Digital Commons Network^™

Students Step Up To The Plate At Sports Career Fair, Aaron Sanborn

UNH Today Archive

No abstract provided.

Flynn Fellowship To Jumpstart Student's Nursing Career, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Adhd & Self-Esteem: A Group Psychotherapy Manual For Young Adults A, Spencer Neisen

Dissertations, Theses, and Projects

Attention-deficit/hyperactivity disorder (ADHD) is a common condition that affects a significant number of the world’s population, especially young adults (CDC, 2022). ADHD has its roots in behaviors of hyperactivity, inattention, and impulsiveness, and while it is new to mental health, these patterns have been observed throughout history. ADHD is a stigmatized diagnosis, and with this stigma can come low self-esteem (Mueller et al., 2012). On the macro and micro levels, the stigma can come from a variety of places, whether it be from cultural attitudes, bullying, body weight, or preferred method of treatment. Another dimension of the stigma is that …

Surgical Intervention For Diffuse Dermal Angiomatosis Of The Breast, Caroline E. Savoie, Bethany S. Acosta, Harley J. Davis, G. William Poche

School of Medicine Faculty Publications

No abstract provided.

Proportion Of Cancer Cases And Deaths Attributable To Potentially Modifiable Risk Factors In Peru, Jhony A De La Cruz-Vargas, Willy Ramos, Willer Chanduví, Lucy E Correa-López, Nadia Guerrero, Joan Loayza-Castro, Irene Tami-Maury, Diego Venegas

Faculty, Staff and Student Publications

BACKGROUND: Limited evidence exists on the population attributable fraction (PAF) of cancer cases and deaths in Latin America. In Peru several studies have been published regarding the PAF of various risk factors and their associated diseases. The objective of this study was to estimate the fraction of cancer cases and deaths attributable to potentially modifiable risk factors in Peru in 2018, before the COVID-19 pandemic in the population of 15 years old and older.

METHODS: An ecological study was conducted using the prevalence of exposure of the Peruvian population to modifiable risk factors for cancer, the relative risk associated with …

Longitudinal Regression Of Covariance Matrix Outcomes, Yi Zhao, Brian S Caffo, Xi Luo

Faculty, Staff and Student Publications

In this study, a longitudinal regression model for covariance matrix outcomes is introduced. The proposal considers a multilevel generalized linear model for regressing covariance matrices on (time-varying) predictors. This model simultaneously identifies covariate-associated components from covariance matrices, estimates regression coefficients, and captures the within-subject variation in the covariance matrices. Optimal estimators are proposed for both low-dimensional and high-dimensional cases by maximizing the (approximated) hierarchical-likelihood function. These estimators are proved to be asymptotically consistent, where the proposed covariance matrix estimator is the most efficient under the low-dimensional case and achieves the uniformly minimum quadratic loss among all linear combinations of the …

Effects Of Family Dignity Interventions Combined With Standard Palliative Care On Family Adaptability, Cohesion, And Anticipatory Grief In Adult Advanced Cancer Survivors And Their Family Caregivers: A Randomized Controlled Trial, Nannan Wang, Kun Wang, Xinyu Lu, Shuyu Zhang, Xuhan Sun, Yuxi Zhang

Faculty, Staff and Student Publications

BACKGROUND: Family involvement and comfort are equally important in palliative care. Dignity undertook a new meaning and novel challenges as a result of restrictions on visits and companionship during the pandemic. Family-centered family dignity interventions have been shown to be effective in increasing patients' sense of dignity, increasing levels of hope, and reducing psychological distress; however, the effectiveness in enhancing family adaptability and intimacy in the survivor-caregiver binary and reducing expected grief have been inconclusive.

OBJECTIVES: The primary objective of this study was to assess the efficacy of family dignity interventions on family adaptability and cohesion. The secondary objective was …

“A Perfect Storm”: Autistic Experiences Of Menopause And Midlife, Miranda J. Brady, Christine A. Jenkins, Rachel L. Moseley, Margaret Janse Van Rensburg

Faculty and Staff Publications

Previous research indicates that menopause can be an extremely difficult transition for some autistic people. This study asks how autistic people experience menopause and how they can better access services, support and information; autistic Community Research Associates played an important role in each stage of the research. Online focus groups and interviews were conducted with 24 autistic participants who lived in Canada (n = 13) or the United Kingdom (n = 11) and had experience with the menopausal transition. Transcripts were coded and analysed by four team members using reflexive thematic analysis. Four themes and eight subthemes were …

Icariin Accelerates Bone Regeneration By Inducing Osteogenesis-Angiogenesis Coupling In Rats With Type 1 Diabetes Mellitus, Sheng Zheng, Guan-Yu Hu, Jun-Hua Li, Jia Zheng, Yi-Kai Li

Faculty, Staff and Student Publications

BACKGROUND: Icariin (ICA), a natural flavonoid compound monomer, has multiple pharmacological activities. However, its effect on bone defect in the context of type 1 diabetes mellitus (T1DM) has not yet been examined.

