Digital Commons Network^™

Optimization Of Chimeric Antigen Receptor T Cells For The Treatment Of Solid Tumors, Hailey Young, Ms

Student Papers, Posters & Projects

T cells have been called the “warriors of the immune system” and for good reason. T cells have many different functions including stimulating B cells to make antibodies; suppressing the immune response when it is no longer needed; killing of foreign, pathogenic, and cancerous cells and several other functions. Despite these key immune system functions, T cells sometimes are deregulated, and this can lead to an increased risk of cancer. Therefore, chimeric antigen receptor (CAR) T cells have been designed. CAR T cells are T cells that have been genetically engineered to possess a T cell receptor derived from murine, …

Comes In Waves: Clinical Overview Of Vibrio Species, Natalie M. Prosser, Ms

Student Papers, Posters & Projects

Earth’s oceans, despite their beauty and vast ecosystems, pose numerous threats to marine life and humans living along the coastline. Vibrio species (spp.) is a common species of oceanic bacteria native to coastal and brackish waters. This bacterium is capable of causing various degrees of human disease among different populations. Three clinically significant species of Vibrio include Vibrio vulnificus, Vibrio parahaemolyticus, and Vibrio cholera; all three species share virulence factors, but each are capable of causing varying degrees of vibriosis infections. Vibriosis infections include but are not limited to wound infections, necrotizing fasciitis, and gastroenteritis. In particular, …

Maggot Therapy And Its Clinical Application In The War Against Microbial Resistance, Nicholas Leidy, Ms

Student Papers, Posters & Projects

Antibiotic resistance poses a growing threat across the globe. The United Nations estimates that up to 10 million deaths by 2050 will be due to superbugs and antimicrobial resistance. Finding effective solutions has been obstructed by the expensive and time-intensive research and development process. Maggot therapy, however, has emerged as a promising, cost-effective approach to wound debridement or cleaning. This unconventional method takes advantage of the natural capabilities of maggots to effectively debride chronic, non-healing wounds, even those infected with multidrug-resistant bacteria. Through the utilization of proteolytic and digestive enzymes, maggots are able to break down necrotic tissue and promote …

Targeting Histone Deacetylase 6 (Hdac6) To Enhance Radiation Therapy In Meningiomas In A 2d And 3d In Vitro Study, Juri Na, Shahana Shaji, C. Oliver Hanemann

Peninsula Medical School

Background: External radiation therapy (RT) is often a primary treatment for inoperable meningiomas in the absence of established chemotherapy. Histone deacetylase 6 (HDAC6) overexpression, commonly found in cancer, is acknowledged as a driver of cellular growth, and inhibiting HDACs holds promise in improving radiotherapeutic efficacy. Downregulation of HDAC6 facilitates the degradation of β-catenin. This protein is a key element in the Wnt/β-catenin signalling pathway, contributing to the progression of meningiomas. Methods: In order to elucidate the associations and therapeutic potential of HDAC6 inhibitors (HDAC6i) in conjunction with RT, we administered Cay10603, HDAC6i, to both immortalised and patient-derived meningioma cells prior …

Assessing Rice Phenological Features With Hyperspectral Imaging Insights From Earth Surface Mineral Dust Source Investigation (Emit), Shahryar Fazli, Wenzhao Li, Surendra Maharjan, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

In California's Central Valley, water management and crop health, particularly in rice cultivation, are critical. This paper details the application of Earth surface Mineral dust source InvesTigation (EMIT) hyperspectral imaging, specifically employing Spectral Correlation Mapper (SCM) and Spectral Information Divergence (SID), for precise phenological analysis. By aligning EMIT data with Hyperion satellite references, we address spectral and geographical discrepancies. Our methodology includes seasonal sampling of spectral curves to capture the phenological stages of rice. Results show a strong correlation (R ² = 0.86) between August EMIT and Reference dataset, emphasizing EMIT's utility in enhancing agricultural practices and water efficiency in …

Advancing Understanding Of Opinions, Perceptions, And Knowledge In Underrepresented Communities In The El Paso Region To Promote Electric Vehicles And Electrified Infrastructure Use To Reduce Environmental Impacts, Liliana Lozada-Medellin

