Digital Commons Network^™

The Wages Of Crying Roe: Some Realism About Dobbs V. Jackson Women’S Health Organization, Neil S. Siegel

Faculty Scholarship

The U.S. Supreme Court’s reasoning in Dobbs v. Jackson Women’s Health Organizationcannot be taken seriously. The Court’s stated rationale for rejecting continued protection of the abortion right—that abortion is not deeply rooted in nineteenth century history and tradition—applies with equal force to other substantive due process rights that the DobbsCourt repeatedly insisted were not under threat even without considering stare decisis, including contraception, sexual intimacy between consenting adults, and same-sex marriage. One should add inter-racial marriage and protection from involuntary sterilization to that list. Rather than applying its draconian version of the “history and tradition” test in a …

The Physical-Emotional Distinction In Tort, Philip Petrov

Faculty Scholarship

Several legal scholars have recently argued that U.S. tort law’s physical-emotional distinction commits tort to the objectionable position of mind-body dualism, but they have not considered the distinction’s role as an aid to judicial cognition and decision-making. Drawing primarily on the law of negligent infliction of emotional distress, this essay argues that tort’s physical-emotional distinction is not a relic of mind-body dualism but a heuristic that judges have used to structure and simplify the difficult but unavoidable task of drawing lines between legally cognizable and non-cognizable harm. The analysis has at least three normative implications: (1) users of tort’s physical-emotional …

Conditional Hepatocyte Ablation Of Pdia1 Uncovers Indispensable Roles In Both Apob And Mttp Folding To Support Vldl Secretion, Zhouji Chen, Shiyu Wang, Anita Pottekat, Alec Duffey, Insook Jang, Benny H Chang, Jaehyung Cho, Brian N Finck, Nicholas O Davidson, Randal J Kaufman

2020-Current year OA Pubs

OBJECTIVES: The assembly and secretion of hepatic very low-density lipoprotein (VLDL) plays pivotal roles in hepatic and plasma lipid homeostasis. Protein disulfide isomerase A1 (PDIA1/P4HB) is a molecular chaperone whose functions are essential for protein folding in the endoplasmic reticulum. Here we investigated the physiological requirement in vivo for PDIA1 in maintaining VLDL assembly and secretion.

METHODS: Pdia1/P4hb was conditionally deleted in adult mouse hepatocytes and the phenotypes characterized. Mechanistic analyses in primary hepatocytes determined how PDIA1 ablation alters MTTP synthesis and degradation as well as altering synthesis and secretion of Apolipoprotein B (APOB), along with complementary expression of intact …

Novel Textbook Outcomes Following Emergency Laparotomy: Delphi Exercise, Beacon Collaborative, David N. Naumann, Aneel Bhangu, Adam Brooks, Matthew Martin, Bryan A. Cotton, Mansoor Khan, Mark J. Midwinter, Lyndsay Pearce, Douglas M. Bowley, John B. Holcomb, Ewen A. Griffiths, Adam Abu-Abeid, Adam Peckham-Cooper, Adam R. Dyas, Ademola Adeyeye, Agron Dogjani, Alasdair C.Y. Ball, Albert M. Wolthuis, Alejandro Quiroga-Garza, Aleksandar R. Karamarkovic, Alessio Giordano, Alexander Fuchs, Alexander Julianov, Alexander W. Phillips, Alexander Zimmermann, Alexandros Charalabopoulos, Alexei A. Birkun, Alexis Rafael Narvaez-Rojas

Peninsula Medical School

Background: Textbook outcomes are composite outcome measures that reflect the ideal overall experience for patients. There are many of these in the elective surgery literature but no textbook outcomes have been proposed for patients following emergency laparotomy. The aim was to achieve international consensus amongst experts and patients for the best Textbook Outcomes for non-trauma and trauma emergency laparotomy. Methods: A modified Delphi exercise was undertaken with three planned rounds to achieve consensus regarding the best Textbook Outcomes based on the category, number and importance (Likert scale of 1–5) of individual outcome measures. There were separate questions for non-trauma and …

Banking-Crisis Interventions Across Time And Space, Andrew Metrick, Paul Schmelzing

Documents

No abstract provided.

