Digital Commons Network^™

Pediatric Oral Health Literacy Among Caregivers Of Young Children, Melissa L. Sullivan

Health Services Research Dissertations

Early childhood caries (ECC) is a common dental condition that affects the primary teeth of infants and young children. ECC can have a significant negative impact on a child’s oral health and overall well-being. Caregivers have an important role in the prevention of early childhood caries through knowledge, understanding, and awareness of good oral hygiene practices. Caregivers who possess adequate oral health literacy (OHL) may be more likely to recognize the risks associated with ECC, implement proper oral hygiene practices, and make informed oral health choices for themselves and their child.

The overarching purpose of this dissertation is to explore …

Fc Engineering By Monoclonal Mammalian Cell Display For Improved Affinity And Selectivity Towards Fcγrs, Zening Wang, Minhyo Kang, Afshin Ebrahimpour, Chuan Chen, Xin Ge

Faculty, Staff and Student Publications

Fc optimization can significantly enhance therapeutic efficacy of monoclonal antibodies. However, existing Fc engineering approaches are sub-optimal with noted limitations, such as inappropriate glycosylation, polyclonal libraries, and utilizing fragment but not full-length IgG display. Applying cell cycle arrested recombinase-mediated cassette exchange, this study constructed high-quality monoclonal Fc libraries in CHO cells, displayed full-length IgG on cell surface, and preformed ratiometric fluorescence activated cell sorting (FACS) with the antigen and individual FcγRs. Identified Fc variants were quantitatively evaluated by flow cytometry, ELISA, kinetic and steady-state binding affinity measurements, and cytotoxicity assays. An error-prone Fc library focusing on the hinge-CH2 region was …

Epigenetic Regulation Of Heart Failure, Manisha Deogharia, Priyatansh Gurha

Faculty, Staff and Student Publications

Purpose of review: The studies on chromatin-modifying enzymes and how they respond to different stimuli within the cell have revolutionized our understanding of epigenetics. In this review, we provide an overview of the recent studies on epigenetic mechanisms implicated in heart failure.

Recent findings: We focus on the major mechanisms and the conceptual advances in epigenetics as evidenced by studies in humans and mouse models of heart failure. The significance of epigenetic modifications and the enzymes that catalyze them is also discussed. New findings from the studies of histone lysine demethylases demonstrate their significance in regulating fetal gene expression, as …

Cycles Of Change: Msw Portfolio, Paul T. Everett

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The purpose of this portfolio is to share my experience with these cycles from the individuals I have worked with, to families, groups and my community, implementing Just Practice’s own core process cycle of cultivating social justice through an integrated approach to practice. Relying on examples from my coursework and practicum opportunities, I offer critical self-reflection of my own values and assumptions shaping my ethical and professional behavior, demonstrating my growth as an advanced integrated practitioner. Incorporated are the theoretical approaches I have utilized in bringing historical, cultural, and political perspectives towards understanding difference, oppression, and social-justice oriented action. I …

Msw: Portfolio, Dorothy Leigh Mccombs

Graduate Student Portfolios, Professional Papers, and Capstone Projects

MSW journey

Beta Lactams Anticancer Effect On Human Breast Cancer, Mcf-7 Cell Line, Ailis A. Abalos

Theses and Dissertations

Cancer is a disease where abnormal cells replicate uncontrollably in that same region and/or other parts of the body. One in eight women are diagnosed with breast cancer, thus making it the second leading cause of cancer-related deaths in the U.S. Chemotherapy, is the utilization of medicinal compounds (drugs) to treat cancer. While most are nonspecific and target both cancer and healthy cells, more emphasis is on developing drugs with specificity (only target tumor cells) and low toxicity. Interestingly, Beta Lactams (β-lactams) have emerged as a class of compounds that are effective in the treatment of various cancers. The benefits …

Unquiet Quitting: The Lived Experiences Of Latinx Teacher Attrition In The Lower Rio Grande Valley, Dolores Araujo Jr.

