Digital Commons Network^™

Experience With A Hybrid Recruitment Approach Of Patient-Facing Web Portal Screening And Subsequent Phone And Medical Record Review For A Neurosurgical Intervention Trial For Chronic Ischemic Stroke Disability (Pisces Iii), Brad J Kolls, Keith W Muir, Sean I Savitz, Lawrence R Wechsler, Julie G Pilitsis, Scott Rahimi, Richard L Beckman, Vincent Holmes, Peng R Chen, David S Albers, Daniel T Laskowitz

Faculty, Staff and Student Publications

BACKGROUND: Recruitment of participants is the greatest risk to completion of most clinical trials, with 20-40% of trials failing to reach the targeted enrollment. This is particularly true of trials of central nervous system (CNS) therapies such as intervention for chronic stroke. The PISCES III trial was an invasive trial of stereotactically guided intracerebral injection of CTX0E03, a fetal derived neural stem cell line, in patients with chronic disability due to ischemic stroke. We report on the experience using a novel hybrid recruitment approach of a patient-facing portal to self-identify and perform an initial screen for general trial eligibility (tier …

Covid-19 Infection Increases The Development Of Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis: A Retrospective Cohort Analysis, Kristen K. Curtis, Meghan M. Dillan, Timmie R. Sharma, Joseph Piktel

Student Scholarship

To the Editor: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a spectrum of severe mucocutaneous reactions characterized by extensive epidermal detachment, most commonly due to medications.1 Some viruses, such as the human immunodeficiency virus, have been found to be an independent risk factor for the development of SJS and TEN, though the mechanism is not completely understood.2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus identified in late 2019, is most commonly associated with mild respiratory illness. However, cutaneous manifestations, including SJS and TEN, have been increasingly reported during and after COVID-19 infection.3 Therefore, the objective …

Goal Attainment And Quality Of Life Through Inclusive College, Kate Strater, Mia Kurkechian, Kassandra Weber

University Faculty Publications and Creative Works

With growing opportunity for students with intellectual and developmental disability to access a variety of inclusive higher education programs comes an increased need for program implementers to evaluate practices and outcomes alongside participants. This mixed method, exploratory study examines self-determined goal setting, goal attainment, and quality of life within an inclusive college program as a measure of participant outcome and program evaluation. Furthermore, it provides implications for the importance of self-determined learning and participant voice within program planning, revision, and implementation.1

Re: Silver Bow Creek Butte Area Npl Site 4th Quarter 2023 Butte Priority Soils Operable Unit Interim Site-Wide Surface Water Monitoring Data Report. Consent Decree- Civil Action No. Cv 89- 039-Bu-She, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Midweek Memo, Georgia Southern University

Midweek Memo

No abstract provided.

Acceptance And Commitment Therapy (Act) Among U.S. Veterans: A Systematic Review, Marissa L. Donahue, Jeremiah E. Fruge, Felicia J. Andresen, Michael P. Twohig

Psychology Faculty Publications

Veterans of the United States military represent a large sample of the population and a distinctive culture. Veterans have a high prevalence rate of a variety of psychological disorders and disabilities. Research on treatments that meet the needs of this culturally unique group is essential. Acceptance and Commitment Therapy (ACT) may meet this need with its unified treatment approach and its focus on functioning rather than diagnosis. In this study we examine the current state of the literature of ACT for U.S. Veterans. A systematic review of 249 papers found 34 unique relevant studies involving 21 single arm studies, eight …

Faculty Senate Minutes, Georgia Southern University, Faculty Senate

Faculty Senate Minutes

No abstract provided.

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Residential Metals Abatement Program (Rmap) Construction Completion Report (Non-Residential Parcels – Indoor Soil) – Butte High School (Dated February 12, 2024), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

A Need For Daycare Unit For Sickle Cell Disease Patients In Oman, Wafa K. Al-Majarfi

Sultan Qaboos University Medical Journal

No abstract provided.

