Digital Commons Network^™

“Middle Schoolers Are Just This Special Kind Of Human Being”: Middle School Teacher Perspectives On Creating Hope For Their Students And Themselves, Sheeba Jacob

LMU Theses and Dissertations

Anxiety and depression have increased for adolescent youth, particularly since the pandemic. For certain students, this anxiety and depression connects to trauma because of inequity and bias in schools. This qualitative study examined successful urban middle school teachers and their perspectives on conditions they created for hope in their classrooms and ways they created hope for themselves. Eight middle school teachers who taught humanities shared their insights through semi-structured interviews. Findings aligned with pedagogical practices the teachers used that centered hope and voice for students: culturally responsive practices, relational practices, and justice-oriented practices. These specific teachers cared deeply about their …

Leadership In Uncertain Times: An Analysis Of Decision-Making Processes Among Catholic Elementary School Principals In Low-Income Serving Communities, Gina Aguilar

LMU Theses and Dissertations

This qualitative study examined the decision-making processes among principals of parish-based Catholic elementary schools in low-income communities within the Archdiocese of Los Angeles, against the backdrop of a decentralized governance structure and increased financial pressures intensified by the COVID-19 pandemic. The study was grounded in a conceptual framework derived from contingency theories of leadership and decision-making research and investigated three areas: (1) the principals’ decision-making processes, (2) the situational factors influencing these processes, and (3) the pandemic’s impact on their decision-making processes. The findings revealed dynamic integration of cognitive, social, and procedural processes, rooted in faith and community collaboration. The …

The Convergence Of Ikigai And Design Thinking: Crafting A Purposeful Framework, Victor Christianto, Florentin Smarandache

Sustainable Machine Intelligence Journal

In an era where innovation is not just about solving problems but also about enhancing human experiences and fostering personal fulfillment, the convergence of Ikigai principles with Design Thinking methodology offers a promising avenue for holistic problem-solving and innovation. This paper explores the intersection of Ikigai—a Japanese concept representing one's reason for being—and Design Thinking—a human-centered approach to innovation. We propose a conceptual framework, termed Ikigai-Driven Design (IDD), which integrates the principles of Ikigai with the stages of Design Thinking. IDD comprises five main stages: Empathize, Define, Ideate, Prototype, and Test, each combining elements of Ikigai and Design Thinking to …

A Qualitative Study Of Leaders’ Experiences Of Handling Challenges And Changes Induced By The Covid-19 Pandemic In Rural Nursing Homes And Homecare Services, Malin Knutsen Glette, Tone Kringeland, Lipika Samal, David W Bates, Siri Wiig

Faculty, Staff and Students Publications

Background: The COVID-19 pandemic had a major impact on healthcare services globally. In care settings such as small rural nursing homes and homes care services leaders were forced to confront, and adapt to, both new and ongoing challenges to protect their employees and patients and maintain their organization's operation. The aim of this study was to assess how healthcare leaders, working in rural primary healthcare services, led nursing homes and homecare services during the COVID-19 pandemic. Moreover, the study sought to explore how adaptations to changes and challenges induced by the pandemic were handled by leaders in rural nursing homes …

Essential Right Heart Physiology For The Perioperative Practitioner Poqi Ix: Current Perspectives On The Right Heart In The Perioperative Period, Matthew D Mcevoy, Paul M Heerdt, Vicki Morton, Raquel R Bartz, Timothy E Miller, Poqi Ix Collaborators

Faculty, Staff and Students Publications

As patients continue to live longer from diseases that predispose them to right ventricular (RV) dysfunction or failure, many more patients will require surgery for acute or chronic health issues. Because RV dysfunction results in significant perioperative morbidity if not adequately assessed or managed, understanding appropriate assessment and treatments is important in preventing subsequent morbidity and mortality in the perioperative period. In light of the epidemiology of right heart disease, a working knowledge of right heart anatomy and physiology and an understanding of the implications of right-sided heart function for perioperative care are essential for perioperative practitioners. However, a significant …

