Digital Commons Network^™

Designing Effective E-Learning Modules: Exploring Best Practices In Module Navigation, Stacie Mae Larreau Christensen, Lukas Pohlmann, Elizabeth Lyden, Elizabeth L. Beam, Stephanie Langel

Posters and Presentations: Physical Therapy

No abstract provided.

Oxytocin-Induced Birth Causes Sex-Specific Behavioral And Brain Connectivity Changes In Developing Rat Offspring, Tusar Giri, Susan E Maloney, Saswat Giri, Young Ah Goo, Jong Hee Song, Minsoo Son, Eric Tycksen, Sara B Conyers, Annie Bice, Xia Ge, Joel R Garbow, James D Quirk, Adam Q Bauer, Arvind Palanisamy

2020-Current year OA Pubs

Despite six decades of the use of exogenous oxytocin for management of labor, little is known about its effects on the developing brain. Motivated by controversial reports suggesting a link between oxytocin use during labor and autism spectrum disorders (ASDs), we employed our recently validated rat model for labor induction with oxytocin to address this important concern. Using a combination of molecular biological, behavioral, and neuroimaging assays, we show that induced birth with oxytocin leads to sex-specific disruption of oxytocinergic signaling in the developing brain, decreased communicative ability of pups, reduced empathy-like behaviors especially in male offspring, and widespread sex-dependent …

Examining The Impact Of A Health Report Card On Follow Through With Fall Risk Recommendations: An Observational Study, Abigail L Kehrer-Dunlap, Rebecca M Bollinger, Brianna Holden, Beau M Ances, Susan Stark

2020-Current year OA Pubs

BACKGROUND: Increasing older adults' awareness of their personal fall risk factors may increase their engagement in fall prevention. The purpose of this study was to explore the impact of and participant satisfaction with a comprehensive occupational therapy fall risk screening and recommendations for evidence-based fall prevention strategies based on personalized fall risk results for community-dwelling older adults.

METHODS: Cognitively normal participants (Clinical Dementia Rating = 0) were recruited from an ongoing longitudinal study of memory and aging. Participants completed 2 annual in-home visits, fall risk questionnaires, and 12 months of fall monitoring between visits. Participants received a health report card …

Evaluation Of Emotional Well-Being In Hospitalized Children Using Their Own Drawings, Alev Üstündağ

Journal of Social, Behavioral, and Health Sciences

Hospitalization can influence a child’s psychological well-being. This study aimed to evaluate the emotional well-being of hospitalized children using their own drawings. Sixty hospitalized children between the ages of 4 to 13 were used for this study, and data were collected using the pictures drawn by the children. The content analysis method was used to analyze data. Data analysis showed that hospitalized children generally did not show age-appropriate developmental characteristics at the drawing development stage; hospitalized children in the younger age groups used more colors and drew happier human figures; and older hospitalized children used fewer colors, and the emotions …

Symphonic Winds, February 16, 2024, Mack Wood, Christopher Bulding, Jillian Kouzel

School of Music Programs

Center for the Performing Arts
February 16, 2024
Friday Evening
8:00 p.m.

Predictive Criterion Validity Of The Parsley Symptom Index Against The Patient-Reported Outcomes Measurement Information System-10 In A Chronic Disease Cohort: Retrospective Cohort Study, Hants Williams, Sarah Steinberg, Kendall Leon, Ryan Vingum, Mengyao Hu, Robin Berzin, Heather Hagg, Patrick Hanaway

Faculty, Staff and Student Publications

BACKGROUND: Approximately 60% of US adults live with chronic disease, imposing a significant burden on patients and the health care system. With the rise of telehealth, patient-reported outcomes measures (PROMs) have emerged as pivotal tools for managing chronic disease. While numerous PROMs exist, few have been designed explicitly for telehealth settings. The Parsley Symptom Index (PSI) is an electronic patient-reported outcome measure (ePROM) developed specifically for telehealth environments.

OBJECTIVE: Our aim is to determine whether the PSI predicts changes in the established Patient-Reported Outcomes Measurement Information System-10 (PROMIS-10) Global Health, a 10-question short form.