AIM: to explore the role and potential mechanism of ICA on bone defect in the context of T1DM.

METHODS: The effects of ICA on osteogenesis and angiogenesis were evaluated by alkaline phosphatase staining, alizarin red S staining, quantitative real-time polymerase chain reaction, Western blot, and immunofluorescence. Angiogenesis-related assays were conducted to investigate the relationship between osteogenesis and angiogenesis. A bone defect model was established in T1DM rats. The …

The Impact Of Patient And Provider Education On Statin Therapy Initiation And Adherence In Type Ii Diabetics, Jane Harlan Bsn-Rn, Lindsey Jacobsen Bsn-Rn, Emily Easterly Bsn-Rn, Mitch King Bsn-Rn, Laura Reed Dnp, Aprn, Fnp-Bc, Cne

Doctor of Nursing Practice Projects

Purpose/Background

Type 2 diabetes mellitus (T2DM) is a common, chronic disease that increases the risk of coronary artery disease and stroke fourfold, which makes protecting cardiac function a priority. The American Diabetes Association (ADA) and American Heart Association (AHA) recommend the prescription of statins to reduce cardiovascular complications. Unfortunately, provider and patient adherence to this recommendation is poor.This study aimed to determine if shared-decision making and patient follow-up within a 6 month period of being newly diagnosed with T2D has an effect on the initiation rate of statin therapy.

Methods

In this retrospective study we requested data from the University …

Sustaining And Increasing Participation Of Rural Seniors In A Senior Center, Michelle L. Fontaine

Walden Dissertations and Doctoral Studies

This case study’s objective was to sustain and increase senior participation in senior center activities by examining the rural senior perception of environmental needs and support of a local senior center. Senior centers assist with aging in place well and aid seniors to be socially active within their communities. Much of the literature around senior centers has focused on urban environments and not on the specific needs of the rural senior. In this study, 24 individuals were interviewed. The questions examined the seniors’ perception about the functionality and accessibility of the senior center to meet their physical and social needs …

Strategies To Enhance The Success Of Six Sigma Process Improvement Projects In Nonmanufacturing Environments, Talondis Whisker

Walden Dissertations and Doctoral Studies

Six Sigma is a fact-based and data-driven methodology for improving products, processes, and services in companies across the world. Many project managers from various industries have tried to implement Six Sigma and have failed, resulting in poor quality of their products, inefficient processes, and cost increases. Grounded in the total quality management framework, the purpose of this qualitative single-case study was to explore strategies that project managers used to implement successful Six Sigma process improvement projects in nonmanufacturing environments. The participants were eight Six Sigma project managers who had experience in enhancing the success rates of Six Sigma process improvement …

Descriptive Study Of Coordination And Treatment In West Virginia’S Behavioral/Mental Health Crisis, Samuel Gordon Weaver

Walden Dissertations and Doctoral Studies

West Virginia’s residents are less likely to have adequate access and effective care coordination when receiving behavioral and mental health treatment as compared to residents of other states. Seeking patterns of relationships can provide administrators with a better understanding of influences that might cause inter and intra-team systemic challenges and how to reorient policies and behaviors to ameliorate micro and macro task failures. The research questions and associated hypotheses involved understanding the nature of associations between three variables - behavioral health treatment status for autism spectrum disorder, behavioral health treatment status for attention-deficit hyperactivity disorder, and professional mental health treatment …

Relationship Between Knowledge, Years Of Licensure, And Attitudes Of Midwives About Female Genital Mutilation And Its Prevalence Among Their Patients In Bawku, Ghana, Frank Debrah