Dropout From Exercise Trials Among Cancer Survivors—An Individual Patient Data Meta-Analysis From The Polaris Study, Benedikte Western, Andreas Ivarsson, Ingvild Vistad, Ingrid Demmelmaier, Neil K. Aaronson, Gillian Radcliffe, Marc Van Beurden, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvão, Rachel Garrod, Martine M. Goedendorp, Kathleen A. Griffith, Wim H. Van Harten, Sandi C. Hayes, Fernando Herrero-Roman, Anouk E. Hiensch, Melinda L. Irwin, Erica James, Marlou-Floor Kenkhuis, Marie J. Kersten, Hans Knoop, Alejandro Lucia, Anne M. May, Alex Mcconnachie, Willem Van Mechelen, Nanette Mutrie, Robert U. Newton, Frans Nollet, Hester S. Oldenburg, Ron Plotnikoff, Martina E. Schmidt, Katie H. Schmitz, Karl-Heinz Schulz, Camille E. Short, Gabe S. Sonke, Karen Steindorf, Martijn M. Stuiver, Dennis R. Taaffe, Lene Thorsen, Miranda J. Velthuis, Jennifer Wenzel, Kerri M. Winters-Stone, Joachim Wiskemann, Sveinung Berntsen, Laurien M. Buffart

Research outputs 2022 to 2026

Introduction: The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of participant and exercise program characteristics were associated with dropout from the exercise arms of RCTs among cancer survivors. Methods: This study used data collected in the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study, an international database of RCTs investigating the effects of exercise among cancer survivors. Thirty-four exercise trials, with a total of 2467 patients …

The Role Of Diet And Gut Microbiota In Alzheimer’S Disease, D. M.Sithara Dissanayaka, Vijay Jayasena, Stephanie R. Rainey-Smith, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (A ) plaques and hyperphosphorylated tau tangles. Currently, Alzheimer’s disease (AD) impacts 50 million individuals, with projections anticipating an increase to 152 million by the year 2050. Despite the increasing global prevalence of AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis and treatment. Recent research suggests a link between gut dysbiosis and the aggregation of A , the development of tau proteins, and the occurrence of neuroinflammation and oxidative stress are associated with AD. However, investigations into the gut–brain axis …

Edsuch: A Robust Ensemble Data Summarization Method For Effective Medical Diagnosis, Mohiuddin Ahmed, A. N. M. B. Rashid

Research outputs 2022 to 2026

Identifying rare patterns for medical diagnosis is a challenging task due to heterogeneity and the volume of data. Data summarization can create a concise version of the original data that can be used for effective diagnosis. In this paper, we propose an ensemble summarization method that combines clustering and sampling to create a summary of the original data to ensure the inclusion of rare patterns. To the best of our knowledge, there has been no such technique available to augment the performance of anomaly detection techniques and simultaneously increase the efficiency of medical diagnosis. The performance of popular anomaly detection …

Pre-Eclampsia Training Needs Of Midwives In A Ghanaian Tertiary Hospital: A Cross-Sectional Study, Isabella Garti, Michelle Gray, Angela Bromley, Jing-Yu (Benjamin) Tan

Research outputs 2022 to 2026

Aim: This study aimed to assess the specific clinical and non-clinical training needs of midwives and determine their preferred approach to enhancing performance. Background: Pre-eclampsia remains one of the leading causes of maternal deaths in low and middle-income countries. Pre-eclampsia-related deaths may be due to reduced midwifery knowledge and inadequate management. Therefore, a training needs assessment is vital in identifying gaps in practice, especially, in poorly resourced settings for maximal use of training resources. Design: A hospital-based cross-sectional study. Setting: The largest tertiary hospital in Ghana. Methods: An online version of the validated WHO Hennessy-Hicks Training Needs Analysis questionnaire was …

The Psychosocial Beliefs, Experiences And Expectations Of Children Living With Obesity, Lisa Newson, Nicola Sides, Amineh Rashidi