METHODS: We conducted a retrospective cohort …

Exploring The Relationship Among Clinical Judgment, Academic Resiliency, Student Predictors, And Exam Remediation In Prelicensure Nuring Students Preparing For Next Generation National Council Licensure Examination [For] Registered Nurses, James F. Oberlander

Dissertations

As the field of nursing becomes increasingly more complex, nursing students are psychologically challenged as they progress through a program of study, prepare for the licensure examination, and enter professional practice. Identifying factors that influence student outcomes is necessary for faculty to effectively guide students toward successful completion of nursing school and passing the National Council Licensure Exam for Registered Nurses (NCLEX-RN). Along with academic and nonacademic demographic variables, the main objective of this exploratory, quantitative research study was to investigate the relationship between clinical judgement, academic resiliency, exam remediation, and NCLEX-RN first attempt pass rates.

Transition Education Designees’ Perceptions Of Implementing Effective Transition Services For High School Students With Autism Spectrum Disorder, Cynthia Kososki

Walden Dissertations and Doctoral Studies

This project study focused on the inconsistencies in transition planning for students with autism spectrum disorders (ASD) by teachers serving as transition education designees (TEDs) in a specific local region of a southern state. Guided by Schlossberg’s transition theory, the purpose of this study was to gain an understanding of the perceptions of teachers serving as TEDs in a southern state regarding the challenges and resources needed for transitioning students with ASD in that region. The research questions addressed in this study included the TED’s perceptions of implementing effective transition services for students with ASD and the perceived challenges they …

The Effects Of Communication, Knowledge Sharing, And Trust On Agile Virtual Team Effectiveness, Ivana Pino

Walden Dissertations and Doctoral Studies

Ongoing globalization and the evolution of technology in the workplace reinforce the need for virtual teamwork. Individuals working together across the globe comprise virtual teams. Many teams across industries value and use agile methodology to manage their projects. Research shows that agile virtual teams face challenges based on social and organizational problems such as lack of trust, knowledge sharing, and suitable communication. Therefore, this quantitative study aimed to address a gap in the current literature on the effect that communication, trust, and knowledge sharing have on agile virtual team effectiveness. Additionally, the aim was to determine the moderating effect of …

“Do The Right Thing”: Immigrant Perspectives Of Social Worker Support In The United States, Abha Rai, Mary Lehman Held, Melody Huslage, Eliza Galvez, Yigermal Demissie Ayalew, Leia Siksay

Social Work: School of Social Work Faculty Publications and Other Works

Social workers play a distinctive role in serving all communities, especially immigrants. Heightened immigrant stress and deteriorating well-being have been reported amid recent anti-immigrant socio-political climate. Given the unique challenges of immigrants, they have distinct needs. In our study, we utilize data from a larger study including a sample of first- and second-generation immigrants, to understand “How can social workers support immigrant communities?” In total, N = 265 participants responded to this prompt. We employed a content analysis approach to analyze participant responses. Our analysis yielded four main themes: (1) Resources for immigrants, (2) Doing right by immigrants, (3) Advocacy, …

Strategies To Combine 3d Vasculature And Brain Cta With Deep Neural Networks: Application To Lvo, Uma M Lal-Trehan Estrada, Arnau Oliver, Sunil A Sheth, Xavier Lladó, Luca Giancardo

Faculty, Staff and Student Publications

Automated tools to detect large vessel occlusion (LVO) in acute ischemic stroke patients using brain computed tomography angiography (CTA) have been shown to reduce the time for treatment, leading to better clinical outcomes. There is a lot of information in a single CTA and deep learning models do not have an obvious way of being conditioned on areas most relevant for LVO detection, i.e., the vasculature structure. In this work, we compare and contrast strategies to make convolutional neural networks focus on the vasculature without discarding context information of the brain parenchyma and propose an attention-inspired strategy to encourage this. …

A Small Molecule With Big Impact: Mrtx1133 Targets The Krasg12d Mutation In Pancreatic Cancer, Daoyan Wei, Liang Wang, Xiangsheng Zuo, Anirban Maitra, Robert S Bresalier

