Digital Commons Network^™

Teaching What Matters: Addressing Social Determinants Of Health In Clinical Practice, N Marian Salas, Suman Pal

HSC Education Days

Social determinants of health (SD0H) account for 50-80% of healthcare outcomes. Despite this, many residents receive minimal training in how to address the negative social determinants of health in their patient populations. We developed a 1.5-hour workshop integrated into GME orientation for all the 167 incoming interns of our institution. We used case-based learning as a proven effective method for both improving knowledge gain and skills acquisition outcomes. Using the input of multiple subject matter experts, we developed four cases from different regions of the state that learners worked through in facilitated small groups supported by intermittent check-ins with the …

Internal Medicine Resident Outcomes After Initiation Of Block Scheduling, Annashia Shera, Michael Louie, Raymond G. Murphy

HSC Education Days

The height of the COVID pandemic took a considerable toll on all healthcare workers and heavily on resident physicians. The long work hours and subsequent effect on mental health required a change to the system not only for wellness but also education. This especially affected the quality of the resident outpatient experience due to the competing high demands of inpatient service. Feedback from residents propelled the decision to implement block scheduling at the University of New Mexico Internal Medicine Residency program in 2021. In this presentation, we share the outcomes of this change in terms of duty hours, wellness, and …

Stacking And Intersecting Nutrient 4rs On Potato, Samuel Hamilton Stapley

Theses and Dissertations

The 4Rs of nutrient management is a global agronomic initiative with an aim to improve the sustainability of major cropping systems and the environment. The objective for this project is to evaluate individual and stacked 4R management practices and how they intersect. A field trial near Grace, Idaho was conducted on potato (Solanum tuberosum L.) in 2020 and 2023. Nitrogen (N) fertilizer treatments included all combinations of two sources [urea or polymer coated urea (PCU)], two rates (82 or 100% of the recommended rate), and/or two timing/placements (all applied at emergence or 84% at emergence + 16% fertigation simulation) compared …

Sox On Tumors, A Comfort Or A Constraint?, Junqing Jiang, Yufei Wang, Mengyu Sun, Xiangyuan Luo, Zerui Zhang, Yijun Wang, Siwen Li, Dian Hu, Jiaqian Zhang, Zhangfan Wu, Xiaoping Chen, Bixiang Zhang, Xiao Xu, Shuai Wang, Shengjun Xu, Wenjie Huang, Limin Xia

Faculty, Staff and Student Publications

The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation of SOX family members is closely associated with tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research to investigate the mechanisms and functions of the SOX family, confusion remains regarding aspects such as the role of the SOX family in tumor immune microenvironment (TIME) and contradictory impacts the SOX family exerts on tumors. This review summarizes …

Functional Epas1/ Hif2a Missense Variant Is Associated With Hematocrit In Andean Highlanders, Elijah S Lawrence, Wanjun Gu, Ryan J Bohlender, Cecilia Anza-Ramirez, Amy M Cole, James J Yu, Hao Hu, Erica C Heinrich, Katie A O'Brien, Carlos A Vasquez, Quinn T Cowan, Patrick T Bruck, Kysha Mercader, Mona Alotaibi, Tao Long, James E Hall, Esteban A Moya, Marco A Bauk, Jennifer J Reeves, Mitchell C Kong, Rany M Salem, Gustavo Vizcardo-Galindo, Jose-Luis Macarlupu, Rómulo Figueroa-Mujíca, Daniela Bermudez, Noemi Corante, Eduardo Gaio, Keolu P Fox, Veikko Salomaa, Aki S Havulinna, Andrew J Murray, Atul Malhotra, Frank L Powel, Mohit Jain, Alexis C Komor, Gianpiero L Cavalleri, Chad D Huff, Francisco C Villafuerte, Tatum S Simonson

Faculty, Staff and Student Publications

Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated with relatively lower hemoglobin concentration in Tibetans. We provide evidence for an association between an adaptive EPAS1 variant (rs570553380) and the same phenotype of relatively low hematocrit in Andean highlanders. This Andean-specific missense variant is present at a modest frequency in Andeans and absent in other human populations and vertebrate species except the coelacanth. CRISPR-base-edited human cells with this variant exhibit shifts in hypoxia-regulated gene expression, while metabolomic analyses reveal both genotype and phenotype associations …

2024 February 9 - From My Notepads Newsletter, Office Of The President, East Tennessee State University, Brian Noland

From My Notepads: A Newsletter from President Brian Noland

No abstract provided.

