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Cardiovascular Disease Analysis And Risk Prediction System, Brooklyn Kelly, Joshua Pohly, Michelle Patel

Research Horizons Day Posters

No abstract provided.

The Epigenetic Evolution Of Glioma Is Determined By The Idh1 Mutation Status And Treatment Regimen., Tathiane M Malta, Thais S Sabedot, Natalia S Morosini, Indrani Datta, Luciano Garofano, Wies Vallentgoed, Frederick S Varn, Kenneth Aldape, Fulvio D'Angelo, Spyridon Bakas, Jill S Barnholtz-Sloan, Hui K Gan, Mohammad Hasanain, Ann-Christin Hau, Kevin C Johnson, Simona Cazacu, Ana C Decarvalho, Mustafa Khasraw, Emre Kocakavuk, Mathilde C M Kouwenhoven, Simona Migliozzi, Simone P Niclou, Johanna M Niers, D Ryan Ormond, Sun Ha Paek, Guido Reifenberger, Peter A Sillevis Smitt, Marion Smits, Lucy F Stead, Martin J Van Den Bent, Erwin G Van Meir, Annemiek Walenkamp, Tobias Weiss, Michael Weller, Bart A Westerman, Bauke Ylstra, Pieter Wesseling, Anna Lasorella, Pim J French, Laila M Poisson, Roel G W Verhaak, Antonio Iavarone, Houtan Noushmehr

Faculty Research 2024

UNLABELLED: Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas in response to therapeutic pressure, we performed an epigenomic analysis of 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) and IDH-mutant (IDHmut) glioma. IDHwt gliomas showed a stable epigenome over time with relatively low levels of global methylation. The epigenome of IDHmut gliomas showed initial high levels of genome-wide DNA methylation that was progressively reduced to levels similar to those of IDHwt tumors. Integration of epigenomics, gene expression, and functional genomics identified HOXD13 as a master regulator …

Improved Dna Extraction And Amplification Strategy For 16s Rrna Gene Amplicon-Based Microbiome Studies., Bo-Young Hong, Mark Driscoll, Dawn Gratalo, Thomas Jarvie, George M. Weinstock

Faculty Research 2024

Next-generation sequencing technology has driven the rapid advancement of human microbiome studies by enabling community-level sequence profiling of microbiomes. Although all microbiome sequencing methods depend on recovering the DNA from a sample as a first critical step, lysis methods can be a major determinant of microbiome profile bias. Gentle enzyme-based DNA preparation methods preserve DNA quality but can bias the results by failing to open difficult-to-lyse bacteria. Mechanical methods like bead beating can also bias DNA recovery because the mechanical energy required to break tougher cell walls may shear the DNA of the more easily lysed microbes, and shearing can …

What's In A Name?, Nancy Mink

Erma Bombeck Writers' Workshop Blog

Names matter. For instance, would you rather live on Stinking Creek Road or Whispering Pines Lane? Do you prefer the area of Buzzard's Roost or Eagle View?

Acute Changes In Microvascular Resistance After Treating Aortic Stenosis, Nils P Johnson, Rob Eerdekens

Faculty, Staff and Student Publications

No abstract provided.

Impact Of Alkaloids Extract Of Moringa Olievera Lam. Leaves On The Development, Fertility And Demography Of The Southern Cowpea Beetle Insect Callosobruchus Maculatus (F.) (Coleoptera: Bruchidae), Tahani Nouri Jassim, Soolaf A Kathiar, Hazim Idan Al Shammari

Baghdad Science Journal

The Southern Cowpea Beetle Callosobruchus maculatus (F.) is one of the most widespread insect pests of stored legumes, causing a considerable loss during storage, decreasing the net weight of the crops, and resulting in reduced the quality of the crops. This study has been conducted to determine the lifetime, fertility and life table parameters of C. maculatus by using an alkaloids extract from Moringa oleifera leaves at different concentrations 1000, 2000, and 3000 ppm. The result was shown that the lowest survival rate was 49% at a concentration of 1000, 2000 ppm, as compared with the control which was 77%. …