Open Access Theses & Dissertations

As the transportation and automotive industries continue growing, environmental and human health impacts remain a growing concern for planners, policy-makers, constructors, and the public as well (Krause et al., 2013; Larson et al., 2014). Although Electric Vehicles (EVs) are entering the market as a green technology solution to counteract greenhouse gas (GHG) emissions from internal combustion engine vehicles (ICEVs), there are still barriers that need to be overcome for widespread diffusion and adoption as the best solution. These include disseminating basic information about the technology for public awareness, considering equity concerns, and ensuring equitable access to infrastructure for all (L. …

Exosomes Derived From Tumor Adjacent Fibroblasts Efficiently Target Pancreatic Tumors, Saini Setua, Poornima Devi Shaji, Ana Martinez Bulnes, Anupam Dhasmana, Swathi Holla, Nirakar Sahoo, Tripti Saini, Mohammed Sikander, Bilal B. Hafeez, Manish K. Tripathi, Vincent Diego, Meena Jaggi, Murali M. Yallapu, Sheema Khan, Subhash C. Chauhan

School of Medicine Publications

The application of extracellular vesicles, particularly exosomes (EXs), is rapidly expanding in the field of medicine, owing to their remarkable properties as natural carriers of biological cargo. This study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues (NAF-EXs) for personalized medicine, which can be derived at the time of diagnosis by endoscopic ultrasound. Herein, we show that exosomes (EXs) derived from NAFs demonstrate differential bio-physical characteristics, efficient cellular internalization, drug loading efficiency, pancreatic tumor targeting and delivery of payloads. NAF-derived EXs (NAF-EXs) were used for loading ormeloxifene (ORM), a potent anti-cancer and desmoplasia inhibitor as …

The Internist's Post V.1 N.5, The University Of Texas Rio Grande Valley. School Of Medicine, Diana Othon Martinez, Edgar Dorsey Trevino, Eunbee Cho, Jian Garcia Cruz, Ramon Elizondo Romo, Roque Mifuji, Martha Solis, Cesar Gutierrez

School of Medicine Publications

No abstract provided.

Abc Efflux Transporters And Solute Carriers In The Early Developing Brain Of A Marsupial Monodelphis Domestica (South American Gray Short-Tailed Opossum), Yifan Huang, Katarzyna M. Dziegielewska, Mark D. Habgood, Fiona Qiu, Ana C. Leandro, Paul D. Callaghan, Joanne E. Curran, John L. Vandeberg, Norman R. Saunders

School of Medicine Publications

This study used a marsupial Monodelphis domestica, which is born very immature and most of its development is postnatal without placental protection. RNA-sequencing (RNA-Seq) was used to identify the expression of influx and efflux transporters (ATP-binding cassettes [ABCs] and solute carriers [SLCs]) and metabolizing enzymes in brains of newborn to juvenile Monodelphis. Results were compared to published data in the developing eutherian rat. To test the functionality of these transporters at similar ages, the entry of paracetamol (acetaminophen) into the brain and cerebrospinal fluid (CSF) was measured using liquid scintillation counting following a single administration of the drug along with …

Moringin, An Isothiocyanate Modulates Multiple Cellular Signalling Molecules In Breast Cancer Cells, Ankit Srivastava, Shruti Mishra, Avadhesh, Anusmita Shekher, Vipin Rai, Anupam Dhasmana, Jayanta Das, Daniele Perenzoni, Renato Iori, Subash C. Gupta

School of Medicine Publications

Highlights

• The cancer patients with changes in Prohibitin (PHB) exhibit significantly reduced ‘overall survival’ in comparison to the cases without alterations in PHB.

• Moringin (MG) is an isothiocyanate that can induce apoptosis in breast cancer cells.

• MG can trigger depolarization in mitochondrial membrane potential suggesting that MG induced apoptosis involves mitochondria.

• MG can suppress p65 nuclear translocation and can modulate lncRNAs expression in breast cancer cells.

• The activities of MG against breast cancer might result from its ability to modulate multiple cancer-related targets.