A Scoping Review Of The Biological, Socioeconomic And Environmental Determinants Of Overweight And Obesity Among Middle Eastern And Northern African Nationalities, Glenn Fd Valdez, Muna Ajzoon, Noor Al Zuwameri

Sultan Qaboos University Medical Journal

Objectives: Globally, and particularly in the Middle East and North Africa (MENA) region, overweight and obesity have become serious public health concerns. This scoping review aimed to identify and summarise the available data on the determinants of overweight and obesity among MENA nationalities. Methods: An extensive search of electronic databases, including Google Scholar, PubMed and ProQuest, for articles published from 2007 until 2022 was conducted. A total of 10 articles, of the 333 that were found in the original search, met the inclusion criteria. Data extraction and quality assessment were applied to each of the selected studies. Results: There is …

Frequency Of Dimethyl Fumarate-Induced Lymphopenia Among Omani Patients With Multiple Sclerosis, Ahmed Jaboob, Abdullah Al Asmi, M Mazharul Islam, Syed Rezvi, Iman Redha, Jaber Al-Khabouri, Ibrahim Al-Zakwani, Ahmed Al-Qassabi, Haifa Al-Abri, Arunodaya R. Gujjar

Sultan Qaboos University Medical Journal

Objectives: Dimethyl fumarate (DMF) is known to cause lymphopenia when used to treat patients with multiple sclerosis (MS). However, research on DMF therapy in the Arab world, especially in Oman, is scarce. This study aimed to analyse the prevalence of lymphopenia among Omani patients with MS and their reasons for discontinuing DMF therapy. Methods: In this retrospective study, the medical records of Omani patients with MS who were treated using DMF at two tertiary hospitals in Muscat, Oman, from February 2017 to February 2023 were reviewed. Their demographic, clinical and laboratory data were retrieved and analysed. Absolute lymphocyte count values …

Predictors Of Developing A Complex Course Of Osteomyelitis In Patients With Sickle Cell Anaemia, Al Zahra Al Hashmi, Ethar Al Fazari, Mustafa Al Ward, Reema Al Masruri, Shahad Al Balushi, Mohammed Al Mutani, Ahmed Al Ghaithi, Wafa Al Baluki

Sultan Qaboos University Medical Journal

Objectives: Despite the numerous advances in management strategies, treating osteomyelitis in individuals with sickle cell disease (SCD) remains a significant challenge, leading to severe long-term consequences. This study aimed to assess the key factors potentially linked to a complex progression of osteomyelitis in patients diagnosed with SCD. Methods: A cohort of 34 patients was identified and their progress was monitored over a span of 12 months during a 10-year period (2010–2020). The variables under investigation encompassed demographic and clinical traits, laboratory analyses and imaging data, as well as the treatment strategies employed. Results: The risk prediction model pinpointed 5 factors …

Frequency Of Asthma Exacerbations And Upper Respiratory Tract Infections Among Adults With Asthma According To Vaccination Status: Does The Annual Influenza Vaccine Have A Protective Effect?, Zalkha Al Kharusi, Rahma Al Kalbani, Rahma Al-Hadhrami

Sultan Qaboos University Medical Journal

Objectives: Annual influenza vaccinations are recommended for asthma patients to prevent seasonal influenza and influenza-triggered asthma exacerbations. However, data on the beneficial effect of this vaccine on the frequency of asthma exacerbations are conflicting. Therefore, this study aimed to assess the effectiveness of the influenza vaccine in terms of reducing the frequency of asthma-related exacerbations and upper respiratory tract infections among adult patients with asthma. Methods: This retrospective cohort study was performed from January to December 2018 in Muscat Governorate, Oman. A total of 466 patients attending 9 randomly selected primary health centres in Muscat Governorate were enrolled in the …

The Effects Of Different Storage Conditions On Leukocytes In Human Breast Milk, Diah K. Putri, Rahimi Syaidah, Ahmad A. Jusuf

