Digital Commons Network^™

Chemotherapy Activates Inflammasomes To Cause Inflammation-Associated Bone Loss, Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu-Amer, Gabriel Mbalaviele

2020-Current year OA Pubs

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including the skeleton, but the underlying mechanisms have yet to be elucidated. Using tumor-free mouse models, which are commonly used to assess direct off-target effects of anti-neoplastic therapies, we found that doxorubicin caused massive bone loss in wild-type mice, a phenotype associated with increased number of osteoclasts, leukopenia, elevated serum levels of danger-associated molecular patterns (DAMPs; e.g. cell-free DNA and ATP) and cytokines (e.g. IL-1β and IL-18). Accordingly, …

Use Of Barium For Diagnosis Of Colonic Perforation Leads To Challenging Barium Peritonitis, Ariana Naaseh, Jorge G Zarate Rodriguez, Matthew J Mchale, Grace M Niziolek, Thoi H Ngo, John P Kirby, Lindsay M Kranker

2020-Current year OA Pubs

No abstract provided.

Impact Of Self-Reported Loss Of Balance And Gait Disturbance On Outcomes Following Adult Spinal Deformity Surgery, Bassel G Diebo, Munish C Gupta, Et Al.

2020-Current year OA Pubs

No abstract provided.

Multisensory Flicker Modulates Widespread Brain Networks And Reduces Interictal Epileptiform Discharges, Lou T Blanpain, Eric R Cole, Emily Chen, James K Park, Michael Y Walelign, Robert E Gross, Brian T Cabaniss, Jon T Willie, Annabelle C Singer

2020-Current year OA Pubs

Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep brain structures and are practical for chronic daily home use are desirable for a variety of therapeutic applications. Repetitive audio-visual stimulation, or sensory flicker, is an accessible approach that modulates hippocampus in mice, but its effects in humans are poorly defined. We therefore quantified the neurophysiological effects of flicker with high spatiotemporal resolution in patients with focal epilepsy who underwent intracranial seizure monitoring. In this interventional trial (NCT04188834) with a cross-over design, subjects underwent different frequencies of flicker stimulation in the same recording session with the effect …

Organizing The Dissemination And Implementation Field: Who Are We, What Are We Doing, And How Should We Do It?, Gretchen J R Buchanan, Lindsey M Filiatreau, Julia E Moore

2020-Current year OA Pubs

Two decades into its tenure as a field, dissemination and implementation (D&I) scientists have begun a process of self-reflection, illuminating a missed opportunity to bridge the gap between research and practice-one of the field's foundational objectives. In this paper, we, the authors, assert the research-to-practice gap has persisted, in part due to an inadequate characterization of roles, functions, and processes within D&I. We aim to address this issue, and the rising tension between D&I researchers and practitioners, by proposing a community-centered path forward that is grounded in equity.We identify key players within the field and characterize their unique roles using …

100% Match Rate For Ninth Consecutive Year, University Of Dayton. School Of Education And Health Sciences

School of Education and Health Sciences Blog Archive

The undergraduate dietetics program is proud to report a 100% match rate for its graduating class for the ninth year in a row.

Enhancing Srna Confidence: Integrating Simulation-Based Crm Training With Didactic Education To Improve Intraoperative Recognition, Communication, And Management Of Intraoperative Cardiac Arrest, Melissa Lee

Doctor of Nursing Practice Scholarly Projects

Within the operating room (OR), the ability to identify deteriorating patient conditions and effectively communicate, is essential to delivering safe and efficient care. Although rare, the critical nature of emergent events necessitates early recognition and prompt intervention by an experienced anesthesia provider. The complexity of emergency management is often related to diagnostic ambiguity, individual provider experience, and disruptions of the fast-paced OR environment, requiring appropriate training methods for proficient execution. However, student registered nurse anesthetists (SRNAs) often lack sufficient exposure to emergent clinical scenarios, leading to delayed intervention and diminished confidence during crisis management. An evidence-based simulation education guideline for …

