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Neural Circuits Expressing The Serotonin 2c Receptor Regulate Memory In Mice And Humans, Hesong Liu, Yang He, Hailan Liu, Bas Brouwers, Na Yin, Katherine Lawler, Julia M. Keogh, Elana Henning, Dong Kee Lee, Meng Yu, Longlong Tu, Nan Zhang, Kristine M. Conde, Junying Han, Zili Yan, Nikolas A. Scarcelli, Lan Liao, Jianming Xu, Qingchun Tong, Hui Zheng, Zheng Sun, Yongjie Yang, Chunmei Wang, Yanlin He, I. Sadaf Farooqi, Yong Xu

Division of Basic Science Faculty Publications

Declined memory is a hallmark of Alzheimer’s disease (AD). Experiments in rodents and human postmortem studies suggest that serotonin (5-hydroxytryptamine, 5-HT) plays a role in memory, but the underlying mechanisms are unknown. Here, we investigate the role of 5-HT 2C receptor (5-HT2CR) in regulating memory. Transgenic mice expressing a humanized HTR2C mutation exhibit impaired plasticity of hippocampal ventral CA1 (vCA1) neurons and reduced memory. Further, 5-HT neurons project to and synapse onto vCA1 neurons. Disruption of 5-HT synthesis in vCA1-projecting neurons or deletion of 5-HT2CRs in the vCA1 impairs neural plasticity and memory. We show that a selective 5-HT2CR agonist, …

Analyzing The Effect Of The Construction Safety Audit Model Using The Business Process Model And Notation (Bpmn) Method On Improving Communication And Collaboration Between Stakeholders., Muhammad Ghazali, Danang Budi Nugroho, Yusuf Latief

CSID Journal of Infrastructure Development

The significant increase in infrastructure development is directly proportional to the rising accident rate in the construction sector, making it one of the highest-risk sectors for accidents. This phenomenon indicates that existing construction safety audits have not been effective in preventing accidents, largely because audits are generally conducted only at the construction stage. Audits at the design stage, however, have the potential to impact accident prevention significantly. Therefore, this research aims to develop a construction safety audit model using the Business Process Model and Notation (BPMN) and analyzes the impacts on stakeholder communication and collaboration. BPMN was chosen because it …

Investigating The Relationship Among The Construction Safety Plan, Knowledge Management, Audit Process, Information System, Web, And Bim With Construction Safety Performance, Zafira Alysha Fadli, Yusuf Latief, Danang Budi Nugroho

CSID Journal of Infrastructure Development

The rapid growth of high-rise building construction in Indonesia has led to a significant increase in accidents, necessitating a robust audit process for construction safety. This research investigates the relationship between construction safety plans (CSPs), audit processes, knowledge management (KM), information systems, the web, and BIM on construction safety performance, aiming to develop a BIM-based KM audit process. To analyze the significance level of various indicators for each variable considerable importance, a mixed-methods approach was employed, combining qualitative insights from expert interviews with quantitative analysis using Structural Equation Modeling (SEM) via SmartPLS. The findings in the study reveal that the …

The Lived Experience Of Stigmatization Due To Chemotherapy-Induced Hair Loss For Young Women With Cancer Who Attend College, Challna Blair

Walden Dissertations and Doctoral Studies

This study investigated the stigmatization experienced by young women in college due to chemotherapy-induced hair loss. Previous research primarily focused on older women, adolescents, and men, leaving a gap in understanding the impact on young college-age women. Using Goffman’s theory of stigma and Giorgi’s descriptive phenomenological method, six young women were interviewed confidentially. The primary research question asked what is the experience of stigma in young women in college who have hair loss during or following chemotherapy cancer treatment? The study revealed that these women often faced being ostracized by peers, received minimal family support, and experienced distressing scrutiny from …

June 28, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Manufacturing Of Aligned Electrospun Nanofiber Yarns For Their Enhanced Mechanical And Piezoelectric Properties, Adaugo Mary-Frances Enuka

Theses and Dissertations

Electrospinning is a widely used technique for producing nanofibers with diverse applications. This method uses polymer solutions and strong electric fields to generate nano-sized fibers with unique properties. This study presents a novel manufacturing approach that enables the production of electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) nanofiber yarns using an automated parallel track system and an adjustable roll-to-roll collector. This research examines the impact of an automated post-drawing system on the polymer chain orientation, crystallinity, tensile strength, morphology, and piezoelectric properties of PVDF-HFP nanofiber yarn. The results reveal that the post-drawing process significantly improves molecular alignment, increases tensile strength, and enhances the …

Leveraging Artificial Intelligence To Adjust Staffing Levels In The Emergency Department, Marisel Perigo, Haydee Fernandez

All Publications

No abstract provided.

