Digital Commons Network^™

Extracting Drug-Protein Relation From Literature Using Ensembles Of Biomedical Transformers, Avisha Das, Zhao Li, Qiang Wei, Jianfu Li, Liang-Chin Huang, Yan Hu, Rongbin Li, Wenjin Jim Zheng, Hua Xu

Faculty, Staff and Student Publications

Automatic extraction of relations between drugs/chemicals and proteins from ever-growing biomedical literature is required to build up-to-date knowledge bases in biomedicine. To promote the development of automated methods, BioCreative-VII organized a shared task - the DrugProt track, to recognize drug-protein entity relations from PubMed abstracts. We participated in the shared task and leveraged deep learning-based transformer models pre-trained on biomedical data to build ensemble approaches to automatically extract drug-protein relation from biomedical literature. On the main corpora of 10,750 abstracts, our best system obtained an F1-score of 77.60% (ranked 4th among 30 participating teams), and on the large-scale corpus of …

An Icd For The Digital World: What Does The Icd-11 Research Show?, Susan H Fenton, Mary H Stanfill, Kathy Giannangelo

Faculty, Staff and Student Publications

The 11th revision of the International Classification of Diseases (ICD) is now available for use. A literature search was conducted to review and summarize the research conducted to date. In addition to the ease of integration into electronic health records using standard digital tools such as uniform resource identifiers and application programming interfaces, ICD-11 and the World Health Organization provided linearization for mortality and morbidity, ICD-11-MMS, promise improved backward compatibility to ICD-10; increased availability in multiple languages; greater detail for clinical use, including traditional Chinese medicine; and enhanced maintenance for continued relevance. The studies reviewed here support the superior content …

Challenges In Selecting Patient-Reported Outcome Measures For Use In A Patient-Facing Technology, Priyank Raj, Youmin Cho, Yun Jiang, Yang Gong

Faculty, Staff and Student Publications

Patient-reported outcome measures (PROMs) have been increasingly integrated into patient-facing technologies to engage and empower patients in cancer self-management at home. However, researchers and developers face several challenges in selecting the best-suited PROMs for patient-facing technologies, due to the complex nature of the disease, the multitude of PROMs with high psychometric quality, and the lack of clear standards for PROM utilization. In this paper, we have discussed these challenges, illustrated by breast cancer instruments.

A Patient-Centered Approach To Collecting And Displaying Patient Identifiers, Christina Van Hal, Jennifer L Mills, Mary Gatmaitan, Yang Gong

Faculty, Staff and Student Publications

Patient identifiers such as name, date of birth, or gender are the first line of defense to ensure the accuracy of the health data displayed in health information exchange. Health data display is the impetus for clinical decisions and patient outcomes and directly correlates with promoting interoperability and health information exchange. Therefore, constant monitoring of quality metrics is imperative for clinical leaders to keep a pulse on what is happening within their organizations. However, the electronic health records (EHRs) designer should also take precautions to ensure the visualizations are not misleading, given that EHRs have been shown in some studies …

A Quantitative Analysis Of Patient-Facing Technologies For Patient Self-Reporting, Mengchen Ding, Youmin Cho, Yun Jiang, Yang Gong

Faculty, Staff and Student Publications

Dramatic improvements in patient-facing technologies have demonstrated the potential to transform healthcare delivery for a 360-degree holistic view of care. A key question regarding how such technologies affect patient self-reporting still needs to be answered. This study presents the technologies and their associated key variables via quantitative analysis. Associations were found between single-platform and web-based applications (apps), Android apps and physician view, mental health disease, and user feedback. The results are intended to inform future design, development, and evaluation of patient-facing technologies. More systematic, theory-driven, framework-based design and evaluation are necessary to fully characterize the effectiveness and maintenance of patient-facing …

User-Centered Data Display For Clinicians To Diagnose And Manage Hypertension, Carly Ho, Oluwatumininu Layinka, Valerie Chukelu, Kevin Phong, Yang Gong

Faculty, Staff and Student Publications

The accurate diagnosis and effective treatment of hypertension are hindered by challenges stemming from limited access to comprehensive blood pressure (BP) data and the need for clinical context surrounding BP readings. Using handwritten tables for home-monitored BP exacerbates issues related to integration of electronic health records (EHRs) and trend analysis. This study employs user-centered design principles to develop prototypes for BP data visualization, with the primary goal of harmonizing disparate BP data sources to empower clinicians in precise hypertension diagnosis and management.