Sultan Qaboos University Medical Journal

Objectives: Breast milk is the best baby food because it contains various nutrients and important factors for the baby's immune system, including leukocytes. This study aimed to determine the effects on morphology, number of cells and breast milk leukocytes count of various ways of storing breast milk based on different temperatures and storage durations. Methods: This study was conducted at the Biochemistry Laboratory, Integrated Laboratory and the Histology Laboratory, Universitas Indonesia, Jakarta, Indonesia from September 2022 to February 2023. Transitional breast milk samples from 7 breastfeeding mothers were utilised in the study. A total of 50 mL was divided into …

Adherence To Medications In Patients With Ischaemic Heart Disease In Oman, Ahmed Al-Maskari, Qasim Al-Maamari, Mariya Al-Abdali, Hajer Al-Shaaibi, Sunil K. Nadar

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate the level of adherence to medication among patients with ischaemic heart disease (IHD) in Oman and assess the related factors. Methods: This cross-sectional questionnaire-based study among patients with IHD attending the outpatient clinic at Sultan Qaboos University Hospital, Muscat, Oman, was performed between January and December 2021. Results: A total of 105 patients (mean age = 49.9 ± 11.1 years, 78.1% male) were recruited. Most of the patients (80%) reported taking the medications by themselves; 77 (73.3%) patients said that over the preceding 2 weeks, they had missed at least 3 doses of their …

Successful Treatment Of A Case Of Crescentic Glomerulonephritis In A Patient With Primary Peritoneal Carcinoma: A Case Report, Aref Zribi, Amro Nagy, Marwa Al Riyami, Ikram A. Burney

Sultan Qaboos University Medical Journal

Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to a tertiary care centre, Muscat, Oman, in 2022. She developed combined immune complex-mediated glomerulonephritis and pauci-immune necrotising crescentic vasculitis simultaneously with the diagnosis of tubo-ovarian/peritoneal cancer. The baseline estimated glomerular filtration rate (eGFR) was 13 mL/min. The patient received two doses of rituximab and three doses of pulse corticosteroids, leading to significant improvement in renal function and the disappearance of her proteinuria. The eGFR improved to >60mL/min; …

Protracted Chemical Peritonitis Following Laparoscopy For Dermoid Cyst: A Management Dilemma, Miriam G. Fenn, Sreedharan V. Koliyadan, Lovina Machado, Shahila Sheik, Nihal Al Riyami

Sultan Qaboos University Medical Journal

Dermoid cysts are common benign ovarian tumours arising from totipotent germ cells. We report a rare case of chemical peritonitis and prolonged fever following laparoscopic salpingo-oophorectomy for torsion of a large ovarian dermoid and discuss the management of this patient with prolonged hospital stay, antibiotics and anti-inflammatory use, repeated drainage of the collection as well as re-laparotomy. The occurrence of this rare condition can be extremely distressing for the patient and treating surgeon alike, as the recommendations for management are limited. The management of chemical peritonitis may require one or more surgical procedures along with prolonged anti-inflammatory therapy.

Keywords: Peritonitis; …

Ramsay Hunt Syndrome Associated With Varicella-Zoster Virus Encephalitis In A Child, Eman Y. Ahmed, Hatem Al Rawahi, Fatema Al Amrani, Laila Al Masaoudi, Laila Al Yazidi

Sultan Qaboos University Medical Journal

Ramsay Hunt syndrome (RHS) is a triad of peri-auricular pain, ipsilateral facial nerve palsy and vesicular rash around the ear pinna. It is caused by reactivation of varicella-zoster virus (VZV) that lies dormant in the geniculate ganglia. It can be complicated by VZV encephalitis rarely. We report the case of an 8-year-old previously healthy boy who presented to a tertiary care hospital in Muscat, Oman in 2021 with fever, progressive left ear pain, vesicular rash around his ear pinna and left-sided facial nerve palsy. His course was complicated by VZV encephalitis where he was managed with intravenous (IV) acyclovir and …

An Unusual Presentation Of Choriocarcinoma In A Postmenopausal Woman: A Case Report, Aref Zribi, Reem Al Mazroui, Raza Sayani, Ikram A. Burney

