Digital Commons Network^™

Transdermal Oestradiol And Exercise In Androgen Deprivation Therapy (Estracise): Protocol, Ilkka Jussila, Juha P. Ahtiainen, Eija K. Laakkonen, Aino Siltari, Antti Kaipia, Tiina Jokela, Minta Kärkkäinen, Rob Newton, Truls Raastad, Heini Huhtala, Teemu J. Murtola, Heikki Seikkula

Research outputs 2022 to 2026

Objective: To report the protocol of a study evaluating the efficacy of transdermal oestradiol (E2) gel in reducing the adverse effects of androgen deprivation therapy (ADT), specifically on sexual function, and to assess the utility of E2 in combination with supervised exercise. Study Design and Methods: The primary endpoint of this open-label Phase IIA randomized controlled trial is the efficacy of transdermal E2 gel. Secondary endpoints include: (i) the occurrence of ADT-induced adverse effects; (ii) the safety and tolerability of E2; (iii) the impact of E2 with or without exercise on physical, physiological, muscle, and systemic biomarkers; and (iv) quality …

Entrypoints For Integrating Computing And Tech Into Teacher Education: Addressing Problems And Opportunities With The Encite Framework, Sara E. Vogel, Aman Yadav, David Phelps, Aankit Patel

Publications and Research

To coherently integrate computing and digital technology into teacher education, stakeholders at teacher preparation institutions must grapple with a complex landscape of problems and opportunities. This paper’s literature review maps that landscape into problems and opportunities that are (1) technological, (2) pedagogical, definitional / (3) ideological, (4) political, and (5) developmental in nature. While existing frameworks respond to particular aspects of these areas (e.g. the popular TPACK framework zooms in on technological and pedagogical questions), stakeholders engaged in curricular planning must think more holistically about how to prepare future teachers. We share EnCITE (Entrypoints to Computing Integrated Teacher Education), a …

Examining Enrollment & Engagement In A Hospital-Based Violence Prevention Intervention Study At A Level 1 Trauma Center, Leigh Frederick

Electronic Theses and Dissertations

BACKGROUND: Violence is a significant healthcare issue that affects the health and well-being of individuals, families, and communities. Violence prevention and intervention programs are a powerful way to stop the revolving door of violent injury in our hospitals and communities. The Health Alliance for Violence Intervention (HAVI), develops and connects violence intervention programs, promotes equity for victims of violence globally, and is dedicated to engaging patients during the window of opportunity when they are recovering in the hospital after a violent injury to reduce the chance of retaliation (related to the injury) and recurrence. A small body of research shows …

Editor-In-Chief’S Forward, Zoë Grimaldi

UC Law Constitutional Quarterly

No abstract provided.

“It’S Not Ok To Not Be Ok”: Suicide, California’S Lanterman-Petris-Short Act, And The Constitution, Christina Strohmann

UC Law Constitutional Quarterly

Individuals who commit suicide are not incompetent or even making an irrational decision. Yet state laws, such as the Lanterman-Petris-Short Act in California, continue to allow mental health professionals to lock up suicidal patients in psychiatric facilities against the patient’s will. These commitments, however, are not always beneficial, and in many instances are detrimental to both the patient and the mental health professional. Patients can be traumatized from the experience, feel more suicidal from lack of hope and feelings of betrayal. Mental health professionals cannot effectively treat suicidal patients when providers are fearful of liability or when their patients refuse …

The Greenbook, Faculty Handbook, 2024-2025, Marshall University Academic Affairs

The Greenbook

This book has been published for the faculty of Marshall University for the specified period of time. This book was created by Academic Affairs and is for the period of 2024-2025.

Evaluating A Precision Sprayer For Detecting Weeds And Spraying Herbicides In Real Time (Spot Spray) For Weed Management In Corn And Soybean, Adam Eric Leise

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Herbicide sprayers are becoming larger and more efficient in applications in crop fields. A precise and efficient herbicide application is advantageous in effective weed control. New precision sprayers were introduced in hopes of reducing the amount of herbicide applied. Greeneye Technology and John Deere have developed precision sprayers for the detection of weeds in crop fields, which come equipped with a dual tank system that allows for two different herbicides to be separated from tank to tip. The objectives of this study were to evaluate the broadleaf and grass weed control efficacy of spot spray (SS) technology when applied in …

