Digital Commons Network^™

Methotrexate-Induced Pancytopenia: A Call For Mindful Medication Practices, Eunbee Cho, Jessica Marcela Daza, Jiye A. Park, Shreel Patel, Seokwon Choi, Daniel Farray

Research Symposium

Introduction: Methotrexate(MTX) is a widely used disease-modifying antirheumatic drug for various conditions including autoimmune diseases or malignancies. Pancytopenia as an adverse effect of methotrexate is rarely reported but sometimes fatal, and requires more attention. This case report shows a 76-year-old woman with a history of rheumatoid arthritis(RA) on MTX therapy, presenting with severe pancytopenia and oral lesions, and highlights the importance of safe medication practices especially in elderly patients with poor health literacy and compliance.

Case Presentation: A 76-year-old female with rheumatoid arthritis presented to the emergency department with a worsening oral lesion. She had been on an unspecified maintenance …

Metagenomic Analysis Unveils The Microbial Landscape Of Pancreatic Tumors, Sheema Khan, Goutam Banerjee, Saini Setua, Daleniece Jones, Anupam Dhasmana, Bhavin Chauhan, Pratik Banerjee, Murali M. Yallapu, Stephen Behrman, Subhash Chauhan

Research Symposium

Background: The composition of resident microbes in the human body is linked to various diseases and their treatment outcomes. Although studies have identified pancreatic ductal adenocarcinoma (PDAC) associated bacterial communities in the oral and gut samples, herein we hypothesize the prevalence of microbiota in pancreatic tumor tissues is different as compared to their matched adjacent, histologically normal appearing tissues and these microbial molecular signatures can be highly useful for PDAC diagnosis/prognosis.

Methods: In this study, we performed comparative profiling of bacterial populations in pancreatic tumors and their respective adjacent normal tissues using 16S rRNA-based metagenomics analysis.

Results: This study …

Mechanistic Investigation Of C—C Bond Activation Of Phosphaalkynes With Pt(0) Complexes, Roberto M. Escobar, Abdurrahman C. Ateşin, Christian Müller, William D. Jones, Tülay Ateşin

Research Symposium

Carbon–carbon (C–C) bond activation has gained increased attention as a direct method for the synthesis of pharmaceuticals. Due to the thermodynamic stability and kinetic inaccessibility of the C–C bonds, however, activation of C–C bonds by homogeneous transition-metal catalysts under mild homogeneous conditions is still a challenge. Most of the systems in which the activation occurs either have aromatization or relief of ring strain as the primary driving force. The activation of unstrained C–C bonds of phosphaalkynes does not have this advantage. This study employs Density Functional Theory (DFT) calculations to elucidate Pt(0)-mediated C–CP bond activation mechanisms in phosphaalkynes. Investigating the …

Little Bit About Liddle: Big Improvement In Blood Pressure, Shreel Patel, Roy Kondapavuluru, Eunbee Cho, Fatimah Bello, Jian Garcia Cruz

Research Symposium

Background: Liddle syndrome is a rare autosomal dominant disorder associated with abnormalities in function of the collecting tubule sodium channel, also called the epithelial sodium channel (ENaC). ENaC function is increased in the Liddle’s syndrome leading to the manifestations of mineralocorticoid excess symptoms, such as hypertension, hypokalemia, and metabolic alkalosis. The diagnosis is made when these features are seen with low renin and low plasma or urinary aldosterone. Genetic testing is not required for the diagnosis of Liddle syndrome. Liddle's syndrome has an excellent response to amiloride.