Theses and Dissertations

Teacher attrition, a critical issue in education, has significant implications for the quality of instruction and student success. The Lower Rio Grande Valley in Texas, known for its substantial Latinx population, faces a concerning trend of high teacher turnover particularly among Latinx educators who leave teaching within their novice years. This inquiry provides a comprehensive examination of the factors contributing to teacher attrition in the region, with a specific focus on the experiences of Latinx teachers. Findings are organized into four thematic categories: "Traversing Organizational Terrain," elucidating the institutional dynamics shaping teachers' experiences; "Interweaving Bonds," highlighting the relational aspects within …

Fight, Eduardo Daniel Guerra

Theses and Dissertations

FIGHT, is a story of a boxers mental health and his struggles before and after every fight. The protagonist, Eddy, is an anxious fighter who experiences a panic attack before his fight and in his panicked state, his mind runs wild as he imagines every possible scenario that can happen. Thus, when the scenarios come true, Eddy, becomes unsure of what is and isn’t true. Which begs the question, is Eddy brain damaged from the fight and stuck living in the traumatic memory that is replaying in his head or is he still in the restroom before the fight, paralyzed …

They See Themselves In The Lesson: Leveraging Students’ Scientific And Cultural Insights Through The Cultural Biohealth Synergy Science Curriculum [Se Ven A Sí Mismos En La Lección: Aprovechando Los Conocimientos Científicos Y Culturales De Los Estudiantes A Través Del Currículo De Ciencias De Sinergia De Bio Salud Cultural], Miriam M. Ortiz

Theses and Dissertations

In response to the global crisis of type 2 diabetes prevalence, this dissertation investigated the impact of a culturally sustaining, health-centric science curriculum contextualized in type 2 diabetes. Using a case study methodology, it explored how the curriculum shaped math and science preservice teachers’ (PSTs) perceptions of science and how it can be taught and how prepared they felt to design and implement culturally sustaining, health-centric lessons. Four themes that emerged across both cases included: 1) connecting health, nutrition, everyday science, and culturally sustaining pedagogy through the CBSS curriculum, 2) connecting science to health and wellness concepts through the CBSS …

Actions Taken At Firm-Level To Mitigate The Adverse Impacts Of Climate Risk, Deepak G. More

Theses and Dissertations

This dissertation comprises of two essays on actions taken at firm-level to mitigate the adverse impacts of climate risk. Our first essay documents a positive relation between firm-level climate change exposure (CCE) and long-term tax avoidance. Our results suggest that firms use tax avoidance to mitigate the adverse impacts of CCE. The positive effect of CCE on tax avoidance is stronger post the release of Stern Review and weaker after the enactment of the Tax Cuts and Jobs Act, 2017. Our study is the first to show that firms with high CCE use tax avoidance to increase cash holdings as …

The Effect Of Advertising On Consumer Self-Improvement Motivation: When And How Advertising Motivates Consumers, Suwakitti Amornpan

Theses and Dissertations

In today's modern world, advertising permeates nearly every facet of consumers’ daily lives, from billboards over city streets to posts seamlessly integrated into social media feeds. The current research identifies a positive unintended consequence of advertising on consumer behavior: increased consumer self-improvement motivation. Across four studies, I find that exposure to mass (vs. luxury) advertising increases consumer motivation to engage in self-improvement. Specifically, I argue that because advertisements for mass (vs. luxury) products prime attainable (vs. unattainable) consumption goals, they increase consumer confidence in their ability to achieve their consumption goals (i.e., they enhance self-efficacy perceptions). This, in turn, puts …

From Motivation To Hinderance: Unveiling Resigned Employees’ Entrepreneurial Intentions And Actions, Shuaijun Zhang

Theses and Dissertations

The phenomenon known as the 'Great Resignation' witnessed a record number of employee resignations since the onset of the COVID-19 pandemic. Reports indicate that approximately 32% of those who resigned during this period transitioned to entrepreneurship. This thesis explores the relationship between resignation and entrepreneurial actions through the lens of creativity. It expands the typology of resignation beyond a simple dichotomy of voluntary and involuntary into four categories: Genius group (voluntarily resigns with high creativity), Traditional group (voluntarily resigns with low creativity), Forced group (involuntarily resigns with high creativity), and Trapped group (involuntarily resigns with low creativity). Previous research suggests …

Application And Analysis Of Machine Learning And Deep Learning Algorithms In Detection Of Ddos Cyberattacks, Dipok Deb