Potential Benefits Of Ethanol Extract Of Anredera Cordifolia For Antiobesity Of High Fat Diet-Induced Obesity In White Male Rat Wistar, Rusdiana Rusdiana, Rozaimah Zain Hamid, Sry Suryani Widjaja, Isti Ilmi Fujiati, Syafruddin Ilyas, Delfitri Munir, Deddi Prima Putra, Muhammad Rusda, Mustafa Mahmud Amin

Baghdad Science Journal

Obesity-related deaths continue to rise, and thus losing weight in overweight and obese patients is critical to prevent complications. Anredera cordifolia (Ten,) Steenis, species of succulent plant of the genus Basellaceae, is widely used in herbal medicine to decrease body weight. This study evaluated the potential benefits of Anredera cordifolia ethanol extract to reduce body weight in high-fat diet-induced obesity rat model. This was an experimental with post-test only control group design study involving 36 obese rats. They were divided into two groups: three control groups (K1, K2, K3) and three treatment groups (P1, P2, P3). All the groups were …

Antimicrobial Activity Of Silver Nanoparticles On Pathogenic Bacteria, Ghada Al Kattan, Mithal Abdulkareem Abdoun, Sahira Hassan Kareem

Baghdad Science Journal

Nosocomial infection is acquired contamination of hospitals and health care units caused by multidrug resistant bacteria. Currently, bacterial resistance to antimicrobial medication represents a complicated public health problem. Recent studies on the antimicrobial activity of silver nanoparticles (AgNPs) attracted researchers worldwide to focus on the safe synthesis of AgNPs as antimicrobial agents against multidrug resistant bacteria. The antimicrobial efficacy of AgNPs on pathogenic bacteria isolated from clinical cases of acquired hospital infection was targeted in this project. Fifty specimens of stool were collected through private laboratories in Baghdad from patients who suffered diarrheal symptoms. Bacterial isolation, identification, and characterization via …

Food Insecurity And Premature Mortality And Life Expectancy In The Us, Hao Ma, Xuan Wang, Xiang Li, Yoriko Heianza, Peter T. Katzmarzyk, Oscar H. Franco, Lu Qi

Population and Public Health Science Faculty Publications

IMPORTANCE Food insecurity has been linked to multiple causes of disease and premature mortality; however, its association with mortality by sex and across racial and ethnic groups remains unknown in the US. OBJECTIVE To investigate the associations of the entire range of food security with all-cause premature mortality and life expectancy across racial and ethnic and sex groups in US adults. DESIGN, SETTING, AND PARTICIPANTS This cohort study included adults (aged ≥18 years) who participated in the National Health and Nutrition Examination Survey from 1999 to 2018, with linkage to the National Death Index through December 31, 2019. Data analysis …

Week Of March 4, 2024, Student Life

College, School and Department Newsletters, Magazines, and Journals

Your weekly hub for events, resources and updates.

Towards The Design And Evaluation Of Clickbait Education Content: Leveraging User Mental Models And Learning Science Principles, A. Shrestha, A. Flood, B. Hackler, Arezou Behfar, M. N. Al-Ameen

Computer Science Student Research

Clickbait refers to sensationalized or misleading post on social networking sites (e.g., Facebook) that can trick users into clicking on malicious links. Clickbait is often used in cyberattacks, especially to conduct 'social engineering attacks' that direct users to malicious websites, resulting in disclosure of users' personal information or installing malicious software (i.e., malware). Thus, clickbait has become a major security concern with the recent boom in social media use. Therefore, security education has become necessary more than ever for the safe and secure use of social media, where there is dearth in security education literature to explore how we could …

Cardiovascular Disease Analysis And Risk Prediction System, Brooklyn Kelly, Joshua Pohly, Michelle Patel

Research Horizons Day Posters

No abstract provided.