Case Presentation: A 56-year-old gentleman, with longstanding uncontrolled hypertension was seen for functional …

Lncrna Impact On Regorafenib Resistance In Colorectal Cancer, Ricardo Pequeno Bracho, Kyle Doxtater, Dennis Kwabiah, Yamile Abuchard Anaya, Sophia Leslie, Mohammad Shabir Hussain, Manish Tripathi

Research Symposium

Cancer metastasis is one of the deadliest aspects of the disease, with about 90% of all cancer-related deaths due to its development at different sites within the body. Colorectal cancer (CRC) is the second leading cause of cancer mortality in the United States, with 40-50% of all patients developing metastasis at some point during their fight with the disease. With the approval of Regorafenib for treating metastatic colorectal cancer, steps have been taken to combat metastasis in colorectal cancer. A vital aspect of the development of metastasis is the development of resistance to first-line chemotherapy. Regorafenib is an oral small-molecule …

Leveraging A Human-Centered Design Framework To Improve Longitudinal Care At A Student Free Clinic : A Quality Improvement Initiative, Rosa E. Martinez, Alexis De Montfort Shepherd, Sahana Prabhu, Katie Se, Krishna Hariprasad, Sanika Mhatre

Research Symposium

Background: Founded in 2009, the CD Doyle Clinic is a student-run free clinic with a mission to provide high-quality equitable care to those in need, regardless of their background. Since 2020, our clinic has served residents at the Esperanza community, a state-sanctioned encampment for people experiencing homelessness in Southeast Austin. The majority of the patients that we serve navigate complex medical and psychosocial conditions. Our clinic operates as an ambulatory care center, primarily addressing acute care and psychiatric concerns. Recognizing our limits as a free clinic, we collaborate alongside community partners, such as Travis County’s CommUnityCare Mobile Health Team, to …

La1-Xsrxcoo3 Perovskite Nanomaterial: Synthesis, Characterization, And Its Biomedical Application, Adhira Tippur, Anyet Shohag, Luke Franco, Ahmed Touhami, Swati Mohan, Mohammed Uddin

Research Symposium

Early cancer detection is paramount for effective treatment and potential cures. This research explores the application of perovskite materials, specifically Sr2+-doped Lanthanum Cobaltite (La1-xSrxCoO3) nanomaterials, in cancer detection, with a focus on rats as an experimental model. The ferroelectric nature of these materials, synthesized through a combination of sol-gel and molten-salt processes, was examined at varying Sr2+ doping levels (1-20 wt%). Rigorous characterization, employing X-ray diffraction and scanning electron microscopy, confirmed the uniform morphology of nano cubes, laying the foundation for subsequent investigations. The magnetic properties of the perovskite nanoparticles were probed, suggesting their potential as a diagnostic tool for …

Jungle Fever: Navigating Malaria In Immigrant Travelers Patient At South Texas: A Case Report, Elimar Gonzalez Morales, Eunbee Cho, Jose Gomez Casanovas, Khairiya Haj-Yahya

Research Symposium

Introduction: Malaria is a severe mosquito-borne illness that can be life-threatening. This infection continues to be a significant global health concern, most prominent in tropical and subtropical regions. Malaria's clinical manifestations exhibit a striking diversity, influenced by geographical variables, the individual's immunity, and age. Diagnosing and treating malaria early is crucial to preventing severe complications and fatalities. This heterogeneity poses unique challenges to its diagnosis and treatment, making it a subject of continuous study and innovation. In this case, we present a case of a patient traveling from an endemic area to a non-endemic area. In this comprehensive examination of …

Investigation Of The Efficacy Local Anesthetics For Perioperative Peripheral Nerve Blocks In Patients With Diabetes: A Retrospective Chart Review, Andrew Kolodziej, Alisha Valdez, Jessica Flores, Kelsey Potter-Baker

Research Symposium

Background: Peripheral nerve neuralgia is a common manifestation of diabetes and can cause patients to have severe episodes of pain. Although pharmacologic treatment with antineuropathic drugs are first line, they often are not effective and can warrant further treatment with peripheral nerve blocks. Further studies support that peripheral nerve blocks should be considered as the first option for anesthesia for lower limb surgery in diabetic patients. The goal of this study is to evaluate local anesthetic agent regimens in the Rio Grande Valley for peripheral nerve blocks in diabetic patients and determine post operative effectiveness and complications.