Abstract

Prohibitin (PHB) is a pleiotropic molecule with a variety of known functions and subcellular locations. PHB's …

Tular Nalar Curriculum To Promote A Culture Of Critical Thinking Among The Elderly, Santi Indra Astuti, Niken Satyawati, Dwitasari Teteki Bernadeta

Jurnal Vokasi Indonesia

In the digital age, fostering a culture of critical thinking is imperative for all societal groups, including the elderly. However, no sufficient effort does appear to resolve the lack of critical thinking among elderly. Facing with this challenge, Tular Nalar program developed unique curriculum which specifically cultivate critical thinking skills among elderly. The designed curriculum become the backbone of capacity buildings which targeted elderly in 38 provinces of Indonesia. This curriculum is accessible to everyone, designed to enhance critical thinking abilities, and enabling individuals, especially the elderly, to identify, analyze, and make rational decisions in filtering information. The paper presented …

Optimalisasi Penggunaan Energi Matahari Dalam Produk Photovoltaic Pada Era Ekonomi Sirkular, Amanda Syifa Adistri, Feriska Ajeng Anantri

Jurnal Vokasi Indonesia

Perubahan iklim menjadi salah satu masalah yang menjadi perhatian khusus bagi beberapa negara, termasuk Indonesia. Penggunaan energi secara terus menerus akan berdampak negatif, yaitu krisis energi dan pencemaran lingkungan berupa emisi karbon. Salah satu solusi yang dapat diimplementasikan untuk mengurangi emisi karbon yaitu dengan menggunakan energi alternatif. Salah satu penggunaan energi alternatif yaitu energi matahari. Energi matahari dapat dimanfaatkan sebagai energi listrik ramah lingkungan. Hal ini dikarenakan tidak adanya dampak negatif dalam penggunaannya serta mendukung adanya ketahanan energi baik di masa sekarang maupun di masa mendatang. Artikel ini bertujuan untuk memberikan pemahaman yang lebih mendalam tentang bagaimana cara mengurangi emisi …

Criticizing The Asset Repatriation Policy For Tax Amnesty In Indonesia: An Interpretive And Comparative Study, Nidya Hapsari

Jurnal Vokasi Indonesia

Indonesia finds tax amnesty as a reliable funding alternative to develop a sustainable economy. Since 1964, Indonesia has implemented five tax amnesty programs. The latest two programs would offer lower amnesty compensation rates if taxpayers repatriated offshore assets back to Indonesia. However, the tax amnesty repatriation policy merely contributed minimal amounts of repatriated assets and low number of participants. Consequently, it failed to raise sufficient liquidity, fiscal revenues, tax compliance and economic growth. Hence, the study aims to (1) determine the justification and mechanism for the asset repatriation policy and (2) criticize the repatriation policy implementation. Applying interpretive and comparative …

In Memoir And Memory: Us Servicewomen In The Iraq War, Kelly Taylor

Voces Novae

No abstract provided.

Post Mendez V. Westminister: Public Education For Mexican Americans 1965-1975, Alejandra Lemus

Voces Novae

No abstract provided.

Cooperating Teachers’ Views And Practices About Teaching Emergent Bilinguals In General Education Classrooms, Tunde Szecsi, Janka Szilagyi

Journal of English Learner Education

Cooperating teachers’ pedagogical beliefs and practices influence teacher candidates’ views and practices. Therefore, this study examined mainstream cooperating teachers’ perceptions about critical components of effective instruction for English learners, and the relationship between these teachers’ perceptions and classroom practices. We interviewed 55 teachers and completed a 90-minute observation in each classroom. We analyzed the interviews for common themes, and we used descriptive statistics to summarize the observation data. The findings indicated that teachers were well-versed in evidence-based instructional activities and strategies. However, many teachers found it challenging to infuse ELs’ language, culture and experiential background into their instruction.

Self-Talk And Self-Leadership: Advancing A New Application Of Goleman’S Leadership Model For Counseling College Students, Liane Weintraub

The Scholarship Without Borders Journal

The self-talk habits of college students can be important factors in determining their success in academia and beyond. The years between childhood and adolescence, known as emerging adulthood, present particular developmental significance. Emerging adults experience heightened psychological and social stressors. They are also more likely to engage in negative self-talk, which puts them at increased risk for mental health problems, including depression and anxiety. Current data indicates a surge in mental health issues among college students (Healthy Minds Network, 2022). Therefore, it is imperative that educators and counselors consider self-talk behaviors as they guide and advise students. This paper considers …

Hustlenomics: Defining The Hustle Economy, Sade M. Onadeko

The Scholarship Without Borders Journal

Hustlenomics is the study of the hustle economy. It is the study of how hustlers produce, distribute, and consume goods and services in order to earn a living. This paper is an attempt to understand and define the hustle economy through the review of literature. Due to limited research on the hustle economy, analogous economies such as the gig/sharing economy and the informal economy (which includes the hidden and shadow economies) were examined in order to obtain the goal of this paper.