Funcpep V20: An Updated Database Of Functional Short Peptides Translated From Non-Coding Rnas, Swati Mohapatra, Anik Banerjee, Paola Rausseo, Mihnea P Dragomir, Ganiraju C Manyam, Bradley M Broom, George A Calin

Faculty, Staff and Student Publications

Over the past decade, there have been reports of short novel functional peptides (less than 100 aa in length) translated from so-called non-coding RNAs (ncRNAs) that have been characterized using mass spectrometry (MS) and large-scale proteomics studies. Therefore, understanding the bivalent functions of some ncRNAs as transcripts that encode both functional RNAs and short peptides, which we named ncPEPs, will deepen our understanding of biology and disease. In 2020, we published the first database of functional peptides translated from non-coding RNAs-FuncPEP. Herein, we have performed an update including the newly published ncPEPs from the last 3 years along with the …

Chromatin Profiles Are Prognostic Of Clinical Response To Bortezomib-Containing Chemotherapy In Pediatric Acute Myeloid Leukemia: Results From The Cog Aaml1031 Trial, Anneke D Van Dijk, Fieke W Hoff, Yihua Qiu, Stefan E Hubner, Robin L Go, Vivian R Ruvolo, Amanda R Leonti, Robert B Gerbing, Alan S Gamis, Richard Aplenc, Edward A Kolb, Todd A Alonzo, Soheil Meshinchi, Eveline S J M De Bont, Terzah M Horton, Steven M Kornblau

Faculty, Staff and Student Publications

The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children's Oncology Group phase 3 trial AAML1031 (NCT01371981). Proteasome inhibition influences the chromatin landscape and proteostasis, and we hypothesized that baseline proteomic analysis of histone- and chromatin-modifying enzymes (HMEs) would identify AML subgroups that benefitted from bortezomib addition. A proteomic profile of 483 patients treated with AAML1031 chemotherapy was generated using a reverse-phase protein array. A relatively high expression of 16 HME was associated with lower EFS and …

Patient Characteristics Of, And Remedial Interventions For, Complaints And Medico-Legal Claims Against Doctors: A Rapid Review Of The Literature, Timothy J Schultz, Michael Zhou, Jodi Gray, Jackie Roseleur, Richard Clark, Dylan A Mordaunt, Peter D Hibbert, Georgie Haysom, Michael Wright

Faculty, Staff and Student Publications

BACKGROUND: It is uncertain if patient's characteristics are associated with complaints and claims against doctors. Additionally, evidence for the effectiveness of remedial interventions on rates of complaints and claims against doctors has not been synthesised.

METHODS: We conducted a rapid review of recent literature to answer: Question 1 "What are the common characteristics and circumstances of patients who are most likely to complain or bring a claim about the care they have received from a doctor?" and Question 2 "What initiatives or interventions have been shown to be effective at reducing complaints and claims about the care patients have received …

The Role Of Computational Methods In Cardiovascular Medicine: A Narrative Review, Salvatore Facciorusso, Stefania Spina, Alessandro Picelli, Alessio Baricich, Gerard E Francisco, Franco Molteni, Jörg Wissel, Andrea Santamato

Faculty, Staff and Student Publications

Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents a comprehensive bibliometric and visual analysis of research concerning BoNT-A treatment of spasticity to elucidate current trends and future directions in this research area. A search was conducted in the Web of Science database for articles focused on the use of BoNT-A in spasticity published between 2000 and 2022. We extracted various metrics, including counts of publications and contributions from different countries, institutions, authors, and journals. Analytical methods in CiteSpace were employed for the examination of co-citations, collaborations, and the co-occurrence …

Wnk Kinase Is A Vasoactive Chloride Sensor In Endothelial Cells, Tessa A C Garrud, Briar Bell, Alejandro Mata-Daboin, Dieniffer Peixoto-Neves, Daniel M Collier, Julio F Cordero-Morales, Jonathan H Jaggar