Theses and Dissertations

A Distributed Denial-of-Service (DDoS) attack involves overwhelming a target system's data bandwidth or computational resources, often using multiple attack systems, aiming to slow down or disable the targeted system. Detecting and mitigating DDoS attacks effectively remains challenging due to their varying characteristics. One of the promising approaches involves developing an AI based Intrusion Detection System (IDS) against cyberattacks. In this study, we aim to develop an AI based Intrusion Detection System (IDS) for DDoS threat detection using Machine Learning, Deep Learning, or hybrid techniques. Different Machine Learning (ML) and Deep Learning (DL) algorithms like Random Forest (RF), Naïve Bayes (NB), …

Development Of A Mechanical Boot For Prevention Of Deep Vein Thrombosis In Outpatients, Julian David Trevino

Theses and Dissertations

This work presents the development of a mechanical boot designed to prevent Deep Vein Thrombosis (DVT) in high-risk individuals such as those who have just had major procedures. DVT is a serious condition characterized by the formation of blood clots in the deep veins, particularly of the lower limbs, which can lead to life-threatening complications if not adequately addressed. The mechanical boot utilizes the principle of Continuous Passive Motion (CPM) to facilitate blood flow in the lower extremities, thereby mitigating the risk of clot formation. Through a combination of mechanical engineering, biomedical research, and user centered design, the project outlines …

Psychosocial Impact Of Assistive Technology On Veterans With Disabilities In Higher Education, Maricela Rosales

Theses and Dissertations

The purpose of this dissertation study was to examine the psychosocial impact of assistive technology (AT) on veterans with disabilities in higher education. A current problem is that there is a research and knowledge gap in the AT needs of student veterans with disabilities living in South Texas, as well as in the psychosocial impact that AT for everyday life activities has on the quality of life of student veterans with disabilities who live with functional limitations. Descriptive and inferential statistics were used to examine the psychosocial impact variables with participants from higher education institutions via online and in-person surveys. …

Licensed Professional Counselors In Texas: The Role Of Stigma In Seeking Counseling Services, Raquel C. Vasquez

Theses and Dissertations

The literature on stigma has revealed this attribute as a deterrent to seeking mental health services. This study encompassed an investigation of the impact of self-stigma and public stigma on the intentions to seek mental health services of Texas Licensed Professional Counselors. A survey was sent via email, social media platforms associated with Licensed Professional Counselors, and snowball sampling to recruit participants. The participants (N = 99) completed self-report measures about self-stigma, public stigma, social desirability characteristics, and attitudes towards seeking mental health help. The results indicated that neither self-stigma nor public stigma was a deterrent to seeking mental health …

Building Sevices Engineering July/August 2024

Building Services Engineering

No abstract provided.

The Combined Effect Of Weisella Cibaria And Fusarium Oxysporum Nanoparticles On Cervical Cancer Cells, Yusra Mb. Muhsin, Huda Zuheir Majeed, Ali Murtatha Hasan, Sundus Qasim Mohammed, Nadia Zuhair Jassim

Baghdad Science Journal

The predicted global cancer burden is expected to surpass 20 million new cancer cases by 2025. Despite recent advancements in tumor therapy, successful cancer treatment remains challenging. The emerging field of nanotechnology offers great opportunities for diagnosis, imaging, as well as treatment of cancer. The biosynthesis of silver nanoparticles by fungi is an ecologically clean and nontoxic method compared to other physical and chemical methods. The purpose of this study is to determine the Synergistic Effect of Combination Nanoparticles Synthesized from Fusarium oxysporum with Weisella cibaria against cervical cancer cells. The study has done from 2022 to March 2023 in …

Inhibition Of Biofilm Formation In Agrobacterium Tumefaciens By Cell-Free Supernatants Of Pseudomonas Aeruginosa Analyzed By Gc-Ms, Najwa Ibrahim Khaleel Al-Barhawee, Sarah Salih Al-Rubyee

Baghdad Science Journal

One of the most economically significant plant pathogenic bacteria is Agrobacterium tumefaciens, infects plants by exploiting biofilms it forms on their surfaces wounds. This article has been concerned with the need for new antibacterial agents due to the limitations of current treatments. The capacity of Pseudomonas aeruginosa cell-free supernatant to inhibit the A. tumefaciens-produced biofilms as well as its chemical makeup were examined in this work. Using the API 20E kit and polymerase chain reaction of the 16S rRNA gene, P. aeruginosa was isolated from the soil and identified. It displayed a 93% identity with the common bacterium Pseudomonas sp.SeaQual …

July 2024 News, Office Of Sustainability

Office of Sustainability Newsletter

No abstract provided.

