Digital Commons Network^™

Impact Of Rural Location On Receipt Of Standard Of Care Treatment And Survival For Locally Advanced Bladder Cancer In Louisiana, Megan Escott, Yong Yi, Ashley Foret, Ting Ting Li, Mei Chin Hsieh, Scott E. Delacroix, Xiao Cheng Wu, Mary E. Westerman

School of Public Health Faculty Publications

Objective: We aim to determine the effect of region of residence (urban vs. rural) on the odds of receiving standard of care treatment for locally advanced BCa in Louisiana and its impact on survival outcomes. Methods: Using the Louisiana Tumor Registry, we identified American Joint Committee on Cancer (AJCC) stage II or III, BCa diagnoses in Louisiana residents between 2010 and 2020. Treatment received was classified as standard or non-standard of care according to American Urological Association (AUA) guidelines and location of residence was determined using Rural Urban Commuting Area-Tract-level 2010 (RUCA). Multivariable logistic regression analyses and multivariate cox proportional …

June 25, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Innate And Adaptive Immune Responses That Control Lymph-Borne Viruses In The Draining Lymph Node, Carolina R. Melo-Silva, Luis J. Sigal

Department of Microbiology and Immunology Faculty Papers

The interstitial fluids in tissues are constantly drained into the lymph nodes (LNs) as lymph through afferent lymphatic vessels and from LNs into the blood through efferent lymphatics. LNs are strategically positioned and have the appropriate cellular composition to serve as sites of adaptive immune initiation against invading pathogens. However, for lymph-borne viruses, which disseminate from the entry site to other tissues through the lymphatic system, immune cells in the draining LN (dLN) also play critical roles in curbing systemic viral dissemination during primary and secondary infections. Lymph-borne viruses in tissues can be transported to dLNs as free virions in …

Long-Term Outcomes In Patients Using Protocol-Directed Active Surveillance For Prostate Cancer, Lisa F. Newcomb, Jeannette M. Schenk, Yingye Zheng, Menghan Liu, Kehao Zhu, James D. Brooks, Peter R. Carroll, Atreya Dash, Claire M. De La Calle, William J. Ellis, Christopher P. Filson, Martin E. Gleave, Michael A. Liss, Frances Martin, Jesse K. Mckenney, Todd M. Morgan, Maria S. Tretiakova, Andrew A. Wagner, Peter S. Nelson, Daniel W. Lin

Markey Cancer Center Faculty Publications

IMPORTANCE: Outcomes from protocol-directed active surveillance for favorable-risk prostate cancers are needed to support decision-making.

OBJECTIVE: To characterize the long-term oncological outcomes of patients receiving active surveillance in a multicenter, protocol-directed cohort.

DESIGN, SETTING, AND PARTICIPANTS: The Canary Prostate Active Surveillance Study (PASS) is a prospective cohort study initiated in 2008. A cohort of 2155 men with favorable-risk prostate cancer and no prior treatment were enrolled at 10 North American centers through August 2022.

EXPOSURE: Active surveillance for prostate cancer.

MAIN OUTCOMES AND MEASURES: Cumulative incidence of biopsy grade reclassification, treatment, metastasis, prostate cancer mortality, overall mortality, and recurrence after …

Intrahousehold Welfare: Theory And Application To Japanese Data, Pierre-André Chiappori, Costas Meghir, Yoko Okuyama

Cowles Foundation Discussion Papers

In this paper we develop a novel approach to measuring individual welfare within house-holds, recognizing that individuals may have both different preferences (particularly regarding public consumption) and differential access to resources. We construct a money metric mea-sure of welfare that accounts for public goods (by using personalized prices) and the allocation of time. We then use our conceptual framework to analyse intrahousehold inequality in Japan, allowing for the presence of two public goods: expenditures on children and other public goods including housing. We show empirically that women have much stronger preferences for both public goods and this has critical implications …

Tn Rehabilitative Initiative In Correction For The Year Ended June 30, 2023, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.

Increasing Access To Non-Dairy Beverages And Commercial Thickeners, Kathleen Carr

General Submissions: Presentations (Oral and Poster)

The primary aim of the project was to identify whether financial assistance in the form of product vouchers for non-dairy (later expanded to include dairy) or commercially available thickeners impacts the time from initial recommendation to identification of a tolerated product. A secondary aim included identifying whether financial assistance in the form of product vouchers for non-dairy (later expanded to include dairy) beverages or commercially available thickeners impacts insurance coverage.