Faculty, Staff and Student Publications

KRAS mutations drive oncogenic alterations in numerous cancers, particularly in human pancreatic ductal adenocarcinoma (PDAC). About 93% of PDACs have KRAS mutations, with G12D (∼42% of cases) and G12V (∼32% of cases) being the most common. The recent approval of sotorasib (AMG510), a small-molecule, covalent, and selective KRASG12C inhibitor, for treating patients with non-small cell lung cancer represents a breakthrough in KRAS targeted therapy. However, there is a need to develop other much-needed KRAS-mutant inhibitors for PDAC therapy. Notably, Mirati Therapeutics recently developed MRTX1133, a small-molecule, noncovalent, and selective KRASG12D inhibitor through extensive structure-based drug design. MRTX1133 has demonstrated potent …

Sting Licensing Of Type I Dendritic Cells Potentiates Antitumor Immunity, Jian Wang, Suxin Li, Maggie Wang, Xu Wang, Shuqing Chen, Zhichen Sun, Xiubao Ren, Gang Huang, Baran D Sumer, Nan Yan, Yang-Xin Fu, Jinming Gao

Faculty, Staff and Student Publications

Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP (cGAMP) in response to self or microbial cytosolic DNA as a danger signal. STING is ubiquitously expressed in diverse cell populations including cancer cells with distinct cellular functions such as activation of type I interferons, autophagy induction, or triggering apoptosis. It is not well understood whether and which subsets of immune cells, stromal cells, or cancer cells are particularly important for STING-mediated antitumor immunity. Here using a polymeric STING-activating nanoparticle (PolySTING) with a “shock-and-lock” dual activation mechanism, we show type 1 conventional dendritic cell (cDC1) is …

Mutant P53 Protects Triple-Negative Breast Adenocarcinomas From Ferroptosis In Vivo, Denada Dibra, Shunbin Xiong, Sydney M Moyer, Adel K El-Naggar, Yuan Qi, Xiaoping Su, Elisabeth K Kong, Anil Korkut, Guillermina Lozano

Faculty, Staff and Student Publications

The TP53 tumor suppressor gene is mutated early in most of the patients with triple-negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations that contribute to tumor aggressiveness. Here, we used an autochthonous somatic TNBC mouse model, in which mutant p53 can be toggled on and off genetically while leaving the tumor microenvironment intact and wild-type for p53 to identify physiological dependencies on mutant p53. In TNBCs that develop in this model, deletion of two different hotspot p53R172H and p53R245W mutants triggers ferroptosis in vivo, a cell death mechanism involving iron-dependent lipid peroxidation. Mutant p53 protects cells …

Inter-Individual Variations In Circadian Misalignment-Induced Nafld Pathophysiology In Mice, Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Isao Tokuda, Yoshiki Tsuchiya, Yuh Sasawaki, Atsushi Umemura, Naoko Masuzawa, Kazuya Yabumoto, Takashi Seya, Akira Sugimoto, Seung-Hee Yoo, Zheng Chen, Kazuhiro Yagita

Faculty, Staff and Student Publications

Pathological consequences of circadian misalignment, such as shift work, show considerable individual differences, but the lack of mechanistic understanding hinders precision prevention to prevent and mitigate disease symptoms. Here, we employed an integrative approach involving physiological, transcriptional, and histological phenotypes to examine inter-individual differences in pre-symptomatic pathological progression, preceding irreversible disease onset, in wild-type mice exposed to chronic jet-lag (CJL). We observed that CJL markedly increased the prevalence of hepatic steatosis with pronounced inter-individual differences. Stratification of individual mice based on CJL-induced hepatic transcriptomic signature, validated by histopathological analysis, pinpoints dysregulation of lipid metabolism. Moreover, the period and power of …

Backfilling Patients In Phase I Dose-Escalation Trials Using Bayesian Optimal Interval Design (Boin), Yixuan Zhao, Ying Yuan, Edward L Korn, Boris Freidlin

Faculty, Staff and Student Publications

In recent years, there has been increased interest in incorporation of backfilling into dose-escalation clinical trials, which involves concurrently assigning patients to doses that have been previously cleared for safety by the dose-escalation design. Backfilling generates additional information on safety, tolerability, and preliminary activity on a range of doses below the maximum tolerated dose (MTD), which is relevant for selection of the recommended phase II dose and dose optimization. However, in practice, backfilling may not be rigorously defined in trial protocols and implemented consistently. Furthermore, backfilling designs require careful planning to minimize the probability of treating additional patients with potentially …

