Digital Commons Network^™

Grb2 Stabilizes Rad51 At Reversed Replication Forks Suppressing Genomic Instability And Innate Immunity Against Cancer, Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed

Faculty, Staff and Student Publications

Growth factor receptor-bound protein 2 (GRB2) is a cytoplasmic adapter for tyrosine kinase signaling and a nuclear adapter for homology-directed-DNA repair. Here we find nuclear GRB2 protects DNA at stalled replication forks from MRE11-mediated degradation in the BRCA2 replication fork protection axis. Mechanistically, GRB2 binds and inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks. In GRB2-depleted cells, PARP inhibitor (PARPi) treatment releases DNA fragments from stalled forks into the cytoplasm that activate the cGAS-STING pathway to trigger pro-inflammatory cytokine production. Moreover in a syngeneic mouse metastatic ovarian cancer model, GRB2 depletion in the context of PARPi treatment …

After A Wildfire: Water Safety Considerations For Agriculture Water Systems, Andrew J. Whelton, P. Coelho

Resilience to Emergencies and Disasters

No abstract provided.

Development Of Quantitative Structure Activity Relationships (Qsars) For Predicting The Aggregation Of Tio2 Nanoparticles Under Favorable Conditions, Jaewoong Lee

Department of Civil and Environmental Engineering: Faculty Publications

This study developed multi-linear regression (MLR) quantitative structure-activity relationships (QSARs) to predict n-TiO₂ aggregation in the presence of high concentrations of representative emerging organic contaminants (EOCs), which presented favorable conditions to interaction with n-TiO₂. The largest diameter change (Δ 517 nm at 0 h and Δ 1164 nm at 12 h) of n-TiO₂ was observed by estrone, while the smallest diameter change (Δ -114 nm at 0 h and – 4 nm at 12 h) was observed by lincomycin during experimental periods. In addition, the zeta potential changes of n-TiO₂ were …

Diagnostic Potential Of Exosomal Extracellular Vesicles In Oncology, Marco Ruiz

All Publications

Liquid biopsy can detect circulating cancer cells or tumor cell-derived DNA at various stages of cancer. The fluid from these biopsies contains extracellular vesicles (EVs), such as apoptotic bodies, microvesicles, exomeres, and exosomes. Exosomes contain proteins and nucleic acids (DNA/RNA) that can modify the microenvironment and promote cancer progression, playing significant roles in cancer pathology. Clinically, the proteins and nucleic acids within the exosomes from liquid biopsies can be biomarkers for the detection and prognosis of cancer. We review EVs protein and miRNA biomarkers identified for select cancers, specifically melanoma, glioma, breast, pancreatic, hepatic, cervical, prostate colon, and some hematological …

Do Gaps Exist Between Preschool And Kindergarten Teachers Regarding Phonological Awareness Knowledge, Carrie Sharp

Theses and Dissertations

The quantitative methods study examined and compared the knowledge of phonological awareness between preschool and kindergarten teachers. A multiple-choice knowledge survey was utilized to determine levels of understanding between the two groups of teachers. The knowledge survey consisted of questions pertaining to definitions of phonological awareness terms and phonological and phonemic awareness tasks. Personal information about literacy trainings the participants had attended and instructional time spent on phonological awareness activities were also included in the knowledge survey. The purpose of the study was to determine if gaps existed between the preschool and kindergarten teachers.

The Acceptance And Use Of Digital Technologies For Self-Reporting Medication Safety Events After Care Transitions To Home In Patients With Cancer: Survey Study, Yun Jiang, Misun Hwang, Youmin Cho, Christopher R Friese, Sarah T Hawley, Milisa Manojlovich, John C Krauss, Yang Gong

Faculty, Staff and Student Publications

BACKGROUND: Actively engaging patients with cancer and their families in monitoring and reporting medication safety events during care transitions is indispensable for achieving optimal patient safety outcomes. However, existing patient self-reporting systems often cannot address patients' various experiences and concerns regarding medication safety over time. In addition, these systems are usually not designed for patients' just-in-time reporting. There is a significant knowledge gap in understanding the nature, scope, and causes of medication safety events after patients' transition back home because of a lack of patient engagement in self-monitoring and reporting of safety events. The challenges for patients with cancer in …