Sunlight Solutions: Optimizing 25(Oh)D Concentrations In Global Maternal Health Strategies To Improve Maternal Outcomes And Preserve Healthcare Resources, Beth Sanford

Global Advocacy

In 2020, the World Health Organization identified the Global maternal mortality rate was a staggering 223 per 100,000. As a result, the United Nations created Sustainable Development Goal 3.1, with the hope of "reducing the global MMR to less than 70 per 100 000 births, with no country having a maternal mortality rate of more than twice the global average" by 2030.

Optimizing 25(OH)D serum concentrations to a minimum of 40 ng/mL (100 nmol/L) has been proven to be a safe, affordable, and effective way to improve perinatal outcomes such as decreasing maternal mortality as well as morbidities such as …

Climate Challenge For Sigma Chapters, Kathy Burlingame, Michelle Dephillips, Michelle Gilbert, Kelly Kuhns, Daria Waszak

Global Advocacy

There are a plethora of health effects connected to climate change's impacts on weather, food, water, air, heat, vectors, allergens, and more. As a trusted voice, nurses are in an opportune position to advocate for climate action and its related impacts on health. Whilst, the topic of climate change should be integrated more consistently through curricula for nurses. With that in mind, The Nurses Climate Challenge, a campaign of the ANHE and Healthcare Without Harm, was launched in 2018. Its initial aim of engaging 50,000 nurses was met, and the initiative is being transferred to ANHE this month.

Foster Parents Assisting Transitioning Foster Care Youth In Maintaining Stable Housing, Cecilann Morrison

Walden Dissertations and Doctoral Studies

Foster Parents Assisting Transitioning Foster Care Youth in Maintaining Stable Housing by Cecilann Morrison MA, National University, 2013 BS, Fresno Pacific University, 2011 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Human and Social Service Walden University June 2024

Strategies For Evaluating Training For Field Engineers In The Aerospace And Defense Industry, Nathan D. Johnson

Walden Dissertations and Doctoral Studies

Inefficient training strategies are just one of the many challenges field engineer managers face in the aerospace and defense industry. Aerospace and defense managers and customers are concerned because inefficient training strategies for field engineers impact how well they can effectively contribute to organizational and customer mission success in operations around the globe. Grounded in the Kirkpatrick model, the purpose of this qualitative pragmatic inquiry was to explore strategies aerospace and defense managers use to evaluate field engineer training programs. The participants were five aerospace and defense managers who successfully implemented training evaluation strategies. Data were collected from semistructured interviews …

Manufacturing Companies’ Strategies To Mitigate Supply Chain Disruptions, Trisha L. George

Walden Dissertations and Doctoral Studies

Supply chain disruption has the potential for adverse business outcomes. In manufacturing facility settings, leaders are concerned that supply chain disruption decreases the quality of productivity and profitability. Grounded in dynamic capability theory, the purpose of this qualitative pragmatic inquiry was to explore strategies leaders used to mitigate supply chain disruptions. The participants were six supply chain leaders from three manufacturing facilities located in Mexico who mitigated supply chain disruption. Data were collected using semistructured interviews and public records. Through thematic analysis, four themes were identified: (a) cultural differences, (b) communication, (c) organizational structures, and (d) disciplines. A key recommendation …

Manufacturing Companies’ Strategies To Mitigate Supply Chain Disruptions, Trisha L. George

Walden Dissertations and Doctoral Studies

Supply chain disruption has the potential for adverse business outcomes. In manufacturing facility settings, leaders are concerned that supply chain disruption decreases the quality of productivity and profitability. Grounded in dynamic capability theory, the purpose of this qualitative pragmatic inquiry was to explore strategies leaders used to mitigate supply chain disruptions. The participants were six supply chain leaders from three manufacturing facilities located in Mexico who mitigated supply chain disruption. Data were collected using semistructured interviews and public records. Through thematic analysis, four themes were identified: (a) cultural differences, (b) communication, (c) organizational structures, and (d) disciplines. A key recommendation …

Quality Improvement: Naloxone Prescribing Practices For Paitent With An Opioid Patient Prescriber Agreement, Moniqueca Helms

Walden Dissertations and Doctoral Studies

The Substance Abuse Mental Health and Human Services Administration (SAMHSA) has set guidelines for opioid prescribing practices. The core principles of SAMHSA are to prevent overdose abuse and to provide appropriate treatment for those with an opioid abuse disorder. The concern addressed by the Doctor of Nursing Practice project was the gap in physician education regarding a Best Practice Alert (BPA) in the Electronic Medical Record that appears when prescribing an opioid to a patient without cancer. The alert indicates best practice is to prescribe naloxone with the opioid prescription. The naloxone BPA education project was implemented using the exploration, …

