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Social Identity And Self Determination: A Case Study Exploring What American Indian Elders' Perspectives Of Residential Boarding Schools Tell Us About The Lasting Effect Of Historical And Intergenerational Trauma, Jessica Boyer Mar 2024

Social Identity And Self Determination: A Case Study Exploring What American Indian Elders' Perspectives Of Residential Boarding Schools Tell Us About The Lasting Effect Of Historical And Intergenerational Trauma, Jessica Boyer

Electronic Theses and Dissertations

Historically, American Indian youth have faced educational challenges due to the lack of American Indian perspective in history, culture, and knowledge in public education. Distrust in public education due to Eurocentric educational policy, addressed in this study that provides American Indian elders' experiences for finding solutions to self-identity for American Indian youth. Investigating the historical trauma barriers further addressed implications on the high-school retention of American Indian students. This qualitative case study involved a group of 10 elders, both men and women, who self-identify as Little Shell Chippewa American Indian Elders. Through semistructured interviews, the results of this study spoke …


Coping Strategies And Stress Of The Undergraduate Nursing Student In The Clinical Setting: An Evidence Based Practice Quantitative Study, Ashley Calverley Mar 2024

Coping Strategies And Stress Of The Undergraduate Nursing Student In The Clinical Setting: An Evidence Based Practice Quantitative Study, Ashley Calverley

Electronic Theses and Dissertations

The assessment of perceived stress and coping behaviors related to first-semester clinical might benefit students in nursing education. The assessment of most common coping behaviors and perceived stress related to the clinical setting is essential due to difference in personalities, learning abilities, and coping behaviors among nursing students today. Previous research has suggested the initial clinical period results in adverse outcomes, such as poor academic performance, elevated burnout levels, and diminished personal well-being. These factors are detrimental to academic success in nursing programs. Evidence supports that helping students develop positive stress/coping abilities will aid in adapting in both the academic …


Dispositional Gratitude At Work Predicts Job Satisfaction Of Software Developers, Jordan Gabriel Tate Mar 2024

Dispositional Gratitude At Work Predicts Job Satisfaction Of Software Developers, Jordan Gabriel Tate

Electronic Theses and Dissertations

Software developers can suffer from negative emotions at work and low job satisfaction. Less is known about how positive emotions at work impact software developers. Gratitude is one positive emotion that has predicted job satisfaction in other studies. The purpose of this quantitative correlational study was to explore how gratitude at work predicts job satisfaction among software developers. The broaden-and-build theory of positive emotions and the find-remind-and-bind theory of gratitude guided the study. Participants included 146 software developers who were recruited via LinkedIn using purposive sampling. Participants completed an online survey, including the Gratitude Questionnaire-Six Item Form and the Appreciation …


The Role Of Organizational Leadership In The Success Of Higher Education Institutions: A Portraiture Study On Ashesi University In Ghana, Amanda Childress-Kannan Mar 2024

The Role Of Organizational Leadership In The Success Of Higher Education Institutions: A Portraiture Study On Ashesi University In Ghana, Amanda Childress-Kannan

Electronic Theses and Dissertations

Research shows that higher education institutions in sub-Saharan Africa are severely under-resourced, systemically lack strong leadership, have low enrollment numbers, lack scholarly productivity, and have high rates of attrition and turnover of students and faculty. Higher education institutions in sub-Saharan Africa do not compete well globally, with low research productivity and failure to retain top scholars. Higher education institutions in Ghana are particularly facing this problem: Ghana has a relatively stable government, society, and economy, with less corruption and other malfeasance as compared to other countries in sub-Saharan Africa. Even with these advantages, Ghana generally fails to establish and maintain …


Against The Mainstreaming Of The Term Sex Work: Advocacy With India's Supreme Court, Pravin Patkar Mar 2024

Against The Mainstreaming Of The Term Sex Work: Advocacy With India's Supreme Court, Pravin Patkar

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.


2024 March, Morehead State University. Office Of Communications & Marketing. Mar 2024

2024 March, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for March of 2024.


Ethics Of Plausible Deniability, John A. Van Til Mar 2024

Ethics Of Plausible Deniability, John A. Van Til

Pro Rege

No abstract provided.