Observation On Efficacy And Underlying Mechanism Of Cheek Acupuncture On Ovulation Induction For Infertile Women With Pcos: Case Series, Yi Yang, Lihua Jin, Shasha Xu, Huijun Ye, Xi Luo, Ruilan Li, Yuebing Yue

Faculty, Staff and Student Publications

RATIONALE: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder among women of childbearing age and is the primary cause of anovulatory infertility, accounting for 70% to 80% of cases. Ovulation induction is the main treatment approach for infertile patients with PCOS. Commonly utilized medications for this purpose are clomiphene citrate (CC) and letrozole (LE). Clomiphene citrate administration results in an ovulation rate ranging from 60% to 85%, while the pregnancy rate is limited to 35% to 40%, and a further reduction is observed in live birth rates. Letrozole demonstrates a slightly higher pregnancy rate and live birth …

The Relationship Between Social Stigma And Career Decisions Of Individualized And Freelance Male Sex Workers, Luis Miguel Dos Santos, Ho Fai Lo

The Qualitative Report

Switching from a white-collar professional to a sex worker is not an easy step, particularly for individuals with a postgraduate degree in South Korea who may have significant expectations from their parents, peers, and communities. Based on the social stigma theory and social cognitive career and motivation theory, this study aims to understand how stress and pressure impact the motivations, career decisions, and decision-making processes of individualized and freelance male sex workers and their career transition experiences in South Korea. Based on the thematic analysis, ten highly educated male sex workers joined and shared their experiences. The researchers categorized three …

“It’S Always An Admixture Of So Many Identities”: Interpretative Phenomenological Analysis Of Indigenous Kalasha Cultural Identity, Fahad Riaz Choudhry Dr, Karen Jennifer Golden, Miriam Sang-Ah Park

The Qualitative Report

This case study examined how an Indigenous Kalasha participant in northern Pakistan makes sense of his multi-faceted identity. The interpretative phenomenological analysis method was used to analyze data from an in-depth, single person case study. Our selected participant was a 36-year-old male postgraduate student from an Indigenous marginalized tribe, which is an ethnic and religious minority group in the northern Hindukush mountain region of Pakistan. Results are presented in four superordinate themes: (1) Identity: admixture of a number of identities, (2) Changing culture and its psychological impact, (3) Cultural protective factors against psychological problems and (4) Mental health perspective. …

Residential Metals Abatement Program Construction Completion Report (Non-Residential Parcels – Indoor Soil) - Butte High School, Environmental Resource Management (Erm)

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Yearly Population Data At Census Tract Level Revealed That More People Are Now Living In Highly Fire-Prone Zones In California, Usa, Slade Lazeweski, Shenyue Jia, Jessica E. Viner, Wesley Ho, Brian Hoover, Seung Hee Kim, Menas C. Kafatos

Institute for ECHO Articles and Research

In California (CA), the wildland-urban interface (WUI) faces escalating challenges due to surging population and real estate development. This study evaluates communities along CA's WUI that have witnessed substantial population growth from 2010 to 2021, utilizing demographic data and the 2020 WUI boundaries by the University of Wisconsin-Madison SILVIS Lab. Employing the Mann-Kendall test, we analyze yearly population trends for each census tract along the CA WUI and assess their significance. House ownership, affordability, and wildfire risk are examined as potential drivers of this demographic shift. Our findings indicate that 12.7% of CA's total population now resides in census tracts …

Transmembrane Domain-Driven Pd-1 Dimers Mediate T Cell Inhibition, Elliot A Philips, Jia Liu, Audun Kvalvaag, Alexander M Mørch, Anna S Tocheva, Charles Ng, Hong Liang, Ian M Ahearn, Ruimin Pan, Christina C Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R Littman, Michael L Dustin, Jun Wang, Xiang-Peng Kong

Faculty, Staff and Student Publications

Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolerance. Antagonism of PD-1 signaling has proven effective in cancer immunotherapy, and conversely, agonists of the receptor may have a role in treating autoimmune disease. Some immune receptors function as dimers, but PD-1 has been considered monomeric. Here, we show that PD-1 and its ligands form dimers as a consequence of transmembrane domain interactions and that propensity for dimerization correlates with the ability of PD-1 to inhibit immune responses, antitumor …

The Student Movement Volume 108 Issue 18: Empow-Her-Ment: Celebrating Women At Andrews, Nate Miller, Andrew Francis, Grace No, Katie Davis, Corinna Bevier, Abby Shim, Alyssa Caruthers, Lexie Dunham, Anna Rybachek