Faculty, Staff and Student Publications

Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune regional organ blood flow and systemic pressure. Chloride (Cl-) is the most abundant anion in ECs and the Cl- sensitive With-No-Lysine (WNK) kinase is expressed in this cell type. Whether intracellular Cl- signaling and WNK kinase regulate EC function to alter arterial contractility is unclear. Here, we tested the hypothesis that intracellular Cl- signaling in ECs regulates arterial contractility and examined the signaling mechanisms involved, including the participation of WNK kinase. Our data obtained using two-photon microscopy and cell-specific inducible knockout mice indicated that acetylcholine, …

Thriving As Educators: A Study On Cultivating Joy And Longevity In Teaching, Stephanie Anne Wilkinson Witt

Theses and Dissertations

This instrumental case study explored the phenomenon of long-term teachers of a school district in the Western United States who continue to enjoy teaching. They were asked about their well-being at work, using the elements of the PERMA theory of well-being--positive emotions, engagement, relationships, meaning, and accomplishments--and how those impacted their enjoyment and their choice to continue teaching. The case consisted of seven teachers who each had at least 10 years of experience teaching. Each participant was interviewed about what they do to enjoy and continue teaching. Through analysis, clear strategies and actionable steps that teachers can take to continue …

Paradisiacal Protection: Exploring Governance In Sustainable Spaces, Rylee Stanton

Honors College Theses

Biosphere reserves exist officially as “learning places for sustainable development,” yet they also embody an attempt to bring together ecological governance with market-based and localized solutions to the problem of economic development (UNESCO, 2020). This thesis investigates the conditions under which biosphere reserves became reimagined as an all-encompassing solution to such a diverse set of global governance challenges. I explore the relationship between biosphere reserves and the evolving discourse on sustainable development within global governance. Drawing on Foucault-inspired literature on governmentality and “technologies of governance,” I examine the practices, discourses, and subjects that have made biosphere reserves visible and governable …

The Winter Olympics, 1924–2026, Stephen Essex, J. R. Gold, M. M. Gold

School of Geography, Earth and Environmental Sciences

This chapter documents and reviews the role of the Winter Olympics in changing and modernizing the built environment of its hosts, together with its long-term legacies. It identifies five sequential phases in the development of the event to offer a framework for organizing and understanding the experiences of the past twenty-four hosts of the Winter Olympic Games from 1924. With its focus on urban centres and regions as hosts, the Winter Olympics now emulates the Summer Olympics in its ability to stimulate regeneration. The concept of the Winter Olympics continues to evolve in its more challenging economic, social, and environmental …

Stigma And Its Implications For Dementia In South Africa: A Multi-Stakeholder Exploratory Study, R Jacobs, M Schneider, N Farina, Toit P Du, S Evans-Lacko

Peninsula Medical School

Stigma and discrimination in relation to dementia has a range of implications for people living with dementia and their families worldwide, including help-seeking, quality of life, social rejection and isolation. Few studies consider the perceptions and stigma towards dementia from multiple perspectives, such as people living with dementia, carers, general public and health-care workers. South Africa has limited evidence on the stigmatisation of people living with dementia, with responses to people living with dementia being driven by poor understanding of the condition, cultural beliefs about causes and social interaction problems associated with memory and cognitive impairment. This study explored the …

Reply Brief Of Edward A. And Doris Zelinsky In The New York Tax Appeals Tribunal, Edward A. Zelinsky, Doris Zelinsky

Amicus Briefs

Three reasons of state law independently compel a refund of the New York income tax Professor Edward A. Zelinsky paid on the Cardozo Law School salary Professor Zelinsky earned during the COVID period from March 15, 2020 through December 31, 2020. That salary was not New York source income because Professor Zelinsky earned that COVID period salary at his home in Connecticut “wholly without” New York’s borders. 20 N.Y.C.R.R. § 132.4(b). In addition, New York’s “convenience of the employer” rule does not apply to that COVID period salary because Professor Zelinsky’s remote work at home was for Cardozo’s necessity rather …