"They Are Usually Borderline Homeless": Exploring The Nexus Of Homelessness, Housing Instability, Successful Reentry, And Long-Term Reintegration, Emily Troshynski, Carolyn Willis

Criminal Justice Faculty Research

For previously incarcerated persons, affordable and safe housing options are scarce. Barriers to securing housing include federal mandates (i.e., eligibility requirements) as well as local rules and regulations (i.e., zoning and ordinances). When housing is available, disclosing criminal history on applications impacts individuals’ chances to rent (Philips & Spencer, 2013). A lack of a consistent rental history, no personal and/or employment references, and securing capital to cover security deposits are added challenges. Since parole rules direct ex-convicts not to associate with others that have a criminal record, living with partners, friends, and family members may not be an option. Research …

Spontaneous Self-Affirmation And Social Context As Moderators Between Stereotype Threat And Online Academic Performance, Katrina Hilton

Walden Dissertations and Doctoral Studies

Despite years of progress, there remains an academic achievement gap among minority and non-minority students in all levels of education. A possible reason for the persistent achievement gap is stereotype threat, which is a situational predicament that prompts individuals to perform in ways that mirror the stereotypes associated with their social groups. Self-affirmation interventions are often used to disrupt the effects of stereotype threat, as students are taught how to focus on their strengths and values to help improve their self-concepts. However, spontaneous self-affirmation techniques may be more impactful because students are able to automatically self-affirm in any psychologically threatening …

Thematic Analysis Through Artificial Intelligence (Ai), Prokopis A. Christou Phd

The Qualitative Report

Thematic analysis, a well-enforced qualitative analytic method, is likely to continue evolving with the adoption of AI technologies. This how-to report does not delve into the details of thematic analysis itself, as there are ample existing studies on the topic. Instead, it acknowledges the potential impacts, dynamics, and pitfalls of AI in thematic analysis while offering valuable advice, particularly for novice analysts, on how to incorporate and document AI tools in each phase of a thematic analysis. The author underscores the importance of not allowing AI to overshadow the analyst's critical evaluative and interpretive skills but instead supporting the use …

2023 Martin Luther King,Jr. Keynote Lecture; Celebrating The Legacy Of Dr. Martin Luther King, Jr., Answering The Call To Public Service, Reginald Shuford

Villanova Law Review (1956 - )

No abstract provided.

February 9, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Against Bankruptcy: Public Litigation Values Versus The Endless Quest For Global Peace In Mass Litigation, Abbe Gluck, Elizabeth Chamblee Burch, Adam Zimmerman

Scholarly Works

Can bankruptcy court solve a public health crisis? Should the goal of “global peace” in complex lawsuits trump traditional litigation values in a system grounded in public participation and jurisdictional redundancy? How much leeway do courts have to innovate civil procedure?

These questions have finally reached the Supreme Court in Harrington v. Purdue Pharma L.P., the $6 billion bankruptcy that purports to achieve global resolution of all current and future opioids suits against the company and its former family owners, the Sacklers. The case provides a critical opportunity to reflect on what is lost when parties in mass torts find …

Comprehensive Landscape Of Braf Variant Classes, Clonalities, And Co-Mutations In Metastatic Colorectal Cancer Using Ctdna Profiling, Benny Johnson, Van Morris, Xuemei Wang, Arvind Dasari, Kanwal Raghav, John Paul Shen, Michael S Lee, Ryan Huey, Christine Parseghian, Jason Willis, Robert Wolff, Leylah M Drusbosky, Michael J Overman, Scott Kopetz

Faculty, Staff and Student Publications

Although V600E accounts for the majority of the BRAF mutations in metastatic colorectal cancer (mCRC), non-V600 BRAF variants have been shown in recent years to represent a distinct molecular subtype. This study provides a comprehensive profile of BRAF variants in mCRC using a large genomic database of circulating tumor DNA (ctDNA) and analyzing clinical outcomes in a cohort of patients with atypical (non-V600) BRAF variants (aBRAF; class II, class III, unclassified). Overall, 1733 out of 14,742 mCRC patients in the ctDNA cohort had at least one BRAF variant. Patients with atypical BRAF variants tended to be younger and …

Risk Factors For Non-Healing Wounds—A Single-Centre Study, Daniel Wolny, Ladislav Štěpánek, Dagmar Horáková, Janet Thomas, Jana Zapletalová, Mihir Sanjay Patel