Long-Term Follow-Up Of Acceptance-Enhanced Behavior Therapy For Trichotillomania, Kathryn E. Barber, Douglas W. Woods, Laura J. Ely, Stephen M. Saunders, Scott N. Compton, Angela Neal-Barnett, Martin E. Franklin, Matthew R. Capriotti, Christine A. Conelea, Michael P. Twohig Mar 2024

Long-Term Follow-Up Of Acceptance-Enhanced Behavior Therapy For Trichotillomania, Kathryn E. Barber, Douglas W. Woods, Laura J. Ely, Stephen M. Saunders, Scott N. Compton, Angela Neal-Barnett, Martin E. Franklin, Matthew R. Capriotti, Christine A. Conelea, Michael P. Twohig

Psychology Faculty Publications

Acceptance-enhanced behavior therapy for trichotillomania (AEBT-TTM) is effective in reducing trichotillomania (TTM) symptoms, but the durability of treatment effects remains in question. This study analyzed 6-month follow-up data from a large randomized clinical trial comparing AEBT-TTM to an active psychoeducation and supportive therapy control (PST). Adults with TTM (N=85; 92% women) received 10 sessions of AEBT-TTM or PST across 12 weeks. Independent evaluators assessed participants at baseline, post-treatment, and 6 months follow-up. For both AEBT-TTM and PST, self-reported and evaluator-rated TTM symptom severity decreased from baseline to follow-up. TTM symptoms did not worsen from posttreatment to follow-up. At …


Diminished Adolescent Social Well-Being During The Covid-19 Pandemic, Michael J. Furlong, Mei-Ki Chan, Erin Dowdy, Karen Nylund-Gibson Mar 2024

Diminished Adolescent Social Well-Being During The Covid-19 Pandemic, Michael J. Furlong, Mei-Ki Chan, Erin Dowdy, Karen Nylund-Gibson

Psychology Faculty Publications

Managing the COVID-19 pandemic involved implementing public health policies that disrupted students' lives, creating conditions that substantially influenced their mental health and well-being. Subsequently, research focused don the mental health sequelae of increased depression and anxiety, but the possible impacts on adolescents' social well-being have been largely unexamined. Social well-being is essential to youth's overall mental health and can be diminished even without symptoms of depression and anxiety. This report explored heterogeneities in changes in adolescents' social well-being from pre-COVID-19 to post-restrictions using longitudinal data from adolescents attending middle and high schools in California (N = 1,299; 49.9% female). …


The Wall Between Latinas And Latinos? Gender And Immigration Enforcement Attitudes Among U.S. Latina/O Voters, Álvaro José Corral Mar 2024

The Wall Between Latinas And Latinos? Gender And Immigration Enforcement Attitudes Among U.S. Latina/O Voters, Álvaro José Corral

Political Science Faculty Publications

Donald Trump’s surprising level of support among U.S. Latina/o voters in 2016 and his improved performance in the 2020 election posed a puzzle for Latina/o politics scholars given his stridently anti-immigrant agenda. Although scholars have acknowledged the political gender gap between Latinas and Latino men, few studies have outlined the theoretical basis or explored the empirical existence of gender differences in Latina/o immigration enforcement attitudes. Building on the Latina politics literature documenting Latinas’ greater engagement in solidarity work with immigrants and their greater desire for cultural transmission and the maintenance of pan-ethnic identity, I test two hypotheses. The first (the …


The Α-Crystallin Chaperones Undergo A Quasi-Ordered Co-Aggregation Process In Response To Saturating Client Interaction, Kirsten Lampi, Adam P. Miller, Susan E. O'Neill, Steve L. Reichow Mar 2024

The Α-Crystallin Chaperones Undergo A Quasi-Ordered Co-Aggregation Process In Response To Saturating Client Interaction, Kirsten Lampi, Adam P. Miller, Susan E. O'Neill, Steve L. Reichow

Chemistry Faculty Publications and Presentations

Small heat shock proteins (sHSPs) are ATP-independent chaperones vital to cellular proteostasis, preventing protein aggregation events linked to various human diseases including cataract. The α-crystallins, αA-crystallin (αAc) and αB-crystallin (αBc), represent archetypal sHSPs that exhibit complex polydispersed oligomeric assemblies and rapid subunit exchange dynamics. Yet, our understanding of how this plasticity contributes to chaperone function remains poorly understood. This study investigates structural changes in αAc and αBc during client sequestration under varying degree of chaperone saturation. Using biochemical and biophysical analyses combined with single-particle electron microscopy (EM), we examined αAc and αBc in their apo-states and at various stages of …


