Digital Commons Network^™

Mba 698.01: Business Internship, Michelle Schwartz

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biob 160n.02: Principles Of Living Systems, Gregory D. Peters

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biob 210n.50: Communicating Biology, Gregory D. Peters

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Bioh 201n.00: Human Anatomy And Physiology I, Lucas Whitcher

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Wild 240.01: Introduction To Biostatistics, Elizabeth G. Simpson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Musi 162a.12: Chamber Ensembles I - Tuba And Euphonium Consort, Benedict A. Kirby

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Danc 108a.01: Dance Forms - Ballroom, Martha J. Newby

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Mitochondrial Quality Control By Tail-Anchored Proteins, Jose M. Delgado

Dartmouth College Ph.D Dissertations

Autophagy is a lysosome-mediated pathway responsible for the degradation of unwanted cytosolic content. During autophagy, cytoplasmic components are enveloped by a newly generated vesicle (the autophagosome), trafficked to the lysosome, and degraded. The power of autophagy lies in its ability to selectively target specific substrates for degradation—a phenomenon known as selective autophagy.

Specialized proteins known as selective autophagy receptors play a crucial role in identifying and targeting autophagy cargo. Although historically overlooked as potential regulators, our understanding of autophagy receptors is evolving beyond the assumption that receptors merely bridge targets to pre-formed autophagosomal membranes. Previous insights were often based on …

Evaluating The Impact Of Desk Appearance Ticket Reform In New York State, Olive Lu, Michael Rempel

Publications and Research

This report addresses the extent to which reform led more people charged with low-level offenses to return home swiftly after an arrest, avoid overnight detention, and limit unnecessary system contact. We focused solely on misdemeanors and Class E felonies where the specific charge is subject to a mandatory DAT (excluding domestic violence, sex offenses, and select other charges) and the individual has not failed to appear in the past two years. Thus, we excluded most cases where police officers retained discretion; however, the data could not isolate all carve-outs, such as people who cannot prove their identity, appear to need …

Integrating Interference Theory, Daiquiri J. Steele

Articles

Robust retaliation protections are an essential component of any effective enforcement regime. Recognizing this, Congress has included a provision prohibiting retaliation in nearly every workplace statute passed in the past century. In statutes more than a century old, like the Civil Rights Act of 1866, where Congress neglected to include an explicit anti-retaliation provision in the statutory language, the Supreme Court has found an implied proscription against retributory behavior. Anti-retaliation protections are undoubtedly integral to effective enforcement. However, they have an equally important counterpart that is often overlooked in compliance discussions-interference protections.

Several workplace statutes contain interference provisions-statutory language that …

Targeting Strategies To Optimize The Therapeutic Potential Of Gold Compounds Against Her2-Positive Breast Cancers, Afruja Ahad

Dissertations, Theses, and Capstone Projects

The overexpression of HER2 accounts for 20-30% of breast cancer tumors and not only serves as a marker for poor predictive clinical outcomes but also as a target for treatment. Antibody-drug conjugates (ADCs) combine the selectivity of monoclonal antibodies (mAbs) with the efficacy of chemotherapeutic drugs to provide targeted treatment without toxicity to normal tissue. Most of the ADCs currently in the clinic for cancer chemotherapy are based on complex organic molecules. In contrast, the conjugation of metallodrugs to mAbs has been overlooked when there is enormous potential in this area with the resurgence of metal-based drugs as prospective cancer …

February 2024 News, Office Of Sustainability

Office of Sustainability Newsletter

No abstract provided.

Vol 69 #1, Melanie Argo

MPLA Newsletter

No abstract provided.

Time To Blood Pressure Control And Predictors Among Patients Receiving Integrated Treatment For Hypertension And Hiv Based On An Adapted Who Hearts Implementation Strategy At A Large Urban Hiv Clinic In Uganda, Willington Amutuhaire, Lewis S. Musoke, George A. Yendewa, Lewis S. Musoke, George A. Yendewa