Faculty, Staff and Student Publications

Background: Chronic wounds present a significant clinical, social, and economic challenge. This study aimed to objectify the risk factors of healing outcomes and the duration of chronic wounds from various etiologies. Methods: Patients treated for non-healing wounds at the surgical outpatient clinic of the Olomouc Military Hospital were involved. Data from patients treated between 8/2021 and 9/2023 were selected. Patients were mostly treated as outpatients, with microbiological follow-up indicated in cases of advanced signs of inflammation. Results: There were 149 patients who met our selection criteria (the mean age was 64.4 years). Predominant causes of wounds involved diabetes (30.9%), post-trauma …

Quaker Campus, February 9, 2024 (Vol. 22, Issue 9), Whittier College

Quaker Campus

No abstract provided.

Barbary Macaques Show Sex-Related Differences In Body Weight Based On Anthropogenic Food Exposure Despite Comparable Female–Male Stable Isotope Ratios, Sana T. Saiyed, Agustin Fuentes, Eric Shaw, Mark R. Schurr, Lee T. Gettler

Faculty Publications

As the human–primate interface expands, many nonhuman primate (NHP) populations exploit anthropogenic foods to survive, while some populations opportunistically target them. Though anthropogenic food consumption is sometimes associated with greater reproductive output and survival in these populations, there is a dearth of research on possible health effects. We explore how differential exposure to anthropogenic foods is linked to variation in isotopic compositions (δ13C and δ15N) and body weights in Barbary macaques (Macaca sylvanus) in the Upper Rock Nature Reserve, Gibraltar. We placed monkeys into three categories based on anthropogenic food exposure. We then analyzed individuals for isotopic signatures (N = …

Intellectual Property Rights And Copyright Laws In The Regime Of Artificial Intelligence (Ai) In India, Hemavathy C

Library Philosophy and Practice (e-journal)

Artificial Intelligence (AI) has been developing for two decades. The application of AI is budding quickly in business dealings, corporate communication and legal services. AI and Law Forms are increasingly important in the legal arena as they play a significant role in the economy and society. Scientists and policymakers together are facing some of the hardest problems with the advancement of machine learning, cryptology and data protection. This paper is very helpful for policymakers, economists, lawyers and technocrats in the aspect of the ethical use of AI in data protection, privacy, security and social corners turns into very relevant issues …

Sandra Lee Carlson Appellee V. Patrick Alfred Carlson : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Honorable Noel S. Hyde

Appeal Of Final Orders in Divorce Decree Second District Court Weber County, State of Utah Honorable Noel S. Hyde ________________________________________________________________________ Trevor Casperson Jason Schow Solon Law, PLLC. Kauffman, Nichols & Kaufman, PLLC Attorney for Appellant

A Scoping Review Of The Oral Health Status, Oral Health Behaviours And Interventions To Improve The Oral Health Of Children And Young People In Care And Care Leavers, Joelle Booth, Jo Erwin, Lorna Burns, Nick Axford, Jane Horrell, Hannah Wheat, Robert Witton, Jill Shawe, Janine Doughty, Sarah Kaddour, Skye Boswell, Urshla Devalia, Abigail Nelder, Martha Paisi

Peninsula Dental School

BACKGROUND: Children and young people (CYP) in care experience poorer physical health and overall wellbeing in comparison to their peers. Despite this, relatively little is known about what their oral health needs and behaviours are. The aim of this scoping review was to provide a global perspective on the oral health status and behaviours of CYP in care and care leavers. It also aimed to synthesise interventions that have been trialled in this population to improve oral health.

METHODS: Five databases were searched, Ovid Embase, Ovid MEDLINE, CINAHL (EBSCOhost), SocINDEX (EBSCOhost) and Dentistry and Oral Sciences Source (EBSCOhost), alongside grey …

Dose Tapering And Discontinuation Of Biologic Dmards In Axial Spondyloarthritis: A Narrative Review (2023 Spartan Annual Meeting Proceedings), Haseeb Chaudhary, Ansaam Daoud, Marina Magrey

Faculty Scholarship

Purpose of Review: Limited data is available for tapering or discontinuation of biologic therapy in patients with axSpA who are in disease remission. The current review concentrates on published studies regarding dose tapering or withdrawal of biologics in axSpA. Recent Findings: Recent evidence in light of randomized controlled trials suggests that tapering of b-DMARDs is a feasible strategy to maintain remission or low disease activity in axSpA patients. TNF inhibitors were the studied biologics in most of these trials. The disease flare rates were comparable to those maintained on standard dose in most of these studies, although with variable tapering …