April 11, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Nardilysin-Regulated Scission Mechanism Activates Polo-Like Kinase 3 To Suppress The Development Of Pancreatic Cancer, Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of apoptotic resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, explaining the often-reduced Plk3 expression in human PDAC. Importantly, a 41-kDa Plk3 (p41Plk3) that contains the entire kinase domain at the N-terminus (1-353 aa) is activated by scission of the precursor p72Plk3 at Arg354 by metalloendopeptidase nardilysin (NRDC), and the resulting p32Plk3 C-terminal Polo-box domain (PBD) is removed by proteasome degradation, preventing the inhibition of p41Plk3 by PBD. We find …

Comorbidity Clusters In Patients With Rheumatoid Arthritis Identify A Patient Phenotype With A Favourable Prognosis, Cynthia S Crowson, Elizabeth J Atkinson, Vanessa L Kronzer, Bradly A Kimbrough, Courtney A Arment, Lynne S Peterson, Kerry Wright, Thomas G Mason, Delamo I Bekele, John M Davis, Elena Myasoedova

Faculty, Staff and Students Publications

Objectives: We aimed to cluster patients with rheumatoid arthritis (RA) based on comorbidities and then examine the association between these clusters and RA disease activity and mortality.

Methods: In this population-based study, residents of an eight-county region with prevalent RA on 1 January 2015 were identified. Patients were followed for vital status until death, last contact or 31 December 2021. Diagnostic codes for 5 years before the prevalence date were used to define 55 comorbidities. Latent class analysis was used to cluster patients based on comorbidity patterns. Standardised mortality ratios were used to assess mortality.

Results: A total of 1643 …

Correction: Covid-19 Outbreaks Surveillance Through Text Mining Applied To Electronic Health Records, Hermano Alexandre Lima Rocha, Erik Zarko Macêdo Solha, Vasco Furtado, Francion Linhares Justino, Lucas Arêa Leão Barreto, Ronaldo Guedes Da Silva, Ítalo Martins De Oliveira, David Westfall Bates, Luciano Pamplona De Góes Cavalcanti, Antônio Silva Lima Neto, Erneson Alves De Oliveira

Faculty, Staff and Students Publications

This corrects the article "COVID-19 outbreaks surveillance through text mining applied to electronic health records", 359.

Promoting Participation In Individuals With Parkinson’S Disease Through The Development Of Accessible Occupation-Based Resources, Kelly Struthers

OTD Capstone Projects

This doctoral capstone project was completed through partnership with Rock Steady Boxing Music City, a non-profit organization that provides boxing classes for individuals diagnosed with Parkinson’s disease and other motor-related disorders. The purpose of this project was to understand the participatory barriers that are common within the Parkinson’s disease community and develop solution-oriented resources in response to these barriers. All developed resources were intentionally created to maximize accessibility and explored areas such as driving, fatigue, caregiving, and memory. These resources were compiled and distributed to the “fighters” of Rock Steady Boxing via an in-person “OT Corner” bulletin board, the weekly …

Supporting Adolescent Parents Involved In Younglives, Rachel Fister

OTD Capstone Projects

This doctoral capstone project focused on creating educational tools and resources for adolescent caregivers, volunteer mentors, and staff associates involved in YoungLives. YoungLives is a branch of the non-profit outreach organization YoungLife, that supports adolescent/teen parents and expecting mothers worldwide. The goal of this project was to supply accessible and user-friendly resources for the population to gain knowledge on pediatric topics such as child development, age appropriate milestones, sensory processing, as well as activities to promote occupational skills. The project outcomes resulted in a guidebook and deliverables for education and training purposes, a social media platform for nationwide connection and …

Providing Sensory Integration Education And Transition Tools For The Tennessee Baptist Children’S Homes, Thuy-Duong D. Huynh

OTD Capstone Projects

This doctoral capstone project was completed through a partnership with the residential department of the Tennessee Baptist Children’s Homes, a state-wide ministry that cares for children whose families are in crisis. There were two primary focuses for this project: (1) providing sensory integration education to house parents and (2) creating tools to ease transitions. Outcomes included a presentation and training on sensory integration, a booklet with easily accessible sensory integration information, a local activity guide for day visits with families, and a routine schedule of home visits to ease transitions.