Investigating An Acceptance And Commitment Therapy-Based Exposure Therapy Intervention In Treatment-Refractory Ocd And Related Disorders: Changes In Psychological Flexibility, Treatment Engagement, And Treatment Perceptions, Nate G. Gruner, Jenifer M. Cullen, Jesse M. Crosby, Stephanie N. Decross, Brittany Mathes, Lauryn Garner, Christina Gironda, Yuanjun Hu, Jason W. Krompinger, Jason A. Elias, Michael P. Twohig Mar 2024

Investigating An Acceptance And Commitment Therapy-Based Exposure Therapy Intervention In Treatment-Refractory Ocd And Related Disorders: Changes In Psychological Flexibility, Treatment Engagement, And Treatment Perceptions, Nate G. Gruner, Jenifer M. Cullen, Jesse M. Crosby, Stephanie N. Decross, Brittany Mathes, Lauryn Garner, Christina Gironda, Yuanjun Hu, Jason W. Krompinger, Jason A. Elias, Michael P. Twohig

Psychology Faculty Publications

While exposure therapy is the most effective psychological treatment for obsessive-compulsive, anxiety, and traumatic stress-related disorders, it is not universally effective, indicating a need for further treatment optimization. This study investigated a shift in approach to exposure therapy with 29 treatment-refractory adults in an OCD clinic not responding to standard treatment, comprising habituation-based exposure therapy. Participants completed a standard exposure as continuation of standard clinic treatment, followed by an Acceptance and Commitment Therapy (ACT) consultation session to assess psychological inflexibility processes interfering with treatment progress, and then an ACT-based exposure targeting behavior change through increasing psychological flexibility. After each exposure, …


Ditmos: Delving Into Diverse Tiny-Model Selection On Microcontrollers, Xiao Ma, Shengfeng He, Hezhe Qiao, Dong Ma Mar 2024

Ditmos: Delving Into Diverse Tiny-Model Selection On Microcontrollers, Xiao Ma, Shengfeng He, Hezhe Qiao, Dong Ma

Research Collection School Of Computing and Information Systems

Enabling efficient and accurate deep neural network (DNN) inference on microcontrollers is non-trivial due to the constrained on-chip resources. Current methodologies primarily focus on compressing larger models yet at the expense of model accuracy. In this paper, we rethink the problem from the inverse perspective by constructing small/weak models directly and improving their accuracy. Thus, we introduce DiTMoS, a novel DNN training and inference framework with a selectorclassifiers architecture, where the selector routes each input sample to the appropriate classifier for classification. DiTMoS is grounded on a key insight: a composition of weak models can exhibit high diversity and the …


Pa2blo: Low-Power, Personalized Audio Badge, Hemanth Sabbella, Dulaj Sanjaya Weerakoon, Manoj Gulati, Archan Misra Mar 2024

Pa2blo: Low-Power, Personalized Audio Badge, Hemanth Sabbella, Dulaj Sanjaya Weerakoon, Manoj Gulati, Archan Misra

Research Collection School Of Computing and Information Systems

We present the hardware design and software pipeline for an ultra-low power device, in the form factor of a wearable badge, that supports energy efficient sensing, processing and wireless transfer of human voice commands and interactions. The proposed system, called PA2BLO, is envisioned to support both: (a) real-time, scalable, authorized voice based interaction and control of devices and appliances, and (b) longitudinal, low-power logging of natural voice interactions. PA2BLO in-troduces two key novel capabilities. First, it includes a low power, low-complexity voice authentication module that is able to reliably authenticate an authorized user only using low sampling rate (500 Hz) …


Age And Ideology: The Emergence Of New Political Cleavages In Thailand’S 2566 (2023) Election, Napon Jatusripitak, Jacob Ricks Mar 2024

Age And Ideology: The Emergence Of New Political Cleavages In Thailand’S 2566 (2023) Election, Napon Jatusripitak, Jacob Ricks

Research Collection School of Social Sciences

The Move Forward Party’s victory in Thailand’s 14 May 2566 (2023 CE) election surprised most observers, defying widespread predictions of a Pheu Thai win. Departing from traditional vote-mobilization strategies, Move Forward’s campaign focused largely on social media and broad calls for political reform while eschewing the vote-canvassing networks and economic policy promises that had delivered victory after victory for Pheu Thai. Does Move Forward’s win indicate changes in Thai voting behaviour? Relying on data from an original survey collected the week before and the week after the election, as well as observations from fieldwork, we identify two political cleavages that …