Walden Dissertations and Doctoral Studies

Female genital mutilation (FGM) is one of the hindrances to girls' development. FGM is often a rite of passage between childhood and adulthood. This cross-sectional study examined the relationship between the knowledge, years of licensure, and attitudes of midwives regarding FGM and the prevalence of FGM among their patients in Bawku, Ghana. Bronfenbrenner's social ecological model served as the theoretical framework to describe the link between midwives' knowledge, attitude, years of licensure, and FGM prevalence. The knowledge and attitude of midwives were classified as exosystem factors. Hence, their direct interaction with patients is likely to affect the patient's practice of …

Influence Of Birthsex On Readmissions Due To Nonadherence To Psychotropic Medications, Moro Osumanu

Walden Dissertations and Doctoral Studies

Hospital directors at psychiatric hospitals in Ghana are struggling to reduce readmissions that are caused by nonadherence to psychotropic medications. Hospital readmissions and their associated costs have become an increasing concern over the last several years. The purpose of this quantitative correlational study was to examine the influence of birthsex on readmissions due to nonadherence to psychotropic medications. The Donabedian model was used as the theoretical framework for this study. The research question was developed to determine which birthsex category has the greatest positive influence on readmissions due to nonadherence to psychotropic medications at the psychiatric hospital study site. The …

Addressing Mental Health Challenges In Graduate Education, Obed A. Boateng

Masters Projects

Graduate students face a multitude of stressors that can negatively impact their mental health and wellbeing, including academic pressures, work-life balance issues, and financial strains. However, minimal attention has been focused the needs of graduate student population, and existing support are limited. More so, student affairs professionals and practitioners (SAPPs) often engage and interact with graduate student. Yet, many SAPPs who are interested in helping address graduate students’ mental health needs lack sufficient training to effectively support graduate students experiencing mental health challenges. The purpose of this project is to develop and implement a comprehensive training program to equip SAPPs …

China Maritime Report No. 37: Re-Engaging With The World: China's Military Diplomacy In 2023, Jie Gao, Kenneth W. Allen

CMSI China Maritime Reports

China’s military diplomacy plays a crucial role in advancing the nation's foreign policy objectives and safeguarding its strategic interests. This report highlights a diverse array of activities within military diplomacy, including senior-level meetings, joint military exercises, naval port calls, UN peacekeeping operations, and academic exchanges. Our findings reveal a significant—but incomplete—recovery in China's military diplomacy activities in 2023, following a period of reduced contacts with foreign militaries during the COVID-19 pandemic. Southeast Asia and Russia remain primary partners for China, with emerging strategic importance also seen in Africa, Oceania, and the Middle East. Overall, China's military diplomacy underscores its efforts …

Safety Profile And Adverse Event Management For Futibatinib, An Irreversible Fgfr1-4 Inhibitor: Pooled Safety Analysis Of 469 Patients, Funda Meric-Bernstam, Antoine Hollebecque, Junji Furuse, Do-Youn Oh, John A Bridgewater, Masashi Shimura, Bailey Anderson, Nanae Hangai, Volker Wacheck, Lipika Goyal

Faculty, Staff and Student Publications

PURPOSE: Futibatinib, a covalently-binding inhibitor of fibroblast growth factor receptor (FGFR)1-4 gained approval for the treatment of refractory, advanced intrahepatic cholangiocarcinoma (iCCA) harboring an FGFR2 fusion/other rearrangement. An integrated analysis was performed to evaluate safety and provide guidance on the management of futibatinib-associated adverse events (AEs) in patients with unresectable/metastatic tumors, including iCCA.

PATIENTS AND METHODS: Data from three global phase I or II studies of futibatinib (NCT02052778; JapicCTI-142552) were pooled. AEs were graded per NCI CTCAE v4.03, where applicable. Safety was analyzed for patients receiving any futibatinib starting dose (overall population) and in those receiving the approved starting dose …

Sensitivity Analysis With Iterative Outlier Detection For Systematic Reviews And Meta-Analyses, Zhuo Meng, Jingshen Wang, Lifeng Lin, Chong Wu

Faculty, Staff and Student Publications

Meta-analysis is a widely used tool for synthesizing results from multiple studies. The collected studies are deemed heterogeneous when they do not share a common underlying effect size; thus, the factors attributable to the heterogeneity need to be carefully considered. A critical problem in meta-analyses and systematic reviews is that outlying studies are frequently included, which can lead to invalid conclusions and affect the robustness of decision-making. Outliers may be caused by several factors such as study selection criteria, low study quality, small-study effects, and so on. Although outlier detection is well-studied in the statistical community, limited attention has been …