Faculty Scholarship

In this cohort study, we determined time to blood pressure (BP) control and its predictors among hypertensive PLHIV enrolled in integrated hypertension-HIV care based on the World Health Organization (WHO) HEARTS strategy at Mulago Immunosuppression Clinic in Uganda. From August 2019 to March 2020, we enrolled hypertensive PLHIV aged ≥18 years and initiated Amlodipine 5 mg mono-therapy for BP (140–159)/(90–99) mmHg or Amlodipine 5 mg/Valsartan 80 mg duo-therapy for BP ≥ 160/90 mmHg. Patients were followed with a treatment escalation plan until BP control, defined as BP < 140/90 mmHg. We used Cox proportional hazards models to identify predictors of time to BP control. Of 877 PLHIV enrolled (mean age 50.4 years, 62.1% female), 30% received mono-therapy and 70% received duo-therapy. In the monotherapy group, 66%, 88% and 96% attained BP control in the first, second and third months, respectively. For patients on duo-therapy, 56%, 83%, 88% and 90% achieved BP control in the first, second, third, and fourth months, respectively. In adjusted Cox proportional hazard analysis, higher systolic BP (aHR 0.995, 95% CI 0.989-0.999) and baseline ART tenofovir/lamivudine/efavirenz (aHR 0.764, 95% CI 0.637–0.917) were associated with longer time to BP control, while being on ART for >10 years was associated with a shorter time to BP control (aHR 1.456, …

Cold-Inducible Rna Binding Protein Impedes Breast Tumor Growth In The Pymt Murine Model For Breast Cancer, Daniel A. Lujan, Joey L. Ochoa, Ellen J. Beswick, Tamara A. Howard, Helen J. Hathaway, Nora I. Perrone-Bizzozero, Rebecca S. Hartley

Markey Cancer Center Faculty Publications

RNA binding proteins (RBPs) post-transcriptionally regulate gene expression by associating with regulatory sequences in the untranslated regions of mRNAs. Cold-inducible RBP (CIRP) is a stress-induced RBP that was recently shown to modulate inflammation in response to cellular stress, where it increases or decreases pro-tumorigenic (proinflammatory) cytokines in different contexts. CIRP expression is altered in several cancers, including breast cancer, but the effects of CIRP on inflammation in breast cancer is not known. Here, we investigate if CIRP alters growth and the inflammatory profile of breast tumors. Transgenic mice overexpressing CIRP in the mammary epithelium were crossed with the PyMT mouse …

Association Between Circulating Inflammatory Markers And Adult Cancer Risk: A Mendelian Randomization Analysis., James Yarmolinsky, Jamie W. Robinson, Daniela Mariosa, Ville Karhunen, Jian Huang, Niki Dimou, Neil Murphy, Kimberley Burrows, Emmanouil Bouras, Karl Smith-Byrne, Sarah J. Lewis, Tessel E. Galesloot, Lambertus A. Kiemeney, Sita Vermeulen, Paul Martin, Demetrius Albanes, Lifang Hou, Polly A. Newcomb, Emily White, Alicja Wolk, Anna H. Wu, Loïc Le Marchand, Amanda I. Phipps, Daniel D. Buchanan, The International Lung Cancer Consortium, The Practical Consortium, Sizheng Steven Zhao, Dipender Gill, Stephen J. Chanock, Mark P. Purdue, George Davey Smith, Paul Brennan, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Chris I. Amos, Rayjean J. Hung, Abbas Dehghan, Mattias Johansson, Marc J. Gunter, Kostas K. Tsilidis, Richard M. Martin

Markey Cancer Center Faculty Publications

BACKGROUND: Tumour-promoting inflammation is a "hallmark" of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear.

METHODS: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were …

Transposition Of The Great Arteries With Intramural Left Main Coronary Artery: Salient Imaging Findings And Description Of Two Operative Techniques, Joshua Holbert, Manasa Gadiraju, Sanket Shah, Edo Bedzra

Posters

Background: Transposition of the great arteries (TGA) is a common cyanotic critical congenital heart disease, with a feasible prenatal diagnosis. Arterial switch operation (ASO) with/without VSD closure is the preferred surgical approach with added challenge when an intramural coronary artery (IMC) is present. ASO is technically quite demanding with IMC, and incidence of post-operative complications and mortality are potentially higher. We present our recent TGA-IMC experience focusing on salient features identified on echocardiography, CT and invasive angiograms, as well as variations in ASO surgical techniques for repair. Methods: Our echo imaging acquisition required high frequency transducers and shallow image depth …

Shoulder Arthroplasty Evolution: Comparing Reverse, Anatomic, And Hemiarthroplasty Trends And Outcomes In Key Demographics At A High-Volume Institution, James Fuchs Gannon, Mitchell Thomas Pfennig, Anthony Arveschoug, Betina Bremer Hinckel, J Michael Wiater, Leonardo M. Cavinatto