Effect Of Russian Current Expert Modes On Quadriceps Muscle Torque In Healthy Adults: A Single-Blinded Randomized Controlled Trial, Ansam Hasan, Ibrahim Moustafa, Tamer Shousha

Faculty, Staff and Student Publications

BACKGROUND: Russian current (RC), a well-known neuromuscular electrical stimulation operating at 2500 Hz, has demonstrated significant strength improvement over traditional exercises due to its high tolerance and low pain provocation. Despite extensive NMES parameter research, the specific effects of expert modes, particularly ON2 and Rest, remain unexplored. This study investigates the direct effect of these expert modes on quadriceps muscle strength in healthy adults.

METHODS: This is a single-blind, randomization-controlled trial. Forty-eight healthy university students (31 females, 17 males) were assigned in two randomized experimental groups either the ON2 or Rest mode for a 15-minute electrical stimulation session. Quadriceps maximum …

The Durability Of Antibody Responses Of Two Doses Of High-Dose Relative To Two Doses Of Standard-Dose Inactivated Influenza Vaccine In Pediatric Hematopoietic Cell Transplant Recipients: A Multi-Center Randomized Controlled Trial., Jennifer E. Schuster, Lubna Hamdan, Daniel E. Dulek, Carrie L. Kitko, Einas Batarseh, Zaid Haddadin, Laura S. Stewart, Anna Stahl, Molly Potter, Herdi Rahman, Spyros A. Kalams, Claire E. Bocchini, Elizabeth A. Moulton, Susan E. Coffin, Monica I. Ardura, Rachel L. Wattier, Gabriela Maron, Michael Grimley, Grant Paulsen, Christopher J. Harrison, Jason L. Freedman, Paul A. Carpenter, Janet A. Englund, Flor M. Munoz, Lara Danziger-Isakov, Andrew J. Spieker, Natasha B. Halasa, Pediatric Hct Flu Study

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Our previous study established a 2-dose regimen of high-dose trivalent influenza vaccine (HD-TIV) to be immunogenically superior compared to a 2-dose regimen of standard-dose quadrivalent influenza vaccine (SD-QIV) in pediatric allogeneic hematopoietic cell transplant (HCT) recipients. However, the durability of immunogenicity and the role of time post-HCT at immunization as an effect modifier are unknown.

METHODS: This phase II, multi-center, double-blinded, randomized controlled trial compared HD-TIV to SD-QIV in children 3-17 years old who were 3-35 months post-allogeneic HCT, with each formulation administered twice, 28-42 days apart. Hemagglutination inhibition (HAI) titers were measured at baseline, 28-42 days following each …

Heart Rate Variability Biofeedback As A Treatment For Military Ptsd: A Meta-Analysis, Jordan Kenemore, Grant Benham, Ruby Charak, Juventino Hernandez Rodriguez

Psychological Science Faculty Publications

Introduction: Emerging research has provided tentative support for the use of heart rate variability biofeedback (HRVB) as a treatment for several psychological disorders, with meta-analyses providing compelling evidence for HRVB as a promising treatment for anxiety, depression, and PTSD. Given the prevalence of PTSD in military veterans and the comparatively lower benefit and higher attrition rate of traditional psychological treatment for PTSD relative to civilian counterparts, it is important to examine complementary and alternative treatment approaches such as HRVB in this population. Although studies of HRVB for PTSD have been conducted with military veterans, they have involved relatively small sample …

Learning From Non-Routine Events And Teamwork In Intensive Care Units: Challenges And Opportunities, Yang Gong, You Chen

Faculty, Staff and Student Publications

Patients admitted to intensive care units (ICUs) have profound and complex illnesses, often fraught with uncertainties in diagnoses, treatments, and care decisions. Clinicians often deviate from best practices to handle ICUs' myriad complexities and uncertainties. Non-routine events (NREs), defined as any aspect of care perceived by clinicians as deviations from optimal care, are latent and frequent safety threats that, if left unchecked, can be precursors to adverse events. Proper identification and analysis of NREs that represent latent safety threats have been proposed as a feasible and more effective approach for performance improvement than traditional root cause analysis for patient safety …

