that require CPE or training on topics related to LGBTQ+ cultural competency or topics related to diversity, equity, and inclusion (DEI) in general. In addition, this study quantified and compared each state’s CPE hours required for each renewal period.

Methods

This cross-sectional study retrospectively …

January 23, 2024, Nichole Mulvey

Minutes

Volume 52, Number 9

Speaker: Director of ITS Ryan Gibson

Human Milk Polyunsaturated Fatty Acids Are Related To Neurodevelopmental, Anthropometric, And Allergic Outcomes In Early Life: A Systematic Review, Saori Mitguard, Olivia Doucette, John Miklavcic

Food Science Faculty Articles and Research

Polyunsaturated fatty acids are critically important for newborn nutrition and in the trajectory of growth and developmental processes throughout early life. This systematic review (PROSPERO ID: CRD42023400059) critically analyzes literature pertaining to how omega-3 and omega-6 fatty acids in human milk are related to health outcomes in early life. Literature selected for the review were published between 2005 and 2020 and included assessments in healthy term children between 0 and 5 years of age. The studies reported the relation between human milk fatty acids docosahexaenoic acid (C22:6n-3, DHA), eicosapentaenoic acid (C20:5n-3, EPA), alpha-linolenic acid (C18:3n-3, ALA), arachidonic acid (C20:4n-6, AA), …

Academic Accelerators: A Unique Channel For Health Care Innovation, Chase Richard, Christian Hernandez

URGENT Matters

No abstract provided.

Joint Senate Meeting Minutes 1-23-24, Unk Student Government

Joint Senate Meeting Minutes

No abstract provided.

W. R. R. V. Attorney General United States Of America

2024 Decisions

Agency

Student Affairs Minutes 1/23/2024, Student Affairs Committee

Student Affairs Committee

No abstract provided.

College Council Meeting Minutes (January 23, 2024), Dmacc

College Council

No abstract provided.

Virgin Coconut Oil (Vco) Supplementation Relieves Symptoms And Inflammation Among Covid-19 Positive Adults: A Single-Blind Randomized Trial, Imelda Angeles-Agdeppa, Jacus S. Nacis, Fabian M. Dayrit, Keith V. Tanda

Chemistry Faculty Publications

A clinical study conducted in 2020 showed that virgin coconut oil (VCO) has been found effective in the rapid relief of COVID-19 symptoms and normalization of the C-reactive protein (CRP) concentration among probable and suspected cases of COVID-19. This present study aimed to validate those results and to evaluate the effects of VCO among COVID-19 patients through a 28-day randomized, single-blind trial conducted among 76 SARS-CoV-2 RT-PCR (reverse transcription-polymerase chain report)-confirmed adults, with VCO given as a COVID-19 adjunct therapy. The results showed that VCO recipients were free from symptoms and had normal CRP concentrations by day 14. In comparison, …

January 23, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Effect Of Teacher Social Support On Students’ Emotions And Learning Engagement: A U.S.-Chinese Classroom Investigation, Moyi Jia, Jiuqing Cheng

Faculty Publications

Psychological and instructional communication researchers increasingly recognize the significance of student emotions in determining their engagement in the classroom. Under the direction of Emotional Response Theory (Mottet, Frymier, & Beebe, 2006), this study aims to establish a model of a college instructor’s social support, student positive and negative emotions, and student engagement in learning. It also attempts to extend this research by examining cultural differences in U.S. and Chinese classrooms and how these factors influence teacher behavior and student emotions. The result demonstrates the mediating effects of student positive emotions between teacher support and student engagement in both cultures. In …

Building Research Capacity In Low- And Middle-Income Countries And Pandemic Preparedness: Lessons Learned And Future Directions, Peter H. Kilmarx, Karen A. Goralesk, Erum Khan, John F. Lindo, Nancy Gore Saravia

Department of Pathology and Laboratory Medicine

Research capacity is a critical component of pandemic preparedness, as highlighted by the challenges faced during the Ebola outbreak in West Africa. Recent global initiatives, such as the Research & Development Task Force of the Global Health Security Agenda and the World Health Assembly's resolution on strengthening clinical trials, emphasize the need for robust research capabilities. This Perspective discusses the experiences of leaders in infectious disease research and capacity building in low- and middle-income countries, focusing on Colombia, Jamaica, and Pakistan. These case studies underscore the importance of collaborative efforts, interdisciplinary training, and global partnerships in pandemic response. The experiences …

Early Immersion In Team-Based Event Review: Experiential Patient Safety Education For Pgy 1 Internal Medicine Residents, Michelle Perkons, Alexis Wickersham, Sonia Bharel, Timothy Kuchera, Rebecca Jaffe

Department of Medicine Faculty Papers

INTRODUCTION: In recent years, there has been a national push to incorporate high-fidelity quality improvement and patient safety (QIPS) education into physician training programs. In fact, integration of robust patient safety education became an Accreditation Council for Graduate Medical Education (ACGME) Common Program Requirement for residency programs in 2017. We developed a curriculum to not only fulfill the ACGME's requirement but also provide PGY 1 internal medicine residents with the skills needed to become active participants in ongoing patient safety work throughout their training and careers.