Digital Smart Room: Nurse-Led Innovation Implementation, Jessica Hucey Nua

All Publications

No abstract provided.

An Evaluation Of The Premack Contingency To Increase Physical Activity In Teenagers With Autism Spectrum Disorder, Shreeya S. Deshmukh

USF Tampa Graduate Theses and Dissertations

The United States Department of Health and Human Services (2018) recommends that teenagers engage in physical activity to improve their cardiovascular health and muscle and bone strength. Yet, most teenagers with and without autism spectrum disorder do not meet the recommended guidelines for physical activity. Research related to promoting physical activity has evaluated group contingencies, reinforcement-based interventions, and antecedent interventions; however, these interventions are time-intensive, require many resources, or are ineffective. The purpose of this study was to extend Allen and Iwata (1980) by reinforcing completion of a low-probability exercise to a specified criterion with access to a high-probability exercise. …

Teaching Bioinformatics Through The Analysis Of Sars-Cov-2: Project-Based Training For Computer Science Students, Pavlin G Poličar, Martin Špendl, Tomaž Curk, Blaž Zupan

Faculty, Staff and Students Publications

MOTIVATION: We learn more effectively through experience and reflection than through passive reception of information. Bioinformatics offers an excellent opportunity for project-based learning. Molecular data are abundant and accessible in open repositories, and important concepts in biology can be rediscovered by reanalyzing the data.

RESULTS: In the manuscript, we report on five hands-on assignments we designed for master's computer science students to train them in bioinformatics for genomics. These assignments are the cornerstones of our introductory bioinformatics course and are centered around the study of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They assume no prior knowledge of molecular …

Considerations For Quality Control Monitoring Of Machine Learning Models In Clinical Practice, Louis Faust, Patrick Wilson, Shusaku Asai, Sunyang Fu, Hongfang Liu, Xiaoyang Ruan, Curt Storlie

Faculty, Staff and Student Publications

Integrating machine learning (ML) models into clinical practice presents a challenge of maintaining their efficacy over time. While existing literature offers valuable strategies for detecting declining model performance, there is a need to document the broader challenges and solutions associated with the real-world development and integration of model monitoring solutions. This work details the development and use of a platform for monitoring the performance of a production-level ML model operating in Mayo Clinic. In this paper, we aimed to provide a series of considerations and guidelines necessary for integrating such a platform into a team's technical infrastructure and workflow. We …

The Effect Of A Contextualized Dosage Calculation Learning Intervention On Pre-Nursing Students' Math Self-Efficacy And Ability To Pass High Stakes Dosage Calculation Examination On First Attempt, Eileen V. Weatherby

Dissertations

Many students in pre-licensure nursing programs struggle with calculating accurate medication dosages even though they meet the numeracy requirements for application to the nursing programs. Most pre-licensure programs require that nursing students pass dosage calculation exams at a specified level of accuracy before progressing to the next term. Students typically have three tries to pass at the specified level and should they not succeed, they must withdraw. If they wish to continue in the program, they must complete the requirements for reentry which may include space availability restrictions. Factors influencing dosage calculation performance include fear of mathematics, low math self-efficacy, …

Online Teacher-Student Rapport In Higher Education, Joshua Fitzgerald

Theses and Dissertations

Rapport developed between teachers and students in a typical classroom setting can provide students with a more positive school experience, an increase in learning and performance, and added feelings of social belonging (Cook, et al., 2018). Online learning is associated with many advantages like a more comfortable setting for students to participate (Majewska & Zvobgo, 2023), but also includes disadvantages like feelings of isolation (Phirangee & Malec, 2020) which can result in rapport being more difficult to develop. Established rapport during online educational settings can yield a multitude of positive outcomes for online students and teachers alike. These outcomes include …

Now And Ever Campaign Shatters Historic $1.5b Goal Early, Tina Hahn

University of Mississippi News

OXFORD, Miss. – With a pop of confetti and toasts of champagne, the University of Mississippi announced it has secured $1.5 billion for Now and Ever: The Campaign for Ole Miss, a goal passed more than a year ahead of schedule.