Literature Analysis On Ontologies Applied In Clinical Decision Support Systems, Xia Jing, Hua Min, Yang Gong, Paul Biondich, David Robinson, Timothy D Law, Christian G Nohr, Arild Faxvaag, Lior Rennert, Nina C Hubig, Ronald W Gimbel

Faculty, Staff and Student Publications

No abstract provided.

Short-Term Impact Of Low-Intensity Exercise With Blood Flow Restriction On Mild Knee Osteoarthritis In Older Adults: A Pilot Study, Kang-Ho Kim, Seung-Ho Kang, Nackhwan Kim, Jaehyeong Choi, Seok Kang

Faculty, Staff and Student Publications

This pilot study aimed to investigate the immediate impact of low-intensity exercises with blood flow restriction (BFR) on older adults with knee osteoarthritis (KOA). Fifteen patients with KOA who were over 50 years old, participated and underwent low-intensity resistance knee exercises at 30% of their one-repetition maximum with BFR three times/week for two weeks. Pre- and post-exercise assessments included pain levels, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, isokinetic knee strength, lower extremity muscle volume (via leg circumference and muscle thickness), functional performance tests (timed up-and-go [TUG] and sit-to-stand [STS]), skeletal muscle index (SMI) using bioelectrical impedance analysis, …

Severe Dysphagia With Eosinophilic Esophagitis Pattern Of Injury Related To Pembrolizumab Therapy, James S Barnett, Kevin K Yu, Xavier Rivera Rivera, Asmeen Bhatt

Faculty, Staff and Student Publications

While immune checkpoint inhibitor (ICI) therapies are effective treatments for many cancers, ICI therapies are associated with immune-related adverse events. We present a 67-year-old man with non-small cell lung carcinoma, who developed severe dysphagia with biopsies from an esophagogastroduodenoscopy showing histopathology consistent with eosinophilic esophagitis while on ICI maintenance therapy with pembrolizumab. The patient's symptoms worsened despite standard therapy. However, he had complete resolution of dysphagia symptoms once pembrolizumab was discontinued. While immune-related adverse events affecting the gastrointestinal system are increasingly recognized, ICI-associated eosinophilic esophagitis is a rare entity.

Mapping Patients' Online Record Access Worldwide: Preliminary Results From An International Survey Of Healthcare Experts, Anna Kharko, Charlotte Blease, Monika Johansen, Anne Moen, Isabella Scandurra, Brian Mcmillan, Maria Hägglund

School of Psychology

While research on the effects of patient access to health records is increasing, a basic understanding of the spread of patient-accessible electronic health records worldwide is lacking. In this survey of healthcare experts with professional and personal experience from 29 countries, we explored the state of patient online record access (ORA). We asked participants whether ORA exists in their country and which information is available through it. Experts in all polled countries reported having some national access to health records, with 6 (21%) countries providing exclusively paper-based records and 23 (79%) countries having ORA. Overview of test/lab results and prescription/medication …

January 25, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Attitudes Of Dental Therapists, Dental Therapy Educators And Dental Therapy Students In The South Of England Towards Domiciliary Dentistry: A Qualitative Study, Robert Emanuel, Joshua Quach, Parul Patel, Robert Witton, Carolina Machuca-Vargas, Eleanor Taylor

Peninsula Dental School

Introduction Dental therapists (DTs) are members of the dental team with a wide scope of practice, who support the provision of dental care to patient groups including those with vulnerabilities. One such group are older patients who are often unable to attend general dental practices to access their dental care. A domiciliary or 'home visit' may be required to deliver this care in a non-clinical setting.Aim To identify how dental therapists and dental therapy educators working in Southern England perceive domiciliary dental services and to explore the possible role of dental therapists in providing domiciliary dentistry.Method A qualitative research design …