Increased Dietary Trp, Thr, And Met Supplementation Improves Performance, Health, And Protein Metabolism Of Weaned Piglets Under Mixed Management And Poor Housing Conditions, Joseane Penteado Rosa Gonçalves, Antonio Diego Brandão Melo, Qinnan Yang, Marllon José Karpeggiane De Oliveira, Danilo Alves Marçal, Manoela Trevisan Ortiz, Pedro Righetti Arnaut, Ismael França, Graziela Alves Da Cunha Valini, Cleslei Alisson Silva, Nate Korth, Natasha Pavlovikj, Paulo Henrique Reis Furtado Campos, Henrique Gastmann Brand, John Kyaw Htoo, João Carlos Gomes-Neto, Andrew K. Benson, Luciano Hauschild

Department of Food Science and Technology: Faculty Publications

A sanitary challenge was carried out to induce suboptimal herd health while investigating the effect of amino acids supplementation on piglet responses. Weaned piglets of high sanitary status (6.33 ± 0.91 kg of BW) were distributed in a 2 × 2 factorial arrangement into two similar facilities with contrasting sanitary conditions and two different diets. Our results suggest that increased Trp, Thr, and Met dietary supplementation could support the immune systems of piglets under a sanitary challenge. In this manner, AA+ supplementation improved the performance and metabolism of piglets under mixed management and poor sanitary conditions. No major temporal microbiome …

Cardiovascular Disease Management With Sodium-Glucose Cotransporter-2 Inhibitors In Patients With Type 2 Diabetes: A Cardiology Primer, Allan Zhang, Ramsey Kalil, Alexander Marzec, Stephanie A Coulter, Salim Virani, Kershaw V Patel, Matthew W Segar

Faculty, Staff and Students Publications

Patients with type 2 diabetes face an elevated risk of cardiovascular disease. This review centers on sodium-glucose cotransporter-2 (SGLT2) inhibitors, a class of drugs that, according to a growing body of evidence, may have major potential for managing cardiovascular disease in patients with type 2 diabetes. This review presents findings from multiple clinical trials suggesting that SGLT2 inhibitors can not only serve as preventive therapeutic agents but also play a role in the active management of heart failure. The discussion includes the mechanism of action of SGLT2 inhibitors, emphasizing that they enhance urinary glucose excretion, which could lead to improved …

Comparing Asian Immigrants Offending Rates With Other Immigrants., Shamim Ara Pia

Theses and Dissertations

Asian Americans are the fastest-growing population in the United States (U.S). They are characterized by parental attachment, school commitment, neighborhood involvement, and belief. The association between Asian immigrants and crime is multifaceted and requires an in-depth investigation. This study aims to compare the offending rates of Asian immigrants with those of other immigrants, such as immigrants from Europe, Central and South America, Australia, and Africa based on Travis Hirschi’s social bonding theory. The data for this study are drawn from the National Longitudinal Study of Adolescent to Adult Health (Add Health), which is a nationally representative study of students in …

The Effect Of Sodium Bicarbonate Supplementation In Markers Of Gut Permeability And Gastrointestinal Discomfort After Exercise In The Heat, Suzana Andrade De Oliveira

Health, Exercise, and Sports Sciences ETDs

Exercise performed under heat stress conditions is associated with an increase in gut permeability, commonly known as "leaky gut.". Recent studies suggest that sodium bicarbonate ingestion (NaHCO3) before exercise in the heat may offer ergogenic benefits. However, NaHCO3 is known to induce gastrointestinal discomfort (GI) and potentially exacerbate gut permeability. Therefore, this study investigated the effects of NaHCO3 on markers of gut permeability and gastrointestinal discomfort after prolonged physical exercise in a hot environment. To test this, we analyzed markers of intestinal permeability and injury pre and post exercise under heat stress comparing a NaHCO3 group to a placebo group. …

Apigenin Alleviates Autistic-Like Stereotyped Repetitive Behaviors And Mitigates Brain Oxidative Stress In Mice, Petrilla Jayaprakash, Dmytro Isaev, Keun-Hang Susan Yang, Rami Beiram, Murat Oz, Bassem Sadek

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Studying the involvement of nicotinic acetylcholine receptors (nAChRs), specifically α7-nAChRs, in neuropsychiatric brain disorders such as autism spectrum disorder (ASD) has gained a growing interest. The flavonoid apigenin (APG) has been confirmed in its pharmacological action as a positive allosteric modulator of α7-nAChRs. However, there is no research describing the pharmacological potential of APG in ASD. The aim of this study was to evaluate the effects of the subchronic systemic treatment of APG (10–30 mg/kg) on ASD-like repetitive and compulsive-like behaviors and oxidative stress status in the hippocampus and cerebellum in BTBR mice, utilizing the reference drug aripiprazole (ARP, 1 …