Methods: …

Investigating Interrater-Reliability In Assessing Social Behavior Of Monodelphis Domestica, Bianca A. Camacho, Johanna Perez, Jatziry L. Escobedo, John L. Vandeberg, Mario Gil

Research Symposium

Background: Reliable, consistent, and objective data is a goal all studies aim to achieve, but many struggle to obtain when subjective biases between researchers can occur. Inter-rater reliability (IRR) is a statistical measure used to quantify the degree of agreement between researchers qualitatively scoring the same phenomenon. The primary goal of this study is to enhance the methodology used to achieve optimal IRR. Using an established ethogram, our team of researchers scored the social behavior of the adult gray short-tailed opossum (Monodelphis domestica) to propose an effective method for achieving high IRR that can contribute to future …

American Police Power Doctrine: The Origin Of The Reasonable Restriction Clause Of The Bangladeshi Constitution, Md Showkot Ali

UNO Student Research and Creative Activity Fair

American Police Power Doctrine: The Origin of the Reasonable Restriction Clause of the Bangladeshi Constitution

Bangladesh got independence through a bloody war in 1971. One of the commitments of the founding fathers of Bangladesh was to ensure fundamental rights for the people of East Pakistan. However, when the framers of the Constitution started drafting, they tried to put some limitations and restrictions upon fundamental rights. The Constitution of Bangladesh guaranteed fundamental rights, but it also put reasonable restrictions on freedom of assembly, freedom of association, and freedom of speech.[1] This paper is going to focus on freedom of speech. …

Negative Impact Of Aging On Gait Autocorrelation: A Mixed-Effects Analysis Of Stride Interval Dynamics, Theodore Deligiannis, Tyler M. Wiles, Seung Kyeom Kim, Nikolaos Stergiou, Aaron Likens

UNO Student Research and Creative Activity Fair

NEGATIVE IMPACT OF AGING ON GAIT AUTOCORRELATION: A MIXED-EFFECTS ANALYSIS OF STRIDE INTERVAL DYNAMICS

Theodore A. Deligiannis^1*, Tyler M. Wiles¹, Seung Kyeom Kim¹, Nick Stergiou^1,2, Aaron D. Likens¹

¹Department of Biomechanics, University of Nebraska at Omaha

*Corresponding author’s email: [email protected]

Presentation preference: Podium

Traditional gait metrics, like speed, cadence, coordination, as well as non-linear measures, appear related to Timed Up and Go (TUG). Timed Up and Go is a clinical measurement related to physical, socioeconomic, and psychological parameters, as well as overall health. TUG can be used as a health …

Validation And Implementation Of Human-Specific Multiplex Analysis To Quantify The Inflammatory Response In The Plasma Of Common Marmosets (Callithrix Jacchus), Donald Rogers

UNO Student Research and Creative Activity Fair

Validation and Implementation of Human-specific Multiplex Analysis to Quantify the Inflammatory Response in the Plasma of Common Marmosets (Callithrix jacchus)

Donald R. Rogers¹, Aliyah Jabenis^1,2, Mackenzie Conrin, M.S.^1,3, Shivdeep Hayer, D.V.M, Ph.D.¹, Claudia Rauter Ph.D.¹, Noel Johnson, D.V.M., M.P.H.⁴, Jonathan B. Clayton, D.V.M., Ph.D.^1,5,6,7, Paul W. Denton, Ph.D.^1,7

¹University of Nebraska at Omaha, Department of Biology

²University of Nebraska Medical Center, Department of Neuroscience

³University of Nebraska Medical Center, Environmental Health and Safety

⁴University of Nebraska Medical Center, Department …

Posteriormedial Ankle Impingement In A Male Division I Ice Hockey Player: A Case Report, Bethany Thompson

UNO Student Research and Creative Activity Fair

The purpose of this case report is to present the case of a 21 year old male Division I collegiate hockey player’s injury during their season, resulting in posteriormedial ankle impingement of the deep posterior tibiotalar ligament, osteochondral lesion of the talus, and tenosynovitis of the tibialis posterior. The patient’s injury did not require surgery; however, they did complete a rehabilitation plan with a physical therapist and receive a cortisone injection. The patient had a positive outcome due to the athletic trainer sending the patient for immediate diagnostic imaging after initial consultation. The patient was able to continue participation in …

The Effectiveness Of Dry Needling For Decreasing Pain And Improving Overall Function In Patients With Hip Osteoarthritis., Chu Han Chen