How Do Women Feel Cold Water Swimming Affects Their Menstrual And Perimenopausal Symptoms?, Megan Pound, Heather Massey, Sasha Roseneil, Ruth Williamson, C. Mark Harper, Mike Tipton, Jill Shawe, Malika Felton, Joyce C. Harper

School of Nursing and Midwifery

Objective: This study aimed to determine how women felt cold water swimming affected their menstrual and perimenopausal symptoms. Study design: An online survey that asked women who regularly swim in cold water about their experiences. The survey was advertised for 2 months on social media. Questions related to cold water swimming habits and menstrual and perimenopausal symptoms were analysed. Main outcome measures: Quantitative and qualitative data including; frequency of menstrual and menopause symptoms, the effect of cold water swimming on these symptoms. Results: 1114 women completed the survey. Women reported that cold water swimming reduced their menstrual symptoms, notably psychological …

Desmoid Tumors: Current Perspective And Treatment, Ankit Mangla, Gary Schwartz

Faculty Scholarship

Desmoid tumors are rare tumors with a tendency to infiltrate locally. The lack of a standard treatment approach makes choosing the most appropriate treatment for patients challenging. Most experts recommend watchful observation for asymptomatic patients as spontaneous regression of tumor is observed in up to 20% of patients. Upfront resection of the desmoid tumor has fallen out of favor due to high morbidity and high relapse rates associated with the tumor. Systemic therapy has evolved over several decades. Where chemotherapy, hormonal therapy, and non-steroidal anti-inflammatory drugs were used over the last several decades, tyrosine kinase inhibitors came to the forefront …

Use Of Virtual Reality In Physical Therapy As An Intervention And Diagnostic Tool, Hamid Bateni, Jenna Carruthers, Rebecca Mohan, Seyedamirhossein Pishva

Student Publications

Within the past decade, the integration of computer-generated virtual realities (VRs) has witnessed a significant rise in the field of healthcare, particularly in diagnosis and treatment applications. These VR systems have found extensive use in physical therapy, rehabilitation, research, and assessment. This narrative review article is aimed at providing a comprehensive overview of the literature regarding the implementation of VR in the physical therapy profession. The primary objective of this review is to provide information to clinicians about the diverse applications of VR and its potential advantages in intervening across various patient populations and diagnoses during rehabilitation therapy. Through in-depth …

Kenyon Collegian - January 25, 2024

The Kenyon Collegian

No abstract provided.

Strategies For Healthcare Professionals To Identify And Assist Migrant Children At Risk Of Labour Exploitation Or Trafficking, Jordan Greenbaum, Melissa I M Torres, Phuong T Nguyen, John H Coverdale, Mollie R Gordon

Faculty, Staff and Students Publications

Increasingly large numbers of children and youth are migrating across international borders with many seeking employment in both formal and informal work sectors. These young people are at high risk of exploitation. Healthcare professionals need to be able to recognise vulnerable patients and advocate for their protection and safety, yet there is a paucity of literature that provides guidance on how to accomplish this. The goal of this paper is to provide guidance to clinicians on identifying and assisting migrant paediatric patients at risk of being exploited in the work sector, including conducting a risk assessment and making decisions about …

Gliopredictor: A Deep Learning Model For Identification Of High-Risk Adult Idh-Mutant Glioma Towards Adjuvant Treatment Planning, Shuhua Zheng, Nikhil Rammohan, Timothy Sita, P Troy Teo, Yilin Wu, Maciej Lesniak, Sean Sachdev, Tarita O Thomas

2020-Current year OA Pubs

Identification of isocitrate dehydrogenase (IDH)-mutant glioma patients at high risk of early progression is critical for radiotherapy treatment planning. Currently tools to stratify risk of early progression are lacking. We sought to identify a combination of molecular markers that could be used to identify patients who may have a greater need for adjuvant radiation therapy machine learning technology. 507 WHO Grade 2 and 3 glioma cases from The Cancer Genome Atlas, and 1309 cases from AACR GENIE v13.0 datasets were studied for genetic disparities between IDH1-wildtype and IDH1-mutant cohorts, and between different age groups. Genetic features such as mutations and …

Faculty Senate Agenda, Georgia Southern University, Faculty Senate

Faculty Senate Agendas

No abstract provided.