METHODS: Our patient safety curriculum was woven into residents' existing protected educational time and …

Hybrid Electro-Plasmonic Modulation Of Neural Activity With Visible-Light-Sensitive Gold Nanotransducer Interface, Ratka Damnjanovic, Parveen Bazard, Robert Dana Frisina, Venkat Rama Bhethanabotla

USF Patents

A method of modulating neural activity using a combination of electrical and optical stimulation transmitted via a gold nanoparticle covered nanoelectrode is presented. The combination of short-duration green visible light optical pulses with the complementary sub-threshold level electric current pulses are capable of producing action potentials in neurons. Cells were found to have a greater than a 5× survival rate using this hybrid stimulation method as compared to pure plasmonic/optical stimulation. The cell stimulation success rate was 3× greater with hybrid stimulation.

Htra1 Prevents And Reverses Α-Synuclein Aggregation, Rendering It Non-Toxic And Seeding Incompetent, Sheng Chen

Arts & Sciences Graduate Student Theses and Dissertations

Protein misfolding and accumulation of misfolded species are associated with multiple neurodegenerative diseases, including Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). α-Synuclein (α-Syn) misfolding and accumulation into Lewy bodies is closely linked to Parkinson’s disease. In ALS and FTD, TDP-43 and FUS are found to be aggregated in disease pathology. These proteins aggregate and associate with both a toxic gain of function of misfolded form and a loss of function due to misfolding. Therefore, it is critical to understand molecular mechanisms by which cells can prevent protein misfolding and how the cell can reverse the aggregation …

Individual And Structural Contributors To Implicit And Explicit Anti-Muslim Bias In The United States, Aeleah M. Granger

Dissertations and Theses

This dissertation consists of two manuscripts addressing the multifaceted nature of Islamophobia in the United States by examining explicit and implicit anti-Muslim bias on individual and structural levels. The first manuscript tests an ideology-threat-attitude-behavior model by estimating the simultaneous mediating effects of threat perceptions on the relationships between individual differences in ideology, Islamophobia (fear of Muslims), and support for an anti-Muslim police surveillance policy. This study (N = 603) finds that individuals who are higher in Social Dominance Orientation (SDO), Right-wing Authoritarianism (RWA), and Nationalism are more likely to perceive Muslims as realistic (power), symbolic (value), and terroristic (safety) …

The Combined And Individual Effects Of Azadirachta Indica L. Oil And Nahco3 On The Inhibition Of F. Oxysporum, Neya Murugesan

Journal of the South Carolina Academy of Science

F. oxysporum is the causal agent of Fusarium wilt. This disease is known to penetrate the roots of plants and wilt the vascular system. The most common method for control is through the use of synthetic fungicides, which are known to cause adverse effects on the environment and human health. Thus, it is necessary that more methods of biocontrol be explored. Current literature shows that various salts and essential oils are effective for the biocontrol of F. oxysporum. However, the two types of substances have not yet been tested together, causing a gap in current research. Due to the antifungal …

The Effect Of The Addition Of Carrot Seed Oil And Raspberry Seed Oil On The Uv Intensity Of A Sunscreen, Isra Siddique

Journal of the South Carolina Academy of Science

With continuous developments in research indicating the potential health risks of chemical sunscreen filters, the novel approach of incorporating natural oils with UV light blocking properties has been explored. Natural oils extracted from fruit and vegetables have been proven to possess photoprotective properties, but their effectiveness in combination with synthetic sunscreen filters has not been as thoroughly investigated. The purpose of this study was to determine whether the addition of carrot and raspberry seed oil to an SPF 30 sunscreen would decrease the UV intensity of UVB light passing through the sunscreen and oil mixture. It was hypothesized that if …

The Effect Of Exposure To Lentinula Edodes And Flammulina Velutipes On The Biodegradation Of Crystallized Polylactic Acid, Iraine Taine

Journal of the South Carolina Academy of Science

Crystallized polylactic acid (CPLA) is a prevalent bioplastic which, despite being biodegradable, is extremely resistant to decomposition in natural environments. As a result, CPLA waste contamination is rapidly becoming a prevalent issue. Lentinula edodes and Flammulina velutipes are two widespread white-rot fungi whose capabilities for bioplastic degradation have not been examined. This study aimed to determine a natural approach for reducing plastic waste by evaluating the ability of L. edodes and F. velutipes to degrade CPLA bioplastic. It was hypothesized that CPLA samples would decrease in mass when individually treated with L. edodes and F. velutipes due to their similarities …