Neoadjuvant Trebananib Plus Paclitaxel-Based Chemotherapy For Stage Ii/Iii Breast Cancer In The Adaptively Randomized I-Spy2 Trial-Efficacy And Biomarker Discovery, Kathy S Albain, Christina Yau, Emanuel F Petricoin, Denise M Wolf, Julie E Lang, A Jo Chien, Tufia Haddad, Andres Forero-Torres, Anne M Wallace, Henry Kaplan, Lajos Pusztai, David Euhus, Rita Nanda, Anthony D Elias, Amy S Clark, Constantine Godellas, Judy C Boughey, Claudine Isaacs, Debu Tripathy, Janice Lu, Rachel L Yung, Rosa I Gallagher, Julia D Wulfkuhle, Lamorna Brown-Swigart, Gregor Krings, Yunn Yi Chen, David A Potter, Erica Stringer-Reasor, Sarah Blair, Smita M Asare, Amy Wilson, Gillian L Hirst, Ruby Singhrao, Meredith Buxton, Julia L Clennell, Ashish Sanil, Scott Berry, Adam L Asare, Jeffrey B Matthews, Angela M Demichele, Nola M Hylton, Michelle Melisko, Jane Perlmutter, Hope S Rugo, W Fraser Symmans, Laura J Van't Veer, Douglas Yee, Donald A Berry, Laura J Esserman

Faculty, Staff and Student Publications

Purpose: The neutralizing peptibody trebananib prevents angiopoietin-1 and angiopoietin-2 from binding with Tie2 receptors, inhibiting angiogenesis and proliferation. Trebananib was combined with paclitaxel±trastuzumab in the I-SPY2 breast cancer trial.

Patients and methods: I-SPY2, a phase II neoadjuvant trial, adaptively randomizes patients with high-risk, early-stage breast cancer to one of several experimental therapies or control based on receptor subtypes as defined by hormone receptor (HR) and HER2 status and MammaPrint risk (MP1, MP2). The primary endpoint is pathologic complete response (pCR). A therapy "graduates" if/when it achieves 85% Bayesian probability of success in a phase III trial within a given subtype. …

Persona Journey Mapping To Drive Equity During An Lms Transition, Kam Moi Lee, Kari Goin Kono, Megan Mcfarland

Office of Academic Innovation Publications

Technology systems that support learning–such as Learning Management Systems, or LMS’s–can change frequently in higher education. This often creates significant challenges for faculty-support staff during a transition–or migration–period. When equitable practice is deprioritized during these migrations, there is a high chance that stakeholders will experience adoption resistance, putting the project’s success and subsequent student experience at risk. Using a vignette and case study qualitative methodological approach, three researchers at a large urban university in the Pacific Northwest detail personas and journey mapping as an equitable design practice during a LMS migration on a rapid development timeline. This paper details how …

Circulating Microrna Panel For Prediction Of Recurrence And Survival In Early-Stage Lung Adenocarcinoma, Mei-Chee Tai, Leonidas E Bantis, Gargy Parhy, Taketo Kato, Ichidai Tanaka, Chi-Wan Chow, Junya Fujimoto, Carmen Behrens, Tetsunari Hase, Koji Kawaguchi, Johannes F Fahrmann, Edwin J Ostrin, Kohei Yokoi, Toyofumi F Chen-Yoshikawa, Yoshinori Hasegawa, Samir M Hanash, Ignacio I Wistuba, Ayumu Taguchi

Faculty, Staff and Student Publications

Early-stage lung adenocarcinoma (LUAD) patients remain at substantial risk for recurrence and disease-related death, highlighting the unmet need of biomarkers for the assessment and identification of those in an early stage who would likely benefit from adjuvant chemotherapy. To identify circulating miRNAs useful for predicting recurrence in early-stage LUAD, we performed miRNA microarray analysis with pools of pretreatment plasma samples from patients with stage I LUAD who developed recurrence or remained recurrence-free during the follow-up period. Subsequent validation in 85 patients with stage I LUAD resulted in the development of a circulating miRNA panel comprising miR-23a-3p, miR-320c, and miR-125b-5p and …