The Student Movement v. 108 (2023-2024)

HUMANS

Women in Adventist Ministry with Kayla Goodman, Interviewed by Nate Miller

A Conversation with Lexie Dunham of WEAAU, Interviewed by Nate Miller

Who are the New AUSA Cabinet Members?, Andrew Francis

Talking Teaching with Professor Anneris Coria-Navia, Interviewed by Grace No

ARTS & ENTERTAINMENT

Fallen Leaves, Grace No

I wish upon a dandelion, Katie Davis

The Secret Identities of The Brontë Sisters, Corinna Bevier

We Watched Every 2023 Best Picture Nominee (so you don't have to), Corinna Bevier and Nate Miller

NEWS

'24-'25 AUSA Cabinet Prepares for Leadership, Andrew Francis

International Women's Day, Katie Davis

IDEAS

Here for a …

Worldwide Accumulation Of Atmospheric Mercury In Glacier Cryoconite, Agnieszka Pasieka, Kamil Brudecki, Przemysław Niedzielski, Alexandra Proch, Nozomu Takeuchi, Roberto Ambrosini, Philip N. Owens, K Zawierucha, Giovanni Baccolo, Caroline Clason, Dylan Beard, Jacob Clement Yde, Edyta Łokas

School of Geography, Earth and Environmental Sciences

Mercury (Hg) is a chemical element recognized as one of the most toxic among all naturally occurring elements, with health risks depending on its form, concentration, route and time of exposure. Mercury appears in the environment as a result of human activities, which include burning coal or lignite, improper waste disposal, oil refining, use of mercury-containing pesticides and fertilizers, and industrial development such as mining, chemical, pharmaceutical and paper industries. The element also appears in the environment as a consequence of natural phenomena, among which are volcanic emissions, rock erosion, biomass burning and geothermal processes, but also as a result …

Observing Change In Pelagic Animals As Sampling Methods Shift: The Case Of Antarctic Krill, Simeon L. Hill, Angus Atkinson, Javier A. Arata, Anna Belcher, Susan Bengtson Nash, Kim S. Bernard, Alison Cleary, John A. Conroy, Ryan Driscoll, Sophie Fielding, Hauke Flores, Jaume Forcada, Svenja Halfter, Jefferson T. Hinke, Luis Hückstädt, Nadine M. Johnston, Mary Kane, So Kawaguchi, Bjørn A. Krafft, Lucas Krüger, Hyoung Sul La, Cecilia M. Liszka, Bettina Meyer, Eugene J. Murphy, Evgeny A. Pakhomov, Frances Perry, Andrea Piñones, Michael J. Polito, Keith Reid, Christian Reiss

School of Geography, Earth and Environmental Sciences

Understanding and managing the response of marine ecosystems to human pressures including climate change requires reliable large-scale and multi-decadal information on the state of key populations. These populations include the pelagic animals that support ecosystem services including carbon export and fisheries. The use of research vessels to collect information using scientific nets and acoustics is being replaced with technologies such as autonomous moorings, gliders, and meta-genetics. Paradoxically, these newer methods sample pelagic populations at ever-smaller spatial scales, and ecological change might go undetected in the time needed to build up large-scale, long time series. These global-scale issues are epitomised by …

The Employment Situation Of Veterans: February 2024, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

Veteran employment trends and statistics among various demographics during February 2024.

Feature Engineering And Supervised Machine Learning To Forecast Biogas Production During Municipal Anaerobic Co-Digestion, Hunter W. Schroer, Craig L. Just

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Municipalities with excess anaerobic digestion capacity accept offsite wastes for co-digestion to meet sustainability goals and create more biogas. Despite the benefits inherent to co-digestion, the temporal and compositional heterogeneity of external waste streams creates operational challenges that lead to upsets or conservative co-digestion. Given the complex microbial bioprocesses occurring during anaerobic digestion, prediction and modeling of the outcomes can be challenging, and machine learning has the potential to improve understanding and control of co-digestion processes. Biogas flows are a surrogate for process health, and here, we predicted biogas production from historical data collected by a water resource recovery facility …

Highly Efficient Dopamine Sensing With A Carbon Nanotube-Encapsulated Metal Chalcogenide Nanostructure, Harish Singh, Jiandong Wu, Kurt A.L. Lagemann, Manashi Nath