Conference Presentation Abstracts

The field of shoulder arthroplasty has changed markedly since the inception of the reverse total shoulder arthroplasty (RTSA) in 2004. With yearly gains of 32%, the RTSA now encompasses the largest portion of shoulder arthroplasty procedures. In contrast, the anatomic total shoulder arthroplasty (ATSA) and hemiarthroplasty (HA) have steadied or decreased in usage. Some have offered several explanations for these trends, such as expanding indications for the RTSA, in particular for pathologies traditionally treated with ATSA such as glenohumeral arthritis with an intact rotator cuff and no major bone loss/deformity. Others have cited superior postoperative outcomes of the RTSA over …

Patient Perception Of Different Autografts In Anterior Cruciate Ligament Reconstruction Using A Validated Online Survey Marketplace, Robert Dean, Tanner J. Hafen, Collin Braithwaite, Kevin Xavier Farley, Robert F. Laprade, Joseph Guettler, James Bicos

Conference Presentation Abstracts

INTRODUCTION: Anterior cruciate ligament (ACL) reconstruction is the gold standard treatment for ACL tears. ACL graft reconstruction is commonly performed with an autograft. Common autograft modalities include bone-patellar tendon-bone (BPTB), quadriceps tendon (QT), and hamstring tendon (HT) grafts. This study sought to evaluate the general population’s perception of the use of BPTB, QT, and HT autografts in ACL reconstruction. METHODS: A prospective cohort study was performed utilizing a 35-question survey. Participants were paid, and the survey was distributed via a clinically, validated, public, online marketplace in June 2023. After collecting baseline demographics, participants were queried on whether they held a …

Ras-Related Associated With Diabetes Genes For Biomarker-Based Therapeutics In Cancer: A Comparative Evolutionary Genomic Study, Mohammed A. Hakami

Saudi Medical Journal

Objectives: To compare Ras-related associated with diabetes (RRAD) across different species and to identify specific biomarkers for cancer therapy. Methods: The study involves comparing the coding sequences, genes, messenger ribonucleic acid (RNA), non-coding RNA, open reading frame, short- and long-sequence repeats, and transcription factors of RRAD genes from 82 species. Various tools and software are employed for these comparisons, and evolutionary analysis was carried out to understand the gene’s evolutionary history. The data are classified based on forward and reverse sequences. Results: Our analysis indicates that ACTG1 may function as a downstream effector of RRAD, offering potential avenues for diabetes …

Investigation Of The Effect Of Belinostat On Mcf-7 Breast Cancer Stem Cells Via The Wnt, Notch, And Hedgehog Signaling Pathway, Zeliha Tuncer, Ercan Kurar, Tugçe Duran

Saudi Medical Journal

Objectives: To evaluate belinostat’s (PXD101) activity on MCF-7 breast cancer stem cells (CSCs) via Wnt, Notch, and Hedgehog. Methods: This research study was carried out at the Department of Medical Biology, Necmettin Erbakan University, Konya, Turkey, from June 2017 to July 2019. The effect of PXD101 on MCF-7 cell viability was determined by cell proliferation kit (XTT). Following belinostat treatment, CD44+/CD24- MCF-7 CSCs were isolated by FACS. Ribonucleic acid isolation and copy-deoxyribonucleic acid synthesis were carried out using HEK-293 cells, MCF-7 cells, and MCF-7 CSCs. Expression changes of metastasis-related genes, Wnt, Hedgehog, Notch, and stem cell markers were analysed by …

Course And Predictors Of Excellent Response To Therapy In Patients With Differentiated Thyroid Cancer At Long-Term Follow-Up, Shaza A. Samargandy, Ghofran N. Qorban, Arwa K. Aljadani, Salihah S. Almufarji, Abdulrahman M. Azab, Mazin A. Merdad, Marwan R. Al-Hajeili, Saad J. Samargandy

Saudi Medical Journal

Objectives: To investigate the long-term outcomes of differentiated thyroid cancer (DTC) and the predictive factors for excellent and incomplete responses to therapy on long-term follow-up of patients. Methods: A retrospective chart review and analysis was carried out at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Demographic, histological, and therapeutic data were collected from patients older than 13 years at the time of diagnosis, with a minimum follow-up of 18 months. Outcomes were divided into excellent, indeterminate, biochemically incomplete, and structurally incomplete responses. Odds ratios (ORs) for predictors of incomplete response at the last visit were determined. We first tested associations …