Reaching An Aim Differently? Corporate Social Responsibility Regulation In Australia And India, Mia Mahmudur Rahim, Mohammad Abu Sayeed

Cardozo International & Comparative Law Review

Businesses incorporate corporate social responsibility principles mainly through voluntary and mandatory approaches. Advocates of the voluntary approach believe that companies can use charitable initiatives as a management tool to meet social and environmental expectations and that mandating Corporate Social Responsibility ("CSR") would not encourage companies to prioritize anything beyond profits. Opponents argue that without legal requirements to drive social responsibility, relying on companies to self-regulate would not effectively integrate social values into corporate behaviors. Instead, they suggest that legal regulation of CSR can offer a more effective strategy. This Article examines the limitations ofthese two approaches by analyzing Australia, which …

The Impact Of Teachers' Emotional Labor On Teachers And Students: A Literature Review, Jingjing Yu

Educational Theory and Practice Faculty Scholarship

Abstract: Emotional labor (EL) is a significant component of teachers' daily work. Duringtheir daily teaching activities, teachers experience various emotional responses. However,they do not always express their genuine emotions, but rather adopt different strategies toregulate their feelings. This process is referred to as emotional labor. Previous studies onteachers' EL have typically focused on a single aspect concerning either teachers or students.Therefore, this study synthesizes the effects of various EL strategies on both the cognitiveand emotional well-being of teachers, as well as on students' academic and emotionaldevelopment. By reviewing prior research on teachers' EL, we summarize the impact of ELon both …

Black Radio’S Contribution To Collective And Cultural Memory: Personnel Perspectives Of Black Radio History In The United States, Kim Fox

Faculty Journal Articles

This interdisciplinary research investigates the significance of the community connection between Black radio personnel and their audiences through the lens of collective and cultural memory narratives. The study addresses two key research questions. First, how do Black radio personnel’s collective and cultural memories contribute to the Black public sphere? Second, what are the defining characteristics in developing parasocial relationships and interactions between Black radio personalities and their audiences? The qualitative research employs an autoethnographic methodology and a questionnaire, utilizing insights gained from the author’s experiences working at a Black-owned radio network and station. The questionnaire, distributed to key informants in …

Ceramide-Mediated Orchestration Of Oxidative Stress Response Through Filopodia-Derived Small Extracellular Vesicles, Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El-Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana N. Nikolova‑Karakashian, Erhard Bieberich

Markey Cancer Center Faculty Publications

Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H 2 O 2 in Hela cells stimulated filopodia formation and the secretion of EVs. EVs were small (150 nm) and labeled for CD44, indicating that they were derived from filopodia. Filopodia-derived small EVs (sEVs) were enriched with the sphingolipid ceramide, consistent with increased ceramide in the plasma membrane of filopo- dia. Ceramide was colocalized with neutral sphingomyelinase 2 (nSMase2) and acid sphingomyelinase (ASM), two sphingomyelinases generating ceramide at the plasma membrane. Inhibition of …

Soxb1 Transcription Factors Are Essential For Initiating And Maintaining Neural Plate Border Gene Expression, Elizabeth Schock, Joshua R. York, Austin P. Li, Ashlyn Y. Tu, Carole Labonne

Markey Cancer Center Faculty Publications

SoxB1 transcription factors (Sox2/3) are well known for their role in early neural fate specification in the embryo, but little is known about functional roles for SoxB1 factors in non-neural ectodermal cell types, such as the neural plate border (NPB). Using Xenopus laevis, we set out to determine whether SoxB1 transcription factors have a regulatory function in NPB formation. Here, we show that SoxB1 factors are necessary for NPB formation, and that prolonged SoxB1 factor activity blocks the transition from a NPB to a neural crest state. Using ChIP-seq, we demonstrate that Sox3 is enriched upstream of NPB genes in …