The Effect Of Various Polyphenols On Associative Memory Loss And Dementia In A Drosophila Melanogaster Model Of Alzheimer’S Disease, Anagha Gowda

Journal of the South Carolina Academy of Science

Alzheimer’s Disease (AD), a prominent neurodegenerative disease (NDD), is the seventh leading cause of death in the United States; however, little is known about prevention. As a result, polyphenols (plant-based compounds) and other natural substances have been studied for their therapeutic potential in improving cognition and memory in AD cases. While the impacts of each polyphenol (phenolic acids, flavonoids, stilbenes, and lignans) contain fundamental similarities, each varies slightly in its impacts on the brain.The purpose of this study was to examine the impacts of polyphenol subgroups on associative memory in AD, tested by building an olfactory association, through the use …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

The Effect Of Rosmarinus Officinalis And Trachyspermum Ammi On The Growth Of Eruca Vesicaria Ssp. Sativa In Hydroponics Versus Natural Soil, Emna Guedhami

Journal of the South Carolina Academy of Science

Despite technology being developed to address the food shortages due to increasing population, current methods of cultivating crops are not sufficient. Scientists are addressing this issue by researching biostimulants that stimulate plant growth without harming the environment and researching the use of hydroponics, a way of growing crops without soil. The purpose of this study was to combine the use of essential oils and growing methods (hydroponics and soil) and measure its impact on the height of E. sativa. It was hypothesized that if E. sativa was grown hydroponically with added Rosmarinus officinalis (REO) and Trachyspermum ammi (TEO) over time, …

The Comparative Impact Of Acesulfame-Potassium, Stevia Extract, And Monk Fruit On The Lifespan Of Drosophila Melanogaster, Beverly Holton

Journal of the South Carolina Academy of Science

Non-nutritive sweeteners (NNS), non-caloric sweetening devices, have been widely commercialized to reduce sugar consumption. This intent has associated NNS with health benefits, though reports have correlated the consumption of these substitutes with noncommunicable diseases. The interaction between NNS and distinct physiological processes has been examined, though research into the broader implications of these interactions, toward longevity, for instance, is lacking. The purpose of this study was to compare the impact of three recently FDA-approved NNS - acesulfame-Potassium (ace-K), stevia, and monk fruit - on the survival of Drosophila melanogaster, a model species for longevity research, to discern the possible impacts …

The Effect Of Crystalline Phase On The Toxicity Of Tio2 Nanoparticles To Chlorella, Jisoo Lee

Journal of the South Carolina Academy of Science

Nanoparticles (NPs), or particles with dimensions that go below 100 nanometers, can be released into the environment in various ways, such as through cosmetic products like sunscreen. Titanium dioxide (TiO₂) is a commonly used nanoparticle in sunscreen, and it has the potential to be harmful to various aquatic organisms including algae. The purpose of this study was to examine how the crystalline phase of TiO₂ NPs (brookite or rutile) influenced their toxicity to the microalgae species Chlorella. It was hypothesized that brookite phase TiO₂ NPs would inhibit the growth of Chlorella more than rutile phase TiO …

Increased Chemokine Production Is A Hallmark Of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-Hiv Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity., Junsuke Nohara, Tyler Evangelous, Madison Berry, Whitney Beck, Sarah Mudrak, Shalini Jha, R Keith Reeves, Kevin J. Wiehe, Justin Pollara, Georgia D. Tomaras, Todd Bradley, Guido Ferrari

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Antibody-dependent cell-mediated cytotoxic (ADCC) response mediated by natural killer (NK) cells correlates with decreased infection risk in studies involving simian immunodeficiency virus (SIV)/simian-human immunodeficiency virus (SHIV), and human immunodeficiency virus (HIV) vaccine candidates. Currently, the heterogeneities of the functional subset of rhesus macaque natural killer (RMNK) cells are under-characterized.

METHOD: We engaged the RMNK cells with ADCC-mediating anti-HIV-1 monoclonal antibodies (ADCCAbs) or anti-CD16 antibodies and used CD107a expression as the surrogate marker for RMNK cells actively involved in ADCC. CD107a⁺ and CD107a- populations were analyzed individually using single-cell RNA sequencing.

RESULTS: Subsets of CD107a⁺ RMNK cells produced …

Public Law 86-272 And The Texas Margin Tax, Marvin J. Williams

St. Mary's Law Journal

No abstract provided.