Research outputs 2022 to 2026

Background: Childhood obesity has been shown to impair psychological health. However, psychological factors are often overlooked in both research evaluations and treatment interventions, and children's perspectives on managing obesity are underexplored. Neglecting psychosocial factors might undermine interventions. This research explored the psychological beliefs, expectations and experiences of children living with obesity (range 7–13) and attending a weight management programme (WMP). Methods: Thirty-four participants (19 females, 15 males, average age 9.5 years) completed a semistructured interview. Recorded interviews were transcribed verbatim and analysed using thematic analysis. Results: Four overarching themes were developed: (1) defining health and self-recognition; (2) external influence; feedback, …

Caregiver Descriptions Of Dystonia In Cerebral Palsy, Fayza Jaleel, Alyssa Rust, Shirley Cheung, Toni S Pearson, Keisuke Ueda, Amy Robichaux-Viehoever, Katie Leger, Keerthana Chintalapati, Danielle Guez-Barber, Michele Shusterman, Bhooma Aravamuthan

2020-Current year OA Pubs

OBJECTIVE: To determine how caregivers describe dystonia in people with cerebral palsy (CP).

METHODS: In this prospective cohort study, paper surveys were administered to caregivers between September 7, 2021 and October 28, 2021 during CP Center visits at a large tertiary care center. Caregivers were asked to describe involuntary movements triggered by voluntary movement or triggered by tactile stimulation in the people with CP they cared for. Their CP Center medical provider separately assessed people with CP for dystonia. Movement features described exclusively by caregivers of people with CP and dystonia were determined using conventional content analysis.

RESULTS: 113 caregivers …

Evidence That Anemia Accelerates As Progression Via Shear-Induced Tgf-Β1 Activation: Heyde's Syndrome Comes Full Circle, Kumar Subramani, Jeffrey Bander, Sixia Chen, Mayte Suárez-Fariñas, Thamizhiniyan Venkatesan, Sandeep Subrahmanian, Rohan Varshney, Annapoorna Kini, Samin Sharma, Daniel B Rifkin, Jaehyung Cho, Barry S Coller, Jasimuddin Ahamed

2020-Current year OA Pubs

The severity of aortic stenosis (AS) is associated with acquired von Willebrand syndrome (AVWS) and gastrointestinal bleeding, leading to anemia (Heyde's syndrome). We investigated how anemia is linked with AS and AVWS using the LA100 mouse model and patients with AS. Induction of anemia in LA100 mice increased transforming growth factor (TGF)-β1 activation, AVWS, and AS progression. Patients age >75 years with severe AS had higher plasma TGF-β1 levels and more severe anemia than AS patients age <75 years, and there was a correlation between TGF-β1 and anemia. These data are compatible with the hypothesis that the blood loss anemia of Heyde's syndrome contributes to AS progression via WSS-induced activation of platelet TGF-β1 and additional gastrointestinal bleeding via WSS-induced AVWS.

Enhanced Or Hindered Research Benefits? A Realist Review Of Community Engagement And Participatory Research Practices For Non-Communicable Disease Prevention In Low- And Middle-Income Countries., Sonja Klingberg, Bipin Adhikari, Catherine Draper, Edna Bosire, Deborah Nyirenda, Priscilla Tiigah, Ferdinand Mukumbang

Brain and Mind Institute

Introduction: Community engagement and participatory research are widely used and considered important for ethical health research and interventions. Based on calls to unpack their complexity and observed biases in their favour, we conducted a realist review with a focus on non-communicable disease prevention. The aim was to generate an understanding of how and why engagement or participatory practices enhance or hinder the benefits of non-communicable disease research and interventions in low- and middle-income countries.

Methods: We retroductively formulated theories based on existing literature and realist interviews. After initial searches, preliminary theories and a search strategy were developed. We searched three …

Clemson University Board Of Trustees, Research And Economic Development Committee , 2024 February 1, Clemson University Board Of Trustees

Minutes

No abstract provided.