Sultan Qaboos University Medical Journal

Choriocarcinoma (CC) is a malignant neoplasm of the trophoblastic tissue, with a potential to metastasise to distant organs. Limited case of gestational CC develops after a long latent period. We report a 52-year-old postmenopausal woman who developed metastatic choriocarcinoma presumably of gestational origin, 8 years after the last pregnancy and 2 years after the last menstrual period. The patient was brought to the emergency room of a tertiary care centre in Muscat, Oman, in 2022 and was diagnosed with CC metastatic to the brain, spleen, lung and the kidney. The β-human chorionic gonadotrophin level was found to be raised (1,292,867 …

Silver Bow Creek Butte Area Npl Site 4th Quarter 2023 Butte Priority Soils Operable Unit Interim Site-Wide Surface Water Monitoring Data Report. Consent Decree- Civil Action No. Cv 89-039-Bu-She, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2024-02-28 The State Of Sgsu: Resignations And Redirection, Caleb Stipkovits, Sam Bunn, Abdullah El-Sherbeeny

The Spectator Online

No abstract provided.

Circular Stag2 Rna Modulates Bladder Cancer Progression Via Mir-145-5p/Tagln2 And Is Considered As A Biomarker For Recurrence, Chris Du, Wayne C Waltzer, Jeremy E Wilusz, Massimiliano Spaliviero, Frank Darras, Victor Romanov

Faculty, Staff and Students Publications

Simple Summary

Bladder cancer (BCa) is a major urologic malignancy with a high potential for death-threatening complications. Successful treatment relies on timely diagnostics and prediction of clinical outcomes. Molecular markers can be helpful for earlier diagnosis and for making treatment decisions. The biomarker landscape for BCa is not satisfactory yet. The discovery of novel diagnostic indicators for making treatment decisions is critical. Biological fluids are the most convenient and reliable source of these molecules. Circular RNAs (CircRNAs), special non-coding RNAs with a stable structure that are formed by a unique backsplicing process, recently became popular candidates for biomarkers in cancer …

Corrigendum: Navigating Formula Shortages: Associations Of Parental Perspectives On Transitioning To Alternative Infant Formulas For Cow's Milk Protein Allergy During The 2022 National Formula Shortage, Abigail Fabbrini, Andrew Farrar, Jerry M. Brown, Lea V. Oliveros, Jared Florio, Jesse Beacker, Luke Lamos, Jessica V. Baran, Michael Wilsey

Student Publications

[This corrects the article DOI: 10.3389/falgy.2023.1333570.].

Rrm3 And Pif1 Division Of Labor During Replication Through Leading And Lagging Strand G-Quadruplex, Mor Varon, Daniel Dovrat, Jonathan Heuzé, Ioannis Tsirkas, Saurabh P Singh, Philippe Pasero, Roberto Galletto, Amir Aharoni

2020-Current year OA Pubs

Members of the conserved Pif1 family of 5'-3' DNA helicases can unwind G4s and mitigate their negative impact on genome stability. In Saccharomyces cerevisiae, two Pif1 family members, Pif1 and Rrm3, contribute to the suppression of genomic instability at diverse regions including telomeres, centromeres and tRNA genes. While Pif1 can resolve lagging strand G4s in vivo, little is known regarding Rrm3 function at G4s and its cooperation with Pif1 for G4 replication. Here, we monitored replication through G4 sequences in real time to show that Rrm3 is essential for efficient replisome progression through G4s located on the leading strand template, …

Meta-Study Of Carbonate Sediment Delivery Rates To Indo-Pacific Coral Reef Islands, Baptiste Ainési, Gerd Masselink, Paul Kench

School of Biological and Marine Sciences

Coral reef islands are amongst the most vulnerable environments to sea-level rise (SLR). Recent physical and numerical modeling studies have demonstrated that overwash processes may enable reef islands to keep up with SLR through island accretion. Sediment supply to these islands from the surrounding reef system is critical in understanding their morphodynamic adjustments, but is poorly constrained due to insufficient knowledge about sediment delivery rates. This paper provides the first estimation of sediment delivery rates to coral reef islands. Analysis of topographic and geochronological data from 28 coral reef islands indicates an average rate of sediment delivery of c. 0.1 …