A Staff Education Program On The Education Of Nurses On Transgender Health Care, Diana Collins

Walden Dissertations and Doctoral Studies

In nursing education, both preregistration and continuing professional development, there is an absence of information about the specific needs of transgender people. The practicum site observed that education on the needs of the transgender community was lacking, discussing a discrepancy in the information offered and the scant attention paid to the unique requirements of transgender individuals. The goal of this project was to create a program that would raise staff members’ understanding of the exceptional health care requirements of the transgender population by providing them with an evidence-based assessment screening tool and training on transgender health care for nurses. The …

Who Helps Tsimane Children And Adults?, Eric Schniter, Daniel K. Cummings, Paul L. Hooper, Jonathan Stieglitz, Benjamin C. Trumble, Hillard S. Kaplan, Michael D. Gurven

ESI Working Papers

We examine various forms of helping behavior among Tsimane Amerindians of Bolivia, focusing on the provision of shelter, childcare, food, sickcare, cultural influence, and traditional story knowledge. Kin selection theory traditionally explains nepotistic nurturing of youth by closely related kin. However, less attention has been given to understanding the help provided by individuals without close genetic relatedness. To explain who provides various forms of help, we evaluate support for several predictions derived from kin selection theory. Our results show that helpers who are most often closely related and from an older generation tend to provide more costly forms of help …

Car T-Cell Expansion: Harmful Or Helpful?, Anath C Lionel, Sattva S Neelapu

Faculty, Staff and Student Publications

No abstract provided.

Psycho-Social Determinants Of Employee Green Behavior Among It Professionals, Jovita Sherin George, K.N. Jayakumar, Amal Tom Jose

Makara Human Behavior Studies in Asia

As environmental degradation and hazards caused by the information technology (IT) industry reach critical levels, promoting pro-environmental behaviors within IT firms is crucial. These behaviors not only reduce operational costs but also enhance employee productivity. The primary objective of this study is to assess the roles of consideration of future consequences (CFC), nature relatedness (NR), and organizational commitment (OC) as determinants of employee green behavior (EGB). Results revealed a significant relationship between CFC and EGB. Specifically, CFC-Future has a significant positive relationship with EGB, whereas CFC-Immediate has a significant negative correlation with EGB. Additionally, the relationship between EGB and NR …

Identity After Impairment: Development Of An Athletic Identity Model Of Filipino Para-Athletes, Marian M. Lagundino, Marc Eric S. Reyes, Ryan Francis O. Cayubit

Makara Human Behavior Studies in Asia

Athletic Identity (AthID) is an aspect of the self-concept that refers to how one identifies with the role of an athlete and seeks acknowledgment of that role. This identity is not salient in all individuals, but AthID is activated for those who regard their athletic role as significant. Our objective was to develop a theoretical model to elucidate how Filipino para-athletes can cultivate their distinct athletic identity after acquiring a disability. The present study explored the athletic identities of 12 Filipino para-athletes, aged 24 to 63, who developed physical impairment and continued participating and competing in their chosen sports. Using …

Molecular Docking Of The Interaction Between Citrus Amblycarpa Extract Contents And Inflammatory Proteins Of Hepatic Steatosis, Lena Rosida, Dewi Indah Noviana Pratiwi, Roselina Panghiyangani, Juliyatin Putri Utami, Nasrul Idhafi, Muhammad Febriansyah, Andi Azizah Maulidia Budiarman

Makara Journal of Science

Citrus amblycarpa possesses various pharmacological activities, such as antioxidant, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. The main active compounds in C. amblycarpa (including gamma (γ)-aminobutyric acid [GABA], hesperidin, naringin, neoeriocitrin, poncirin, quercetin, and rutin) show potential to interact with the inflammatory proteins in hepatic steatosis (such as nuclear factor kappa beta [NF-kB], tumor necrosis alpha [TNF-alpha], interleukin-6 [IL-6], c-Jun NH2-terminal kinase [JNK], and adiponectin). Molecular docking simulations were performed using Swiss Dock (http://www.swissdock.ch/), and analysis and visualization were conducted using Discovery Studio 4.1. Rutin, poncirin, hesperidin, and neoeriocitrin exhibit high affinities to NF-κB, TNF-alpha, IL-6, and adiponectin …