Inverse Association Between Exercising Blood Pressure Response And Left Ventricular Chamber Size And Mass In Women Who Habitually Resistance Train, Evan L. Matthews, John J. Guers, Meghan G. Ramick, Peter A. Hosick

Department of Kinesiology Scholarship and Creative Works

Exercise is a major modifiable lifestyle factor that leads to temporarily increased systolic blood pressure (SBP), which is thought to influence left ventricular mass normalized to body surface area (LVM/BSA). This relationship has never been studied in women who habitually perform resistance exercise. Purpose: To determine if a direct correlation exists between the SBP response to resistance exercise (change from rest; eSBP) and LVM/BSA in young healthy women who habitually resistance train. Methods: Leg extension resistance exercise was performed while continuously monitoring blood pressure using finger plethysmography. LVM was estimated using echocardiography. Data are shown as mean ± SD. Results: …

Exploring Factors Enabling Hearing Aid Usage: Perspectives Of Hearing Aid Users And Audiologists, Maria Jose, Archana Gundmi, P. G. Bhargavi

Open Access archive

Background of the Research: Higher prevalence of hearing loss is reported among older adults. Hearing aids have been proven to be a viable option to reduce the burden associated with hearing impairment. Despite these positive aspects, there is no increase seen in hearing aid adoption or usage among individuals with hearing impairment. Objective: To explore the aspects favoring hearing aid usage among individuals with hearing impairment based on hearing aid users’ and audiologists’ perspectives. Method: The present study used inductive thematic analysis. The participants were 12 hearing aid users and 12 Audiologists. The study was conducted in interview mode either …

The Role Of Testosterone Level In Women With Osteopenia, Muzahem Mohialdeen Taha, Ekhlass M. Taha, Suhayla K. Mohammed

Baghdad Science Journal

There is substantial data supporting the importance of both endogenous and exogenous estrogen in maintaining reproductive health and preventing chronic disease, androgens in women's health are rarely discussed. This is one of the first researches to investigate correlates of blood testosterone concentrations in women with osteopenia, in anticipation of the growing interest in the role of androgens in women's health. A 65 volunteer women were enrolled in the current study, they were divided into two groups, 35 postmenopausal women with osteopenia were in the first group, and the second group contained 30 postmenopausal women without osteopenia as a control. Blood …

Improving The Efficiency And Security Of Passport Control Processes At Airports By Using The R-Cnn Object Detection Model, Elhoucine Ouassam, Yassine Dabachine, Nabil Hmina, Belaid Bouikhalene

Baghdad Science Journal

The use of real-time machine learning to optimize passport control procedures at airports can greatly improve both the efficiency and security of the processes. To automate and optimize these procedures, AI algorithms such as character recognition, facial recognition, predictive algorithms and automatic data processing can be implemented. The proposed method is to use the R-CNN object detection model to detect passport objects in real-time images collected by passport control cameras. This paper describes the step-by-step process of the proposed approach, which includes pre-processing, training and testing the R-CNN model, integrating it into the passport control system, and evaluating its accuracy …

Significance Of Facet Fluid Index In Anterior Cervical Degenerative Spondylolisthesis, Yunsoo Lee, Jeremy Heard, Mark J Lambrechts, Nathaniel Kern, Bright Wiafe, Perry Goodman, John J. Mangan, Jose A. Canseco, Mark F. Kurd, Ian D. Kaye, Alan S. Hilibrand, Alex R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder, Jeffrey A. Rihn

Department of Orthopaedic Surgery Faculty Papers

STUDY DESIGN: Retrospective cohort study.

PURPOSE: To correlate cervical facet fluid characteristics to radiographic spondylolisthesis, determine if facet fluid is associated with instability in cervical degenerative spondylolisthesis, and examine whether vertebral levels with certain facet fluid characteristics and spondylolisthesis are more likely to be operated on.

OVERVIEW OF LITERATURE: The relationship between facet fluid and lumbar spondylolisthesis is well-documented; however, there is a paucity of literature investigating facet fluid in degenerative cervical spondylolisthesis.

