Digital Commons Network^™

Structural Biases In Disordered Proteins Are Prevalent In The Cell, David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph Mcanelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, Shahar Sukenik

2020-Current year OA Pubs

Intrinsically disordered proteins and protein regions (IDPs) are prevalent in all proteomes and are essential to cellular function. Unlike folded proteins, IDPs exist in an ensemble of dissimilar conformations. Despite this structural plasticity, intramolecular interactions create sequence-specific structural biases that determine an IDP ensemble's three-dimensional shape. Such structural biases can be key to IDP function and are often measured in vitro, but whether those biases are preserved inside the cell is unclear. Here we show that structural biases in IDP ensembles found in vitro are recapitulated inside human-derived cells. We further reveal that structural biases can change in a sequence-dependent …

Predicting And Identifying Factors Associated With Undernutrition Among Children Under Five Years In Ghana Using Machine Learning Algorithms, Eric Komla Anku, Henry Ofori Duah

College of Nursing Faculty Research and Publications

Background Undernutrition among children under the age of five is a major public health concern, especially in developing countries. This study aimed to use machine learning (ML) algorithms to predict undernutrition and identify its associated factors. Methods Secondary data analysis of the 2017 Multiple Indicator Cluster Survey (MICS) was performed using R and Python. The main outcomes of interest were undernutrition (stunting: height-for-age (HAZ) < -2 SD; wasting: weight-for-height (WHZ) < -2 SD; and underweight: weight-for-age (WAZ) < -2 SD). Seven ML algorithms were trained and tested: linear discriminant analysis (LDA), logistic model, support vector machine (SVM), random forest (RF), least absolute shrinkage and selection operator (LASSO), ridge regression, and extreme gradient boosting (XGBoost). The ML models were evaluated using the accuracy, confusion matrix, and area under the curve (AUC) receiver operating characteristics (ROC). Results In total, 8564 children were included in the final analysis. The average age of the children was 926 days, and the majority were females. The weighted prevalence rates of stunting, wasting, and underweight were 17%, 7%, and 12%, respectively. The accuracies of all the ML models for wasting were (LDA: 84%; Logistic: 95%; SVM: 92%; RF: 94%; LASSO: 96%; Ridge: 84%, XGBoost: 98%), stunting (LDA: 86%; Logistic: 86%; SVM: 98%; RF: 88%; LASSO: 86%; Ridge: 86%, XGBoost: 98%), and for underweight were (LDA: 90%; Logistic: 92%; SVM: 98%; RF: 89%; LASSO: 92%; Ridge: 88%, XGBoost: 98%). The AUC values of the wasting models were (LDA: 99%; Logistic: 100%; SVM: 72%; RF: 94%; LASSO: 99%; Ridge: 59%, XGBoost: 100%), for stunting were (LDA: 89%; Logistic: 90%; SVM: 100%; RF: 92%; LASSO: 90%; Ridge: 89%, XGBoost: 100%), and for underweight were (LDA: 95%; Logistic: 96%; SVM: 100%; RF: 94%; LASSO: 96%; Ridge: 82%, XGBoost: 82%). Age, weight, length/height, sex, region of residence and ethnicity were important predictors of wasting, stunting and underweight. Conclusion The XGBoost model was the best model for predicting wasting, stunting, and underweight. The findings showed that different ML algorithms could be useful for predicting undernutrition and identifying important predictors for targeted interventions among children under five years in Ghana.

The Black Map Project: A Black People’S Epistemology Of Healing, Britton Williams

Dissertations, Theses, and Capstone Projects

This work is a love letter to Mary Turner and her descendants, by which I mean all Black people, that lifts recipes and roadmaps of Black creative healing and liberatory praxes. It is a freedom dream (Kelley, 2002) that dares to (re)imagine mental health care by holding Black healing and liberation centrally in mind. I do not seek to prove through this work but rather to provoke [thought|action|repair]. In this work, I unsettle prescribed notions of therapy that have long dismissed/erased/ignored the needs and [therapeutic] practices of Black people. The Black MAP Project resists epistemologies of ignorance (Mills, 2022)—born in …

Visualizing Ancient Empire In Tudor England: Imperial Monarchy, Reformation, And The Antique Soldier In The Title Page To Richard Grafton’S Large Chronicle (1569), Peter Nicholas Otis