Current And Emerging Antiviral Agents In The Prevention And Treatment Of Cytomegalovirus In Pediatric Transplant Recipients, Kristen G Valencia Deray, Lara A Danziger-Isakov, Kevin J Downes

Faculty, Staff and Students Publications

Despite current prophylaxis regimens, cytomegalovirus (CMV) is common in hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) and remains a significant cause of morbidity and mortality. Newer antiviral medications are reshaping the landscape for prevention and treatment of CMV DNAemia, infection, and disease. Letermovir is approved for CMV prevention in adult HCT patients and is attractive due to the absence of marrow suppression seen with ganciclovir/valganciclovir. Letermovir should not be routinely used for CMV treatment due to its low threshold for resistance. Maribavir is approved for the treatment of refractory or resistant CMV disease in HCT and SOT recipients …

Energetic Trade-Offs In Migration Decision-Making, Reproductive Effort And Subsequent Parental Care In A Long-Distance Migratory Bird, Alexander R Schindler, Anthony D Fox, Christopher K Wikle, Bart M Ballard, Alyn J Walsh, Seán B A Kelly, Lei Cao, Larry R Griffin, Mitch D Weegman

Faculty, Staff and Student Publications

Migratory species trade-off long-distance movement with survival and reproduction, but the spatio-temporal scales at which these decisions occur are relatively unknown. Technological and statistical advances allow fine-scale study of animal decision-making, improving our understanding of possible causes and therefore conservation management. We quantified effects of reproductive preparation during spring migration on subsequent breeding outcomes, breeding outcomes on autumn migration characteristics and autumn migration characteristics on subsequent parental survival in Greenland white-fronted geese (

Macromolecular Crowding, Phase Separation, And Homeostasis In The Orchestration Of Bacterial Cellular Functions, Begoña Monterroso, William Margolin, Arnold J Boersma, Germán Rivas, Bert Poolman, Silvia Zorrilla

Faculty, Staff and Student Publications

Macromolecular crowding affects the activity of proteins and functional macromolecular complexes in all cells, including bacteria. Crowding, together with physicochemical parameters such as pH, ionic strength, and the energy status, influences the structure of the cytoplasm and thereby indirectly macromolecular function. Notably, crowding also promotes the formation of biomolecular condensates by phase separation, initially identified in eukaryotic cells but more recently discovered to play key functions in bacteria. Bacterial cells require a variety of mechanisms to maintain physicochemical homeostasis, in particular in environments with fluctuating conditions, and the formation of biomolecular condensates is emerging as one such mechanism. In this …

Causal Influence Of Linguistic Learning On Perceptual And Conceptual Processing: A Brain-Constrained Deep Neural Network Study Of Proper Names And Category Terms, Phuc T U Nguyen, Malte R Henningsen-Schomers, Friedemann Pulvermüller

Faculty, Staff and Student Publications

Language influences cognitive and conceptual processing, but the mechanisms through which such causal effects are realized in the human brain remain unknown. Here, we use a brain-constrained deep neural network model of category formation and symbol learning and analyze the emergent model's internal mechanisms at the neural circuit level. In one set of simulations, the network was presented with similar patterns of neural activity indexing instances of objects and actions belonging to the same categories. Biologically realistic Hebbian learning led to the formation of instance-specific neurons distributed across multiple areas of the network, and, in addition, to cell assembly circuits …

Formulating Utopian Pasts: Time As A Coping Method For Lgbtq+ Floridians, Elise M. Kuechle

USF Tampa Graduate Theses and Dissertations

Florida has emerged in recent years as a breeding ground for a new generation of anti-LGBTQ+ legislation. The state has introduced 10 anti-LGBTQ+ laws so far in 2023, touching on issues such as bathroom access, healthcare, and education. This paper analyzes the experiences of queer and transgender people living in Florida to ask: How do LGBTQ+ people in Florida cope phenomenologically with rising anti-LGBTQ+ discrimination? Drawing on data from 22 interviews with LGBTQ+ people situated in and around Florida in 2023, this paper captures a distinct political moment for the people that I spoke with, as anti-LGBTQ+ sentiments continue to …