Multi-Omics Analysis Reveals Immune Features Associated With Immunotherapy Benefit In Patients With Squamous Cell Lung Cancer From Phase Iii Lung-Map S1400i Trial, Edwin Roger Parra, Jiexin Zhang, Dzifa Yawa Duose, Edgar Gonzalez-Kozlova, Mary W Redman, Hong Chen, Ganiraju C Manyam, Gayatri Kumar, Jianhua Zhang, Xingzhi Song, Rossana Lazcano, Mario L Marques-Piubelli, Caddie Laberiano-Fernandez, Frank Rojas, Baili Zhang, Len Taing, Aashna Jhaveri, Jacob Geisberg, Jennifer Altreuter, Franziska Michor, James Provencher, Joyce Yu, Ethan Cerami, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Hsin-Hui Huang, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, James Lindsay, Roshni Biswas, Stephen Van Nostrand, Seunghee Kim-Schulze, Jhanelle E Gray, Roy S Herbst, Ignacio I Wistuba, Scott Gettinger, Karen Kelly, Lyudmila Bazhenova, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Cara Haymaker

Faculty, Staff and Student Publications

PURPOSE: Identifying molecular and immune features to guide immune checkpoint inhibitor (ICI)-based regimens remains an unmet clinical need.

EXPERIMENTAL DESIGN: Tissue and longitudinal blood specimens from phase III trial S1400I in patients with metastatic squamous non-small cell carcinoma (SqNSCLC) treated with nivolumab monotherapy (nivo) or nivolumab plus ipilimumab (nivo+ipi) were subjected to multi-omics analyses including multiplex immunofluorescence (mIF), nCounter PanCancer Immune Profiling Panel, whole-exome sequencing, and Olink.

RESULTS: Higher immune scores from immune gene expression profiling or immune cell infiltration by mIF were associated with response to ICIs and improved survival, except regulatory T cells, which were associated with worse …

$2.3 Million Gift To Uab Establishes Student Scholarships To Help Improve Health Care In Wiregrass Area, Alicia Rohan

Browse All News

No abstract provided.

Asl-Catboost Method For Wind Turbine Fault Detection Integrated With Digital Twin, Hongtao Liang, Lingchao Kong, Guozhu Liu, Wenxuan Dong, Xiangyi Liu

Journal of System Simulation

Abstract: In view of the low visibility of the current wind farm status monitoring and insufficient realtime operation and maintenance, based on the concept of digital twin five-dimensional model, the framework of wind farm digital twin five-dimensional model is constructed. Aiming at the insufficient fault detection capability of traditional algorithms and unbalanced positive and negative samples in fan fault data set, the improved ASL-CatBoost algorithm is proposed to achieve the accurate detection of fan fault status. Based on the digital twinning platform, combined with MATLAB/Simulink, the simulation mathematical model of doubly-fed wind turbine under the condition of blade mass imbalance …

Lanthorn, Vol. 58, No. 17, April 15, 2024, Grand Valley State University

Volume 58, August 7, 2023 - April 15, 2024

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Identifying Covariate-Related Subnetworks For Whole-Brain Connectome Analysis, Shuo Chen, Yuan Zhang, Qiong Wu, Chuan Bi, Peter Kochunov, L Elliot Hong

Faculty, Staff and Student Publications

Whole-brain connectome data characterize the connections among distributed neural populations as a set of edges in a large network, and neuroscience research aims to systematically investigate associations between brain connectome and clinical or experimental conditions as covariates. A covariate is often related to a number of edges connecting multiple brain areas in an organized structure. However, in practice, neither the covariate-related edges nor the structure is known. Therefore, the understanding of underlying neural mechanisms relies on statistical methods that are capable of simultaneously identifying covariate-related connections and recognizing their network topological structures. The task can be challenging because of false-positive …

Translation And Validation Of The Health Literacy Score-14 Questionnaire For Vietnamese Patients With Diabetes, Khoa Tuan Vo, Khue Thy Nguyen, Hirohide Yokokawa, Aya Goto, Toshio Naito

Faculty, Staff and Student Publications

Introduction:

Health literacy (HL) is a crucial indicator for health promotion and diabetes care improvement, but the available measurements are mostly in English. This study aimed to translate and validate the 14-item Health Literacy Scale (HLS-14) questionnaire from English to Vietnamese for patients with diabetes in Vietnam.