Dissertations, Theses, and Capstone Projects

This thesis analyzes the iconography and visual sources of the title page to the first volume of A chronicle at large and meere history of the affayres of Englande (1569) by the Tudor author Richard Grafton. Representing the visual synthesis of several distinct but interrelated currents that developed in the preceding century, the title page to the Large Chronicle offers a rare glimpse into a transitional moment in the middle Tudor perception and visual representation of the British past. These currents include imperializing royal iconography, with origins in antecedent representations in the late fifteenth century; the entry of the ‘classicizing’ …

Knowing The Patient As A Person: Social Media Listening And Gadamerian Analysis Of Nurses’ Expressions Shared During The Covid-19 Global Health Pandemic, Janusz A. Kaleta

Dissertations, Theses, and Capstone Projects

Background: COVID-19 has dramatically changed human-to-human interactions from in-person to the nonhuman domain of virtual space. In January 2021, every 28 seconds one person died of COVID-19 in the United States. An average of 3,100 Americans died each day during the deadliest month of the pandemic. As of January 2023, the number of COVID-19 deaths in the USA surpassed 1.000.000 people. In hospitals, human-to-human interactions were often limited to seeing one’s eyes behind the face shields, and respirator masks, and hearing a muffled voice, or sounds of the ventilators. In New York State 452 nurses died during the pandemic.

Research …

Cancer In Pajamas: Radio, Podcasts, And The Politics Of Free Time In The Digital Age, Daniel Grjonko

Dissertations, Theses, and Capstone Projects

The podcast, an extremely potent fermentation of the radio which was so central to many of the Frankfurt School thinkers, is an important political subject to consider in light of rekindled social discussions concerning a society straddling the line between fascism and socialism. Especially the political podcast, which has become a pulse of intellectual discussion and historical analysis, promises itself simultaneously as a medium of entertainment, pedagogy, and translation into real-world organizing for a different world, true for both the left and the right. The truth, I propose, is a sinister other experience, one which maintains the status quo …

Interviews And Perspectives Among Community Members Working With Undocumented Female Border Crossers In The States Along The United States-Mexico Border, Melissa M. Frasco

Dissertations, Theses, and Capstone Projects

In order to discuss immigration in the context of the United States, we must dispel the myth that immigration is monolithic. Therefore, when we discuss national identity, gender equality, policy, employment rates, and countless other ordinary topics, we are discussing immigration, as it is embedded in our history and our future. The goal of my research is to delineate the experiences of violence that female border crossers undergo in the process of crossing into the United States via the southernmost border. The data collection process involved four semi-structured interviews to collect oral histories from workers at community-based organizations. These organizations …

Containerization Of Seafarers In The International Shipping Industry: Contemporary Seamanship, Maritime Social Infrastructures, And Mobility Politics Of Global Logistics, Liang Wu

Dissertations, Theses, and Capstone Projects

This dissertation discusses the mobility politics of container shipping and argues that technological development, political-economic order, and social infrastructure co-produce one another. Containerization, the use of standardized containers to carry cargo across modes of transportation that is said to have revolutionized and globalized international trade since the late 1950s, has served to expand and extend the power of international coalitions of states and corporations to control the movements of commodities (shipments) and labor (seafarers). The advent and development of containerization was driven by a sociotechnical imaginary and international social contract of seamless shipping and cargo flows. In practice, this liberal, …

Seeing Safety In Red: Expressions Of Interpersonal Gratitude Affects Conservatives’ Political Attitudes In The United States, Kyle M. Anderson

Dissertations, Theses, and Capstone Projects

The current research focuses on how the expression of interpersonal gratitude might affect conservative attitudes, behaviors, and policy support in the United States. This was investigated either through expressions of gratitude or receiving gratitude to an interpersonally close other, as in Studies 1 and 2, or expressing gratitude to an authority figure or equal in one’s life, as in Study 3. Study 1 showed that expressing gratitude, relative to receiving gratitude, reduced support for general conservative ideology. Using serial mediation analyses, Study 2 demonstrated that expressions of gratitude, relative to receiving gratitude, directly reduced perceptions of relational uncertainty, which increased …

Algorithmic Love: Twenty-First Century Organizations Of The Romantic, Sandra Moyano Ariza

Dissertations, Theses, and Capstone Projects

This dissertation investigates the highly computed and accelerated experiences of digital love as well as their cultural and artistic representations in order to shed light on the human and more-than-human entanglements producing the algorithmic love experience. The recent turn to love in critical theory and cultural studies examines how love circulates in neoliberal societies and in the subjective processes of the users, foregrounding the control of populations and the very much lamented “end of love” (Illouz 2019). My study of love supplements the neoliberalist critique of algorithmic love with a posthuman and media theory approach that attends to the material …