14-3-3Ζ Suppresses Rankl Signaling By Destabilizing Traf6, R. Ayyasamy, S. Fan, P. Czernik, B. Lecka-Czernik, Somsubhra Chattopadhyay, R. Chakravarti

Markey Cancer Center Faculty Publications

Macrophages are essential regulators of inflammation and bone loss. Receptor activator of nuclear factor-κβ ligand (RANKL), a pro-inflammatory cytokine, is responsible for macrophage differentiation to osteoclasts and bone loss. We recently showed that 14-3-3ζ-knockout (Ywhaz^KO) rats exhibit increased bone loss in the inflammatory arthritis model. 14-3-3ζ is a cytosolic adaptor protein that actively participates in many signaling transductions. However, the role of 14-3-3ζ in RANKL signaling or bone remodeling is unknown. We investigated how 14-3-3ζ affects osteoclast activity by evaluating its role in RANKL signaling. We utilized 14-3-3ζ-deficient primary bone marrow–derived macrophages obtained from wildtype and Ywhaz^{KO …}

Discussions Of Cancer Survivorship Care Needs: Are There Rural Versus Urban Inequities?, Tyrone F. Borders, Lindsey R. Hammerslag

Markey Cancer Center Faculty Publications

Background: Rural cancer survivors may face greater challenges receiving survivorship care than urban cancer survivors.

Purpose: To test for rural versus urban inequities and identify other correlates of discussions about cancer survivorship care with healthcare professionals.

Methods: Data are from the 2017 Medical Expenditure Panel Survey (MEPS), which included a cancer survivorship supplement. Adult survivors were asked if they discussed with a healthcare professional 5 components of survivorship care: need for follow-up services, lifestyle/health recommendations, emotional/social needs, long-term side effects, and a summary of treatments received. The Behavioral Model of Health Services guided the inclusion of predisposing, enabling, and need …

Diffuse Reflectance Spectroscopy For Optical Characterizations Of Orthotopic Head And Neck Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu

Markey Cancer Center Faculty Publications

We demonstrated an easy-to-build, portable diffuse reflectance spectroscopy device along with a Monte Carlo inverse model to quantify tissue absorption and scattering-based parameters of orthotopic head and neck cancer models in vivo. Both tissue-mimicking phantom studies and animal studies were conducted to verify the optical spectroscopy system and Monte Carlo inverse model for the accurate extraction of tissue optical properties. For the first time, we reported the tissue absorption and scattering coefficients of mouse normal tongue tissues and tongue tumor tissues. Our in vivo animal studies showed reduced total hemoglobin concentration, lower tissue vascular oxygen saturation, and increased tissue scattering …

A Probabilistic Approach To Estimate The Temporal Order Of Pathway Mutations Accounting For Intra-Tumor Heterogeneity, Menghan Wang, Yanqi Xie, Jinpeng Liu, Austin Li, Li Chen, Arnold Stromberg, Susanne Arnold, Chunming Liu, Chi Wang

Markey Cancer Center Faculty Publications

The development of cancer involves the accumulation of somatic mutations in several essential biological pathways. Delineating the temporal order of pathway mutations during tumori- genesis is crucial for comprehending the biological mechanisms underlying cancer development and identifying potential targets for therapeutic intervention. Several computational and statistical methods have been introduced for estimating the order of somatic mutations based on mutation profile data from a cohort of patients. However, one major issue of current methods is that they do not take into account intra-tumor heterogeneity (ITH), which limits their ability to accurately discern the order of pathway mutations. To address this …

Response To Replication Stress And Maintenance Of Genome Stability By Wrn, The Werner Syndrome Protein, David K. Orren, Amrita Machwe

Markey Cancer Center Faculty Publications

Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. WS is a segmental progeroid disease and shows early onset or increased frequency of many characteristics of normal aging. WRN possesses helicase, annealing, strand exchange, and exonuclease activities and acts on a variety of DNA substrates, even complex replication and re- combination intermediates. Here, we review the genetics, biochemistry, and probably physiological functions of the WRN protein. Although its precise role is unclear, evidence suggests WRN plays a role in pathways that respond to replication stress and maintain genome stability particularly in telomeric regions.