Methods:

We translated HLS-14 into Vietnamese in accordance with the World Health Organization guidelines and conducted a cross-sectional survey among 571 outpatients with type 2 diabetes using the HLS-14 Vietnamese version (HLS-14 VN). The reliability and validity of the tool were assessed using Cronbach’s alpha, composite reliability (CR), average variance extracted (AVE), and …

Vitamin A Status Modulates Epithelial Mesenchymal Transition In The Lung: The Role Of Furin, M Teresa Cabezuelo, Luis Torres, Elena Ortiz-Zapater, Gerardo López-Rodas, M Pilar Marín, Joaquín Timoneda, Juan R Viña, Rosa Zaragozá, Teresa Barber

Faculty, Staff and Student Publications

Vitamin A deficiency (VAD) induced TGF-β hyperactivation and reduced expression of cell adhesion proteins in the lung, suggesting that the disruption of retinoic acid (RA) signaling leads to epithelial-mesenchymal transition (EMT). To elucidate the role of lung vitamin A status in EMT, several EMT markers and the expression of the proprotein convertase furin, which activates TGF-β, were analyzed in two experimental models. Our in vivo model included control rats, VAD rats, and both control rats and VAD rats, treated with RA. For the in vitro studies, human bronchoalveolar epithelial cells treated with RA were used. Our data show that EMT …

Hammerhead-Type Fxr Agonists Induce An Enhancer Rna Fincor That Ameliorates Nonalcoholic Steatohepatitis In Mice, Jinjing Chen, Ruoyu Wang, Feng Xiong, Hao Sun, Byron Kemper, Wenbo Li, Jongsook Kemper

Faculty, Staff and Student Publications

The nuclear receptor, farnesoid X receptor (FXR/NR1H4), is increasingly recognized as a promising drug target for metabolic diseases, including nonalcoholic steatohepatitis (NASH). Protein-coding genes regulated by FXR are well known, but whether FXR also acts through regulation of long non-coding RNAs (lncRNAs), which vastly outnumber protein-coding genes, remains unknown. Utilizing RNA-seq and global run-on sequencing (GRO-seq) analyses in mouse liver, we found that FXR activation affects the expression of many RNA transcripts from chromatin regions bearing enhancer features. Among these we discovered a previously unannotated liver-enriched enhancer-derived lncRNA (eRNA), termed FXR-induced non-coding RNA (

Assessment Of Potentially Toxic And Mineral Elements In Paddy Soils And Their Uptake By Rice (Oryza Sativa L) With Associated Health Hazards In District Malakand, Pakistan, Asghar Khan, Muhammad Saleem Khan, Munib Ahmed Shafique, Qaisar Khan, Ghulam Saddiq

Faculty, Staff and Student Publications

Rice, a primary food source in many countries of the world accumulate potentially harmful elements which pose a significant health hazard to consumers. The current study aimed to evaluate potentially toxic and mineral elements in both paddy soils and rice grains associated with allied health risks in Malakand, Pakistan. Rice plants with intact root soil were randomly collected from paddy fields and analyzed for mineral and potentially toxic elements (PTEs) through inductively coupled plasma optical emission spectrometry (ICP‒OES). Through deterministic and probabilistic risk assessment models, the daily intake of PTEs with allied health risks from consumption of rice were estimated …

Predictors Of Adherence To A Publicly Available Self-Guided Digital Mental Health Intervention, Mercedes G. Woolley, Korena S. Klimczak, Carter H. Davis, Michael E. Levin

Psychology Faculty Publications

Low adherence to self-guided digital mental health interventions (DMHIs) have raised concerns about their real-world effectiveness. Naturalistic data from self-guided DMHIs are often not available, hindering our ability to assess adherence among real-world users. This study aimed to analyze 3 years of user data from the public launch of an empirically supported 12-session self-guided DMHI, to assess overall program adherence rates and explore predictors of adherence. Data from 984 registered users were analyzed. Results showed that only 14.8% of users completed all 12 modules and 68.6% completed less than half of the modules. Users who were younger, had milder depression, …

Adaptability Of A Vertical Transfer Student, Dylan Barron

Masters Projects

Due to the growing population of transfer students, institutions need to prepare the proper resources to mitigate the feeling of transfer shock. This project explores literature pertaining to transfer students and what resources are offered that can either make this transition smooth or rough. Creating a day-long orientation to promote the resources that different offices offer, as well as providing peer mentors to share their knowledge of the institution. To ensure thorough assessment of the acquired knowledge of transfer students in this program and to determine any necessary program adjustments, surveys are conducted.