Revisiting The Clinical Utilization Of Cardiopulmonary Exercise Testing In Saudi Arabia After 2 Decades: A Cross-Sectional Study, Monira I. Aldhahi, Abdulfattah S. Alqahtani, Hazzaa M. Al-Hazzaa

Saudi Medical Journal

Objectives: To assess the prevalence of cardiopulmonary exercise testing (CPET) usage and identify barriers among major hospitals and medical centers in Saudi Arabia. We also aim to compare these findings with data from nearly 2 decades ago. Methods: In this cross-sectional study, 70 major hospitals and medical centers were contacted, and 52 (74.2%) responded. The participants involved in this study were healthcare providers proficient in carrying out CPET from different specialties. The survey comprised 21 items covering CPET utilization, exercise mode characteristics, common protocols, types of patients or disorders, and barriers to not carrying out CPET. Results: The majority (n=37; …

Neonatal Group B Streptococcus Infection At A Single Center In Al-Madinah Al-Munawarah, Saudi Arabia, Amal M. Surrati, Khulood M. Alharbi, Walaa Mohammedsaeed, Hanaa F. Almohammadi

Saudi Medical Journal

Objectives: To determine the occurrence of Group B Streptococcus (GBS) infection in neonates and its associated risk factors in Al-Madinah Al-Munawarah, Saudi Arabia. Methods: This retrospective study was carried out at the Maternity and Child Hospital in Al-Madinah Al-Munawarah, between 2017-2022. The laboratory and clinical data of 64 neonates were collected and analyzed using GraphPad Prism 7 software. Results: Out of 16,022 neonates admitted to the nursery, 64 infants were diagnosed with GBS infection. Approximately 53.1% were male, 46.9% female, 15.6% were preterm, and 84.4% were full-term. Vaginal births accounted for 71.9%. The mean onset age was 10±12.4 days. Among …

Acute Side Effects And Health Care Requirements In Breast Cancer Patients Treated With Radiotherapy, Gamze Temiz, Gul Cankaya, Aslıhan Ozturk, Zerrin Ozgen

Saudi Medical Journal

Objectives: To identify the unmet needs of breast cancer patients undergoing radiotherapy Methods: A pretest-posttest single-group experimental design, a variation of the experimental research approach, was employed in this investigation. The study’s sample consisted of 28 breast cancer patients undergoing radiotherapy at the radiation oncology clinic of a training and research hospital between November 2021 and April 2022. The sample size was determined using G*Power 3.1 software. Data were collected using an Information Form, Radiotherapy Acute Side Effects Follow-up Form, and the Supportive Care Needs Scale (SCNS-SF34). Results: Participants reported experiencing side effects such as difficulty swallowing, sore throat, cough, …

Comment On: Universal In-House Neonatal Hips Ultrasonography Screening In The United Arab Emirates, Raid Al Baradie, Faizan Z. Kashoo, Abdullah K. Aljandal, Abdulaziz A. Aljish, Rashed N. Alburaqi, Fallaj B. Alharbi, Ashwaq D. Almutairi, Naif A. Binroshod, Bader A. Althumayri, Nina Đorđević

Saudi Medical Journal

No abstract provided.

Urgent Action Needed To Protect Children And Prevent The Uptake Of E-Cigarettes

Saudi Medical Journal

No abstract provided.

Who Prequalifies A Second Malaria Vaccine, A Significant Milestone In Prevention Of The Disease

Saudi Medical Journal

No abstract provided.

Early Goal-Directed Hemostatic Therapy For Severe Acute Bleeding Management In The Intensive Care Unit: A Narrative Review., Tomaz Crochemore, Klaus Görlinger, Marcus Lance

Anaesthesiology, East Africa

This is a narrative review of the published evidence for bleeding management in critically ill patients in different clinical settings in the intensive care unit (ICU). We aimed to describe “The Ten Steps” approach to early goal-directed hemostatic therapy (EGDHT) using point-of-care testing (POCT), coagulation factor concentrates, and hemostatic drugs, according to the individual needs of each patient. We searched National Library of Medicine, MEDLINE for publications relevant to management of critical ill bleeding patients in different settings in the ICU. Bibliographies of included articles were also searched to identify additional relevant studies. English-language systematic reviews, meta-analyses, randomized trials, observational …

A King In Our Midst, Katie Umans

UNH Today Archive

No abstract provided.