Negative Work-To-Family Spillover Stress And Heightened Cardiovascular Risk Biomarkers In Midlife And Older Adults, Andree Hartanto, K.T.A.Sandeeshwara Kasturiratna, Meilan Hu, Shu Fen Diong, Verity Y. Q. Lua Mar 2024

Negative Work-To-Family Spillover Stress And Heightened Cardiovascular Risk Biomarkers In Midlife And Older Adults, Andree Hartanto, K.T.A.Sandeeshwara Kasturiratna, Meilan Hu, Shu Fen Diong, Verity Y. Q. Lua

Research Collection School of Social Sciences

Objectives: The current study aimed to investigate the health implications of negative work-to-family spillover on cardiovascular risk biomarkers. Methods: In a large-scale cross-sectional dataset of working or self-employed midlife and older adults in the United States (N = 1179), we examined five biomarkers linked to cardiovascular risk, including high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, triglyceride, interleukin-6, and C-reactive protein. Negative work-to-family spillover, measured using a four-item self-reported questionnaire, was included into our model to study its association with these cardiovascular risk biomarkers. Results: Our findings indicate a significant association between negative work-to-family spillover and cardiovascular risk biomarkers – higher …


Within-Development Density And Housing Prices In Singapore, Eric Fesselmeyer, Haoming Liu, Louisa Poco Mar 2024

Within-Development Density And Housing Prices In Singapore, Eric Fesselmeyer, Haoming Liu, Louisa Poco

Research Collection College of Integrative Studies

This paper measures how much more households pay for less density in their immediate surroundings. Using transaction and administrative data and exploiting the introduction of a regulation that restricted the number of housing units for certain land lots, we find that households discount density: a 10% increase in within-development density decreases the price per square meter by 5%. Further, the mean price per square meter of the average development increased by 1%–3% after the regulation was introduced, while the amount of built-up space remained constant. The increase in total revenue suggests developers may underestimate the externality caused by density.


Grievance Politics And Technocracy In A Developmental State, Ijlal Naqvi, Federico M. Rossi, Rayner Kay Jin Tan Mar 2024

Grievance Politics And Technocracy In A Developmental State, Ijlal Naqvi, Federico M. Rossi, Rayner Kay Jin Tan

Research Collection School of Social Sciences

This article uses a process-tracing approach to understand changes in Singapore’s health sector from the start of self-rule in 1959 to the end of the COVID-19 pandemic in 2022. Singapore is a developmental state recognized for its effective management of healthcare costs and its lack of political freedom. In both respects, the ‘Singapore model’ is of interest to other cities and nations. The standard narrative is one of technocratic proficiency in a context in which civic freedoms are heavily constrained, but this article identifies the surprisingly important role of social voices at key moments. It finds episodes in which effective …


Clinical And Biomechanical Effectiveness Of Foot‐Ankle Exercise Programs And Weight‐Bearing Activity In People With Diabetes And Neuropathy: A Systematic Review And Meta‐Analysis, Netten Jj Van, Isabel C.N. Sacco, Lawrence Lavery, M Monteiro‐Soares, Joanne Paton, Anne Rasmussen, Anita Raspovic, Sicco A. Bus Mar 2024

Clinical And Biomechanical Effectiveness Of Foot‐Ankle Exercise Programs And Weight‐Bearing Activity In People With Diabetes And Neuropathy: A Systematic Review And Meta‐Analysis, Netten Jj Van, Isabel C.N. Sacco, Lawrence Lavery, M Monteiro‐Soares, Joanne Paton, Anne Rasmussen, Anita Raspovic, Sicco A. Bus

School of Health Professions

Background. Most interventions to prevent foot ulcers in people with diabetes do not seek to reverse the foot abnormalities that led to the ulcer. Foot‐ankle exercise programs target these clinical and biomechanical factors, such as protective sensation and mechanical stress. Multiple RCTs exist investigating the effectiveness of such programs, but these have never been summarised in a systematic review and meta‐analysis. Methods. We searched the available scientific literature in PubMed, EMBASE, CINAHL, Cochrane databases and trial registries for original research studies on foot‐ankle exercise programs for people with diabetes at risk of foot ulceration. Both controlled and non‐controlled studies were …