Chromatin Profiles Are Prognostic Of Clinical Response To Bortezomib-Containing Chemotherapy In Pediatric Acute Myeloid Leukemia: Results From The Cog Aaml1031 Trial., Anneke D. Van Dijk, Fieke W. Hoff, Yihua Qiu, Stefan E. Hubner, Robin L. Go, Vivian R. Ruvolo, Amanda R. Leonti, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S J M De Bont, Terzah M. Horton, Steven M. Kornblau

Manuscripts, Articles, Book Chapters and Other Papers

The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children's Oncology Group phase 3 trial AAML1031 (NCT01371981). Proteasome inhibition influences the chromatin landscape and proteostasis, and we hypothesized that baseline proteomic analysis of histone- and chromatin-modifying enzymes (HMEs) would identify AML subgroups that benefitted from bortezomib addition. A proteomic profile of 483 patients treated with AAML1031 chemotherapy was generated using a reverse-phase protein array. A relatively high expression of 16 HME was associated with lower EFS and higher 3-year …

Dynamic Sars-Cov-2 Surveillance Model Combining Seroprevalence And Wastewater Concentrations For Post-Vaccine Disease Burden Estimates., Rochelle H. Holm, Grzegorz A. Rempala, Boseung Choi, J. Michael Brick, Alok R. Amraotkar, Rachel J. Keith, Eric C. Rouchka, Julia H. Chariker, Kenneth E. Palmer, Ted Smith, Aruni Bhatnagar

Faculty and Staff Scholarship

Background

Despite wide scale assessments, it remains unclear how large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination affected the wastewater concentration of the virus or the overall disease burden as measured by hospitalization rates.

Methods

We used weekly SARS-CoV-2 wastewater concentration with a stratified random sampling of seroprevalence, and linked vaccination and hospitalization data, from April 2021–August 2021 in Jefferson County, Kentucky (USA). Our susceptible (S" role="presentation" style="box-sizing: inherit; display: inline-block; line-height: normal; font-size-adjust: none; word-spacing: normal; overflow-wrap: normal; text-wrap-mode: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; …

Nanocavity-Mediated Purcell Enhancement Of Er In Tio2 Thin Films Grown Via Atomic Layer Deposition, Cheng Ji, Michael T Solomon, Gregory D Grant, Koichi Tanaka, Muchuan Hua, Jianguo Wen, Sagar Kumar Seth, Connor P Horn, Ignas Masiulionis, Manish Kumar Singh, Sean E Sullivan, F Joseph Heremans, David D Awschalom, Supratik Guha, Alan M Dibos

Faculty, Staff and Student Publications

The use of trivalent erbium (Er3+), typically embedded as an atomic defect in the solid-state, has widespread adoption as a dopant in telecommunication devices and shows promise as a spin-based quantum memory for quantum communication. In particular, its natural telecom C-band optical transition and spin-photon interface make it an ideal candidate for integration into existing optical fiber networks without the need for quantum frequency conversion. However, successful scaling requires a host material with few intrinsic nuclear spins, compatibility with semiconductor foundry processes, and straightforward integration with silicon photonics. Here, we present Er-doped titanium dioxide (TiO2) thin film growth on silicon …

Funcpep V20: An Updated Database Of Functional Short Peptides Translated From Non-Coding Rnas, Swati Mohapatra, Anik Banerjee, Paola Rausseo, Mihnea P Dragomir, Ganiraju C Manyam, Bradley M Broom, George A Calin

Faculty, Staff and Student Publications

Over the past decade, there have been reports of short novel functional peptides (less than 100 aa in length) translated from so-called non-coding RNAs (ncRNAs) that have been characterized using mass spectrometry (MS) and large-scale proteomics studies. Therefore, understanding the bivalent functions of some ncRNAs as transcripts that encode both functional RNAs and short peptides, which we named ncPEPs, will deepen our understanding of biology and disease. In 2020, we published the first database of functional peptides translated from non-coding RNAs-FuncPEP. Herein, we have performed an update including the newly published ncPEPs from the last 3 years along with the …