METHODS: Patients diagnosed with cervical degenerative spondylolisthesis were identified from a hospital's medical records. Demographic and surgical characteristics were collected through a structured query language search and …

Predictive Algorithm For Surgery Recommendation In Thoracolumbar Burst Fractures Without Neurological Deficits, Charlotte Dandurand, Nader Fallah, Cumhur F. Öner, Richard J. Bransford, Klaus Schnake, Alex R. Vaccaro, Lorin M. Benneker, Emiliano Vialle, Gregory D. Schroeder, Shanmuganathan Rajasekaran, Mohammad El-Skarkawi, Rishi M. Kanna, Mohamed Aly, Martin Holas, Jose A. Canseco, Sander Muijs, Eugen Cezar Popescu, Jin Wee Tee, Gaston Camino-Willhuber, Andrei Fernandes Joaquim, Ory Keynan, Harvinder Singh Chhabra, Sebastian Bigdon, Ulrich Spiegel, Marcel F. Dvorak

Department of Orthopaedic Surgery Faculty Papers

STUDY DESIGN: Predictive algorithm via decision tree.

OBJECTIVES: Artificial intelligence (AI) remain an emerging field and have not previously been used to guide therapeutic decision making in thoracolumbar burst fractures. Building such models may reduce the variability in treatment recommendations. The goal of this study was to build a mathematical prediction rule based upon radiographic variables to guide treatment decisions.

METHODS: Twenty-two surgeons from the AO Knowledge Forum Trauma reviewed 183 cases from the Spine TL A3/A4 prospective study (classification, degree of certainty of posterior ligamentous complex (PLC) injury, use of M1 modifier, degree of comminution, treatment recommendation). Reviewers' regions …

A Municipal Modernity: Women, Architecture, And Public Health In Working-Class New York, 1913–1950, Jessica Fletcher

Dissertations, Theses, and Capstone Projects

“A Municipal Modernity” is the first study to analyze the architectural history of the district health centers in New York City that women reformers and their allies founded to address poor health in working-class communities. It reveals that women’s philanthropic adaptive re-use was foundational to the architecture of the public health care in New York and led to a program of municipal district health centers. Philanthropic reformers adapted buildings in the 1910s and 1920s to provide affordable health care for low-income women and children in European immigrant and Black neighborhoods. During the New Deal, municipal officials followed the example set …

The Divided Self: Internal Conflict In Literature, Philosophy, Psychology, And Neuroscience, Yulia Greyman

Dissertations, Theses, and Capstone Projects

This thematic project examines the notion of self-division, particularly in terms of the conflict between cognition and metacognition, across the fields of philosophy, psychology, and, most recently, the cognitive and neurosciences. The project offers a historic overview of models of self-division, as well as analyses of the various problems presented in theoretical models to date. This work explores how self-division has been depicted in the literary works of Edgar Allan Poe, Don DeLillo, and Mary Shelley. It examines the ways in which artistic renderings alternately assimilate, resist, and/or critique dominant philosophical, psychological, and scientific discourses about the self and its …

Interracial Instagram: Depictions Of Interracial Couples On Instagram, Christie Sillo

Dissertations, Theses, and Capstone Projects

This dissertation examines depictions of interracial romantic relationships on Instagram, a popular photo- and video-sharing social networking site. Social networking sites like Instagram, whereby users connect with each other by creating, sharing, and consuming content, are prime sites for sociological study because ideas are constantly being (re)made on them. On Instagram, meaning-making is mainly done through the construction of a profile and the posting of images and/or videos. Using a mixed-methods research design of hashtag analysis, digital ethnography, discourse and image analysis, I critically analyze Instagram profiles that depict interracial romantic relationships. In doing so, I develop a contemporary, social …

Trees In Urban Environments: How Soil Quality Impacts Tree Performance, Saidan Qi

Dissertations, Theses, and Capstone Projects

Cities around the world are increasingly investing in reforestation and afforestation efforts to mitigate impacts from climate change and population growth. However, urban soil conditions can be unfavorable for tree growth. Street trees are widely known to suffer from poor soil quality, but there has been no comprehensive review of this topic so far. Clean soils can be transported from nonurban areas to support cities’ green projects, but this approach is not sustainable. Artificial (constructed) soils can be created from various materials and have been proposed as an alternative medium for urban tree growth, but no research has been done …

"My First Best Love": Women's Writing On College Friendships 1880–1905, Alyssa J. Kayser-Hirsh