Coordinated Population Forecast For Multnomah County, Its Urban Growth Boundaries (Ugb), And Area Outside Ugbs 2024-2074, Neal Marquez, Ethan Sharygin, Suniva Thangaraj, Huda Alkitkat, Gilbert Montcho, David Swanson, Joshua Wilde

Oregon Population Forecast Program

This report for population forecasts for Multnomah County was made in compliance with Oregon House Bill 2253 relating to population forecasts for land use planning. Portland State University Population Research Center is tasked with creating population projections for all Oregon counties except Multnomah, Clackamas, and Washington as well as population forecasts for all Urban Growth Boundaries (UGBs), except for the Metro area UGB. These population forecasts are generated using standardized demographic methods with input and feedback from county, city, and other local stakeholders.

Coordinated Population Forecast For Hood River County, Its Urban Growth Boundaries (Ugb), And Area Outside Ugbs 2024-2074, Neal Marquez, Ethan Sharygin, Huda Alkitkat, Suniva Thangaraj, Gilbert Montcho, David Swanson, Joshua Wilde

Oregon Population Forecast Program

This report for population forecasts for Columbia County was made in compliance with Oregon House Bill 2253 relating to population forecasts for land use planning. Portland State University Population Research Center is tasked with creating population projections for all Oregon counties except Multnomah, Clackamas, and Washington as well as population forecasts for all Urban Growth Boundaries (UGBs), except for the Metro area UGB. These population forecasts are generated using standardized demographic methods with input and feedback from county, city, and other local stakeholders.

Coordinated Population Forecast For Tillamook County, Its Urban Growth Boundaries (Ugb), And Area Outside Ugbs 2024-2074, Neal Marquez, Ethan Sharygin, Huda Alkitkat, Suniva Thangaraj, Gilbert Montcho, David Swanson, Joshua Wilde

Oregon Population Forecast Program

This report for population forecasts for Tillamook County was made in compliance with Oregon House Bill 2253 relating to population forecasts for land use planning. Portland State University Population Research Center is tasked with creating population projections for all Oregon counties except Multnomah, Clackamas, and Washington as well as population forecasts for all Urban Growth Boundaries (UGBs), except for the Metro area UGB. These population forecasts are generated using standardized demographic methods with input and feedback from county, city, and other local stakeholders.

Individual Differences In The Cognitive-Behavioral Model Of Chronic Back Pain In Patients Receiving Spine Surgery: Towards Precision Phenotypes, Madelyn Frumkin

Arts & Sciences Graduate Student Theses and Dissertations

Chronic back pain impacts over 20 million adults in the United States and represents the costliest condition in our healthcare system. Treatments for chronic back pain range from cognitive-behavioral therapy to opioid pain medications and spine surgery. At present, it is extremely difficult to determine which treatments are likely to maximize benefit and minimize risk for a given patient. As such, the goal of this study was to examine whether individual differences in the cognitive-behavioral model of chronic back pain were associated with baseline characteristics or surgical outcomes. Patients (N = 95) with chronic back pain who were receiving spine …

Porphyrin Overdrive In Cancer: Unraveling The Mechanisms And Therapeutic Potential, Pravin D. Meshram

USF Tampa Graduate Theses and Dissertations

The increased understanding of cancer cell metabolism has shown options for novel treatment strategies. This thesis looks at the role of heme metabolism, specifically "porphyrin overdrive," in cancer progression and treatment. Cancer cells are hypermetabolic and rely on heme synthesis. When treated with δ-aminolevulinic acid (ALA), they abnormally accumulate heme intermediates. This metabolic weakness presents an opportunity to exploit heme synthesis in targeted cancer therapy. In this study, we suggest a "Bait and Kill" technique that uses exogenous ALA to induce protoporphyrin IX (PpIX) buildup in cancer cells, making them more susceptible to oxidative stress. We investigate the possibility of …

The Crosstalk Between Amyloid-Β, Retina, And Sleep For The Early Diagnosis Of Alzheimer's Disease: A Narrative Review, Isaiah Lorenzo De Guia, Shaun Eslick, Sharon L. Naismith, Swathi Kanduri, Tejal M. Shah, Ralph N. Martins