Too Much Of A Good Thing? Exploring Affective Commitment’S Negative Impact, Cecil W. Johnson Iii

The Scholarship Without Borders Journal

Strategies to increase organizational commitment in employees to increase retention, productivity and performance are common approaches used by leaders facilitated by human resource departments. In the past two years, there has been a surge of resignations by employees re-evaluating their relationship with employers. The employee exits have focused employers on increasing employee commitment to their organization by deploying human resource management (HRM) strategies. Organizations must reflect on the negative impact high commitment can have on employees and the companies in which they work.

This paper is an exploration of the negative impact of affective organizational commitment on employees and employers. …

Organizational Challenges: The Impact Of Role Clarity On Burnout In A Technology Division, Jessica Arriaza

The Scholarship Without Borders Journal

Organizations grapple with significant challenges such as burnout, turnover, and low job satisfaction. Studies indicate that emotional exhaustion, influenced by job demands and available resources, significantly impacts job performance positively or negatively. This quantitative study uses secondary data from the Work, Family, and Health Study to investigate the relationship between role clarity and burnout within Tomo, the technology division of a Fortune 500 company in the United States. The findings reveal a significant inverse correlation between role clarity and burnout, with participants reporting "Never" experiencing burnout more likely to have well-defined roles. Supported by chi-square and linear regression analyses, these …

The Best Scenario For The Development Of Public Green Open Space Zones In Malang, Indonesia, Indra Purnama Putra, Amin Setyo Leksono, Rita Parmawati, Tiankun Li

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

The establishment of green open spaces is closely correlated with the advancement of urban development, as they offer a multitude of benefits, including ecological, environmental, socio-cultural, and economic advantages. According to data from the Department of Public Works, Spatial Planning, Housing, and Settlement Areas of Malang City, public green open spaces have yet to be established in all settlements in Malang City. Consequently, the benefits of these spaces are not yet accessible to all residents. This research project focuses on the development of scenarios for the development of public green open spaces, authorized by the Malang City Government, which will …

Remote Sensing And Geographic Information System For Flooding Vulnerability Zoning In Majalaya, Indonesia, Lili Somantri

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

The flood risk in Majalaya District, Bandung Regency, is on the rise due to climate change, alterations in river basin conditions, and changes in land use. Flood disasters pose significant threats to communities and the environment. To initiate disaster mitigation measures, it is imperative to conduct flood hazard mapping in the area. This study employs a quantitative descriptive approach using remote sensing and Geographic Information Systems analysis. The results reveal three flood vulnerability zones: low, moderate, and high. The high vulnerability zone, which covers 720 hectares and comprises nine villages, is predominantly situated in the northern part of the district. …

The Efficacy Of Field Study In Augmenting Proficiency In Mapping And Comprehending Natural And Cultural Landscapes, Rita Noviani, Istiyanti Nur Marfu’Ah, Getur Adi Tjahjono, Pipit Wijayanti

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Field study is a crucial learning tool in Geography as it provides numerous opportunities for learners to observe, listen, inquire, gather data, and explore phenomena more freely. This study evaluates the effectiveness of field studies in enhancing the ability to describe natural and cultural landscapes, as well as proficiency in reading maps. It used a quantitative descriptive method, while the data collection was performed using a questionnaire. Effectiveness analysis compares students' understanding of mapping materials, landscapes, and cultural landscapes before and after implementing field study activities. The research findings suggest that field study is highly effective in aiding learning, specifically …

The Impact Of Childbearing-Age Married Women's Behavior On Fertility In Tambakbayan Hamlet, Neighborhood Unit 012/004, Ika Karunia Fatmala, Sri Rum Giyarsih, Djaka Marwasta, Sri Rahayu Budiani

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Fertility represents one of the demographic components that influence population dynamics. The factors that determine fertility conditions include social norms, culture, and demographic characteristics, as well as the economic conditions of married women of childbearing age. These factors then develop within the context of the community environment, ultimately influencing the fertility behavior of the society. As a consequence of the agglomeration area, childbearing age married women in Tambakbayan Hamlet, Indonesia, are considered to be the majority with a low desire to have children. Consequently, further studies are required to investigate the fertility conditions and behavior of childbearing-age women in the …

Geography Teacher Profile Towards Geospatial Technology Usage For Geography Learning In Senior High School, Siti Nur Farihah, Listyo Yudha Irawan, Agus Dwi Febrianto, Dedi Sasmito Utomo, Ivy Geok-Chin Tan, Nabila Nurul Hawa, Ruhi Begum