Effects Of Transcranial Direct Current Stimulation On Metamemory Vary By Task Difficulty, Tiffanie T. Li

Dissertations, Theses, and Capstone Projects

Metamemory is broadly defined as the awareness of one’s memory and consists, in part, of a process referred to as monitoring, where one is assessing the contents of their memory. Feeling of knowing (FOK) is one metamemory monitoring judgment where one rates how strongly they believe they will remember a currently unrecalled item. Prior work has shown that HighDefinition Transcranial Direct Current Stimulation (HD-tDCS) over the dorsal lateral prefrontal cortex (DLPFC) led to greater metamemory accuracy and that HD-tDCS over the anterior temporal lobe (ATL) led to better recall for medium difficulty questions. Other work has also shown that effects …

Border Confinement And Assistance Markets In Tijuana: Mexican Deportees’ Experiences Of Labor And Violence Between Mexico And The United States, Christian Pacheco-Gómez

Dissertations, Theses, and Capstone Projects

This dissertation is an ethnography of deportation and describes how Tijuana’s (Baja California, Mexico) border redevelopment and spatial redesign has impacted in Mexican job seekers’ mobilities, incorporation, and stigmatization after experiencing forced removals from the United States. The dissertation explores three processes interwoven in the deportees’ class experiences of migration and deportation.

First, I trace Mexican job seekers’ trajectories of labor and migratory movement before, during, and after deportation as well as their incorporation stories in Tijuana. Second, I reconstruct the political economy of reception immigrant subjects encounter after being deported from the United States and subjected by Tijuana’s border …

No Ela Without Ella: Understanding The Naming And Crafting Of Gendered Subjectivities In Puerto Rico, Carmín Quijano Seda

Dissertations, Theses, and Capstone Projects

At the beginning of the 20th century, the official metadiscourses about gendered job titles sedimented the idea that names or indexes pointing to women should be interpreted as unskilled, cheap, or even free labor in Puerto Rico (Azize, 1985; Muñiz Mas, 1998; Baerga-Santini, 1999). For this reason, Puerto Rican women organized and fought for equality in work settings. Furthermore, they became more active in politics and the government. Nevertheless, the Estado Libre Asociado (ELA) and local media discourses and interpretations about women’s labor discouraged them from participating in more senior positions (Acevedo Gaud, 2012).

However, this interpretation seemed to have …

The Role Of The Infralimbic-Basal Forebrain Pathway In Fear Extinction, Carolina Maria Fernandes Henriques

Dissertations, Theses, and Capstone Projects

The medial prefrontal cortex (mPFC) is a key region for emotion regulation, and its failure to regulate extinction of aversive memories is associated with Post Traumatic Stress Disorder. Study of how the Infralimbic cortex (IL), a subregion of the mPFC, directly communicates with the Basolateral Amygdala (IL-BLA), has thus far failed to uncover the circuit mechanisms that lead to mPFC-mediated amygdala suppression of firing and diminished fear responses during extinction retrieval. One problem of this model is that it doesn’t incorporate indirect IL communication with the BLA. A key region to help understand how IL modulates extinction is the basal …

Ethnic Minorities And Family Health History: An Autoethnography Of Guyanese Americans And Kidney Disease, Dhaneesha R. Bahadur

Dissertations, Theses, and Capstone Projects

Exploring family health histories (FHHs) has emerged in recent years as an inexpensive genomic tool in public health. Families and clinicians can also use them to uncover family histories and experiences, which could inform better lifestyle choices to prevent or delay the onset of diseases. Exploring family health histories focuses on an individual’s genetic makeup and considers differences in lifestyle and environment. Despite national campaigns, it is an underutilized tool that could lead to engagement in effective strategies and better health outcomes. One important and serious condition that families should be more aware of is chronic kidney disease (CKD). One …

Stereospecific Cross-Coupling Reactions Of Vinyl Triflates And An Investigation Of The Synthesis And Reactivity Of Activated Alkyltricyclohexylstannanes, Pejman Ghaemimohammadi

Dissertations, Theses, and Capstone Projects

Organic chemistry exists in all aspects of everyday life from polymers to pharmaceutics. Formation of carbon-carbon bonds is essential for the synthesis of complex organic compounds. This goal can be achieved by using transition metal catalysts. Second-row transition metals such as Pd, Pt, Rh, and Ir have shown remarkable efficacy in these reactions. Metal-catalyzed cross-coupling reactions form carbon-carbon bonds between electrophiles and nucleophiles using transition metal catalysts. Pd is mainly used in this reaction.