Survivorship Care For Women Living With Ovarian Cancer: Protocol For A Randomized Controlled Trial, Elizabeth Kvale, Farya Phillips, Samiran Ghosh, Jayanthi Lea, Claire Hoppenot, Anthony Costales, Jan Sunde, Hoda Badr, Eberechi Nwogu-Onyemkpa, Nimrah Saleem, Rikki Ward, Bijal Balasubramanian

Faculty, Staff and Student Publications

BACKGROUND: Ovarian cancer ranks 12th in cancer incidence among women in the United States and 5th among causes of cancer-related death. The typical treatment of ovarian cancer focuses on disease management, with little attention given to the survivorship needs of the patient. Qualitative work alludes to a gap in survivorship care; yet, evidence is lacking to support the delivery of survivorship care for individuals living with ovarian cancer. We developed the POSTCare survivorship platform with input from survivors of ovarian cancer and care partners as a means of delivering patient-centered survivorship care. This process is framed by the chronic care …

Patient And Public Involvement In Abortion Research: Reflections From The Shaping Abortion For Change (Sacha) Study, The Sacha Study Team N/A, Rebecca Blaylock, Maria Lewandowska, Charlotte Kelly, Becky Gunn, Rebecca Meiksin, Rachel H. Scott, Melissa J. Palmer, Kaye Wellings, Patricia A. Lohr, Rebecca S. French, Jill Shawe, Wendy Norman, Sharon Cameron, Clare Murphy, Geoffrey Wong, Paula Baraitser, Caroline Free, Annette Aronsson, Jennifer Reiter, Sally Sheldon, Louise Keogh, Rachel Scott, Natasha Salaria, Ona Mccarthy

School of Nursing and Midwifery

Patient and public involvement (PPI) is limited within abortion-related research. Possible reasons for this include concerns about engaging with a stigmatised patient group who value confidentiality and may be reluctant to re-engage with services. Structural barriers, including limited funding for abortion-related research, also prevent researchers from creating meaningful PPI opportunities. Here, we describe lessons learnt on undertaking PPI as part of the Shaping Abortion for Change (SACHA) Study, which sought to create an evidence base to guide new directions in abortion care in Britain. Two approaches to PPI were used: involving patients and the public in the oversight of the …

Agreement Among High-Sensitivity Cardiac Troponin Assays And Non-Invasive Testing, Clinical Outcomes, And Quality-Of-Care Outcomes Based On The 2020 European Society Of Cardiology Guidelines, Júlia Karády, Thomas Mayrhofer, James L Januzzi, James E Udelson, Jerome L Fleg, Bela Merkely, Michael T Lu, William F Peacock, John T Nagurney, Wolfgang Koenig, Maros Ferencik, Udo Hoffmann

Faculty, Staff and Students Publications

AIMS: Quality-of-care and safety of patients with suspected acute coronary syndrome (ACS) would benefit if management was independent of which high-sensitivity cardiac troponin (hs-cTn) assay was used for risk stratification. We aimed to determine the concordance of hs-cTn assays to risk-stratify patients with suspected ACS according to the European Society of Cardiology (ESC) 2020 Guidelines.

METHODS AND RESULTS: Blood samples were obtained at arrival and at 2 h from patients with suspected ACS using four hs-cTn assays. The patients were classified into rule-out/observe/rule-in strata based on the ESC 2020 Guidelines. Concordance was determined among the assays for rule-out/observe/rule-in strata. The …

Experiences Of An Inpatient Penicillin Allergy De-Labelling Pathway: Capturing The Patient Voice, Neil Powell, Mathew Upton, Bridie Kent, Jonathan Sandoe, Sarah Tonkin-Crine

School of Nursing and Midwifery

Background: Non-allergist-delivered penicillin allergy de-labelling (PADL) is supported by UK and other national guidelines but is not yet routine practice in UK hospitals. Those who have undergone PADL report high rates of acceptance, but it is unknown why some continue to avoid penicillin, and why some decline testing. Objectives: To explore the experiences of patients recently approached for penicillin allergy (penA) assessment and de-label by non-allergists in a UK hospital to determine the barriers and enablers to patient acceptance of PADL. Methods: Qualitative study using semi-structured interviews with patients who were penA assessed and delabelled during an inpatient stay between …