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

In the current era, the utilization of WebGIS technology in geographical learning is not yet optimized by educators. This is due to the fact that their knowledge and abilities in this field are still limited. Consequently, it is crucial to identify the variables that impact the integration of WebGIS in educational settings. This research endeavors to ascertain the influence of age, teaching tenure, and teacher gender on the utilization of WebGIS. This research employed a quantitative approach with multiple linear regression analysis techniques. The sampling method involved distributing a Google form to member teachers who had attended a webinar on …

The Use Of Landsat-8 In Google Earth Engine To Analyze Urban Heat Island In Bogor City, Khalifah Insan Nur Rahmi, Marfandi Ramadhan Pane, Tiara Risky Adella, Jalu Tejo Nugroho, Nur Febrianti, Kurnia Ulfa

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Landsat-8 imagery contains a time series thermal image from 2013 to the present, which could be utilized to identify changes in land surface temperature (LST). Google Earth Engine (GEE) has provided straightforward access to the Landsat-8 thermal time series image. The LST alterations in urban areas are influenced by urban physical development and the impact of climate change, which has a detrimental effect on environmental conditions. This leads to the Urban Heat Island (UHI) phenomenon. This research aims to ascertain the spatial distribution of the Urban Heat Island (UHI) phenomenon in Bogor City, Indonesia, utilizing Landsat-8 OLI/TIRS satellite imagery in …

T. Boudieri Extract Potentiates The Effects Of Capecitabine Treatment In Human Colon Cancer Cells, Katia Sawaya, Mahmoud Khalil, Ghada Khawaja

BAU Journal - Science and Technology

Resistance to chemotherapy remains a major challenge for colorectal cancer patients worldwide, hence the persistent need to uncover alternative treatments as well as new adjunct therapies in the fight against cancer. Natural extracts constitute an excellent source of bioactive substances that have a promising potential in that regard, with minimal negative side effects. We have previously demonstrated that both the ethanolic as well as the water extracts of Terfezia boudieri, a black desert truffle abundant in and part of the cuisine of the Mediterranean region, have significant antiproliferative effects against colon cancer cells. Our aim in this study was …

Uses Of Herbal Extracts In Endodontology: A Literature Review, Reem Chamseddine, Roula S. Abiad

BAU Journal - Science and Technology

The use of natural herbal extracts in the field of dentistry, and specifically in endodontology had gained a high popularity in the past few years. The main objective of endodontic treatment is to prevent and eliminate the infection from the root canal, seize the invasion of microorganisms to periradicular tissues and preserve the natural dentition. Studies had shown that some herbs are better alternatives to traditional chemical irrigants or medicaments used in root canal treatment, based on their potential antimicrobial effect, smear layer removal capabilities, tissue dissolution effect, antioxidant, anti-inflammatory and regenerative properties. Aim: The purpose of this literature review …

Cryotherapy In The Field Of Endodontics: A Literature Review, Amena Al Bast, Roula S. Abiad

BAU Journal - Science and Technology

Cryotherapy is a recent approach in the field of endodontics. It is a remedy that subject tissue to low temperature. Low temperature induces vasoconstriction limiting inflammation, pain and edema and analgesia by reducing the nerve conduction velocity. The aim of this review is to point out the different and recent clinical applications of cryotherapy in the field of endodontics and to describe its physiology and its effect regarding postoperative pain and inflammation. A literature search from PubMed, Scopus, ScienceDirect and EBSCO databases and other resources using specific keywords results in articles to determine the effect of applying cryotherapy in the …

A Strategic Framework For Attaining Golden Leed Certification For Resorts, Mohamad Soliman, Hadi Jawad, Mariam Younes, Oussama El Hamaoui, Saadeddine Ramadan

BAU Journal - Science and Technology

The contemporary landscape of engineering is witnessing a pivotal shift towards sustainability, encapsulated in the catchphrase "GO GREEN". This global trend underscores a strategic emphasis on sustainable design, where engineering projects prioritize a delicate balance among environmental, societal, and economic considerations.” However, a persistent challenge in construction projects lies in their tendency to neglect environmental impact, contributing to increased contamination levels. This paper aims to introduce the "Lodge in the Green" project, meticulously aligned with LEED Certification principles. LEED, or Leadership in Energy and Environmental Design, stands as the foremost green building rating system, highlighting its relevance in contemporary sustainable …