Development Of A Practical Nomogram For Personalized Anemia Management In Patients Treated With Ataxia Telangiectasia And Rad3-Related Inhibitor Camonsertib, Ezra Rosen, Timothy A Yap, Elizabeth K Lee, Martin Højgaard, Niharika B Mettu, Stephanie Lheureux, Benedito A Carneiro, Ruth Plummer, Adrian J Fretland, Danielle Ulanet, Yi Xu, Robin Mcdougall, Maria Koehler, Elisa Fontana

Faculty, Staff and Student Publications

PURPOSE: Camonsertib is a highly selective and potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Dose-dependent anemia is a class-related on-target adverse event often requiring dose modifications. Individual patient risk factors for the development of significant anemia complicate the selection of a "one-size-fits-all" ATR inhibitor (ATRi) dose and schedule, possibly leading to suboptimal therapeutic doses in patients at low risk of anemia. We evaluated whether early predictors of anemia could be identified to ultimately inform a personalized dose-modification approach.

PATIENTS AND METHODS: On the basis of preclinical observations and a mechanistic understanding of ATRi-related anemia, we identified several potential …

Administrators’ Perceptions Of School Resource Officers’ Preparedness To Work With Black Girls, Kashon N. Lopes

Seton Hall University Dissertations and Theses (ETDs)

School safety is a topic of concern across the nation today because images of mass shootings and violence in schools receive heavy media coverage. Different strategies have been enacted to keep people safe including metal detectors, video surveillance, strict discipline policies, and armed personnel. Some of these strategies such as zero tolerance policies and school resource officers have received scrutiny from activist groups such the American Civil Liberties Union because they are attributed with the trend known as the school-to-prison pipeline (ACLU, 2013). This trend poses that strict policies and the presence of law enforcement in schools pushes minority children …

Stigma On Mental Illness And Help-Seeking Among Nigerians In The United States, Olabode Akinbobola

Walden Dissertations and Doctoral Studies

Although the number of Nigerian immigrants to the United States has increased in the past few years, few studies have explored their mental health experiences. This study explored the lived experience of Nigerian immigrants living in the United States (US). Belief perseverance theory was utilized as a lens of analysis to understand if prior experiences, perceptions, and/or stigma can influence help-seeking behavior and expectations through face-to-face, semi-structured, and audiotaped interviews. The study explored a sample of 10 Nigerian immigrants lived experiences, understanding, perceptions, and stigma of mental illness and whether or not they seek psychological help. Interpretative phenomenological analysis (IPA) …

Virtual Facilitation Best Practices And Research Priorities: A Scoping Review, Asya Agulnik, Derrecka Boykin, Denalee M O'Malley, Julia Price, Mia Yang, Mark Mckone, Geoffrey Curran, Mona J Ritchie

Department of Pediatrics Faculty Papers

BACKGROUND: Facilitation is an implementation strategy that supports the uptake of evidence-based practices. Recently, use of virtual facilitation (VF), or the application of facilitation using primarily video-based conferencing technologies, has become more common, especially since the COVID-19 pandemic. Thorough assessment of the literature on VF, however, is lacking. This scoping review aimed to identify and describe conceptual definitions of VF, evaluate the consistency of terminology, and recommend "best" practices for its use as an implementation strategy.

METHODS: We conducted a scoping review to identify literature on VF following the PRISMA-ScR guidance. A search of PubMed, Embase, Web of Science, and …

" Does Educational Level Affect The Outcome Of Myocardial Infarction? ", Ahmed Magdy Ahmed Elsayed

Theses and Dissertations

Background: Heath awareness plays a major role in determining the outcomes of serious medical conditions specially when response time is crucial. STEMI patients are prone to serious compilations if they didn’t receive the appropriate treatment on time. Raising the health awareness of the community would result in seeking medical help at earlier stage of the disease. Earlier presentation to the medical center would result in better health outcomes. Certain factors form the health awareness of the community. This includes educational level, previous exposure to similar situations, and exposure to health awareness materials.