Triticale As A Source Of Resistance To Wheat Streak Mosaic Virus And Triticum Mosaic Virus, Marcos Winicius Goncalves De Souza

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Wheat streak mosaic virus (WSMV) and Triticum mosaic virus (TriMV) present a great threat to wheat production in the Great Plains area of the United States due to the loss of photosynthetic area causing reductions in crop yields. Effective control of these viruses is limited to a few available strategies including controlling volunteer wheat and using currently identified resistant genes to both the vector and viruses. While effective, these genes show temperature sensitivity and yield drag, and evidence that the vectors and viruses can overcome them has been found. Thus, new methods of genetic resistance are urgently needed. Field observations …

Tech Note 2024-1 A Novel Framework To Estimate Social And Private Value Created Through Commercialization Of A Pharmaceutical Product, Paula Chaves De Silva, Fred D. Ledley

CISI Publication

This framework posits that the value created by a new medicine is embodied in the total health value (health benefit) provided to those using the products. This value is then distributed between social value and private value by the price paid for the product and how these revenues are expensed for different purposes. In this framework, the social value created includes the residual health value (net price paid) along with the scientific value, jobs creation, and social payments to public sector organizations. The private value created includes shareholder value (change in market capitalization plus cash distributions to shareholders) as well …

Analysis Of Policy Implementation: Improving Reading Proficiency Outcomes For All Students, Mariela Magro-Malo

Education Theses and Dissertations

This dissertation investigates the implementation and impact of reading improvement initiatives mandated by Texas House Bill 3 (2019) within a Texas school district. By applying improvement science principles, the study employs a mixed-methods embedded research design to evaluate the alignment of district practices with the Science of Reading and assess the effectiveness of systemic approaches in enhancing student reading outcomes. The research identifies statistically significant improvements in reading achievement, particularly in kindergarten, following the adoption of a phonics curriculum and mandated reading assessment tools. However, the findings also reveal challenges, notably the disconnect between policy understanding and practical implementation among …

Green Public Procurement: How To Fulfill The Promise Of Decarbonizing The Hard-To-Abate Sectors, Laura Garcia Cancino, Perrine Toledano, Ingrid Zhou

Columbia Center on Sustainable Investment

Public procurement represents a significant segment of the global economy, accounting for approximately 12% of the global GDP, according to a World Bank's 2020 report. Moreover, steel and cement are among the most carbon-intensive commodities, contributing about 14-16% of global energy-related CO2 emissions. Our latest publication under the COMET initiative, Green Public Procurement: How to Fulfill the Promise of Decarbonizing the Hard-to-Abate Sectors, analyzes Green Public Procurement (GPP) and its pivotal role in decarbonizing hard-to-abate sectors like steel manufacturing.

This comprehensive study delves into how governments can use their extensive purchasing power to shift market dynamics towards low-carbon alternatives, effectively …

Climate Impact Screening And Reporting: A Venture Capital Perspective, Ajay S. Jagdish, Perrine Toledano, Ana M. Camelo Vega

Columbia Center on Sustainable Investment

According to the International Energy Agency’s (IEA) Net-Zero Scenario, about one-third of the emissions reductions needed by 2050 depend on technologies that are currently in development. Additionally, climate adaptation finance faces an even larger investment gap.

The Climate Venture Capital community must demonstrate tangible climate impact to truly earn its reputation.

However, accurately and reliably screening, evaluating, and monitoring climate impact is challenging, with many metrics and methods still needing to be ascertained, clarified, and standardized.

With the support of Princeville Capital, CCSI offers insights into unresolved issues:

1. Attribution and baselining
2. Paris-aligned thresholds for prioritization
3. Indirect impact and tailored KPIs …

Empirical Tests Of The Existence Of Industry Momentum On The Indonesian Stock Exchange, Irene Natalia Verda

The Indonesian Capital Market Review

Momentum is one of strategy to generate return for profit seeker. This research was conducted to see the existence of momentum strategy at the industry level with the object of all stocks on the Indonesia Stock Exchange consists of 880 stocks grouped into 11 industries based on ICB (Industry Classifi- cation Benchmark). Research period start in July 2014 until December 2023. There are 6 industry momentum strategies, 3 strategies to form portfolio quarterly and 3 strategies to form portfolio in each semester. Tests are conducted on mean returns and risk-adjusted returns using the Fama-French Three Factor model. The method of …