Transition metal-catalyzed cross-coupling reactions that form a bond between two C(sp²) carbons have been widely studied over the past decades. C(sp²)-C(sp^{3 …}

Synthesis And Characterization Of Donor-Acceptor Fluorescent Conjugated Polymers By Acyclic Diene Metathesis (Admet) And Suzuki Polycondensation (Spc), Hamid Ardolic Jr.

Dissertations, Theses, and Capstone Projects

Conjugated polymers are useful in a wide variety of applications including production of Light Emitting Diodes (LEDs), Field Effect Transistors (FETs) and organic photovoltaics. Our work in the lab focuses on the development of materials for use in Polymer Solar Cells (PSCs) using various electron donating and electron accepting units to individually tune the Highest Occupied Molecular Orbital (HOMO) and Lowest Unoccupied Molecular Orbital (LUMO) respectively and produce a small but controlled band gap. This is accomplished through the synthesis of several precursors and their subsequent polymerization using Acyclic Diene Metathesis (ADMET) and Suzuki Polycondensation (SPC). Moderately strong electron donors, …

Clustering Of Patients With Heart Disease, Mukadder Cinar

Dissertations, Theses, and Capstone Projects

Heart disease, a leading cause of mortality worldwide, presents complex challenges in public health due to its varied manifestations. Accurate diagnosis and patient stratification are essential for effective management and improved outcomes. In response, this study employed machine learning techniques to analyze heart disease data obtained from UCI Machine Learning Repository, aiming to enhance patient care through advanced data analysis.

The study began with the application of K-Nearest Neighbors (KNN) classification, which categorized patients into 'Disease' and 'No Disease' groups. This preliminary step provided initial insights into the structure of the dataset. Subsequently, K-means clustering was applied in two rounds, …

An Examination Of Factors Associated With Ipv Victimization, Ipv Disclosure, And Help-Seeking Among Partnered Sexual Minority Men: An Integrated Theoretical Approach, Stephen Bosco

Dissertations, Theses, and Capstone Projects

The emerging body of research illustrates that sexual minority cis men (SMM) in a relationship experience intimate partner violence (IPV) at rates comparable to those reported by cis women in a heterosexual relationship. Although research on IPV in male relationships has increased, it is a phenomenon that remains considerably understudied compared to research examining IPV in a heterosexual relationship. Despite comparable rates of IPV victimization, SMM are less likely to disclose and use informal and formal support services compared to heterosexual women. To conceptualize and understand challenges to disclosure and help-seeking as well as identify facets to develop relevant and …

Examining The Health Risks Of Particulate Matter 2.5 In New York City: How It Affects Marginalized Groups And The Steps Needed To Reduce Air Pollution, Freddy Castro

Dissertations, Theses, and Capstone Projects

The following examines the impact of particulate matter 2.5 (PM2.5) on public health, focusing on its sources and effects on vulnerable populations in New York City. PM2.5 is a particle that is 2.5 micrometers or less in diameter and, because of its size, can enter the bloodstream affecting the respiratory and cardiovascular systems and further complicating the health of the immunocompromised. Recent studies have shown that PM2.5 can come from various sources, including transportation and industrial emissions, as well as indoor sources like cigarettes and gas-operated stoves. Despite reduced levels of PM2.5 due to recent policy changes and initiatives taken …

Visualizing A Life, Uprooted: An Interactive, Web-Map And Scroll-Driven Exploration Of The Oral History Of My Great-Grandfather – From Ottoman Cilicia To Lebanon And Beyond, Alyssa Campbell

Dissertations, Theses, and Capstone Projects

This project is an interactive data visualization narrative of the oral history of my great-grandfather, Hovsep Aghek Yeni-Komshian, born April 2, 1895 to an Armenian family in Kilis, Cilicia, Ottoman Empire.