Genetics And Pathologic Landscape Of Lineage Switch Of Acute Leukemia During Therapy, Ting Zhou, Choladda V Curry, Mahsa Khanlari, Min Shi, Wei Cui, Deniz Peker, Weina Chen, Endi Wang, Juehua Gao, Qi Shen, Wei Xie, Fatima Z Jelloul, Rebecca L King, Ji Yuan, Xiaoqiong Wang, Chen Zhao, Ifeyinwa E Obiorah, Elizabeth L Courville, Eric Nomura, Sindhu Cherian, Mina L Xu, W Richard Burack, Hong-Xing Liu, Elias J Jabbour, Koichi Takahashi, Wei Wang, Sa A Wang, Joseph D Khoury, L Jeffrey Medeiros, Shimin Hu

Faculty, Staff and Students Publications

No abstract provided.

Implementation Of Closing And Disbursement Of The International Travel Insurance Policy In Relation With Covid-19 Disease, Kurnia Togar Pandapotan Tanjung, Athaya Yumna, Janthi Dharma Shanty

Journal of Indonesian Tourism and Policy Studies

In life, one is always faced with uncertain risks. In the case of the COVID-19 pandemic, a person traveling abroad for business or tourism purposes has the risk of being infected with COVID-19. One of the efforts that one can make to minimize the risk of being infected with the COVID-19 is to transfer the risk to the Insurer by registering with an Insurance Company to get a Travel Insurance. The COVID-19 International Travel Insurance provides a guarantee of protection to someone traveling internationally from the risk of being infected with the COVID-19 so that the trip becomes comfortable, safe, …

Internet Der Dinge, Reza Hatami

COD in Lingua

For my German essay, I chose to write about smart devices, also called the internet of things (IoT). Smart watches, smart TVs, smart plugs, smart lights, and other smart electronics are becoming increasingly hard to avoid as technology continues to advance exponentially. Having weighed the pros and cons of these devices, I wrote an essay mentioning the advantages and disadvantages. The use of smart devices can improve our lives and make them more convenient, but they come with several risks and downsides as well. There are several risks involved in this, including privacy concerns, security vulnerabilities, and potential health risks. …

Discerning Climate Change Information And Responses, Janette Plunkett

Day of Common Learning

Climate Change can feel like an overwhelming topic. We will discuss good strategies for intaking news, discerning truth, responding, and maintaining hope and agency. How can lament, anger and grief be helpful? This will be a lecture format with a Q&A.

Full Issue, Volume 3

CSU Journal of Sustainability and Climate Change

Full issue for volume 3

Designing Dual-Purpose Management Strategies For Sheep Production And Pollinators In Dryland Pastures, Mia Caudillo, Andony Melathopoulos, Mary Smallman, Sarah A. Kinkaid, David E. Prado-Tarango, Serkan Ates

IGC Proceedings (1977-2023)

Development of novel grazing management practicesfor both livestock production and pollinator health is becoming increasingly crucial in pasture-based farming systems. The effect of pasture type and spring closing dates on lamb liveweight gain, pasture production, botanical composition, bloom density and bee visitation was monitored over 2 years at the Oregon State University in Corvallis. Total annual dry matter yield (DMY) of diverse pastures in 2020/2021 was 8.8 t DM ha^-1 and this was greater (P-1) and legume pastures (6.6 t DM ha^-1). In successive years, lambs grew faster in legume pastures (287, 215 g per head d …

Effect Of Soil Source And Variety On The Heavy Metal Contents Of Guinea Grass, C. C. Anotaenwere, P. O. Bankole, P. A. Dele, Alaba O. Jolaosho

IGC Proceedings (1977-2023)

The aim of this study was to evaluate the heavy metal content in soils and grasses planted on selected contaminated soils. The study was a 3 x 2 factorial experiment in a completely randomized design comprising of two factors which are: 3 soil sources (i.e., industrial site, dump site and Fadama (a lowland around a river/stream) which was used as the control) and 2 varieties of Megathyrsus maximus (var. Local and Ntchisi) replicated four times. Soils were collected from the three sites and planting was done in a greenhouse. Soil samples were collected before and after planting. Samples of the …