Infrared Investigation In Singapore (Iris) Observatory: Urban Heat Island Contributors And Mitigators Analysis Using Neighborhood-Scale Thermal Imaging, Clayton Miller, Vasantha Ramani, Clayton Miller Mar 2024

Infrared Investigation In Singapore (Iris) Observatory: Urban Heat Island Contributors And Mitigators Analysis Using Neighborhood-Scale Thermal Imaging, Clayton Miller, Vasantha Ramani, Clayton Miller

Research Collection College of Integrative Studies

This paper studies heat fluxes from contributors and mitigators of urban heat islands using thermal images and weather data. Thermal images were collected by a rooftop observatory between November 2021 and April 2022. Over the same period, weather stations were operating at several locations on a university campus in Singapore. From collected data, a method was defined to estimate sensible and latent heat fluxes from building façades, vegetation, and traffic. Before analyzing heat fluxes using the method, thermal images were calibrated against measurements made with contact surface sensors. Results show that the method can be used to study heat fluxes …


Severe Stiff-Person Syndrome After Covid: The First Video-Documented Covid Exacerbation And Viral Implications, Marinos C. Dalakas Mar 2024

Severe Stiff-Person Syndrome After Covid: The First Video-Documented Covid Exacerbation And Viral Implications, Marinos C. Dalakas

Department of Neurology Faculty Papers

OBJECTIVES: To describe a patient with mild GAD-positive stiff-leg syndrome (SLS) who developed severely disabling stiff-person syndrome (SPS) 1 week after mild COVID-19 and discuss the impact of viral implications.

METHODS: Video-documented serial clinical observations at baseline, after acute COVID-19, and after IVIG treatments.

RESULTS: A 39-year-old man with left-SLS was stable during a 2-year follow-up with low-dose antispasmodics, working fully and functioning normally, even able to run. One week after mild COVID-19, he started to experience generalized SPS symptomatology that steadily worsened the following 2-3 weeks, becoming unable to walk, requiring a walker, with significant thoracolumbar and bilateral leg …


March 2024 Checking In & Title Changes, Kurt Blythe Mar 2024

March 2024 Checking In & Title Changes, Kurt Blythe

NASIG Newsletter

No abstract provided.


March 2024 Full Issue, Faye O'Reilly Mar 2024

March 2024 Full Issue, Faye O'Reilly

NASIG Newsletter

No abstract provided.


Application Of Collaborative Learning Paradigms Within Software Engineering Education: A Systematic Mapping Study, Rita Garcia, Christoph Treude, Andrew Valentine Mar 2024

Application Of Collaborative Learning Paradigms Within Software Engineering Education: A Systematic Mapping Study, Rita Garcia, Christoph Treude, Andrew Valentine

Research Collection School Of Computing and Information Systems

Collaboration is used in Software Engineering (SE) to develop software. Industry seeks SE graduates with collaboration skills to contribute to productive software development. SE educators can use Collaborative Learning (CL) to help students develop collaboration skills. This paper uses a Systematic Mapping Study (SMS) to examine the application of the CL educational theory in SE Education. The SMS identified 14 papers published between 2011 and 2022. We used qualitative analysis to classify the papers into four CL paradigms: Conditions, Effect, Interactions, and Computer-Supported Collaborative Learning (CSCL). We found a high interest in CSCL, with a shift in student interaction research …


Metagenomic Analysis Unravels Novel Taxonomic Differences In The Uterine Microbiome Between Healthy Mares And Mares With Endometritis, Aeknath Virendra, Sarita U Gulavane, Zulfikar A Ahmed, Ravi Reddy, Ravindra J Chaudhari, Sandeep M Gaikwad, Raju R Shelar, Shailesh D Ingole, Varsha D Thorat, Afroza Khanam, Firdous A Khan Mar 2024

Metagenomic Analysis Unravels Novel Taxonomic Differences In The Uterine Microbiome Between Healthy Mares And Mares With Endometritis, Aeknath Virendra, Sarita U Gulavane, Zulfikar A Ahmed, Ravi Reddy, Ravindra J Chaudhari, Sandeep M Gaikwad, Raju R Shelar, Shailesh D Ingole, Varsha D Thorat, Afroza Khanam, Firdous A Khan

Faculty, Staff and Students Publications

BACKGROUND: The application of high throughput technologies has enabled unravelling of unique differences between healthy mares and mares with endometritis at transcriptomic and proteomic levels. However, differences in the uterine microbiome are yet to be investigated.