Aging- And Alcohol-Associated Spatial Transcriptomic Signature In Mouse Acute Pancreatitis Reveals Heterogeneity Of Inflammation And Potential Pathogenic Factors, Rachel R. Tindall, Yuntao Yang, Isabella Hernandez, Amy Qin, Jiajing Li, Yinjie Zhang, Thomas H. Gomez, Mamoun Younes, Qiang Shen, Jennifer M. Bailey-Lundberg, Zhongming Zhao, Daniel Kraushaar, Patricia Castro, Yanna Cao, W. Jim Zheng, Tien C. Ko

School of Medicine Faculty Publications

Abstract: The rapidly aging population is consuming more alcohol, leading to increased alcohol-associated acute pancreatitis (AAP) with high mortality. However, the mechanisms remain undefined, and currently there are no effective therapies available. This study aims to elucidate aging- and alcohol-associated spatial transcriptomic signature by establishing an aging AAP mouse model and applying Visium spatial transcriptomics for understanding of the mechanisms in the context of the pancreatic tissue. Upon alcohol diet feeding and caerulein treatment, aging mice (18 months) developed significantly more severe AAP with 5.0-fold increase of injury score and 2.4-fold increase of amylase compared to young mice (3 months). …

Loss Of Hormone Receptor Expression After Exposure To Fluid Shear Stress In Breast Cancer Cell Lines, Jonathan Cuccia, Braulio Andres Ortega Quesada, Ethan P. Littlefield, Alejandra M. Ham, Matthew E. Burow, Adam T. Melvin, Elizabeth C. Martin

School of Medicine Faculty Publications

Following metastatic spread, many hormone receptor positive (HR(+)) patients develop a more aggressive phenotype with an observed loss of the HRs estrogen receptor (ER) and progesterone receptor (PR). During metastasis, breast cancer cells are exposed to high magnitudes of fluid shear stress (FSS). Unfortunately, the role for FSS on the regulation of HR expression and function during metastasis is not fully understood. This study was designed to elucidate the impact of FSS on HR(+) breast cancer. Utilizing a microfluidic platform capable of exposing breast cancer cells to FSS that mimics in situ conditions, we demonstrate the impact of FSS exposure …

Beyond The Surface: A Scoping Review Of Vision-Based Underwater Experience Technologies And User Studies, Oksana Hagen, Amir Aly, Ray Jones, Marius Varga, Dena Bazazian

School of Engineering, Computing and Mathematics

Exploring the underwater world presents significant physical and financial barriers. Telepresence technologies offer a potential solution by a providing a more accessible version of an underwater experience. Our research involved a scoping review to consolidate previous findings on vision-based technologies that aim to recreate underwater experiences and their user evaluations. We searched 5 academic databases for papers describing or evaluating technologies providing visual underwater experiences without actual submersion. We systematically searched YouTube to include immersive experiences not documented in academic publications. Our review included 45 academic papers and 23 YouTube videos classified by their level of ‘reality’, ‘degrees of freedom’, …

Neutrophil To Lymphocyte Ratio As A Prognostic Marker For Cardiovascular Outcomes In Patients With St-Segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention: A Systematic Review And Meta-Analysis, Hassan Ul Hussain, Kanwal Ashok Kumar, Marium Zahid, Muhammad Husban Burney, Zayeema Khan, Muqaddus Asif, Syeda Tayyaba Rehan, Huzaifa Ahmad Cheema, Sarya Swed, Farah Yasmin, Waqas Ullah, M. Chadi Alraies

Abington Jefferson Health Papers

BACKGROUND: Neutrophil to lymphocyte ratio (NLR) has been considered a prognostic biomarker of mortality and other major cardiac events. This study investigates NLR's efficacy in predicting in-hospital and long-term outcomes in patients with ST-segment elevated myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI).