On The Value Of A Premium College Football Player: Evaluating The Literature, Jeremy M. Losak, Benjamin J. Posmanick, Raymond Sauer

Sport Management - All Scholarship

Over the past decade, the issue of player compensation in college sports has been the subject of several successful legal challenges. Athletes contend that the compensation they receive falls significantly short of the value they generate, attributing this gaps to unlawful NCAA restrictions. Numerous tools exist in the sport economic literature that estimate the value of colelge athletes, with an emphasized focus towards premium college football players. In addition to providing updated estimate of player marginal revenue product (MRP), we review past and contemporary methodologies for esitmating colllege player MRPs. We contend that, while presenting some evidence that restrictions on …

Between The Stacks, 03-2024, Anna Swearengen, Michelle Dry

Between the Stacks

The March 2024 edition of the University Libraries monthly newsletter presenting a calendar of events for the spring semester, library announcements, information about an exhibition of political cartoons and memes in Special Collections, and an update on the library's new Courtesy and Noise Policy.

Children Observing Violence And Public Health Outcomes, Andrew N. Rowan

WellBeing News

Children observing violence is a public health threat that deserves increased global awareness.

Changes In Real-World Dispensing Of Adhd Stimulants In Youth From 2019 To 2021 In California, Anika Patel, Rishikesh Chavan, Cyril Rakovski, Richard C. Beuttler, Sun Yang

Mathematics, Physics, and Computer Science Faculty Articles and Research

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common pediatric neurobehavioral disorders in the U.S. Stimulants, classified as controlled substances, are commonly used for ADHD management. We conducted an analysis of real-world stimulants dispensing data to evaluate the pandemic’s impact on young patients (≤ 26 years) in California.

Methods: Annual prevalence of patients on stimulants per capita across various California counties from 2019 and 2021 were analyzed and further compared across different years, sexes, and age groups. New patients initiating simulants therapy were also examined. A case study was conducted to determine the impact of socioeconomic status on patient …

Genomic Epidemiology Of Mycobacterium Abscessus At An Adult Cystic Fibrosis Programme Reveals Low Potential For Healthcare-Associated Transmission, Jane E. Gross, James D. Finklea, Silvia M. Caceres, Katie R. Poch, Nabeeh A. Hasan, Fan Jia, Elaine L. Epperson, Ettie M. Lipner, Charmie K. Vang, Jennifer R. Honda, Matthew J. Strand, Vinicius Calado Nogueira De Moura, Charles L. Daley, Michael Strong, Jerry A. Nick

School of Medicine Faculty Publications and Presentations

Rationale Nontuberculous mycobacteria (NTM) has been reported to be transmitted between people with cystic fibrosis (CF) attending CF centres. A suspected Mycobacterium abscessus outbreak was investigated at the University of Texas Southwestern (UTSW) Adult CF Program using a combination of pathogen genomic sequencing and epidemiologic methods. The objectives of the present study were to apply the Healthcare-Associated Links in Transmission of NTM (HALT NTM) study to investigate the occurrence of potential healthcare-associated transmission and/or acquisition of NTM among people with CF infected with genetically similar NTM isolates. Methods Whole-genome sequencing of respiratory M. abscessus isolates from 50 people with CF …

Prevalence, Morbidity, And Mortality Of Men With Sex Chromosome Aneuploidy In The Million Veteran Program Cohort, Shanlee Davis, Craig Teerlink, Julie Lynch, Bryan Gorman, Meghana Pagadala, Aoxing Liu, Matthew Panizzon, Victoria Merritt, Giulio Genovese, Judith Ross, Richard Hauger

Department of Pediatrics Faculty Papers

IMPORTANCE: The reported phenotypes of men with 47,XXY and 47,XYY syndromes include tall stature, multisystem comorbidities, and poor health-related quality of life (HRQOL). However, knowledge about these sex chromosome aneuploidy (SCA) conditions has been derived from studies in the less than 15% of patients who are clinically diagnosed and also lack diversity in age and genetic ancestry.