Climate Change, Migration, And Health: (Near-) Global Evidence, Brian Thiede

Sustainability Seminar Series

Climate change is expected to have widespread impacts on social and environmental systems, with implications for human health and wellbeing. The expansion of georeferenced data on population health and mobility provides new opportunities to measure these impacts. In this seminar, I will discuss new findings from analyses of climate effects on health and migration using “big microdata” from censuses and surveys around the world. I will also discuss the non- trivial limitations to these data and outline how they can be integrated with mixed-methods approaches to better-understand the social costs of climate change.

Benefits Of A Community-Based Occupational Therapy Wellness Program For Unhoused Or Recently Housed Individuals, Peyton Babin, Bailey Hempfill, Megan Talamo, Sloane Tatarski

School of Health Professions Research Day

Introduction. There have been no prior studies that have specifically researched the benefits of a community-based occupational therapy wellness program with the unhoused and recently housed population. We find it important to close the gap in research, as occupational therapists are well-equipped to work with the unhoused and recently housed population.

Purpose. To determine if there is a need for a community based occupational therapy wellness program for unhoused and recently housed individuals.

Methods. Six participants who were unhoused or recently housed completed the Canadian Occupational Performance Measure (COPM) and semi structured interviews. Interview transcripts were reviewed separately using the …

Leadership Tools To Support The Transformational Leadership Style, Emily P. Haire, Dr. Catherine E. Barrett, Dr. Ashley C. Johnson, Dr. Bradley Mills

Academic Leadership Journal in Student Research

The lives of many have been impacted by the COVID-19 pandemic (Dumulescu & Mutiu, 2021). In higher education, students, professors, instructional aids, and other school staff were sent home from institutions to protect health and safety. There became an immediate need for clear, straightforward leadership to guide and lead higher education students and professionals through these unprecedented times, and amid the COVID-19 global pandemic, transformational leaders have been effective in changing the world of higher education institutions. This paper will explore the findings of effective leadership styles for individuals after going through a global pandemic.

Opioid Prescribing Habits Of Emergency Department Providers In Response To An Educational Intervention, Tory A. Makela, Benjamin Aaker

Aesculapius Journal (Health Sciences & Medicine)

Opioid prescribing habits of Emergency Department providers in response to an educational intervention

Tory Makela, MS4; Benjamin Aaker, MD

Introduction: Prescription opioid misuse and dependency has been a rising cause for concern in the United States in recent years, and many of these cases began with an initial prescription in the Emergency Department (ED). Prior studies found that patients seen by “high intensity” prescribers, who prescribe greater quantities of opioids than 75% of other ED physicians within the same hospital, are significantly more likely to suffer from long-term opioid use. Other studies have shown that educational interventions on appropriate opioid …

Enhancing First-Year Stem Student Success Through Peer Mentoring, Nkasa Bolumbu

INSPIRE Student Research and Engagement Conference

Peer education plays a pivotal role in supporting first-year undergraduate students, especially those pursuing STEM fields like biology. STEM students are no exception when it comes to the benefits of peer mentoring. In this presentation, we will delve into the role of supplemental instruction, mentorship, and collaborative learning.

"Redlining" : The Significant Impact It Created On Health In Waterloo, Iowa, Madeline Bickley

INSPIRE Student Research and Engagement Conference

Following the Great Depression, FDR created The New Deal. The New Deal included The National Housing Act of 1934. Since more people were able to afford homes, The Home Owners Loan Corporation (HOLC) created Residential Security Maps, to “ensure” that the recipients of these loans would be able to repaid the banks. These maps were the redlining maps responsible for housing segregation in many cities within America.

Redlining maps color-coded neighborhoods based on the “quality” and “financial risk” that each neighborhood reflected. One common pattern within redlined neighborhoods, was that recipients were considered higher risks for loans. Often times, the …