Chemical and Biochemical Engineering Faculty Research & Creative Works

Carbon nanotube-encapsulated nickel selenide composite nanostructures were used as nonenzymatic electrochemical sensors for dopamine detection. These composite nanostructures were synthesized through a simple, one-step, and environmentally friendly chemical vapor deposition method, wherein the CNTs were formed in situ from pyrolysis of a carbon-rich metallo-organic precursor. The composition and morphology of these hybrid NiSe2-filled carbon nanostructures were confirmed by powder X-ray diffraction, Raman, X-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy images. Electrochemical tests demonstrated that the as-synthesized hybrid nanostructures exhibited outstanding electrocatalytic performance toward dopamine oxidation, with a high sensitivity of 19.62 μA μM-1 cm-2, low detection limit, broad linear …

Activator Protein Transcription Factors Coordinate Human Il-33 Expression From Noncanonical Promoters In Chronic Airway Disease, Heather E. Raphael, Ghandi F. Hassan, Omar A. Osorio, Lucy S. Cohen, Morgan D. Payne, Ella Katz-Kiriakos, Ishana Tata, Jamie Hicks, Derek E. Byers, Bo Zhang, Jen Alexander-Brett

2020-Current year OA Pubs

IL-33 is a cytokine central to type 2 immune pathology in chronic airway disease. This cytokine is abundantly expressed in the respiratory epithelium and increased in disease, but how expression is regulated is undefined. Here we show that increased IL33 expression occurs from multiple noncanonical promoters in human chronic obstructive pulmonary disease (COPD), and it facilitates production of alternatively spliced isoforms in airway cells. We found that phorbol 12-myristate 13-acetate (PMA) can activate IL33 promoters through protein kinase C in primary airway cells and lines. Transcription factor (TF) binding arrays combined with RNA interference identified activator protein (AP) TFs as …

An Mhealth Intervention To Address Depression And Improve Antiretroviral Therapy Adherence Among Youths Living With Hiv In Uganda: Protocol For A Pilot Randomized Controlled Trial, Proscovia Nabunya, Patricia Cavazos-Rehg, James Mugisha, Erin Kasson, Olive Imelda Namuyaba, Claire Najjuuko, Edward Nsubuga, Lindsey M Filiatreau, Abel Mwebembezi, Fred M Ssewamala

2020-Current year OA Pubs

BACKGROUND: People living with HIV often struggle with mental health comorbidities that lower their antiretroviral therapy (ART) adherence. There is growing evidence that depression treatment may improve ART adherence and result in improved HIV outcomes. Given that mental health services are severely underequipped in low-resource settings, including in Uganda, new solutions to increase access to mental health care and close the treatment gap are urgently needed. This protocol paper presents the Suubi-Mhealth study, which proposed to develop a mobile health (mHealth) intervention for use among Ugandan youths (14-17 years) with comorbid HIV and depression, taking into account their unique contextual, …

Policies For Place: How To Make Sustainable Investments In Communities, Kathleen Bolter, Timothy J. Bartik, Brad J. Hershbein, Michelle Miller-Adams, Lee Adams, Brian J. Asquith, Alfonso Hernandez, Kyle Huisman, Iryna V. Lendel, Gabrielle Pepin, Bridget Timmeney, Beth C. Truesdale, Yulya Truskinovsky

Reports

No abstract provided.

2024 Draft Final Insufficiently Reclaimed Sites Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Graduate Medical Education Well-Being Directors In The United States: Who Are They, And What Does The Role Entail?, Larissa R Thomas, Jonathan A Ripp, Jennifer G Duncan

2020-Current year OA Pubs

BACKGROUND: Institutional Graduate Medical Education (GME) Well-being Director (WBD) roles have recently emerged in the United States to support resident and fellow well-being. However, with a standard position description lacking, the current scope and responsibilities of such roles is unknown. This study describes the scope of work, salary support, and opportunities for role definition for those holding institutional leadership positions for GME well-being.