OBJECTIVES: The present study was aimed at evaluating the differences in uterine microbiome between healthy mares and mares with endometritis.

METHODS: Low-volume lavage (LVL) samples were collected from the uterus of 30 mares classified into healthy (n = 15) and endometritis (n = 15) based on their reproductive history, intrauterine fluid accumulation, gross appearance of LVL samples, endometrial cytology and bacterial culture. The samples …


Community Recommendations On Cryoem Data Archiving And Validation, Gerard J Kleywegt, Paul D Adams, Sarah J Butcher, Catherine L Lawson, Alexis Rohou, Peter B Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R Baldwin, John M Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I Croll, Radostin Danev, Sai J Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J Bernard Heymann, Juha T Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C Lander, Shee Mei Lok, Steven J Ludtke, Garib N Murshudov, Ryan Pye, Grigore D Pintilie, Jane S Richardson, Carsten Sachse, Osman Salih, Sjors H W Scheres, Gunnar F Schroeder, Carlos Oscar S Sorzano, Scott M Stagg, Zhe Wang, Rangana Warshamanage, John D Westbrook, Martyn D Winn, Jasmine Y Young, Stephen K Burley, Jeffrey C Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar Mar 2024

Community Recommendations On Cryoem Data Archiving And Validation, Gerard J Kleywegt, Paul D Adams, Sarah J Butcher, Catherine L Lawson, Alexis Rohou, Peter B Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R Baldwin, John M Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I Croll, Radostin Danev, Sai J Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J Bernard Heymann, Juha T Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C Lander, Shee Mei Lok, Steven J Ludtke, Garib N Murshudov, Ryan Pye, Grigore D Pintilie, Jane S Richardson, Carsten Sachse, Osman Salih, Sjors H W Scheres, Gunnar F Schroeder, Carlos Oscar S Sorzano, Scott M Stagg, Zhe Wang, Rangana Warshamanage, John D Westbrook, Martyn D Winn, Jasmine Y Young, Stephen K Burley, Jeffrey C Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar

Faculty, Staff and Students Publications

In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 47 experts in data processing, model building and refinement, validation, and archiving of such structures. This report describes the workshop's motivation and history, the topics discussed, and the resulting consensus recommendations. Some challenges for future methods-development efforts in this area are also highlighted, as is the implementation to date of some of the recommendations.


Centriole And Transition Zone Structures In Photoreceptor Cilia Revealed By Cryo-Electron Tomography, Zhixian Zhang, Abigail R Moye, Feng He, Muyuan Chen, Melina A Agosto, Theodore G Wensel Mar 2024

Centriole And Transition Zone Structures In Photoreceptor Cilia Revealed By Cryo-Electron Tomography, Zhixian Zhang, Abigail R Moye, Feng He, Muyuan Chen, Melina A Agosto, Theodore G Wensel

Faculty, Staff and Students Publications

Primary cilia mediate sensory signaling in multiple organisms and cell types but have structures adapted for specific roles. Structural defects in them lead to devastating diseases known as ciliopathies in humans. Key to their functions are structures at their base: the basal body, the transition zone, the "Y-shaped links," and the "ciliary necklace." We have used cryo-electron tomography with subtomogram averaging and conventional transmission electron microscopy to elucidate the structures associated with the basal region of the "connecting cilia" of rod outer segments in mouse retina. The longitudinal variations in microtubule (MT) structures and the lumenal scaffold complexes connecting them …


The Relevance Of Arterial Blood Pressure In The Management Of Glaucoma Progression: A Systematic Review, Jan Van Eijgen, Jesus D. Melgarejo, Jana Van Laeken, Claire Van Der Pluijm, Hanne Matheussen, Micheline Verhaegen, Karel Van Keer, Gladys E. Maestre, Lama A Al Aswad, Ingeborg Stalmans Mar 2024

The Relevance Of Arterial Blood Pressure In The Management Of Glaucoma Progression: A Systematic Review, Jan Van Eijgen, Jesus D. Melgarejo, Jana Van Laeken, Claire Van Der Pluijm, Hanne Matheussen, Micheline Verhaegen, Karel Van Keer, Gladys E. Maestre, Lama A Al Aswad, Ingeborg Stalmans

School of Medicine Publications

Background: Glaucoma is one of the leading causes of global blindness and is expected to co-occur more frequently with vascular morbidities in the upcoming years, as both are aging-related diseases. Yet, the pathogenesis of glaucoma is not entirely elucidated and the interplay between intraocular pressure, arterial blood pressure (BP) and ocular perfusion pressure is poorly understood.