Dissertations, Theses, and Capstone Projects

In the late nineteenth and early twentieth century, American society encouraged strong bonds between women. As separate sphere ideology took hold, highly-structured female relationships were created and maintained through shared rituals, language, and expectations. The resulting friendships enabled women to build a range of emotional ties with one another. At the same time, an expanding array of gender segregated educational institutions further promoted homosocial networks. Women’s college students built community through their shared experience inhabiting a collective space, forging social circles as well as one-on-one intimate relationships. This thesis examines women’s experiences of friendship within the college setting between 1880 …

In-Work Recovery Among Hybrid Employees: Examining The Relationships Between Stressors, Recovery Experiences, And Strains, Stefanie Larsen

Dissertations, Theses, and Capstone Projects

There has been a drastic increase in the number of hybrid employees (i.e., employees who work remotely for part of a workweek) since the COVID-19 pandemic. While previous research has highlighted some of the benefits and costs of remote work, research on hybrid work is still in its early stages. One area that remains unclear is how hybrid work relates to stressor experiences and in-work recovery from work. The present study examined how levels of specific stressors (i.e., workload, availability pressure) vary depending on whether employees work remotely or in the office, and how the variations of these stressors across …

Migrant Children And Legislation: Integrating Knowledge About Trauma Into Policy, Yolennys E. Albornoz

Dissertations, Theses, and Capstone Projects

This study seeks to integrate some knowledge about trauma into migration policies in the U.S. regarding children. Migration is not a novel concept; it is a dynamic phenomenon that experiences continuous changes and constantly increases in numbers. Globally, the United States has been the primary destination for foreign migrants for a long time, and most of them are Latinos who cross the U.S. and Mexico border. Here, I explore how children face trauma in their home country, which forces them to migrate. Also, while they migrate and after they have migrated, exposing the three stages of trauma for migrant children. …

Digital Rhetoric Of The Invisible: Bisexual Literacy Practices On Tiktok, 2020–2021, Olivia Wood

Dissertations, Theses, and Capstone Projects

This dissertation uses auto- and digital-ethnographic methods to analyze the literacy practices of bisexual TikTok users primarily during the first year of the Covid-19 pandemic in the United States, during which time TikTok exploded in popularity among U.S. social media users, especially among young adults. It is also an exercise in neuroqueer composing, diverging at times from the norms of academic writing and the dissertation genre to perform and intentionally draw attention to neuroqueer styles of thinking and communication. I argue that bisexual invisibility and contemporary bi+ rhetorical activity must be understood within the context of LGBTQ+ political history, particularly …

Investigation Of Algorithmic Nudging On Decision Quality: Evidence From Randomized Experiments In Online Recommendation Settings, Yuxiao Luo

Dissertations, Theses, and Capstone Projects

Most recently, academic research has started to address the relationship between nudges and Artificial Intelligence/Machine Learning (AI/ML) and found that personalized targeting algorithms can influence individual and collective behaviors in ways that may lead to undesired consequences for both end-users and firms. This dissertation investigates the effects of digital nudging, particularly algorithmic nudging, on user’s decision quality in online badge recommendations in the e-commerce context. Nudge is a choice architecture that alters individual’s behavior in a predictable way while preserving all available options and keeping the same economic incentives. In this dissertation, I conducted three independent and relevant studies and …

Salmonella In The Environment: A Review On Ecology, Antimicrobial Resistance, Seafood Contaminations, And Human Health Implications, Mohammad Maruf Billah, Md Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Salmonella is a genus of Gram-negative bacteria that is responsible for numerous food poisoning outbreaks worldwide. With 93.8 million food-borne illnesses and 155,000 fatalities annually, it has emerged as a significant global public health issue. There are currently more than 2,500 distinct Salmonella serotypes, and more than half of them are associated with Salmonella enterica. An increasing global public health concern for humans and animals is antimicrobial resistance by Salmonella species worldwide. Salmonella infections can be lethal; conditioned with an increased prevalence of multi-drug resistant (MDR) strains in the future. The emergence of MDR Salmonella serotypes is considerably …