Before World War I and the fall of the Ottoman Empire, millions of Armenians lived throughout what is today Eastern Turkey, their nearly 3000-year history in the region making them one of the oldest indigenous groups of the area. However, today the Armenian presence in Anatolia has largely been erased due to the Armenian Genocide (1915-1923), during which nearly the entire local Armenian population was murdered or forcibly deported …

Towards Sociobiogeochemistry: Critical Perspectives On Anthropogenic Alterations To Soil Nitrogen Chemistry Via U.S. Urban And Suburban Development, Christopher D. Ryan

Dissertations, Theses, and Capstone Projects

The ecological impacts of changes to land use are relevant to concerns about climate change, eutrophication of waterbodies, and reductions in biodiversity. As a foundational component of ecosystem functioning, changes to soil biogeochemistry have significant effects on overall ecosystem health. With cities continuing to grow and develop in extent, the impacts of urbanization and suburbanization on soils are of particular concern. Despite a wide range of natural climatic and geologic conditions, several factors have driven similar patterns of land transformation and management across the United States. In particular, federal initiatives including the Home Owners Loan Corporation, the Federal Housing Administration, …

Complicating Confidence: A Critical Analysis Of Confidence In A Girls' Empowerment Organization, Kimberly M. Belmonte

Dissertations, Theses, and Capstone Projects

In the popular imagination, confidence is thought of as a positive or healthy state. Yet there is also a pervasive belief that adolescent girls are at risk of losing their confidence or of not having enough confidence, particularly compared to boys. The larger field of youth development theorists and practitioners see confidence as a positive, normative, and measurable aspect of healthy adolescent development (e.g., Lerner et al., 2015). Conversely, critical feminist scholars assert that confidence has become hegemonic, mandated, and commodified (e.g., Banet-Weiser, 2015; Gill & Orgad, 2016)—taken up by a neoliberal, post-feminist climate as a technology of the self …

The Clinical And Economic Impact Of Extended Battery Longevity Of A Substernal Extravascular Implantable Cardioverter Defibrillator., Bradley P Knight, Nicolas Clémenty, Anish Amin, Ulrika M Birgersdotter-Green, Henri Roukoz, Reece Holbrook, Jaimie Manlucu

Heart and Vascular Articles

INTRODUCTION: The extravascular implantable cardioverter defibrillator (EV ICD) has extended projected battery longevity compared to the subcutaneous implantable cardioverter defibrillator (S-ICD). This study used modeling to characterize the need for generator changes, long-term complications, and overall costs for both the EV ICD and S-ICD in healthcare systems of various countries.

METHODS: Battery longevity data were modeled using a Markov model from averages reported in device labeling for the S-ICD and with engineering estimates based on real life usage from EV ICD Pivotal Study patient data to introduce variability. Clinical demographic data were derived from published literature. The primary outcomes were …

Celiac Artery Occlusion From Median Arcuate Ligament Compression Complicating A Hemorrhagic Duodenal Ulcer Repair., Anthony N Rizzo, Marc Seligson, William O'Brien, David Laczynski, Anthony Rizzo

Heart and Vascular Articles

We present a case of a hemorrhagic duodenal ulcer complicated by occlusion of the celiac artery (CA) by acute median arcuate ligament (MAL) compression. Angiography revealed retrograde flow through the gastroduodenal artery (GDA) to the hepatic artery, with occlusion at the CA origin. This unique presentation required coordinated release of the MAL to reestablish antegrade CA flow before pyloroplasty and GDA ligation. The presence of preexisting MAL compression of the CA should be considered during the repair of bleeding duodenal ulcers through embolization or ligation of the GDA, because impaired CA perfusion could result in foregut ischemia.

Zinc And Manganese Effect Seed Quality And Germination In Common Bean (Phaseolus Vulgaris L.), Mehrdad Yarnia, Masoud Soltani̇ Bouljak, Parisa Bolouri, İnci̇ Tolay

Turkish Journal of Agriculture and Forestry

Zinc (Zn) and manganese (Mn) are important micronutrients in plant growth and development. In this study, the effect of Zn and Mn sulfate treatments at different growth stages of mother plants in common bean on seed production and germination potential was carried out. Results showed that zinc sulfate (ZnSo4) treatments significantly affected yield and pod number per plant compared to manganese sulfate tetrahydrate (MnSO4) treatments. Treatment in any form or at any stage of growth increased yield and its components in common bean. The highest efficiency of ZnSO4 was obtained in the pod production stage; MnSO4 enjoyed greater efficiency in …