OBJECTIVES: To determine the prevalence of clinically diagnosed and undiagnosed X or Y chromosome aneuploidy among men enrolled in the Million Veteran Program (MVP); to describe military service metrics of men with SCAs; and to compare morbidity and mortality outcomes between men with …

Western Science And Eastern Zen To Seek The Origin Of Truth: Philosophical Background Of Scale Modeling, Kozo Saito

Progress in Scale Modeling, an International Journal

This article was written to introduce philosophical background of scale modeling, where Zen philosophy was applied to overcome the limitation of logical thinking and hypotheses-driven deductive science. Three specific reasons are as follows. The first is related to the law approach in scale modeling; it uses the kufu principle, originated in Zen Buddhism, together with the other three scientific methods: experimental, theoretical, and computational. The second reason is because scale modeling seeks relativistic understanding by attempting to realize similarity; the concept is closer to Eastern philosophy rather than absolute understanding cultivated by deductive science. The third is in the educational …

Epivar Browser: Advanced Exploration Of Epigenomics Data Under Controlled Access., David R. Lougheed, Hanshi Liu, Katherine A. Aracena, Romain Grégoire, Alain Pacis, Tomi Pastinen, Luis B. Barreiro, Yann Joly, David Bujold, Guillaume Bourque

Manuscripts, Articles, Book Chapters and Other Papers

MOTIVATION: Human epigenomic data has been generated by large consortia for thousands of cell types to be used as a reference map of normal and disease chromatin states. Since epigenetic data contains potentially identifiable information, similarly to genetic data, most raw files generated by these consortia are stored in controlled-access databases. It is important to protect identifiable information, but this should not hinder secure sharing of these valuable datasets.

RESULTS: Guided by the Framework for responsible sharing of genomic and health-related data from the Global Alliance for Genomics and Health (GA4GH), we have developed an approach and a tool to …

03.04.2024 Orsp Connect, Liz Williamson

ORED Newsletter

ORSP On-demand Training for PIs, Liz Williamson spotlight, Grant for Studying Clean Energy Production Awarded, NIH Simplified Peer Review Framework.

The Echo: March 4, 2024, Taylor University

2023-2024 (Volume 111)

No abstract provided.

Evaluating The Fibroblast Growth Factor-23 And Phosphate In Iraqi Patients With Acromegaly, Sara A. Kashash, Areej Sh. Hameed

Baghdad Science Journal

Fibroblast growth factors-23 (FGF-23) are a class of cell signaling proteins produced by macrophages. They have a range of roles, but they play a particularly important role in the development of animal cells, where they are essential for appropriate growth. Phosphate, which is found in the body as both organic and mineral phosphate, plays crucial roles in cell structure, communication, and metabolism. Most phosphate in the body resides in bone, teeth, and inside cells, with less than 1% circulating in serum. The aim of the study is to evaluate the levels of the Fibroblast Growth Factors-23 and phosphate and receiver …

Head And Neck Squamous Cell Carcinoma Of Unknown Primary: A Diagnostic Work-Up, Noah Kalman, Guilherme Rabinowits

All Publications

The current work-up of the primary tumor site of a head and neck squamous cell carcinoma of unknown primary is not standardized and results in several time-consuming procedures that delay treatment initiation. This article seeks to consolidate contemporary strategies used to identify the primary tumor site of an unknown primary head and neck squamous cell carcinoma and offer recommendations based on current literature review.

Regert And Police Reporting Among Individuals Who Have Experienced Sexual Assault, Carol Anne Marchetti

Dissertations

Sexual assault (SA) is the most widely underreported violent crime in the United States. Reporting is significant because it is through this process that people access resources that can mitigate psychiatric and other health consequences of SA. The purpose of this study was to describe regret among individuals who have experienced SA regarding their decision of whether or not to report the assault to the police. The Ottawa Decision Support Framework underpins this study and posits that evaluation of regret, a powerful negative emotion, influences the decision-making process.