Gain: An Integrative Tool Utilizing Generative Adversarial Neural Networks For Augmented Gene Expression Analysis, Michael R Waters, Matthew Inkman, Kay Jayachandran, Roman M Kowalchuk, Clifford Robinson, Julie K Schwarz, S Joshua Swamidass, Obi L Griffith, Jeffrey J Szymanski, Jin Zhang

2020-Current year OA Pubs

Big genomic data and artificial intelligence (AI) are ushering in an era of precision medicine, providing opportunities to study previously under-represented subtypes and rare diseases rather than categorize them as variances. However, clinical researchers face challenges in accessing such novel technologies as well as reliable methods to study small datasets or subcohorts with unique phenotypes. To address this need, we developed an integrative approach, GAiN, to capture patterns of gene expression from small datasets on the basis of an ensemble of generative adversarial networks (GANs) while leveraging big population data. Where conventional biostatistical methods fail, GAiN reliably discovers differentially expressed …

Srf-Deficient Astrocytes Provide Neuroprotection In Mouse Models Of Excitotoxicity And Neurodegeneration, Surya Chandra Rao Thumu, Monika Jain, Sumitha Soman, Soumen Das, Vijaya Verma, Arnab Nandi, David H Gutmann, Balaji Jayaprakash, Deepak Nair, James P Clement, Swananda Marathe, Narendrakumar Ramanan

2020-Current year OA Pubs

Reactive astrogliosis is a common pathological hallmark of CNS injury, infection, and neurodegeneration, where reactive astrocytes can be protective or detrimental to normal brain functions. Currently, the mechanisms regulating neuroprotective astrocytes and the extent of neuroprotection are poorly understood. Here, we report that conditional deletion of serum response factor (SRF) in adult astrocytes causes reactive-like hypertrophic astrocytes throughout the mouse brain. These

Investigating The Genetic Makeup Of The Major Histocompatibility Complex (Mhc) In The United Arab Emirates Population Through Next-Generation Sequencing, Nour A. D. Marzouka, Halima Alnaqbi, Amira Al-Aamri, Guan Tay, Habiba Alsafar

Research outputs 2022 to 2026

The Human leukocyte antigen (HLA) molecules are central to immune response and have associations with the phenotypes of various diseases and induced drug toxicity. Further, the role of HLA molecules in presenting antigens significantly affects the transplantation outcome. The objective of this study was to examine the extent of the diversity of HLA alleles in the population of the United Arab Emirates (UAE) using Next-Generation Sequencing methodologies and encompassing a larger cohort of individuals. A cohort of 570 unrelated healthy citizens of the UAE volunteered to provide samples for Whole Genome Sequencing and Whole Exome Sequencing. The definition of the …

Large Airway T Cells In Adults With Former Bronchopulmonary Dysplasia, Jing Gao, Petra Um-Bergström, Melvin Pourbazargan, Eva Berggren-Broström, Chuan X. Li, Heta Merikallio, Riitta Kaarteenaho, Nichole S. Reinke, Craig E. Wheelock, Erik Melén, Lindén Anders, Åsa M. Wheelock, Georgios Rassidakis, Cristian Ortiz-Villalon, Magnus C. Sköld

Research outputs 2022 to 2026

Background: Bronchopulmonary Dysplasia (BPD) in infants born prematurely is a risk factor for chronic airway obstruction later in life. The distribution of T cell subtypes in the large airways is largely unknown.

Objective: To characterize cellular and T cell profiles in the large airways of young adults with a history of BPD.

Methods: Forty-three young adults born prematurely (preterm (n = 20), BPD (n = 23)) and 45 full-term-born (asthma (n = 23), healthy (n = 22)) underwent lung function measurements, and bronchoscopy with large airway bronchial wash (BW). T-cells subsets in BW were analyzed by immunocytochemistry.

Results: The proportions …

Detection And Relative Quantitation Of Changes In Gene Expression Of Hippo Proteins In Doxorubicin-Exposed Human Cells By Rt-Qpcr, Lillian Fleisher, Tricia Domingo, Christopher So, Stephen Lee

Annual Research Symposium

The HIPPO signaling pathway plays a key role in cell proliferation and tumor suppression. It consists of serine/threonine kinase cascades, including MST1/2, LATS1/2, YAP, and TAZ. When the HIPPO pathway is activated, gene expression is altered. Dysfunction of the activity of this cascade may contribute to cancer development and chemoresistance. FAT4 is an intracellular protein that may regulate the HIPPO signaling. The purpose of this study is to determine the relative changes of mRNA of the HIPPO pathway members and FAT4 in doxorubicin-treated and vehicle-treated in vitro cell lines.