An Examination Of Educators’ Approaches And Strategies When Facilitating Field Study Science Observations, Steph Dean, Devin A. Jones

Publications

The untapped potential of field study science is not being fully recognized or explored within the United States despite the recorded benefits of outdoor learning within K-12 settings. This research study contributes to the broader understanding of the affordances of field study science as an essential component of science education by investigating the approaches teachers adopt when facilitating scientific observations in an outdoor setting as well as specific strategies that support implementation. Engaging in qualitative content analysis allowed us to consider the descriptive concepts represented within K-12 teachers’ narratives as we determined patterns within the transcript documents. Seven themes were …

Looking For Full Text Access At The Tmc Library?, Joanne Romano

TMC Library Newsletter (2015-)

The TMC Library provides access to over 70,000 online journals, over a million ebooks and over 300 databases. Need help accessing full text articles and ebook chapters?

Need more help? Please click the Ask A Librarian button to the right.

Examining Internesting Habitat Use Of Northwest Atlantic Leatherback Sea Turtles (Dermochelys Coriacea), Christina I. Mauney

Capstone Projects and Master's Theses

Understanding the spatial ecology of highly migratory marine animals is essential for effective conservation strategies, particularly in the face of climate change and increasing anthropogenic pressures. This study investigates the nesting characteristics, habitat use, and behavior of leatherback sea turtles (Dermochelys coriacea) in the Northwest Atlantic population nesting at Sandy Point National Wildlife Refuge (SPNWR) in St. Croix, US Virgin Islands.

Ten female leatherbacks were studied during the internesting interval of the 2020 and 2021 nesting seasons. The study’s objectives were to examine leatherback nesting characteristics, delineate critical internesting habitats, and characterize behaviors during the internesting interval. Data collection included …

Can Nutrition Education Reduce Division Iii Female Athlete's Risk Of Developing Low Energy Availability, Coby Stover

Masters Theses/Capstone Projects

Context: Low Energy availability (LEA) is widely acknowledged as a state in which an individual does not have sufficient energy to support normal functions within the body after energy has been expended through exercise. In sports environments, athletes can exhibit LEA for a variety of reasons. These reasons range from improper food intake to effectively fuel and re-fuel their body for the energy demands of their specific sport, to eating disorders (ED) and eating disorder behaviors. Access to appropriate nutrition knowledge is also a major factor that can place athletes at risk for developing LEA. Both males and females …

Report On Findings From Household Needs Study, Paulin T. Straughan, Mathew Mathews

ROSA Research Briefs

The Household Needs Study (HNS) aimed to capture public perspectives on essential items and activities that are deemed necessary for a normal life in Singapore and to understand the extent to which Singaporeans are able to access these items and activities. To do so, the study adopted the Living Standards Approach (Saunders, Naidoo & Wong, 2022), which purports that individuals experience relative deprivation and/or social exclusion if they do not have access to items and activities that are deemed to be essential by society. In this study, a survey was conducted with a nationally representative sample of around 4,000 respondents …

Development Of The Paediatric Society Of The African League Against Rheumatism (Paflar) Jia Registry And Clinical Profile Of Jia In Africa From The Paflar Jia Registry, Angela Migowa, Wafa Hamdi, Soad Hashad, Hala Etayari, Awatif Abushhaiwia, Hanene Ferjani, Dorra Nessib, Lobna Kharrat, Rachel Odhiambo, James Orwa

Paediatrics and Child Health, East Africa

No abstract provided.

Incorporating Human Movement Variability In Bimanual Multifrequency Coordination, Marilena Kalaitzi Manifrenti

Theses, Dissertations, and Student Creative Activity

Coordination is the organization of a system’s components to achieve collective behavior, whether within an individual or across systems. Coordination may be either monofrequency, the systems oscillating at the same frequency (e.g. 1:1), or multifrequency, the systems oscillating at unique frequencies (e.g. 1:3). Multifrequency coordination is typically described by the sine circle map (SCM); however, several limitations arise when describing human movement. Healthy young adults' movements exhibit Pink noise, a pattern in the timing of their actions that enables them to adapt flexibly to environmental changes by resulting in well-coordinated behavioral adjustments. The SCM fails to capture the natural variability …