UNO Student Research and Creative Activity Fair

Clinical scenario: Dry needling has become a common practice in managing knee OA pain as related to the treatment of active myofascial trigger points (MTrPs). However, existing hip OA studies do not appear to consider the use of DN and targeting MTrPs. The purpose of this study was to determine the short-term effects of DN in active MTrPs of the hip muscles to manage symptoms in patients with hip OA. Clinical question: In patients with hip osteoarthritis, is dry needling an effective intervention to decrease pain and improve function? Summary of key findings: Three high-quality randomized double-blind controlled trial (RCT) …

Influence Of Neurotoxin Load On Parkinson’S Disease Pathophysiology, Abhishekh Pokhrel, Daniel Salinas, Nawaz Hack, Kelsey Potter-Baker

Research Symposium

Background: Parkinson’s disease (PD) is a debilitating neurodegenerative disorder impacting movement, mood, and cognition. Among those affected, veterans, due to their occupational exposures, are particularly susceptible, contributing to over 110,000 PD cases in the United States. Studies have largely attributed this increased prevalence among veterans to environmental neurotoxins such as Agent Orange, MPTP, and 6-OHDA. However, it remains unclear how neurotoxin exposure load influences biological mechanisms in PD. This study aims to elucidate the influence of neurotoxin load on PD-associated molecular changes, neuroplasticity, neurodegeneration, and cognitive and motor function within a clinical population of the Rio Grande Valley region …

Case Based Interprofessional Learning Versus Traditional Teaching Methods For Medical, Nursing, And Physiotherapy Students, Seema Saini, Ganesh Kamath, Mary Mathew, Derek Dsouza

Internet Journal of Allied Health Sciences and Practice

Introduction: The traditional teaching method is a teacher centric approach with little involvement from the students. In contrast to that, case-based interprofessional learning (CBIL) is a self-directed learning strategy using case scenarios with the understanding of interprofessional roles and is a student centric learning. Introducing CBIL as a teaching/learning (T/L) strategy for undergraduate healthcare students and assessing its effects on students were the goals of this project. Methods: 134 MBBS, physiotherapy, and nursing final-year students participated in the study. In both traditional teaching and CBIL as self-directed learning techniques, cases with distal end radius fracture and prolapsed intervertebral disc were …

“My Dog Needs A Job”: Identifying The Motivations Of Therapy Animal Volunteers, Jean Kirnan, Anna Ciarrocca, Matthew Malloy, Shawne Hoehne, Grace Norris, Marc Nuzzo

People and Animals: The International Journal of Research and Practice

Volunteers provide billions of hours in free labor annually and are essential for the success of many organizations. Understanding who volunteers as well as the motivating factors that attract and retain volunteers is critical. This study explored the motivations of therapy animal volunteers (TAVs) identifying commonality with general volunteerism as well as unique motivators. Respondents were 748 TAVs with Pet Partners who completed an online survey. The Volunteer Functions Inventory (VFI) was used to allow comparisons to prior research. Supplemental items specific to animal handler motivation were added to the 30 VFI items. Additionally, participants responded to an open-ended question …

Subacute To Chronic Subdural Hematoma In An 18-Year-Old Male Football Player, Peyton Bodemann

UNO Student Research and Creative Activity Fair

The purpose of the report is to present the case of a high school football player who survived two brain surgeries to treat a subacute subdural hematoma that turned chronic (cSDH). This case proves to be unique due to the lack of mechanism, the age of the patient, the complications from surgery, and the recovery.^9,12,16 The patient underwent an MMA (middle meningeal artery) embolization to treat the subacute hematoma, followed by a double burr hole craniotomy with drainage of chronic subdural hematoma. It is important for athletic trainers along with other members of the health care system to work …

Acute Simultaneous Medial And Lateral Ankle Sprain In A Collegiate Football Player: A Case Report, Ian Matlack