METHODS: In November 2021, 43 members of a national network of GME WBDs in the United States were invited to complete a cross-sectional survey that included questions about job responsibilities, percent effort, and dedicated budget, and a …

The Decline Of The Non-Hispanic White Population In The United States Of America, Richard R. Verdugo, David A. Swanson

Publications, Reports and Presentations

Objectives: The question of a declining non-Hispanic white (NHW) population has sparked debate in the United States. In examining this question, three bodies of research have emerged. One group reports that the decline is real, a second argues that it is an illusion, and the third provides evidence that the decline is concentrated within socio-economic segments of the NHW population. We use the third groups’ insight as the starting point for our research objective. Methods: In conjunction with data from Census Bureau sources, we use a series of Regression Models in this inquiry. Results: Our results show that the decline …

Fort Hays State University Tiger Weekly, March 08, 2024, University Relations

Tiger Weekly Newsletters

No abstract provided.

A Structured, Journal-Led Peer-Review Mentoring Program Enhances Peer Review Training, Ariel Maia Lyons-Warren, Whitley W Aamodt, Kathleen M Pieper, Roy E Strowd

Faculty, Staff and Students Publications

BACKGROUND: Peer review is essential to the advancement of knowledge. However, training on how to conduct peer review is limited, unorganized, and not well studied. Thus, we sought to determine if a structured mentored peer-review program improved peer review training as measured by multiple quantitative and qualitative assessments.

METHODS: This pre-post intervention study enrolled 55 mentees across 5 cohorts from 2020 to 2023. Each cohort completed pre-program evaluations, participated in 2 mentored reviews, and completed post-program evaluations over 6 months. Mentors and mentees completed pre-program demographic and review experience questionnaires. Outcome measures included (1) total and sub-scores on the modified …

Antioxidant Responses And Phytochemical Accumulation In Raphanus Species Sprouts Through Elicitors And Predictive Models Under High Temperature Stress, María-Trinidad Toro, Roberto Fustos-Toribio, Jaime Ortiz, José Becerra, Nelson Zapata, María Dolores López-Belchí

Faculty, Staff and Students Publications

Crop production is being impacted by higher temperatures, which can decrease food yield and pose a threat to human nutrition. In the current study, edible and wild radish sprouts were exposed to elevated growth temperatures along with the exogenous application of various elicitors to activate defense mechanisms. Developmental traits, oxidative damage, glucosinolate and anthocyanin content, and antioxidant capacity were evaluated alongside the development of a predictive model. A combination of four elicitors (citric acid, methyl jasmonate—MeJa, chitosan, and K2SO4) and high temperatures were applied. The accumulation of bioactives was significantly enhanced through the application of two elicitors, K2SO4 and methyl …

Evaluation Of Perioperative Care And Drivers Of Cost In Geriatric Thoracolumbar Trauma, Omar Tarawneh, Rajkishen Narayanan, Michael Mccurdy, Tariq Issa, Yunsoo Lee, Olivia Opara, Nicholas Pohl, Alexa Tomlak, Matthew Sherman, Jose Canseco, Alan Hilibrand, Alex Vaccaro, Gregory Schroeder, Christopher Kepler

Department of Orthopaedic Surgery Faculty Papers

INTRODUCTION: As the population of elderly patients continues to rise, the number of these individuals presenting with thoracolumbar trauma is expected to increase.

RESEARCH QUESTION: To investigate thoracolumbar fusion outcomes for patients with vertebral fractures as stratified by decade. Secondarily, we examined the variability of cost across age groups by identifying drivers of cost of care.

MATERIALS AND METHODS: We queried the United States Nationwide Inpatient Sample(NIS) for adult patients undergoing spinal fusion for thoracolumbar fractures between 2012 and 2017. Patients were stratified by decade 60-69(sexagenarians), 70-79(septuagenarians) and 80-89(octogenarians). Bivariable analysis followed by multivariable regression was performed to assess independent …

Co‐Producing Ethics Guidelines Together With People With Learning Disabilities, M Bottomley, J Bradley, L Clark, Nk Hayden, Et Al

Peninsula Medical School

Background We are a research team of clinical, academic and advocacy-based researchers with and without learning disabilities, working on the Humanising Healthcare (for people with learning disabilities) project. The project is dedicated to finding and sharing healthcare practices that enhance the lives of people with learning disabilities. As part of our ethics applications to access National Health Service study sites for fieldwork, we worked together to write guiding principles for co-producing research ethics with researchers with learning disabilities. In this paper, we introduce these Participatory Ethics Good Practice Guidelines and reflect on our collaboration. Methods We reflect on developing the …