Contribution Of Dentoalveolar Heights On Facial Heights In Class I And Class Ii Untreated Subjects, Mira Bharat Suvagia

Master's Theses (2009 -)

Objective: This research aims to investigate the impact of dentoalveolar heights on craniofacial growth and the development of Class I and Class II malocclusions in untreated subjects aged 6-18 years. The study seeks to establish relationships between dentoalveolar heights and anterior and posterior facial heights. The findings contribute to understanding the dynamic interplay between dentoalveolar growth, mandibular rotation, and facial height establishment, shedding light on critical aspects of craniofacial development. Materials and Methods: The study draws upon cephalograms from the University of Michigan Growth Study, encompassing untreated Class I and Class II subjects aged 6-18 years. A subsample of 408 …

The Validation Of Remote-Synchronous And Remote-Asynchronous Physical Performance-Based Outcome Measurements, Kieran James Mullen

Master's Theses (2009 -)

Performance-based outcome measures are used by clinical and research communities to identify health risks, assess change in physical function over time, and assess the success of treatment. With the onset of COVID-19, remote assessments were sought as alternatives to in-person testing, however there is inadequate literature on the validity of remote performance-based outcome measurement to assess physical function. Current literature is limited to small cohort studies, and none take advantage of novel comparison of agreement methodology. This study assessed the level of agreement between three methods of performance-based outcome data collection: in-person data collection, remote synchronous data collection, and remote …

Missing History Of A Modern Domesticate: Historical Demographics And Genetic Diversity In Farm-Bred Red Fox Populations, Halie M. Rando, Emmarie P. Alexander, Sophie Preckler-Quisquater, Cate B. Quinn, Jeremy T. Stutchman, Jennifer L. Johnson, Estelle R. Bastounes, Beata Horecka, Kristina L. Black, Michael P. Robson, Darya V. Shepeleva, Yury E. Herbeck, Anastasiya V. Kharlamova, Lyudmila N. Trut, Jonathan N. Pauli, Benjamin N. Sacks, Anna V. Kukekova

Computer Science: Faculty Publications

The first record of captive-bred red foxes (Vulpes vulpes) dates to 1896 when a breeding enterprise emerged in the provinces of Atlantic Canada. Because its domestication happened during recent history, the red fox offers a unique opportunity to examine the genetic diversity of an emerging domesticated species in the context of documented historical and economic influences. In particular, the historical record suggests that North American and Eurasian farm-bred populations likely experienced different demographic trajectories. Here, we focus on the likely impacts of founder effects and genetic drift given historical trends in fox farming on North American and Eurasian farms. A …

Wooster Magazine: Summer 2024, Caitlin Paynich Stanowick

Wooster Magazine: 2021-2030

In the summer 2024 issue of Wooster magazine students and alumni share what inspired their capstone scholarship at Wooster and where it led them. The Class of 2024 drew from their own interests to design scholarly research and creative expression unique to them; students featured include Athena Tharenos, Levi Gainer, Briana Mosley, Corey Knauf, and Tyara Thompson. For some students, I.S. uncovers a wonder and eagerness to further their study in the area. This issue also shares the stories of alumni who built upon the foundation of their I.S. for ongoing research, professional work, and everyday inspiration including John Trainor …

Enacting Data Context: Fixing Meaning In Transparency Data Initiatives, Lindsay Poirier

Statistical and Data Sciences: Faculty Publications

This article documents the “context cultures” underpinning efforts to develop regulations for collecting and reporting data in a United States public database known as Open Payments. Open Payments is a dataset published annually by the US Center for Medicare and Medicaid Services that documents the transfers of value from pharmaceutical and medical device manufacturers to physicians, prescribing non-physicians, and teaching hospitals. In the article, I show context became a manifold concern as differentially-situated actors engaged in modes of public advocacy and social action around not only what data meant, but also what it meant to make data meaningful. I show …

Decentralized Clinical Trials For Medications To Reduce The Risk Of Dementia: Consensus Report And Guidance, Leanne Howard, Carla Abdelnour, Erin Abner, Ricardo F. Allegri, Hiroko H. Dodge, Serge Gauthier, Camilla M. Hoyos, Gregory Jicha, Patrick G. Kehoe, Catherine J. Mummery, Adesola Ogunniyi, Nikolaos Scarmeas, Xiaoying Chen, Jodie R. Titiner, Christopher R. Weber, Ruth Peters

Neurology Faculty Publications

INTRODUCTION: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication trials, but we currently lack specific recommendations for their delivery in the dementia field.