METHODS: Electronic databases (PUBMED, Cochrane CENTRAL, ERIC, Embase, Ovid, and Google Scholar) were searched till June 2022 to identify studies having STEMI patients who underwent PCI. Risk ratios and mean differences (MDs), along with their corresponding 95% confidence intervals (Cis) and standard deviations (SDs), were pooled using a random-effect model. This meta-analysis has been registered on Prospero …

The Conflict Between The United States And Iran And Its Effect On Iraq, Sarah Alsalih

Dissertations and Theses

This thesis examines the dynamic interplay between the United States and Iran and its repercussions on Iraq in the post-9/11 era. Against a backdrop of historical adversities, the research delves into the evolving relationship between the U.S. and Iran, elucidating its multifaceted dimensions and the consequential effects on Iraq. The central inquiry driving this investigation is: "Against the adversarial historical backdrop of U.S.-Iran relations, how has the relation between the two countries changed and impacted Iraq throughout the post 9/11 era?"

Drawing upon a comprehensive analysis through the lens of diplomatic interactions, military interventions, and regional dynamics, this study seeks …

May 2024 Berkeley Pit Migratory Waterfowl Protection Monthly Report, Mark Thompson, Loren Burmeister

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

In Situ Diffuse Reflectance Spectroelectrochemistry Of Cathode Materials In Lithium-Ion Batteries, Lu-Lu Chen, Hao-Ran Li, Wei-Yi Liu, Wei Wang

Journal of Electrochemistry

Developing in situ spectroelectrochemistry methods, which can provide detailed information about species transformation during electrochemical reactions, is very important for studying electrode reaction mechanisms and improving battery performance. Studying real-time changes in the surface of electrode materials during normal operation can be an effective way to assess and optimize the practical performance of electrode materials, thus, in situ and in operando characterization techniques are particularly important. However, batteries are hard to be studied by in situ characterization measurements due to their hermetically sealed shells, and there is still much room for battery characterizations. In this work, a specially designed battery …

Redefining Culture And Climate In The Alternative Setting: Dumping Grounds Or Where Students Are Found?, Joan Louise Barbagiovanni

Theses and Dissertations

This autoethnographic study aims to answer the following questions: How can a school leader design a culturally sensitive, inclusive alternative education program? What type of systemic change does an alternative school leader believe to be most effective in supporting students in attaining a high school diploma and a solid postsecondary plan to become productive members of society? What characteristics of culture and climate are most critical in an alternative school setting? The study focused on 4 years and tells how a school leader successfully changed the school culture and climate to best serve students and staff in the alternative school …

Obesity Is Associated With Muscle Atrophy In Rotator Cuff Tear, Simone D Herzberg, Robert H Brophy, Matthew V Smith, Et Al.

2020-Current year OA Pubs

OBJECTIVE: The primary goal of this study is to evaluate the relationship between Body Mass Index (BMI) and muscle atrophy in individuals with rotator cuff tears.

METHODS: This study consists of patients with rotator cuff tears identified by MRI from two independent cohorts, the Rotator Cuff Outcomes Workgroup (ROW) and the Multicenter Orthopaedic Outcomes Network (MOON). Presence of atrophy (yes/no) and severity of atrophy (as an ordinal variable) were assessed on MRI by expert physicians. We used multivariable regression models to evaluate the relationship between BMI and muscle atrophy while adjusting for age and sex in each study, conducted sensitivity …

Review On Mitigation Of Paraffin Wax Formation Using Jatropha-Based Inhibitor, Amirul Syafiq Noor Azhar, Hazlina Husin

Platform: A Journal of Engineering (PAJE)

Wax deposition in pipelines and wells is one of the problems in the oil and gas industry. Wax deposition can lead to pipeline blockages, reduced flow capacity, and even production facility or pipeline closures. Various methods and techniques have been developed to mitigate wax deposition, including chemical, mechanical, and thermal methods. Inhibition of wax deposition using chemical methods involves using chemical additives to prevent or reduce wax buildup on pipelines or wellbores. Chemical methods for mitigating wax deposition can include using plant-based inhibitors as effective additives. Biosurfactants, which are surfactants derived from plant-based sources, can be used in chemical methods …

Polyurethane-Asphaltic Concrete As An Alternative Solution For Road Pavement Distress - A Review, Diana Che Lat, Atiqah Najwa Zainuddin, Siti Nur Aishah Mohd Noor, Doris Asmani Mat Yusof, Ismacahyadi Bagus Mohamed Jais

Platform: A Journal of Engineering (PAJE)