UNO Student Research and Creative Activity Fair

The purpose of this case report is to present a twenty-year-old African American male with a complex ankle injury. During a collegiate football game, the athlete injured his left ankle, damaging his deltoid ligament complex, and lateral ankle complex, causing several bone bruises and tearing his peroneal retinaculum. With surgery being declined, standard rehabilitation protocols of POLICE for initial management of inflammation, strengthening, and ROM exercises were conducted. Manual therapies consisting of milking massage, scraping, and joint mobilizations were added to aid in pain and edema control. Comparative case studies suggest that the athlete may have experienced a subluxation of …

Service Learning To Benefit Graduate Students And Meet Community Needs, Brittany Sullivan, Hannah Canady

UNO Student Research and Creative Activity Fair

This poster session will share with faculty members, graduate students, and practicing school psychologists what service learning partnerships are, highlight potential benefits that could come from service learning, and indicate how service learning partnerships can be developed.

Human Blood Cell Isolation: The Critical First Step In Our Laboratory’S Immunobiology Experimental Protocals, Victor Rivero

UNO Student Research and Creative Activity Fair

HUMAN BLOOD CELL ISOLATION: THE CRITICAL FIRST STEP IN OUR LABORATORY’S IMMUNOBIOLOGY EXPERIMENTAL PROTOCALS

Victor Rivero1 Paul W. Denton1, [email protected]

1Department of Biology, University of Nebraska at Omaha, Omaha, NE

The Denton Immunobiology Laboratory focuses on enhancing human natural killer (NK) cell killing capabilities, particularly in the context of combating cancer. NK cells are immune cells that have the ability to kill diseased cells via two mechanisms: direct killing, and antibody-dependent cell-mediated cytotoxicity (ADCC). We recently published our novel approach to testing both methods of killing by using NK cells derived from the same human donor. Our testing approach allows …

Improving Health And Sustainability In Construction Through The Use Of Ai-Based Models For Prediction And Mitigation Of Environmental Cancer Risks, Sana Khan, Asif Shah

Research Symposium

Introduction: Sustainable construction practices face significant challenges in eliminating toxic building materials, driven by a lack of awareness among professionals and economic influences shaping regulatory decisions. This study proposes a solution to address these challenges through the implementation of artificial intelligence (AI) models capable of analyzing vast datasets to predict material toxicity, with a particular focus on identifying carcinogenic materials. The objective is to provide real-time insights to architects and civil engineers, fostering environments free from harmful building materials and preventing potential health hazards, including cancer. The presence of carcinogenic materials in construction processes poses severe health risks. Asbestos, a …

Impact Of A Costello Syndrome-Causing Mutation On Learning And Myelin-Producing Cells, Carlos A. Cisneros, Daniella Hernandez, Saul Lopez, Celeste Martinez, Kaelah Araiza, Ana J. Gutierrez, Alejandro Lopez-Juarez

Research Symposium

Background:Costello Syndrome (CS) is a rare genetic disorder caused by hyperactivating mutations in the HRAS gene, which controls the RAS/MAPK intracellular pathway. Symptoms of CS typically include neurocognitive developmental delays, increased risk of autism spectrum disorder, intellectual disabilities, and other neurological issues. Additionally, most CS patients present with white matter (WM) abnormalities. WM has been proposed to regulate learning due to its roles in increasing/synchronizing action potentials and protecting neuronal axons. Females of a myelin-focused mouse model of CS (PlpCre;HRasG12V; pHRas) show learning deficits in a myelin-regulated test (the complex running wheel; CW) that resolve with time. To shed …

Highlights Of The 2023 Brano Heart Failure Forum, Bela Merkely, Rajko Radovancevic, Bojan Vrtovec, Igor D. Gregoric

The VAD Journal

Since 2007, the Branislav “Brano” Radovancevic Heart Failure Forum (BHFF) has been held annually to provide a venue for experts to present and discuss “Innovations and New Treatment Strategies in Heart Failure.” Clinicians and researchers gather yearly in a different Eastern European city to discuss the latest in heart failure diagnostics and therapeutics. The 2023 BHHF forum was held on the 13^th thru 15^th of September 2023 in Budapest, Hungary. It was attended by over 100 faculty from 16 countries. In addition, participation through online streaming was available. Throughout the forum, 16 sessions focused on challenges and solutions …