METHODS: A modified Delphi method engaged an expert panel to develop recommendations for the conduct of decentralized medication trials in dementia prevention. A working group of researchers and clinicians with expertise in dementia trials further refined the recommendations.

RESULTS: Overall, the recommendations support the delivery of decentralized trials in dementia prevention …

Type-2 Diabetes, Pancreatic Amylin, And Neuronal Metabolic Remodeling In Alzheimer's Disease, Noah Leibold, James R. Bain, Florin Despa

Neurology Faculty Publications

Type-2 diabetes raises the risk for Alzheimer’s disease (AD)-type dementia and the conversion from mild cognitive impairment to dementia, yet mechanisms connecting type-2 diabetes to AD remain largely unknown. Amylin, a pancreatic 𝜷-cell hormone co-secreted with insulin, participates in the central regulation of satiation, but also forms pancreatic amyloid in persons with type-2 diabetes and synergistically interacts with brain amyloid 𝜷 (A𝜷) pathology, in both sporadic and familial Alzheimer’s disease (AD). Growing evidence from studies of tumor growth, together with early observations in skeletal muscle, indicates amylin as a potential trigger of cellular metabolic reprogramming. Because the blood, cerebrospinal fluid, …

A Mini-Review Of Strategies For Recruiting Older African Americans To Alzheimer's Disease Research., Darlingtina Esiaka, Christina C Yarborough, Bernadette A Fausto, Mark A Gluck

Behavioral Science Faculty Publications

African Americans experience higher incidence and prevalence of Alzheimer's disease (AD). Yet, they continue to be underrepresented in AD research, limiting the ability to generalize findings to the increasingly diverse US population. To reduce AD disparities, targeted efforts are needed to increase the representation of African Americans in AD research. This mini review identified evidence-based strategies that increased research participation among older African Americans. Four recruitment strategies emerged from eight published peer-reviewed studies that directly evaluated the effectiveness of strategies aimed at increasing the number of African American participants in Alzheimer's research. The strategies include community outreach and education, face-to-face …

Extended-Release 7-Day Injectable Buprenorphine For Patients With Minimal To Mild Opioid Withdrawal., Gail D'Onofrio, Andrew A. Herring, Jeanmarie Perrone, Kathryn Hawk, Elizabeth A. Samuels, Ethan Cowan, Erik Anderson, Ryan Mccormack, Kristen Huntley, Patricia Owens, Shara Martel, Mark Schactman, Michelle R. Lofwall, Sharon L. Walsh, James Dziura, David A. Fiellin

Behavioral Science Faculty Publications

IMPORTANCE: Buprenorphine is an effective yet underused treatment for opioid use disorder (OUD).

OBJECTIVE: To evaluate the feasibility (acceptability, tolerability, and safety) of 7-day injectable extended-release buprenorphine in patients with minimal to mild opioid withdrawal.

DESIGN, SETTING, AND PARTICIPANTS: This nonrandomized trial comprising 4 emergency departments in the Northeast, mid-Atlantic, and Pacific geographic areas of the US included adults aged 18 years or older with moderate to severe OUD and Clinical Opiate Withdrawal Scale (COWS) scores less than 8 (minimal to mild), in which scores range from 0 to 7, with higher scores indicating increasing withdrawal. Exclusion criteria included methadone-positive …

A Pathologic Study Of Perivascular Ptdp-43 Lin Bodies In Late-Nc, Ryan K. Shahidehpour, Peter T. Nelson, Adam D. Bachstetter

Neurology Faculty Publications

Background TAR DNA-Binding Protein 43 (TDP-43) pathological inclusions are a distinctive feature in dozens of neurodegenerative pathologies, including limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC). Prior investigations identified vascular-associated TDP-43-positive micro-lesions, known as “Lin bodies,” located on or near the brain capillaries of some individuals with LATE-NC. This study aimed to investigate the relationship between the accumulation of Lin bodies and glial cells in LATE-NC and the potential co-localization with ferritin, a protein associated with iron storage. Using multiplexed immunohistochemistry and digital pathology tools, we conducted pathological analyses to investigate the relationship between Lin bodies and glial markers (GFAP for …