2024 Undergraduate Research Symposium Program, Coastal Carolina University

Undergraduate Research Symposium Programs

15th Annual Undergraduate Research Symposium, April 10-11, 2024.

Engineering Mesenchymal Stromal Cells To Suppress Inflammation And Increase Beta-Cell Mass For Treating Type 1 Diabetes, Dhruva Patel

MUSC Theses and Dissertations

Type 1 diabetes (T1D) is a life-threatening autoimmune disease where the immune system destroys the insulin producing beta-cells in the pancreas. There is no cure for the disease, and the current treatment involves life-long, daily injection of insulin. An ideal therapy for T1D will be the suppression of autoimmunity and increased functional beta-cell mass. The immune regulatory cytokine IL10 can suppress inflammation in various autoimmune diseases. On the other hand, several growth factors and peptide hormones are known to promote an increase in beta-cell mass, through neogenesis and beta-cell proliferation. However, efficient induction of increased beta-cell mass requires preferential and …

Chhs Graduate Programs Make Nation's Top 100, Jill Buchanan

UNH Today Archive

No abstract provided.

The Current - Volume 34 Issue 12, Nova Southeastern University

Student Newspapers

No abstract provided.

Mindfulness Exercises For Educators, Eric B. Miller

Open Educational Resources

This compilation of mindfulness exercises includes a curated selection of online resources, as well as mindfulness exercises description generated via prompt to ChatGPT 3.5.

How The Arts Benefit The Whole Child, Sophie Rose Fudim

Whittier Scholars Program

This literature review draws on insights from scholars and arts advocates, it delves into the significance of incorporating artistic practices in schools and advocates for including arts education in public schools. This literature review utilizes studies, peer-reviewed research papers, and governmental recommendations based on current research. Art has a highly transformative power. It benefits the development of complex thought processes and offers insights into children's abilities. By integrating art into education, educators can address the evolving challenges of early childhood education and cultivate environments where students can be engaged by enthusiastic, trained teachers and get excited about learning. Art prepares …

Independent- Apr. 11, 2024, Leslie Lozada

The Independent (1988-present)

No abstract provided.

Upstarts T3: An Asynchronous And Cohort-Based Entrepreneurship Train-The-Trainer Program, Surin Kim, Maria Rosario T. De Guzman, Kieu-Anh Do, Irene Padasas, Claire Nicholas, Olivia Kennedy, Anna Erdmann, Andy Larson

Journal of Extension

UpStarts is a reverse-mentoring youth program designed to foster an entrepreneurial mindset among participants and a sense of connection between youth and adults. Effective facilitators are critical to the success of the program. This paper describes an asynchronous, cohort-based virtual train-the-trainer (T3) program for potential UpStarts facilitators that was developed to navigate the challenges posed by the COVID pandemic. Participants of the initial UpStarts T3 program reported positive feedback for the training and a high sense of efficacy in implementing UpStarts in their communities. The current T3 model is emerging as a promising means of preparing facilitators to implement UpStarts …

The Effects Of Neuromuscular Electrical Stimulation On Chronic Dysphagia Following Anterior Cervical Disc Fusion Surgery: A Case Report, Anna Munson

Honors Theses

Background: Current literature is lacking an understanding of the physiological mechanisms underlying dysphagia (impairment in swallowing function) that manifests as the result of anterior cervical discectomy and fusion (ACDF). ACDF is a common cervical spinal procedure that, due to its anterior to posterior (front-to-back) approach, risks significant injury to the larynx, which is critical for swallowing food and liquid safely. Furthermore, the general therapeutic approaches available to individuals with dysphagia after ACDF lack specificity of what is being targeted (Ko, et al. 2022). This project is a single subject case report of an individual who underwent ACDF and received neuromuscular …