Human Papilloma Viruses Infection And Pre-Malignant Lesions In Women On The Texas Mexico Border, Noe Garza, M. Gomez Gutierrez, Candace Robledo, Ihsan Salloum

Research Symposium

Background: In United States, 24-40 million women have had at least one Human Papillomavirus (HPV) infection. While HPV infection is responsible for over 93% of cervical cancer cases worldwide, it is relatively uncommon in US given screening programs and the introduction of the Papanicolaou test. In Texas, where cervical screening and uptake of the HPV vaccine is lower, the incidence of cervical cancer is 12 cases per 100,000 women. Along the border with Mexico the incidence of cervical cancer rises to 16 cases per 100,000 women, mirroring Mexico’s public health problem: cervical cancer is the leading cause of death in …

Healthcare Professional’S Attitudes Towards Interprofessional Collaboration, Martin Ekoumou, Jerome Fischer

Research Symposium

Background: Traditional healthcare has been characterized as a field where professionals work independently, creating an environment with multiple providers in multiple locations duplicating services, adding to the ineffectiveness and waste of resources. The fragmentation of healthcare provision promotes isolation, competition and attempts to preserve power among professions. Accordingly, patient care is less than optimum. To begin to ameliorate this situation Interprofessional Education has been developed. However, a significant part of this education is effective interprofessional collaboration (IPC) which creates higher patient satisfaction, better coordination of patient care, efficient use of healthcare services and higher professional job satisfaction. The purpose of …

Honey Targets Ribosome Biogenesis Process In Human Pancreatic Cancer Cells To Inhibit Their Growth And Metastatic Phenotypes, Aun A. Bangash, Muhammad Bangash, Haider Ahsan, Shiza Khan, Mudassier Ahmad, Dae Joon Kim, Sahir Alvi, Bilal Hafeez

Research Symposium

Background: Pancreatic cancer (PanCa) is the fourth deadliest cancer worldwide and is expected to become the second deadliest cancer by 2030. In the USA, the National Cancer Institute put forth a grim prediction stating that there will be 64,050 new cases in 2023 alone and about 50,000 of these patients will die. Existing therapeutic regimens against PanCa are not that effective and show unacceptable toxicities. Therefore, developing highly effective new agents with less toxicity is urgently required, which could be used as a monotherapy or as an adjuvant to treat PanCa patients. Honey is known for its tremendous health benefits …

Gene By Environment Interaction: The Social Determinants Of Health And Depression, Sowmya Duddu, Eron Manusov, Vincent Diego, Marcio Almeida, Sandra Laston, John Blangero, Sarah Williams-Blangero

Research Symposium

Background: Social Determinants of Health (SDoH) influence health through psychological, social, environmental, and cultural domains according to the psychosocial-cultural model of health. This report provides evidence of the intricate relationship between genetics, depression, and the Social Determinants of Health (SDoH). We applied a joint interaction model to account for G×Sex and G×SDoH interaction in the face of depression to establish if both types of interactions are important and independent of one another in the setting of depression. We estimated the corresponding genetic effect and extracted envophenotypes using Best Linear Unbiased Prediction to remove the influence of genetic variation on expression. …

Aorto-Superior Vena Cava Fistula Secondary To Ascending Aortic Dissection, Talal Al-Assil, Aiden Michael Van Loo, Bakri Kaakeh, Bashar Al Jayyousi, Rania Esteitie

Journal of Shock and Hemodynamics

Aortic fistulas are a rare condition that can be fatal if not detected early. They can occur spontaneously or after trauma or vascular procedures. The most common aortic fistulas occur with the esophagus, intestines, atrium, and bronchi. Aorto-superior vena cava (SVC) fistulas are exceedingly rare finding. We present a patient with a dissected aortic pseudoaneurysm complicated by an aorto-SVC fistula, leading to left-to-right shunting. This caused increased pulmonary blood flow, left ventricular volume overload, and eventual high-output heart failure. This is a unique case of an aorto-SVC fistula as a complication of subacute/chronic ascending aortic dissection in a patient who …