Research outputs 2022 to 2026

Alzheimer's disease (AD) is the most common type of dementia, which is characterised by progressive memory loss and accumulation of hallmark markers amyloid-β (Aβ) and neurofibrillary tangles in the diseased brain. The current gold standard diagnostic methods have limitations of being invasive, costly, and not easily accessible. Thus, there is a need for new avenues, such as imaging the retina for early AD diagnosis. Sleep disruption is symptomatically frequent across preclinical and AD subjects. As circadian activity, such as the sleep-wake cycle, is linked to the retina, analysis of their association may be useful additions for achieving predictive AD diagnosis. …

Centennial Records Of Microplastics In Lake Cores In Huguangyan Maar Lake, China, Qingsong Ji, Yanxia Zhang, Yubao Xia, Xinkai Wang, Maoyong He, Yi Yang, Clive E. Sabel, Bin Huang, Fengxiao Zhu, Min Shao, Enze Xie, Guojing Yan, Guonai Li, Aoyu Zhou, Huan He, Limin Zhang, Zhangdong Jin

School of Geography, Earth and Environmental Sciences

Microplastic records from lake cores can reconstruct the plastic pollution history. However, the associations between anthropogenic activities and microplastic accumulation are not well understood. Huguangyan Maar Lake (HML) is a deep-enclosed lake without inlets and outlets, where the sedimentary environment is ideal for preserving a stable and historical microplastic record. Microplastic (size: 10-500 μm) characteristics in the HML core were identified using the Laser Direct Infrared Imaging system. The earliest detectable microplastics appeared unit in 1955 (1.1 items g^-1). The microplastic abundance ranged from n.d. to 615.2 items g^-1 in 1955-2019 with an average of 134.9 items …

Microencapsulation Of Cosmos Caudatus Kunth Extract Using Sodium Alginate And In Vitro Antioxidant Activity Test, Safina Samara Nur Fadlila, Oktavia Eka Puspita, Zubaidah Ningsih, Anna Safitri

Makara Journal of Science

This study aims to encapsulate Cosmos caudatus K. leaf extract in sodium alginate crosslinked with calcium chloride (CaCl₂) as coating materials through freeze-drying. Antioxidant assays were performed to evaluate the applicability of the microcapsules as antidiabetic medicines. Their characteristics, antioxidant activity, and encapsulation efficiency (EE) were also examined. Results indicated that the concentration of sodium alginate and pH influenced the manufacturing process of the microcapsules. The highest EE was obtained at pH 6 and alginate concentration of 2% (w/v). The IC₅₀ for the antioxidant activity of the microcapsules was 139.96 ± 1.094 μg/mL. Scanning electron microscopy confirmed …

Synthesis, Biological Activity, And Molecular Docking Study Of Xanthenol And Its Disproportionation Products As Anticancer And Antimalarial Agents, Ardhya Ayu Pratama, Jumina Jumina, Chairil Anwar

Makara Journal of Science

Xanthone and its derivatives are well known for their broad biological activities. This research aims to investigate the anticancer and antimalarial activities of synthesized xanthenol and xanthene compounds and to elucidate their mechanisms of action through molecular docking. The xanthenol compound was obtained through xanthone reduction with sodium triacetoxyborohydride, and xanthene synthesis was studied through three different reaction conditions: uncatalyzed and catalyzed by Lewis acid or Bronsted acid. The reduction reaction produced xanthenol in 30.50% yield, whereas the three reaction conditions produced xanthene and xanthone in 39.35–75.48% yield. An anticancer assay for Vero, WiDr, HeLa, and T47D cell lines was …

Benefits Of Plant Pigment, Quercetin, For Fish And Prawn, Yos Adi Prakoso, Jasir Hakim Hidayah, Michael Richard Sanjaya, Agga Dhigayuka Pratama, Annisha Permata Nurul Azhar, Arya Surya Kuswanto, Berlian Ronaldi April, Intan Karisma Utami, Mahera Sandi Sasmita Putra, Maria Paulina Wukak, Naufal Farros Satria

Makara Journal of Science

Quercetin is an important phytochemical that belongs to the flavonoid group of plant pigments. It has potential benefits as an antioxidant, antiviral, and anti-inflammatory agent. However, the utilization of quercetin in aquaculture is not optimal. Hence, this study conducted a literature review to analyze the potential benefits of quercetin in aquaculture, especially for fish and prawn. Results showed that quercetin can be isolated from herbs using several methods, including sonication, maceration, and fractionation. Its amount in plants can be potentially determined using high-performance liquid chromatography and thin-layer chromatography. Some of the plants containing high quercetin levels include shallot, garlic, apple …