Methods: This is a cohort study in …

The Student Movement Volume 108 Issue 16: Next On Ai's Conquest List: Love, Savannah Tyler, Erin Beers, Reagan Mccain, Lauren Kim, Aiko J. Ayala Rios, Amelia Stefanescu, Madison Vath, Katie Davis, Andrew Francis, Anna Rybachek, Sumin Lee, Reagan Westerman, Chris Ngugi, Alyssa Caruthers, Scott Moncrieff

The Student Movement v. 108 (2023-2024)

HUMANS

Dr. Hatfield, Interviewed by Savannah Tyler

Is Love Romantic? An Aromantic Perspective, Interviewed by Erin Beers

Student Experiences at the CTC, Interviewed by Reagan McCain

Viral Jesus Podcast with Dr. Heather Thompson Day, Interviewed by Lauren Kim

ARTS & ENTERTAINMENT

Where AI cannot Beat a human... yet - AI in music, Aiko J. Ayala Rios

Artists and AI: A Liberating New Tool or the Beginning of the End?, Reagan McCain

The History of Black History Month at AU, Amelia Stefanescu

Las Cintas Rojas, Reagan McCain

"The Orange" and Finding Love in the Mundane, Madison Vath

NEWS

AI's Changing Landscape, …

2024 Furman University Scholarship Reception Program, Madeline Eastergard, Kathie Sloan

Libraries Institutional Records

On February 16, 2024, the Libraries and the Office of the Provost hosted the Furman University Scholarship Reception. The reception showcased scholarly publications, creative works, and professional accomplishments of Furman faculty or staff from the 2024 calendar year. It highlighted Furman faculty and staff who completed a degree, received a grant from an external funding source totaling more than $1,000, and/or published books, book chapters, journal articles, exhibits, recordings, performances, films, or other works. The following Furman presenters provided four-minute speeches about their scholarly or creative works:

• Chris Alvin, Associate Professor of Computer Science
• Caroline Davis, Assistant Professor of Theatre …

Epidemiology And Survival Factors Of Appendicular Myxofibrosarcoma: A Seer-Retrospective Study, Juan Pretell

All Publications

Background: The low incidence of myxofibrosarcoma (MFS) makes high power studies difficult to perform. Demographic and prognostic factors for MFS and how they differ from all extremity soft tissue sarcomas (STS) are not well understood. The purpose of this study was to characterize a large cohort of patients with MFS and evaluate epidemiologic and survival factors when compared to all STS.

Materials and methods: We performed a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) database from 2000 to 2015 to identify 1,440 patients diagnosed with MFS and 12,324 with STS. Survival curves were creased using Kaplan-Meier, and …

Board Of Trustees Minutes, Feb. 16 2024, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Cpsf3 Inhibition Blocks Pancreatic Cancer Cell Proliferation Through Disruption Of Core Histone Mrna Processing, Abdulrahman A Alahmari, Aditi H Chaubey, Venkata S Jonnakuti, Arwen A Tisdale, Carla D Schwarz, Abigail C Cornwell, Kathryn E Maraszek, Emily J Paterson, Minsuh Kim, Swati Venkat, Eduardo Cortes Gomez, Jianmin Wang, Katerina V Gurova, Hari Krishna Yalamanchili, Michael E Feigin

Faculty, Staff and Students Publications

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited effective treatment options, potentiating the importance of uncovering novel drug targets. Here, we target cleavage and polyadenylation specificity factor 3 (CPSF3), the 3′ endonuclease that catalyzes mRNA cleavage during polyadenylation and histone mRNA processing. We find that CPSF3 is highly expressed in PDAC and is associated with poor prognosis. CPSF3 knockdown blocks PDAC cell proliferation and colony formation in vitro and tumor growth in vivo. Chemical inhibition of CPSF3 by the small molecule JTE-607 also attenuates PDAC cell proliferation and colony formation, while it has no effect on cell proliferation …

Setting Research Priorities For Global Pandemic Preparedness: An International Consensus And Comparison With Chatgpt’S Output, Peige Song, Davies Adeloye, Chulwoo Park, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Background

In this priority-setting exercise, we sought to identify leading research priorities needed for strengthening future pandemic preparedness and response across countries.

Methods

The International Society of Global Health (ISoGH) used the Child Health and Nutrition Research Initiative (CHNRI) method to identify research priorities for future pandemic preparedness. Eighty experts in global health, translational and clinical research identified 163 research ideas, of which 42 experts then scored based on five pre-defined criteria. We calculated intermediate criterion-specific scores and overall research priority scores from the mean of individual scores for each research idea. We used a bootstrap (n = 1000) to …