Objectives: This systematic review aims to provide clinicians with the latest literature regarding the management of arterial BP in glaucoma patients.

Methods: A systematic search was performed in Medline, Embase, Web of Science and Cochrane Library. Articles written in English assessing the influence of …


Prognostic Significance Of Acute Kidney Injury Stage 1b In Hospitalized Patients With Cirrhosis: A Us Nationwide Study, Kavish R Patidar, Giuseppe Cullaro, Mobasshir A Naved, Shaowli Kabir, Ananth Grama, Eric S Orman, Salvatore Piano, Andrew S Allegretti Mar 2024

Prognostic Significance Of Acute Kidney Injury Stage 1b In Hospitalized Patients With Cirrhosis: A Us Nationwide Study, Kavish R Patidar, Giuseppe Cullaro, Mobasshir A Naved, Shaowli Kabir, Ananth Grama, Eric S Orman, Salvatore Piano, Andrew S Allegretti

Faculty, Staff and Students Publications

Understanding the prognostic significance of acute kidney injury (AKI) stage 1B [serum creatinine (sCr) ≥1.5 mg/dL] compared with stage 1A (sCr < 1.5 mg/dL) in a US population is important as it can impact initial management decisions for AKI in hospitalized cirrhosis patients. Therefore, we aimed to define outcomes associated with stage 1B in a nationwide US cohort of hospitalized cirrhosis patients with AKI. Hospitalized cirrhosis patients with AKI in the Cerner-Health-Facts database from January 2009 to September 2017 (n = 6250) were assessed for AKI stage 1 (≥1.5-2-fold increase in sCr from baseline) and were followed for 90 days for outcomes. The primary outcome was 90-day mortality; secondary outcomes were in-hospital AKI progression and AKI recovery. Competing-risk multivariable analysis was performed to determine the independent association between stage 1B, 90-day mortality (liver transplant as a competing risk), and AKI recovery (death/liver transplant as a competing risk). Multivariable logistic regression analysis was performed to determine the independent association between stage 1B and AKI progression. In all, 4654 patients with stage 1 were analyzed: 1A (44.3%) and 1B (55.7%). Stage 1B patients had a significantly higher cumulative incidence of 90-day mortality compared with stage 1A patients, 27.2% versus 19.7% ( p < 0.001). In multivariable competing-risk analysis, patients with stage 1B (vs. 1A) had a higher risk for mortality at 90 days [sHR 1.52 (95% CI 1.20-1.92), p = 0.001] and decreased probability for AKI recovery [sHR 0.76 (95% CI 0.69-0.83), p < 0.001]. Furthermore, in multivariable logistic regression analysis, AKI stage 1B (vs. 1A) was independently associated with AKI progression, OR 1.42 (95% CI 1.14-1.72) ( p < 0.001). AKI stage 1B patients have a significantly higher risk for 90-day mortality, AKI progression, and reduced probability of AKI recovery compared with AKI stage 1A patients. These results could guide initial management decisions for AKI in hospitalized patients with cirrhosis.


Systemic Lupus Erythematosus And Lupus Nephritis Presenting As Severe Constitutional Symptoms, Ton La, Sahifah Ansari, Ethan Ha, Matthew Novakovic Mar 2024

Systemic Lupus Erythematosus And Lupus Nephritis Presenting As Severe Constitutional Symptoms, Ton La, Sahifah Ansari, Ethan Ha, Matthew Novakovic

Faculty, Staff and Students Publications

Systemic lupus erythematosus (SLE) is a remitting-relapsing systemic autoantibody and immune complex disease with a similar clinical presentation to that of malignancy and infection. The authors report a case of newly diagnosed SLE and lupus nephritis in a 48-year-old woman with constitutional symptoms and unintentional weight loss. Her presentation was further complicated by pericardial effusion and methicillin-resistant Staphylococcus aureus (MRSA) facial cellulitis and bacteremia. In the context of nonspecific symptoms and a wide initial differential diagnosis, the early consideration of rheumatologic etiologies and the involvement of consultant services led to appropriate diagnostic testing and a timely diagnosis.