The Effects Of Therapy Dogs On Students, Chloe Romack

Honors Theses

This thesis explores the effects therapy dogs have on students. It begins with a literature review of 17 articles that involve animal-assisted interventions with students and children. The main topics covered include the definition of a therapy animal and how dogs can influence learning, socialization, emotional well-being, anxiety, and depression. It also discusses how dogs can be used in therapy and special education classrooms as well as the major concerns of dogs in schools. Drawing upon the previous research, a survey was sent to school staff in the Paw Paw Public School District. The participants of this study consisted of …

Virtual Gaming, Actual Damage: Video Game Design That Intentionally And Successfully Addicts Users Constitutes Civil Battery, Allison Caffarone

Duke Law & Technology Review

In recent years, there has been increased academic interest in both the neurological effects of compulsive gaming and the potential tort liability of game developers who scientifically engineer games in order to addict users. Scholars from various disciplines are currently debating the scope and potential solutions to the problems associated with Gaming Disorder, now a globally recognized illness. This article contributes to this discussion by offering a multidisciplinary analysis of the scope of video game addiction, its neurological bases, and its relation to the legal rights and responsibilities of victims and game developers. In addition, this article explores the practical …

Protecting American Children: A Social-Ecological Analysis Of Pactp4, Julia Rossmiller

Student Works

The quantity of pesticides used annually in the United States exceeds one billion pounds every year, and the amount is only rising. The current law that governs the use of pesticides—The Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), permits the use of 72 known pesticides that have been proven harmful and are banned in other countries. Research links the usage of pesticides to the health of individuals, families, and whole communities within the environment. Moreover, dangerous pesticides have been shown to disproportionately affect children, agricultural workers, people of color, and low-income communities. Despite the mounting evidence that confirms the adverse …

Shared Genomic Segments Analysis Identifies Mhc Class I And Class Iii Molecules As Genetic Risk Factors For Juvenile Idiopathic Arthritis, Cecile N. Avery, Nicole D. Russell, Cody J. Steely, Aimee O. Hersh, John F. Bohnsack, Sampath Prahalad, Lynn B. Jorde

Markey Cancer Center Faculty Publications

Juvenile idiopathic arthritis (JIA) is a complex rheumatic disease encompassing several clinically defined subtypes of varying severity. The etiology of JIA remains largely unknown, but genome-wide association studies (GWASs) have identified up to 22 genes associated with JIA susceptibility, including a well-established association with HLA-DRB1. Continued investigation of heritable risk factors has been hindered by disease heterogeneity and low disease prevalence. In this study, we utilized shared genomic segments (SGS) analysis on whole-genome sequencing of 40 cases from 12 multi-generational pedigrees significantly enriched for JIA. Subsets of cases are connected by a common ancestor in large extended pedigrees, increasing the …

Identifying A Group Of Factors Predicting Cognitive Impairment Among Older Adults, Longgang Zhao, Yuan Wang, Eric Mishio Bawa, Zichun Meng, Jingkai Wei, Sarah Newman-Norlund, Tushar Trivedi, Hatice Hasturk, Roger Newman-Norlund, Julius Fridriksson Ph.D., Anwar T. Nerchant

Faculty Publications

Background

Cognitive impairment has multiple risk factors spanning several domains, but few studies have evaluated risk factor clusters. We aimed to identify naturally occurring clusters of risk factors of poor cognition among middle-aged and older adults and evaluate associations between measures of cognition and these risk factor clusters.

Methods

We used data from the National Health and Nutrition Examination Survey (NHANES) III (training dataset, n = 4074) and the NHANES 2011–2014 (validation dataset, n = 2510). Risk factors were selected based on the literature. We used both traditional logistic models and support vector machine methods to construct a composite score …

Spectator 2024-04-11, Editors Of The Spectator

The Spectator

No abstract provided.

Kenyon Collegian - April 11, 2024

The Kenyon Collegian

No abstract provided.