Quaternary Ammonia Compounds In Disinfectant Products: Evaluating The Potential For Promoting Antibiotic Resistance And Disrupting Wastewater Treatment Plant Performance, Zihao Lu, Anna K. Mahony, William A. Arnold, Christopher Marshall, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Quaternary ammonium compounds (QACs) are a class of compounds that were widely used as disinfectants during the COVID-19 pandemic and continue to be used as disinfecting agents. After consumer usage, QAC concentrations are diluted in wastewater as they enter wastewater treatment plants. At sub-inhibitory concentrations, QACs may have unintended repercussions, including increased antibiotic resistance and inhibition of process performance in wastewater treatment plants. This review first summarizes how QACs inhibit bacteria and then highlights the mechanisms by which QACs can promote antibiotic resistance in general. Reported environmental concentrations of QACs are compared to concentrations that are suspected to impact antibiotic …

Guidance For Assessment Of The Inflammation Etiologic Criterion For The Glim Diagnosis Of Malnutrition: A Modified Delphi Approach., Gordon L Jensen, Tommy Cederholm, Maria D Ballesteros-Pomar, Renee Blaauw, M Isabel T D Correia, Cristina Cuerda, David C Evans, Ryoji Fukushima, Juan Bernardo Ochoa Gautier, M Cristina Gonzalez, Andre Van Gossum, Leah Gramlich, Joseph Hartono, Steven B Heymsfield, Harriët Jager-Wittenaar, Renuka Jayatissa, Heather Keller, Ainsley Malone, William Manzanares, M Molly Mcmahon, Yolanda Mendez, Kris M Mogensen, Naoharu Mori, Maurizio Muscaritoli, Guillermo Contreras Nogales, Ibolya Nyulasi, Wendy Phillips, Matthias Pirlich, Veeradej Pisprasert, Elisabet Rothenberg, Marian De Van Der Schueren, Han Ping Shi, Alison Steiber, Marion F Winkler, Charlene Compher, Rocco Barazzoni

Ambulatory and Primary Care Articles

BACKGROUND: The Global Leadership Initiative on Malnutrition (GLIM) approach to malnutrition diagnosis is based on assessment of three phenotypic (weight loss, low body mass index, and reduced skeletal muscle mass) and two etiologic (reduced food intake/assimilation and disease burden/inflammation) criteria, with diagnosis confirmed by fulfillment of any combination of at least one phenotypic and at least one etiologic criterion. The original GLIM description provided limited guidance regarding assessment of inflammation, and this has been a factor impeding further implementation of the GLIM criteria. We now seek to provide practical guidance for assessment of inflammation.

METHODS: A GLIM-constituted working group with …

The Safety And Efficacy Of Posterior Lumbar Interbody Fusions In The Outpatient Setting., Hunter F Pharis, Daniel T Degenova, Braden J Passias, Taylor J Manes, Grace Parizek, Daryl Sybert

Surgery Articles

Introduction Outpatient surgical procedures have shown reduced costs, improved patient outcomes, and decreased postoperative complications. Interest in moving orthopedic and neurosurgical spine procedures to the outpatient setting has grown in recent years because of these factors. Studies investigating open posterior lumbar interbody fusions (PLIFs) in the outpatient setting are sparse. Methods The patients who underwent an open PLIF with pedicle screw and rod construct from 2014 to 2018 were retrospectively reviewed. Outpatient procedures were defined by patient discharge being on the same day of the procedure, without admittance to an inpatient ward. Pertinent demographic, clinical, radiographic, and surgical data were …

No Difference In Pullout Strength Between A Bio-Inductive Implant And A Semitendinosus Tendon Graft In A Biomechanical Study Of Medial Patellofemoral Ligament Repair Augmentation., Austin Wetzler, Sean Mcmillan, Erik Brewer, Aakash Patel, Samuel Handy, Merrick Wetzler

Orthopedic Surgery Resident Research

PURPOSE: To compare the pullout strength of a bio-inductive implant (BI) used to augment a medial patellofemoral ligament (MPFL) repair with the pullout strength of semitendinosus graft in a biomechanical cadaveric model.

METHODS: Six matched pairs of cadavers (12 knees) were used in the biomechanical testing comparing semitendinosus tendon (Semi-T) versus a BI. The Semi-T was harvested from 1 of the matched pairs. A standard double-bundle technique using 2 sockets in the upper two-thirds of the patella 15 mm apart was performed. After docking of the graft into the patella, the patella was dissected free of soft tissues and potted …