Independent- Mar. 4, 2024, Leslie Lozada

The Independent (1988-present)

No abstract provided.

Understanding Student Perceptions Of A High School Wellness Center: An Interpretive Phenomenological Analysis Qualitative Study, Devan Audrey Clayton

Theses and Dissertations

Adolescents face many challenges at home and at school which impact various areas of their lives, including their academics. Schools have worked to ensure better student mental health outcomes by hiring school counselors, school psychologists, and school social workers. School wellness centers can be an additional resource that students utilize to address mental health challenges during their school day. The purpose of this study is to understand adolescent perceptions of a school-based wellness center. Perceptions of populations who utilize the wellness center and those who do not utilize the wellness center were studied within one high school to understand how …

The Epigenetic Evolution Of Glioma Is Determined By The Idh1 Mutation Status And Treatment Regimen, Tathiane M Malta, Thais S Sabedot, Natalia S Morosini, Indrani Datta, Luciano Garofano, Wies Vallentgoed, Frederick S Varn, Kenneth Aldape, Fulvio D'Angelo, Spyridon Bakas, Jill S Barnholtz-Sloan, Hui K Gan, Mohammad Hasanain, Ann-Christin Hau, Kevin C Johnson, Simona Cazacu, Ana C Decarvalho, Mustafa Khasraw, Emre Kocakavuk, Mathilde C M Kouwenhoven, Simona Migliozzi, Simone P Niclou, Johanna M Niers, D Ryan Ormond, Sun Ha Paek, Guido Reifenberger, Peter A Sillevis Smitt, Marion Smits, Lucy F Stead, Martin J Van Den Bent, Erwin G Van Meir, Annemiek Walenkamp, Tobias Weiss, Michael Weller, Bart A Westerman, Bauke Ylstra, Pieter Wesseling, Anna Lasorella, Pim J French, Laila M Poisson, Consortium The Glass, Roel G W Verhaak, Antonio Iavarone, Houtan Noushmehr

Faculty, Staff and Student Publications

Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas in response to therapeutic pressure, we performed an epigenomic analysis of 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) and IDH-mutant (IDHmut) glioma. IDHwt gliomas showed a stable epigenome over time with relatively low levels of global methylation. The epigenome of IDHmut gliomas showed initial high levels of genome-wide DNA methylation that was progressively reduced to levels similar to those of IDHwt tumors. Integration of epigenomics, gene expression, and functional genomics identified HOXD13 as a master regulator of …

Differential Treatment Effects Of Subgroup Analyses In Phase 3 Oncology Trials From 2004 To 2020, Alexander D Sherry, Andrew W Hahn, Zachary R Mccaw, Joseph Abi Jaoude, Ramez Kouzy, Timothy A Lin, Bruce Minsky, C David Fuller, Tomer Meirson, Pavlos Msaouel, Ethan B Ludmir

Faculty, Staff and Student Publications

IMPORTANCE: Subgroup analyses are often performed in oncology to investigate differential treatment effects and may even constitute the basis for regulatory approvals. Current understanding of the features, results, and quality of subgroup analyses is limited.

OBJECTIVE: To evaluate forest plot interpretability and credibility of differential treatment effect claims among oncology trials.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included randomized phase 3 clinical oncology trials published prior to 2021. Trials were screened from ClinicalTrials.gov.

MAIN OUTCOMES AND MEASURES: Missing visual elements in forest plots were defined as a missing point estimate or use of a linear x-axis scale for hazard …

Intouch Week Of March 4, 2024, New York Medical College

InTouch

• HeLa Conference Navigates the Future of AI and Health Care Equity
• 2024 Alpha Omega Alpha Inductees Personify the Art of Healing
• Members of SOM Class of 2025 Recognized for Humanism in Medicine
• Department of Pathology, Microbiology and Immunology Hosts Research Symposium
• Advancing Biomedical Research Abroad Through the OVERWORLD Program
• LCME Element of the Week