Road traffic accidents are the primary source of injuries and fatalities worldwide, accounting for 20–50 million long term disabilities and 1.25 million deaths annually. Pavement conditions ranked as the second most common cause of traffic accidents. The combined effects of environmental factors and traffic loads lead to pavement discomfort. Ensuring proper pavement design and maintenance can assist in reducing accident rates and preventing long-term disability associated with drivers. Physical maintenance procedures like overlays, seal coatings, patching, and filling joints are carried out in practice; nevertheless, they only offer temporary fixes by treating the symptoms rather than the underlying issue. An …

Dynamic Modeling And Tracking Of 3-Wheels Omni-Directional Mobile Robot With Manual Pid Tuning Method, Soe Soe Htay, Khaing Win Phyu, Su Yadanar, Wut Yi Win, Min Thu Soe

Platform: A Journal of Engineering (PAJE)

This paper presents the dynamic modelling and tracking control of a holonomic 3-wheel omni-directional mobile robot. A proportional integral derivative (PID) controller is used, and its performance depends on the dynamic model’s accuracy. The controller design for the switched non-linear system is based on both a dynamic model and a kinematic design. A proposed dynamic model averages the contact radius of the 3-wheels. The resultant dynamic model, on average, is non-linear and smooth, serving as a potential solution for model-based control design. The closed-loop simulation results clearly illustrate the dynamic characteristics of the 3-wheels omni-directional mobile robot, offering valuable insights …

Mhealth-Based Just-In-Time Adaptive Intervention To Improve The Physical Activity Levels Of Individuals With Spinal Cord Injury: Protocol For A Randomized Controlled Trial, Rachel Carey, Ha Le, Donna Coffman, Inbal Nahum-Shani, Mohanraj Thirumalai, Cole Hagen, Laura Baehr, M. Schmidt-Read, Marlyn Lamboy, Stephanie A Kolakowsky-Hayner, Ralph Marino, Stephen Intille, Shivayogi Hiremath

Moss-Magee Rehabilitation Papers

BACKGROUND: The lack of regular physical activity (PA) in individuals with spinal cord injury (SCI) in the United States is an ongoing health crisis. Regular PA and exercise-based interventions have been linked with improved outcomes and healthier lifestyles among those with SCI. Providing people with an accurate estimate of their everyday PA level can promote PA. Furthermore, PA tracking can be combined with mobile health technology such as smartphones and smartwatches to provide a just-in-time adaptive intervention (JITAI) for individuals with SCI as they go about everyday life. A JITAI can prompt an individual to set a PA goal or …

Chemotherapy Drug Release From Hollow Core Polyethyleneimine Nanoparticles, Brian Boyle

Theses and Dissertations

Novel anticancer delivery vehicles are arising from engineered nanostructured materials. This work involved the synthesis, characterization, and release of novel hollow core polymeric nanoparticles (HCPNPs) for controlled drug delivery. Polyethyleneimine (PEI) was bound to AuNPs, forming polymer-shell nanoparticles with dissolution of the gold core via iodine forming HCPNPs with drug intercalated DNA bound to the surface. A high density (85 molecules/particle) of DNA intercalated with daunorubicin was conjugated. Particles were spherical with an average diameter of 105.7 ± 17.3 nm and zeta potential of 20.4 ± 3.54 mV. We hypothesize the DNA backbone electrostatically condensed to the primary amines on …

Python Tooth–Inspired Fixation Device For Enhanced Rotator Cuff Repair, Iden Kurtaliaj, Ethan D. Hoppe, Yuxuan Huang, David Ju, Jacob A. Sandler, Donghwan Yoon, Lester J. Smith, Silvio Torres Betancur, Linda Effiong, Thomas Gardner, Liana Tedesco, Sohil Desai, Victor Birman, William N. Levine

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Rotator cuff repair surgeries fail frequently, with 20 to 94% of the 600,000 repairs performed annually in the United States resulting in retearing of the rotator cuff. The most common cause of failure is sutures tearing through tendons at grasping points. To address this issue, we drew inspiration from the specialized teeth of snakes of the Pythonoidea superfamily, which grasp soft tissues without tearing. To apply this nondamaging gripping approach to the surgical repair of tendon, we developed and optimized a python tooth–inspired device as an adjunct to current rotator cuff suture repair and found that it nearly doubled repair …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program Mandan Park Soil Rawp (Dated May 10, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.